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Sat, 07 Jan 2017 10:28:00 -0600 en text/html https://www.cambridge.org/core/books/peacebuilding-puzzle/155E4450DEEE8533AADA45F659E6A0A6
Killexams : Analysis of Panel Data

A masterful new edition of Hsiao's classic text on panel data. This is a superbly comprehensive and accessible source for panel data with modern approaches to inference and identification, helpful to econometricians and other quantitative social scientists.

Esfandiar Maasoumi - Emery University

The latest edition of Cheng Hsiao's panel data monograph is most welcome to the econometrics profession. Benefitting from Professor Hsiao's deep understanding and insight, it has, since its first edition, not only become required memorizing for students, researchers and practitioners, but surely deserves no small credit for the huge growth of interest and activity in panel data. In this 4th edition, Professor Hsiao has very successfully built on the foundations of the earlier ones.

Peter M. Robinson - London School of Economics

Professor Hsiao has done it again. This edition provides a lucid and comprehensive account of often complex problems, ranging from the analysis of panel data models with interactive effects, heterogeneity, spatial dependence, simultaneous dynamic models, to program evaluation – many areas to which he himself has made significant and lasting contributions. I have learned a great deal from the past three editions, and I very much look forward to the fourth edition and strongly recommend it to both students and research scholars of panel data alike.

Hashem Pesaran - John Elliot University of Southern California

Cheng Hsiao's Analysis of Panel Data has undoubtedly become the classic text book reference on panel data econometric methods. It is to be recommended for the clarity and deepness of its exposition, its wide coverage of the abundant and rapidly developing specialized literature, and its remarkable capacity to focus on what is most essential in this literature.

Jacques Mairesse - Collège de France

Sun, 29 Aug 2021 07:51:00 -0500 en text/html https://www.cambridge.org/core/books/analysis-of-panel-data/C24D71CDE5844F602E3F43526E207C70
Killexams : The HER2 testing conundrum

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Allison, M. The HER2 testing conundrum. Nat Biotechnol 28, 117–119 (2010). https://doi.org/10.1038/nbt0210-117

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Killexams : Indiana Public Media News

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ask-the-mayor-nashville-zoning,-new-utility-board,-tree-trimming| ask-the-mayor-bloomingtons-hamilton-on-udo-zoning-changes,-hospital-site-redevelopment| ask-the-mayor-terre-hautes-bennett-on-vaccination-progress,-another-casino-delay| ask-the-mayor-columbus-lienhoop-on-new-vaccination-age-limit,-urban-grocer-development| nashvilles-municipal-consultant-dax-norton-on-tourist-boom-during-pandemic| ask-the-mayor-bloomingtons-hamilton-on-vaccine-availability,-seminary-park| ask-the-mayor-terre-hautes-bennett-on-insurrection,-vaccine-distribution| ask-the-mayor-columbus-lienhoop-on-vaccinations,-urban-grocer| ask-the-mayor-bloomingtons-hamilton-on-covid-vaccine,-city-park-overnight-camping| ask-the-mayor-terre-hautes-bennett-on-contracting-covid-19,-restrictions| ask-the-mayor-columbus-lienhoop-on-covid-hospital-spike,-downtown-development| ask-the-mayor-bloomingtons-hamilton-on-covid-spike,-election| ask-the-mayor-bloomingtons-hamilton-on-long-early-voting-lines,-covid-case-increases| ask-the-mayor-terre-hautes-bennett-on-coronavirus-spike,-holiday-events| ask-the-mayor-columbus-lienhoop-on-early-voting,-overpass-opening,-halloween| Ask The Mayor Bloomingtons Hamilton On Convention Center, Housing| )

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April 21, 2021

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Ask The Mayor: Bloomington's Hamilton On COVID Metrics, Upzoning, And Your Questions

The mayor addresses COVID metrics, uptick in cases, Rescue Plan funding, herd immunity, senior citizen parking downtown, UDO zoning, IU's new president, and more.

