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CEN Certified Emergency Nurse candidate | http://babelouedstory.com/

CEN candidate - Certified Emergency Nurse Updated: 2024

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Exam Code: CEN Certified Emergency Nurse candidate January 2024 by Killexams.com team

CEN Certified Emergency Nurse

The CEN exam is for nurses in the emergency department setting who want to demonstrate their expertise, knowledge and versatility in emergency nursing.



Killexams is the only source for emergency nursing professionals and their employers to obtain recognized certification with proven results for greater knowledge and performance. Enhance your knowledge, your career, and patient care with specialty certification in emergency nursing.



One of the more common questions we get from our customers is about the difference between a certification and a certificate. Here is the difference in a nutshell:



A certificate comes from an educational program where a certificate is awarded after the individual successfully completes the offering. Examples of certificates are Advanced Cardiac Life Support (ACLS) or Trauma Nursing Core Course (TNCC).



A certification, like the Certified Emergency Nurse (CEN) is an earned credential that demonstrates the individuals specialized knowledge and skills. Certification is awarded by a third-party organization, such as Board of Certification for Emergency Nursing. Individuals receive their certification after meeting strict eligibility requirements and successfully completing the required examination. In addition, certifications have ongoing requirements that must be meant to maintain the credential, ensuring the holder has maintained their level of expertise in the specialty area. Certifications are nationally recognized and are often utilized as part of the earners signature.



Earning professional certifications such as the CEN, CPEN, CFRN, CTRN and TCRN offered by BCEN, and completing certificate programs such as ACLS, PALS, ENCP and TNCC, are critical to the work emergency nurses do, but there are significant differences.


1. Cardiovascular Emergencies 20

A. Acute coronary syndrome

B. Aneurysm/dissection

C. Cardiopulmonary arrest

D. Dysrhythmias

E. Endocarditis

F. Heart failure

G. Hypertension

H. Pericardial tamponade

I. Pericarditis

J. Peripheral vascular disease (e.g., arterial, venous)

K. Thromboembolic disease (e.g., deep vein thrombosis [DVT])

L. Trauma

M. Shock (cardiogenic and obstructive)

2. Respiratory Emergencies 16

A. Aspiration

B. Asthma

C. Chronic obstructive pulmonary disease (COPD)

D. Infections

E. Inhalation injuries

F. Obstruction

G. Pleural effusion

H. Pneumothorax

I. Pulmonary edema, noncardiac

J. Pulmonary embolus

K. Respiratory distress syndrome

L. Trauma

3. Neurological Emergencies 16

A. Alzheimer's disease/dementia

B. Chronic neurological disorders (e.g., multiple sclerosis, myasthenia gravis)

C. Guillain-Barré syndrome

D. Headache (e.g., temporal arteritis,migraine)

E. Increased intracranial pressure (ICP)

F. Meningitis

G. Seizure disorders

H. Shunt dysfunctions

I. Spinal cord injuries, including neurogenic shock

J. Stroke (ischemic or hemorrhagic)

K. Transient ischemic attack (TIA)

L. Trauma

4. Gastrointestinal, Genitourinary, Gynecology, and Obstetrical Emergencies 21

A. Gastrointestinal

1. Acute abdomen (e.g., peritonitis, appendicitis)

2. Bleeding

3. Cholecystitis

4. Cirrhosis

5. Diverticulitis

6. Esophageal varices

7. Esophagitis

8. Foreign bodies

9. Gastritis

10. Gastroenteritis

11. Hepatitis

12. Hernia

13. Inflammatory bowel disease

14. Intussusception

15. Obstructions

16. Pancreatitis

17. Trauma

18. Ulcers

B. Genitourinary

1. Foreign bodies

2. Infection (e.g., urinary tract infection, pyelonephritis, epididymitis, orchiitis, STDs)

3. Priapism

4. Renal calculi

5. Testicular torsion

6. Trauma

7. Urinary retention

C. Gynecology

1. Bleeding/dysfunction (vaginal)

2. Foreign bodies

3. Hemorrhage

4. Infection (e.g., discharge, pelvic inflammatory disease, STDs)

5. Ovarian cyst

6. Sexual assault/battery

7. Trauma

D. Obstetrical

1. Abruptio placenta

2. Ectopic pregnancy

3. Emergent delivery

4. Hemorrhage (e.g., postpartum bleeding)

5. Hyperemesis gravidarum

6. Neonatal resuscitation

7. Placenta previa

8. Postpartum infection

9. Preeclampsia, eclampsia, HELLP syndrome

10. Preterm labor

11. Threatened/spontaneous abortion

12. Trauma

5. Psychosocial and Medical Emergencies 25

A. Psychosocial

1. Abuse and neglect

2. Aggressive/violent behavior

3. Anxiety/panic

4. Bipolar disorder

5. Depression

6. Homicidal ideation

7. Psychosis

8. Situational crisis (e.g., job loss, relationship issues, unexpected death)

9. Suicidal ideation

B. Medical

1. Allergic reactions and anaphylaxis

2. Blood dyscrasias

a. Hemophilia

b. Other coagulopathies (e.g., anticoagulant medications, thrombocytopenia)

