Researchers are proposing using artificial intelligence technology to help diagnose autism spectrum disorder.

In a recent article published in Scientific Reports, researchers from Brazil, France and Germany reportedly used magnetic resonance imaging to train a machine learning algorithm. 

The work – in which the "quantitative diagnostic method" is proposed – was based on brain imaging data for 500 people, with more than 240 that had been diagnosed with autism. 

WHAT IS ARTIFICIAL INTELLIGENCE (AI)?

Machine learning techniques were applied to the data.

"We began developing our methodology by collecting functional magnetic resonance imaging [fMRI] and electroencephalogram [EEG] data," Francisco Rodrigues, the last author of the article and a professor at the University of São Paulo’s Institute of Mathematics and Computer Science, explained in a statement. 

AS AI SHOWS UP IN DOCTORS' OFFICES, MOST PATIENTS ARE GIVING PERMISSION AS EXPERTS ADVISE CAUTION

"We compared maps of people with and without ASD and found that diagnosis was possible using this methodology," he added.

The machine learning algorithm was fed with the maps, and the system was able to determine which brain alterations were associated with autism with above 95% mean accuracy. 

While previous research proposes methods for diagnosing autism based on machine learning, the article notes it often uses a single statistical parameter that is not brain network organization. 

CALIFORNIA MAN WITH SEVERE AUTISM BEATS RUBIK'S CUBE WORLD RECORD: 'EXUBERANCE IN OUR HEARTS'

Analyzing the fMRI data showed changes in certain brain regions associated with cognitive, emotional, learning and memory processes, and the cortical networks of autism patients showed more segregation, less distribution of information and less connectivity compared to controls.

"Until a few years ago, little was known about the alterations that lead to the symptoms of ASD. Now, however, brain alterations in ASD patients are known to be associated with certain behaviors, although anatomical research shows that the alterations are hard to see, making diagnosis of mild ASD much harder. Our study is an important step in the development of novel methodologies that can help us obtain a deeper understanding of this neurodivergence," Rodrigues said.

The methodology is under development and will take years to implement, according to the São Paulo Research Foundation, which supported the research.

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About one in 36 children has been identified with autism spectrum disorder, according to the Centers for Disease Control and Prevention. 

Diagnosing the developmental disability can be difficult because there is no medical test, like a blood test, to do so. 

As part of its mission to advocate for parity in employment, compensation and recognition for women theatre practitioners through industry-wide initiatives and public policy, the League of Professional Theatre Women has launched an industry-wide, comprehensive pay equity research study. Focusing on New York City and New York State theatre professionals in a variety of disciplines, the study will include qualitative and qualitative data collected through anonymous surveys and interviews in order to assess economic equity and hiring practices during the 2018 - 2022 seasons.

The Study is developed in partnership with the research firm Network for Culture & Arts Policy (NCAP) to examine pay equity, opportunities, negotiation practices, and the financial needs of theatre professionals across New York. It will be distributed to theatre professionals through unions, membership organizations, theatre staff, and guilds. All theatre professionals are encouraged to participate. All responses will be collected anonymously.

The study will remain open through December 23, 2022. All theatre professionals working or living in New York State can access the survey here: https://www.surveymonkey.com/r/LPTWEquity

Puzzles, chess and writing journals may be more than pure amusements to pass the time. These brain activities could help reduce the risk of dementia. 

According to a recent study in JAMA Network Open, activities related to adult literacy, such as taking classes, using a computer or writing journals, as well as active mental tasks like games, cards, or crossword puzzles, were related to a reduced dementia risk over 10 years.

A study published this week could help doctors to identify patients with brain injuries, in seemingly unresponsive states, who are more likely to recover.

In the study, published in the journal Brain on Monday, researchers identified what may be the source of a curious phenomenon known as "hidden consciousness" or cognitive motor dissociation (CMD).

Hidden consciousness is seen in patients with acute brain injury who appear to be in a coma or other unresponsive state.

Patients with CMD seem to be able to hear and comprehend verbal commands even though they cannot carry out those instructions because the body does not respond, study author Jan Claassen, a researcher at Columbia University and critical care neurologist at New York-Presbyterian/Columbia University Irving Medical Center, said in a statement.

The CMD phenomenon has only been identified in the past few years and is still poorly understood.

Methods have been developed to detect CMD in unresponsive patients. These include analyzing changes in electrical activity or cerebral blood flow recorded by an electroencephalogram (EEG) or functional magnetic resonance imaging (fMRI) respectively. But both of these methods currently have their limitations.