Fri, 05 Aug 2022 12:00:00 -0500 en text/html https://indianapublicmedia.org/news/topics/ask-the-mayor.php
Killexams : How to Upgrade NetBeans

Casey Anderson is a part-time writer and full-time marketer who has been published on websites such as Opposing Views and Salon. She has also contributed articles to local Detroit Magazines, Strut and Orbit. A Wayne State University Master of Business Administration graduate, Nation began her writing career in 2001 and has extensive experience in business and research writing.

Mon, 17 Aug 2020 01:01:00 -0500 en-US text/html https://smallbusiness.chron.com/upgrade-netbeans-47523.html
Killexams : How to Update Microsoft Works

Casey Anderson is a part-time writer and full-time marketer who has been published on websites such as Opposing Views and Salon. She has also contributed articles to local Detroit Magazines, Strut and Orbit. A Wayne State University Master of Business Administration graduate, Nation began her writing career in 2001 and has extensive experience in business and research writing.

Mon, 23 Jul 2018 21:52:00 -0500 en-US text/html https://smallbusiness.chron.com/update-microsoft-works-51783.html
Killexams : Security Appliances Market is Anticipated to Reach $229.74 billion by 2030, Registering at a CAGR of 12.81% from 2021 to 2030

Advancements in industrial-grade digital technology, an increase in inclination toward cloud-based security appliances software, and a rise in need for improved supply chain and customer relationship management majorly contribute to the growth of the market. However, the lack of IT infrastructure in underdeveloped nations and the increase in security & privacy concerns hamper the growth of the security appliances market.

Major industry players such as – Cisco Systems, Inc., Check Point Software Technologies Ltd., Symantec Corporation, Intel Corporation, Fortinet, Inc., Palo Alto Networks, Inc., Bosch Sicherheitssysteme GmbH, Honeywell International Inc., Johnson Controls International plc. and Juniper Networks, Inc. 

The security appliances market size was valued at $69.18 billion in 2020, and is estimated to reach $229.74 billion by 2030, growing at a CAGR of 12.81% from 2021 to 2030.

Depending on the deployment model, the on-premise segment garnered the largest share in 2020, and is expected to continue this trend during the forecast period. This is attributed to numerous benefits provided by this on-premise deployment such as high level of data security and safety. On-premise deployment model enables installation of the software and permits applications to run on systems present in the premises of the organization, rather than at a distant facility such as server space or cloud. This model is appropriate for specific applications such as financial applications and health records with critical data that entail large data transfers and operations.  However, the cloud segment is expected to witness highest growth in the upcoming years. As cloud deployment does not need any investment in IT infrastructure as all data is stored on cloud server, which increases the demand for of security appliances software in small and medium scale organizations. Cloud-based deployment is an application licensing and delivery model, where a vendor or a service provider hosts applications remotely. This deployment model provides the IT team with a greater prospect to facilitate real business value to the organization through lower expected cost and an improved ability to focus on innovation and differentiation.

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On the basis of type, the content management segment dominated the overall security appliances industry in 2020 and is expected to continue this trend throughout the forecast period. Increased markets for cloud-based and cross-platform solutions have created opportunities for market expansion. In addition, integration with parallel products such as customer relationship management, analytics-driven content management, and cross-channel integration are some of the trends that have enhanced the adoption of content management among end-user industries. However, the unified threat management (UTM) segment is expected to witness the highest growth, and this trend is expected to continue during the forecast period. UTM is a solution that allows organizations and IT personnel to monitor and manage a wide variety of security-related applications and components, making them available to users in a secure manner. The development of such solutions that fulfill the impending need to secure an employee’s personal data at the workplace is expected to supplement the growth of UTM. The facility to prevent accidental and malicious data breaches by scanning text and common files is projected to boost market growth. The functionalities offered by UTM such as reduced network complexity and single-point and single-window administration for all security functions are anticipated to further facilitate the growth of the UTM market.

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As per Security Appliances Market Analysis. The COVID-19 outbreak had a positive impact on the growth of the security appliances market as the new technologies are helping enterprises to address the extensive capacity demand of security appliances even after the restrictions imposed by the governments and remote working. The outbreak of COVID-19 has affected communities globally while governments and companies are trying their best to respond faster to the challenges posed by this pandemic. However, from the first quarter of 2020, the COVID-19 pandemic created an unbalanced health situation, with stringent restrictions to maintain social distancing and lockdown implemented across the world. Thus, with a major aim to contain this pandemic, the majority of the economies have enforced a complete shutdown, thereby leading to decline in business operations. Sectors such as manufacturing and transportation have been severely impacted, worsening the business scenario and resulting in colossal monetary and employment losses. However, this pandemic has elevated the growth of the security appliances market and is expected to exhibit an increase during the forecast period.

Latest news and industry developments in terms of market expansions, acquisitions, growth strategies, joint ventures and collaborations, product launches, market expansions etc. are included in the report.

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Killexams : Little-Known Ways to Save Hundreds Year-Round With Your Student ID

Hey, we all like free things from time to time. But for college students living on part-time wages and handouts from Mom and Dad, free is a way of life. The lure of free food brings many teenagers to events they wouldn’t typically attend, and the endless supply of free T-shirts is half the fun of arriving at school during orientation week.

Good news: The free or discounted services you can receive as a student don’t end on campus. By showing your student ID or providing a university e-mail address, you can save money on everything from laptops to museum tickets.

And if you’ve graduated, don’t assume that you can’t still receive discounts. Taking even one course at a community college will grant you student status.

Score deals in these 18 categories and more:

Everything. With the Amazon Student program, your university e-mail address gets you free two-day shipping on eligible items from Amazon’s vast selection, unlimited digital photo storage and exclusive offers for students during a free six-month trial. After the trial is up, you can upgrade to Amazon Student Prime for 50% off.

For your bulk purchases, try Sam’s Club. If you pay $40 for a yearlong college membership, you’ll receive a $15 gift card, as well as special savings on electronics, dorm-room essentials and more.

Clothes. Many clothing stores offer student discounts, which may be especially appealing to soon-to-be graduates assembling a wardrobe for job interviews, internships and their first full-time gigs. Club Monaco offers the best student discount we’ve found: 20% off full-price or sale items, online or in-store. Banana Republic and Ann Taylor offer a 15% discount on in-store, full-price purchases, and the 15% discount at J. Crew and Madewell applies to all in-store purchases. For stores with online-only discounts, look to Levi’s (15% off) or Topshop (10% off).

Computers. Apple offers varying discounts—as much as $100 in savings on the purchase of Mac computers and as much as $20 in savings on the purchase of an iPad. Microsoft offers 10% off or more in its Education Store, which sells products such as PCs, Surface tablets and Xboxes. At Best Buy, students save $100 on all MacBook Air and MacBook Pro computers, as well as $150 on select Microsoft Surface devices. Lenovo discounts laptops upward of 22%. HP encourages students to sign up for HP Academy, a program that includes up to 20% product discounts and free shipping.

Software. If you’re looking for software to load onto your new computer, you have several options. Many colleges offer their students free Microsoft Office 365 (check here to see if you’re eligible), which includes program installation on as many as five laptops or mobile devices. Microsoft's Visual Studio Community developer tool is free for all students. Those interested in graphic design will enjoy getting 60% off Adobe Creative Cloud, which includes programs such as Photoshop and InDesign. If you’re trying to learn a new language, try Rosetta Stone at a 10% discount. And save 50% on Norton software that will protect your computer from viruses.

Phone plans. To save on your monthly phone bill, check with your provider to see if you qualify for a student discount. Sprint and AT&T offer discounts to students at eligible schools. Sprint’s discount is typically between 10% and 23%, and AT&T’s is about 17%.

Food. Although most national chains don’t advertise their student discounts, some restaurants, such as Dairy Queen, deduct about 10% off your purchase. Check with your local franchises, as not all locations offer a discount.

Local restaurants may also have student discounts. Check online, or ask in person.

Movie tickets. With discounts that vary by location, student movie buffs can visit participating AMC theaters for a lower price every day after 4 p.m. Cinemark theaters also offer student discounts that vary by location.