Nevertheless, it is thought that around 15 to 20 percent of patients who appear to be in a coma or another unresponsive state display signs of CMD when evaluated with such methods, Claassen told Newsweek. The detection of CMD is reshaping our understanding of patients in comatose or other unresponsive states.

Associated With Recovery of Consciousness

Clinicians define when a patient is in a "coma" purely based on the clinical examination, Claassen said. They apply this label to patients who display a complete absence of arousal (for example, eye opening) and awareness.

Patients with CMD do not seem to be able to follow commands and may in clinical examination appear to be in a coma.

But an analysis of EEG or functional MRI, recorded while patients are given verbal commands, reveals that the brains of these unresponsive patients are being activated in a similar way to conscious patients, Claassen said. This supports the interpretation that patients with CMD are to some degree conscious.

Identifying patients with CMD has important clinical implications for interactions, communication with families and the guidance of therapeutic decisions, according to the study.

Importantly, in prior research, Claassen and colleagues have been able to associate CMD with the recovery of consciousness and long-term recovery of independence in brain-damaged patients.

Researchers have been trying to develop more effective screening methods to identify which patients are likely to be in a state of hidden consciousness. But progress has been hampered by the fact that the brain mechanisms underlying the phenomenon have remained a mystery. This is where the latest study comes in.

In previous research, Claassen and colleagues found that subtle brainwaves detectable with EEG are the strongest predictor of hidden consciousness and eventual recovery for patients with brain injuries.

Many Patients With Hidden Consciousness Remain Undiagnosed.

For the latest study, the scientists used EEG to examine 107 unresponsive patients with acute brain injury. Almost half of the patients appeared comatose, while one quarter were in a vegetative state—i.e. their eyes were open but they could not follow commands.

The remaining patents were in a minimally conscious state—meaning they could track an examiner with their eyes or look at them but were not able to follow any commands.

Using the EEG, scientists can identify when patients are trying, but are unable, to respond to a command such as "keep opening and closing your right hand."

This method detected CMD in 21 of the patients. The scientists then analyzed structural MRI brains scans from all the patients.

Using a special analysis technique, the team were able to identify patterns of brain injury that the patients with CMD shared and contrast those to the individuals who did not display signs of hidden consciousness.

The researchers found that all of the CMD patients had intact brain structures related to arousal and command comprehension. This supports the idea that they were able to hear and understand the verbal commands.

But they also found that the CMD patients had damage to brain regions responsible for integrating and carrying out motor commands, which is why they were unable to take action.

"Our study suggests that patients with hidden consciousness can hear and comprehend verbal commands, but they cannot carry out those commands because of injuries in brain circuits that relay instructions from the brain to the muscles," Claassen said in the statement.

The findings could lead to more frequent and earlier diagnosis of CMD. This, in turn, could help better predict which brain-injured individuals are more likely to recover with rehabilitation, according to the scientists.

More research is required before the approaches documented in the study can be applied to clinical practice. But the latest study shows that it may be possible to screen for CMD using widely available structural brain-imaging techniques.

Due to the technical complexity of CMD detection, at this time it is only available in a few academic centers. As a result, the vast majority of patients with hidden consciousness in the United States and around the world remain undiagnosed.

"Not every critical care unit may have resources and staff that is trained in using EEG to detect hidden consciousness, so MRI may offer a simple way to identify patients who require further screening and diagnosis," Claassen said in the statement.

Fact checked by Sarah Scott

• A new study suggests that taking vitamin D supplements may help protect older adults from major cardiovascular events, like heart attacks.

• The study is relatively small and researchers and outside medical professionals alike emphasize the need for further research in order to clarify vitamin D's ability to contribute to heart health in this way.

• Experts agree that lifestyle factors, like diet and exercise, are still the primary ways individuals can focus on prevention of heart attacks and other cardiovascular-related events.

Taking vitamin D supplements may help reduce the risk of major cardiovascular events (like heart attacks) for older adults, according to a new study.

The trial, which was based out of Australia, assessed 21,315 people who ranged from 60 to 84 years old. They randomly gave one group of 10,662 participants one capsule of 60,000 IU vitamin D, while a placebo was given to 10,653 participants.

The supplements and the placebo were taken orally by participants at the beginning of each month for up to 5 years, with the clinical trial starting in 2014 and concluding in 2020.

Researchers excluded people from the trial with a history of hypercalcemia, or high calcium levels, overactive thyroid, or hyperparathyroidism, kidney stones, osteomalacia, or "soft bones," sarcoidosis, which is an inflammatory disease, or who were already taking more than 500 IU per day of vitamin D supplements.