Newspaper and magazine subscriptions. Student readers receive a discount on subscriptions to the New York Times, the Wall Street Journal and the Economist. You can also receive a free digital subscription to the Washington Post.

Music. Student music lovers can access Spotify Premium for 50% off per month.

Shows and events. Cities across the country have discounts on entertainment for students. In New York, students can save with $25 weekday tickets to the Metropolitan Opera or $29 day-of orchestra tickets to the American Ballet Theatre. Normally, these tickets cost more than $100, and sometimes closer to $200. For Broadway tickets and other performances in the area, try Student Rush, a website that offers up-to-date savings tips.

You can also find a variety of entertainment discounts in the nation’s capital. The Kennedy Center and Wolf Trap, two popular performance venues, sell tickets to students for 50% off.

The Houston Ballet sells $10 “rush” tickets to students 90 minutes before select performances, and the Memphis Symphony Orchestra offers $5 concert tickets to students. Check with your local venues to see what discounts they offer.

Museums. Big-city museums offer discounts, too. For example, New York City’s Metropolitan Museum of Art has $12 student tickets, and the American Museum of Natural History has $17 student tickets.

In D.C., the Newseum, a journalism museum, has a 10% ticket discount, and the Phillips Collection, an art gallery, offers student tickets for $10 Tuesday through Sunday.

Sporting events. If you’re a baseball fan, you can find discounted tickets to Major League games. Teams such as the Washington Nationals, the Boston Red Sox and the New York Yankees sell student tickets for as much as 50% off. If you can’t make it to a live game, you can subscribe to MLB.TV instead at a 35% discount.

Gym memberships. If you’re starting a new fitness regime to fight the effects of college dining hall food, try joining Gold’s Gym, which has a student membership discount at select locations, or Core Power Yoga, which offers specialty rates for students.

Travel. If you’re planning on studying or traveling abroad, consider buying an International Student ID card ($25). Cardholders earn discounts on services in 125,000 locations across 130 countries, including up to 60% off tickets to West End theater performances, 25% off a graffiti and street art walking tour in Brooklyn, and 50% off a subscription to the Financial Times. To keep track of discounts on the go, obtain the ISIC Benefits app.

For cheaper global travel arrangements, you can use Student Universe or STA Travel, two free websites with a variety of student rates on flights and hotels. Eurail, a European train service, offers a 35% discount on passes for anyone between 12 and 26.

For travel within the U.S., consider buying a Student Advantage card ($22.50). It gives you discounts on Greyhound tickets and Choice Hotel bookings, as well as breaks at an assortment of places unrelated to travel, such as Lenovo, AMC and Foot Locker. For those who prefer traveling by train, Amtrak offers a 15% discount. Students at certain New York schools, including Cornell University, Ithaca College and Vassar College, have access to Shortline bus tickets at discounts of 15%.

Cars. Being a student can even help you buy your own car. The GM College Discount Program allows students to purchase or lease vehicles at a reduced price—for example, you could save $2,297 off the MSRP on a 2016 Chevrolet Equinox.

Insurance. To protect your car, consider Allstate, State Farm or Geico insurance. All three offer discounts to full-time students with good grades, and the discounts are available even if the policy is under your parents’ names. Allstate also gives a 35% discount to students who attend college 100 or more miles away from where their car is garaged. State Farm offers a similar discount if a student uses his or her car only during school breaks.

Local food and entertainment. New York University offers specially priced tickets for events around the city (including Broadway shows), and the College of William & Mary provides students with free Collegiate Passes to historic sites in Colonial Williamsburg.

Students bearing a University of Michigan ID card have access to a whopping 400+ discounts on local products and services, ranging from scuba equipment to organic pizza. Rice University’s Hedgehopper program encourages local businesses to offer discounts that help students experience Houston. About 20 restaurants, boasting fare as varied as Turkish food and a “chocolate bar,” supply students 10% to 25% off, and several non-food businesses participate, too.

Savings websites. If you would like to hear about daily student deals, sign up for websites such as Save the Student, UNiDAYS and StudentRate. These sites inform members about discounts on everything from clothing to technology. You can also use non-student-focused websites such as RetailMeNot; simply search “student discounts.”

The best rule for finding student discounts is to ask. Look for deals at restaurants, clothing stores, museums and more. Even if a discount isn’t advertised by a business, one may be available.

Tue, 02 Aug 2022 12:00:00 -0500 en text/html https://www.kiplinger.com/article/college/t063-c011-s001-save-hundreds-year-round-with-your-student-id.html
Killexams : Vismodegib as First-Line Treatment of Mutated Sonic Hedgehog Pathway in Adult Medulloblastoma

Medulloblastoma (MB) is an aggressive, primitive neuroectodermal tumor mainly affecting pediatric patients and with frequent involvement of the posterior fossa and extraneural metastasis. MB has a low incidence in adults (< 1% of adult brain tumors) and treatment protocols for adult patients have been adapted from pediatric oncology.1,2

PTCH13 tumor suppressor gene functions as an inhibitor of smoothened (SMO) and downstream sonic hedgehog (SHH) signaling. SHH ligand connects to the receptor on PTCH1, which results in SMO suppression (Fig 1). PTCH1 germline inactivating mutations are associated with Gorlin syndrome, which is associated with a high incidence of basal cell carcinoma (BCC) and predisposition to MB.4-6 This association is strengthened because somatic mutations that inactivate PTCH1 are frequently found in the sporadic forms of these types of cancers. Genomic analyses of MB have identified PTCH1 a mutation incidence of 3%-7% of MB cases. On the basis of gene expression profiling, four molecular subgroups of MB have been identified: WNT, SHH, group 3, and group 4.7 The prognosis for patients within the SHH subgroup MB differs greatly upon TP53 mutation status, wherein patients with wild-type TP53 have a significantly better 5-year overall survival rate (76%) compared with those with TP53 mutation (41%).8

Although several case reports showed promising results for molecular targeted therapy in the population of adults with MB,9 to our knowledge, this is the second reported case treated with target therapy as first-line treatment.10 Vismodegib is an SHH pathway inhibitor that acts as an SMO development suppressor; it has been approved for BCC treatment4,6 but not for adult MB.

Here, we present a new approach for the treatment of adult MB based on genomic findings. A young woman without evidence of Gorlin syndrome presented with an unresectable, multifocal, and predominantly spinal form of SHH-type MB and was treated with vismodegib as first-line therapy. She showed positive and sustained response. Although this is a notoriously aggressive neoplasm, this patient is presently alive after 15 months of treatment, presenting leptomeningeal spread of the tumor. This represents a promising treatment and suggests that resistance is slow to develop, which should also spark additional investigation.

A 24-year-old woman was admitted to the hospital because of a 6-month history of unsteadiness and worsening lower-limb paresthesia. Neurologic evaluation revealed a fully conscious and oriented patient with normal cranial nerves, lower extremity dysmetria, subxiphoid paresthesia, and grade 3/5 paraparesis. Spinal computed tomography (CT) was normal. Brain and spinal magnetic resonance imaging revealed heterogeneous, nonenhancing right cerebellar and vermis lesions with multiple spinal intramedullary lesions causing significant cord compression (Fig 2). The patient underwent urgent decompressive laminectomy with maximal safe resection.