Study author Rachel Neale, PhD, told Health that there have been plenty of observational studies suggesting that the concentration of 25 hodroxy vitamin D [25(OH)D—the molecule that is measured to determine vitamin D status—in the bloodstream is "inversely associated with health outcomes."

The opposite has been examined less.

While the largest clinical trial of its kind, the researchers acknowledge that the study was relatively small, and more work needs to be done to understand the effectiveness of these kinds of supplements, especially in people who are taking statins or other medications to manage cardiovascular disease.

Neale, who also serves as the deputy coordinator of the Population Health Department at QIMR Berghofer Medical Research Institute, noted that the association between vitamin D and cardiovascular health risk may not be causal.

"Randomized controlled trials are needed to determine whether supplementing people with vitamin D would Improve health outcomes," she said.

Taking Vitamin D Supplements Could Protect Your Heart

Over the course of the trial, 1,336 of the participants experienced a major cardiovascular event—this was evenly divided between the placebo and vitamin D supplement groups.

The research team found that 6.6% of those in the placebo group and 6% in the supplement group experienced a cardiovascular event during those five years.

Those in the vitamin D supplement group seemed better protected from these heart disease events; this group experienced a rate of major cardiovascular events that was 9% lower compared to what was seen in the placebo group.

This comes out to about 5.8 fewer cardiovascular events per 1,000 participants. The heart attack and coronary rates were 19% and 11% lower, respectively, in the vitamin D group. That being said, the rate of stroke showed no difference between the placebo and supplement groups.

Related: 26 Symptoms of Low Vitamin D You Need to Know About

How Vitamin D Impacts the Heart

When asked what is known about vitamin D and its impact on heart health, Boback Ziaeian, MD, PhD, an assistant professor of medicine at the David Geffen School of Medicine at UCLA in the Division of Cardiology, told Health that there are many studies out there on vitamin D "that span basic sciences, observational research, and clinical trials."

That being said, it's only very recently that we've started seeing large randomized trials like this one that focus on vitamin D supplements as a mechanism to prevent cardiovascular disease, cancer, and even dementia.

"These trials have all largely been negative for their primary endpoint design. The recent Australian study is the first large study to suggest a possible benefit and that is very uncertain," said Ziaeian, who is unaffiliated with this clinical trial.

Essentially, more needs to be examined here.

Neale said that there are a number of different potential mechanisms inherent in vitamin D that could be beneficial for your heart.

She mentioned that vitamin D "can influence the renin-angiotensin-aldosterone system, which influences blood volume and vascular resistance." She also noted that vitamin D can also lower inflammation and "reduce cardiac remodeling."

"People have hyped Vitamin D for a long time, but blood levels are heavily confounded by other lifestyle factors like how much time someone spends outdoors or not having other chronic diseases," Ziaeian said.

"So, overall, there's no good evidence that supplementing people with vitamin D does anything beneficial for their health unless they cannot produce it, such as patients with severe kidney disease."

What Future Studies Need to Clarify

Ziaeian said that he doesn't believe we will see a future where vitamin D supplementation will be part of a prescription from your doctor.

"Looking at the literature overall, I think it is very unlikely that we would find many benefits for any vitamin supplementation that for vitamins we normally ingest with normal food intake or that our body produces," he said.

Neale said that "uncertainty in the evidence may not ever be completely resolved." She said this leaves medical providers in a "somewhat difficult position" when it comes to prescribing vitamin D supplements, outside of treating vitamin D deficiency.

"I would emphasize that even if our findings do indicate a real effect of vitamin D, it is not a magic bullet," she said. "Diet and exercise will play a much more important role."

Related: 12 Foods That Are Good Sources of Vitamin D

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Read the original article on Health.

1. Stress Is Too Much to Bear

Stress is a biological response to what your brain perceives as a threatening situation. Neurotransmitters within the brain activate the amygdala, which is responsible for the flight-or-fight response, notes Yale Medicine. Typical causes of stress include major life changes like a divorce or a medical diagnosis, work-related pressure or financial issues.

Stress is a part of life but prolonged periods of stress can lead to negative physical health effects such as a weakened immune system. “A person who is constantly stressed can suffer from consistent headaches, gastrointestinal issues and even muscle pain,” says Kaur. “Our bodies are usually first to tell us that something is wrong and we need to slow down to decrease our stress levels. It’s one of the reasons taking time to relax or meditate can be so helpful.”

If stress overtakes your life, or that of someone you know, it may make sense to see a psychologist, psychiatrist or licensed professional counselor, who could develop a treatment plan that works for your needs.