Histopathology showed a small, round, blue cell tumor infiltrating spinal meninges that was composed of nodular, reticulin-free zones of variable sizes and surrounded by densely packed, highly proliferative cells, occasional nuclear molding, without vascular proliferation or necrotic foci. Pathologic findings indicated metastatic desmoplastic/nodular MB, WHO grade IV. Immunohistochemistry of the internodular hypercellular areas was consistent with SHH-type MB with wild-type TP53, as described Figure 3A-3E). In addition, next-generation sequencing–based assay11 (Foundation Medicine, Cambridge, MA) identified nonsense mutation in PTCH1 gene R135*. Moreover, microsatellite instability–stable, low tumor mutational burden, and variants of uncertain significance (VUS) were identified as described in Figure 3F. Positron emission tomography (PET)-CT showed postoperative spinal intramedullary hypermetabolic uptake (Fig 4A, blue arrow). Chemoradiotherapy was recommended to the patient as standard treatment. However, because of the patient's aversion to chemotherapeutic agents, she was treated only with radiotherapy. Treatment protocol consisted of 36 Gy in 20 fractions to the entire craniospinal axis, followed by a boost of 18 Gy in nine fractions to the posterior fossa and 8 Gy in four fractions to the spinal drop metastases. PET-CT scan after radiation therapy showed extraneural bilateral proximal humorous (Fig 4B, blue arrow) and a new, small, lung opacification (Fig 4B, green arrow), most probably due to radiation pneumonitis. On the basis of the patient mutational profile, vismodegib was initiated as compassionate treatment at 150 mg orally daily after local institutional review board approval. Six months later, there was no clinical or radiologic evidence of MB lesions, including complete response of extraneural lesions (Fig 4C). Currently, 15 months since starting treatment, the patient shows significant clinical symptoms improvement and is under rehabilitation treatment.

We describe here a case of adult MB with mutation in the PTCH1 gene that achieved a remarkable and prolonged clinical and radiologic response to the SHH pathway inhibitor vismodegib as first-line therapy following craniospinal irradiation. Although vismodegib is not approved by the US Food and Drug Administration for this indication, the treatment was given as compassionate therapy after the molecular findings.

The identification of molecular drivers involved in MB tumorigenesis, including WNT, SHH, and groups 3 and 4, has enabled the identification of additional prognostic markers to the established histopathologic typing.12 MB with SHH subtype is associated with desmoplastic histology in the vast majority of reported cases, including pediatric and most adult patients, and has been associated with better prognostic outcomes.13 Moreover, loss of heterozygosity (LOH) of PTCH1 has been associated with prolonged progression-free survival in a setting of second-line therapy with vismodegib, whereas in the same setting, mutations in the SHH pathway downstream to SMO did not respond to the treatment.14 The patient presented in this case has a nonsense mutation in position R135* of PTCH1 and mutation allele frequency of 97%, which could be an indication of LOH. Moreover, the patient has a mutation in the promoter of TERT, which has significant co-occurrence with small nuclear RNA mutations and subsequently could be indicative of PTCH1 inactivation; Figure 3F presents details about VUS mutations.15 The promising findings in this case demonstrate that vismodegib may be considered a first-line treatment in adult patients with MB with SHH-type MB with mutations upstream to SMO in the SHH pathway.

© 2020 by American Society of Clinical Oncology

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/po/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Laila C. Roisman

Stock and Other Ownership Interests: Teva

Honoraria: Pfizer, Roche, AstraZeneca, Takeda

Consulting or Advisory Role: AllScripts

Patents, Royalties, Other Intellectual Property: Approved interferon patents

Nir Peled

Honoraria: AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, MSD Oncology, Novartis, Pfizer, Roche, Takeda

Consulting or Advisory Role: AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, MSD Oncology, Novartis, Pfizer, Roche

Research Funding: MSD Oncology (Inst), Roche (Inst), AstraZeneca (Inst), Takeda (Inst), Merck Serono (Inst), Novartis (Inst)

Travel, Accommodations, Expenses: Roche (Inst), MSD Oncology, AstraZeneca, Pfizer (Inst)

No other potential conflicts of interest were reported.

We thank the patient and the patient's family for their cooperation during the whole treatment. The patient’s informed consent has been obtained for the publication of the finding and figures presented in this report.

1. Kumar LP, Deepa SFAJ, Moinca I, et al: Medulloblastoma: A common pediatric tumor: Prognostic factors and predictors of outcome. Asian J Neurosurg 10:50, 2015 Google Scholar
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4. Fellner C: Vismodegib (Erivedge) for advanced basal cell carcinoma. Pharm Ther 37:670-682, 2012 Google Scholar
5. Lo Muzio L, Pastorino L, Levanat S, et al: Clinical utility gene card for: Gorlin syndrome. Eur J Hum Genet 19:3, 2011 Google Scholar
6. Fecher LA, Sharfman WH: Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors. Biologics 9:129-140, 2015 Google Scholar
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