2. Anxiety Becomes Debilitating

Anxiety is similar to stress, as it’s your brain’s response to a perceived threat. Symptoms may include increased heart rate, difficulty breathing and feeling nervous, notes the National Institute of Mental Health. Anxiety is often experienced as a result of a tense or stressful event and resolves over time. However, an anxiety disorder involves repetitive worry when the threat is no longer present, according to Kaur. “When the anxiety has manifested itself to a point where you are unable to function, it’s important to seek help,” she says.

3. Depression Is Your New Normal

Depression is a common mental health disorder that negatively impacts your ability to function. Neurons are not able to connect as easily with other neurons in the brain as depression occurs, as noted by Yale Medicine. Symptoms of depression may include social withdrawal, poor sleeping, weight changes or aches and pain. Someone who is depressed will also experience feelings of sadness, guilt and loss of previously enjoyed activities.

There are multiple treatments that can help, but it’s important to talk to a professional who can determine if a poor mood is fleeting or a sign of clinical depression.

4. Mania Causes Extreme Emotions

Mania is characterized by extreme emotional highs or lows, where a person can become uncontrollable. Symptoms can include racing thoughts, rapid speech, irritability and paranoia. Manic episodes are an indicator of mental health conditions such as bipolar I or schizoaffective disorder.

“Mood swings can be triggered by stress, but if a person is cycling between a high (manic episode) and a low (depression) consistently, it’s a definite sign to seek help from a provider,” says Kaur.

BUFFALO, N.Y. – A background in music helps speakers learn a tonal language, such as Mandarin, a new University at Buffalo study suggests.

People with musical training — whether instrumental or vocal — are better at imitating pitch than someone without that training. Understanding pitch structure is critical with tonal languages that rely on inflection to communicate meaning.

Unlike English, where the inflection placed on a single word can alter a word’s pitch in ways that convey emphasis or emotion, altering pitch in a tonal language can change a word’s meaning.

“Both a musical background and a Mandarin language background influences the ability to match pitch,” says Chihiro Honda, a graduate student of psychology in the UB College of Arts and Sciences, and first author of the paper published in the Journal of Experimental Psychology: Human Perception and Performance. “These findings imply that teachers might want to introduce music as part of their instruction for those trying to acquire a second language.”

This research also speaks to the long-standing debate about whether our brains have separate networks for language and music, according to Peter Pfordresher, PhD, a UB professor of psychology and one of the paper’s co-authors.

“This paper isn’t the final say on that debate, but we seem to have the same network at work for both behaviors,” he says. “We might rely on different features of that network depending on whether we’re in a language or a music situation. If you’re attuned to paying attention to pitch through learning a tonal language or through music, that training is going to help you in either situation.”

The research team recruited 127 participants for the study: Mandarin and English speakers, both with and without a background in music. The researchers created 96 short sentences in each language phrased as both a statement and a question — “The children can’t sleep,” for instance.

The authors then used computer software to create pitch patterns based on the spoken sentences, and then composed short melodies based on the pitch of each syllable. Participants listened to and then vocally reproduced these synthetic pitch patterns and melodies, but never heard the original spoken sentences.

After collecting data, the researchers calculated the differences between target pitch and what participants produced.

“Musicians were more accurate in matching absolute pitch across syllables and musical notes than non-musicians,” says Honda. “Mandarin speakers were more accurate at imitating changes within and across pitch patterns compared to English speakers.

Replacing some fats like margarine or mayonnaise with olive oil in your diet could help reduce the risk of dying from dementia—a particularly important finding as many countries face rising rates of Alzheimer’s disease and related dementias.

The claim comes from a new study presented Monday at NUTRITION 2023, the annual meeting of the American Society of Nutrition. It’s the first study to investigate the relationship between diet and dementia-related death.

“Our study reinforces dietary guidelines recommending vegetable oils such as olive oil and suggests that these recommendations not only support heart health but potentially brain health, as well,” presenting study author Anne-Julie Tessier, RD, PhD, a postdoctoral fellow at the Harvard T.H. Chan School of Public Health, said in a news release. “Opting for olive oil, a natural product, instead of fats such as margarine and commercial mayonnaise is a safe choice and may reduce the risk of fatal dementia.”

Dementia is not a specific condition but an umbrella term for a range of conditions that involve losing the ability to think and remember enough to interfere with daily life and activities. Alzheimer’s disease, which affects more than 6 million Americans, is the most common form of dementia. It’s also considered fatal because it has no cure.