c. Leukemia

d. Sickle cell crisis

3. Disseminated intravascular coagulation (DIC)

4. Electrolyte/fluid imbalance

5. Endocrine conditions:

a. Adrenal

b. Glucose related conditions

c. Thyroid

6. Fever

7. Immunocompromise (e.g., HIV/AIDS, patients receiving chemotherapy)

8. Renal failure

9. Sepsis and septic shock

6. Maxillofacial, Ocular, Orthopedic and Wound Emergencies 21

A. Maxillofacial

1. Abscess (i.e., peritonsillar)

2. Dental conditions

3. Epistaxis

4. Facial nerve disorders (e.g., Bells palsy, trigeminal neuralgia)

5. Foreign bodies

6. Infections (e.g., Ludwig'sangina, otitis, sinusitis, mastoiditis)

7. Acute vestibular dysfunction (e.g., labrinthitis, Ménière's disease)

8. Ruptured tympanic membrane

9. Temporomandibular joint (TMJ) dislocation

10. Trauma

B. Ocular

1. Abrasions

2. Burns

3. Foreign bodies

4. Glaucoma

5. Infections (e.g., conjunctivitis, iritis)

6. Retinal artery occlusion

7. Retinal detachment

8. Trauma (e.g., hyphema, laceration, globe rupture)

9. Ulcerations/keratitis

C. Orthopedic

1. Amputation

2. Compartment syndrome

3. Contusions

4. Costochondritis

5. Foreign bodies

6. Fractures/dislocations

7. Inflammatory conditions

8. Joint effusion

9. Low back pain

10. Osteomyelitis

11. Strains/sprains

12. Trauma (e.g., Achilles tendon rupture, blast injuries)

D. Wound

1. Abrasions

2. Avulsions

3. Foreign bodies

4. Infections

5. Injection injuries (e.g., grease gun, paintgun)

6. Lacerations

7. Missile injuries (e.g., guns, nail guns)



8. Pressure ulcers

9. Puncture wounds

10. Trauma (i.e., including degloving injuries)

7. Environment and Toxicology Emergencies, and Communicable Diseases 15

A. Environment

1. Burns

2. Chemical exposure (e.g., organophosphates, cleaning agents)

3. Electrical injuries

4. Envenomation emergencies (e.g., spiders, snakes, aquatic organisms)

5. Food poisoning

6. Parasite and fungal infestations (e.g., giardia, ringworm, scabies)

7. Radiation exposure

8. Submersion injury

9. Temperature-related emergencies (e.g., heat, cold, and systemic)

10. Vector borne illnesses:

a. Rabies

b. Tick-borne illness (e.g., Lyme disease, Rocky Mountain spotted fever)

B. Toxicology

1. Acids and alkalis

2. Carbon monoxide

3. Cyanide

4. Drug interactions (includingalternative therapies)

5. Overdose and ingestions

6. Substance abuse

7. Withdrawal syndrome

C. Communicable Diseases

1. C. Difficile

2. Childhood diseases (e.g., measles, mumps, pertussis, chicken pox,

diphtheria)

3. Herpes zoster

4. Mononucleosis

5. Multi-drug resistant organisms (e.g., MRSA, VRE)

6. Tuberculosis



8. Professional Issues 16

A. Nurse

1. Critical Incident Stress Management

2. Ethical dilemmas

3. Evidence-based practice

4. Lifelong learning

5. Research

B. Patient

1. Discharge planning

2. End of life issues:

a. Organ and tissue donation

b. Advance directives

c. Family presence

d. Withholding, withdrawing, and palliative care

3. Forensic evidence collection

4. Pain management and procedural sedation

5. Patient safety

6. Patient satisfaction

7. Transfer and stabilization

8. Transitions of care

a. external handoffs

b. internal handoffs

c. patient boarding

d. shift reporting

9. cultural considerations (e.g., interpretive services, privacy, decision making)

C. System

1. Delegation of tasks to assistive personnel

2. Disaster management (i.e., preparedness, mitigation, response, and recovery)

3. Federal regulations (e.g., HIPAA, EMTALA)

4. Patient consent for treatment Performance improvement

6. Risk management

7. Symptom surveillance

a. recognizing symptom clusters

b. mandatory reporting of diseases

D. Triage
Certified Emergency Nurse
Medical Certified candidate

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Medical
CEN
Certified Emergency Nurse
https://killexams.com/pass4sure/exam-detail/CEN
Question: 1
An elderly female client presents to the ED with complaints of chest pain and a history of angina.
After the initial triage, what would be the next appropriate interventions?
A. cardiac monitor, oxygen, and sublingual nitroglycerin
B. cardiac monitor, sublingual nitroglycerin, and Foley catheter
C. cardiac monitor, IV, oxygen, and sublingual nitroglycerin
D. oxygen, sublingual nitroglycerin, and Foley catheter
Answer: C
Question: 2
A 7-year-old child is brought to the emergency department after multiple bee stings about 30
minutes previously. He complains of itching, swollen lips, and difficulty breathing. Wheezing
and stridor are heard. What is the most immediate treatment required?
A. epinephrine 0.1 mg intramuscularly
B. intravenous corticosteroid
C. intravenous antihistamine
D. broad-spectrum antibiotic
Answer: A
Question: 3
After an auto accident, x-rays of the patient's leg show a transverse fracture of the midfemur with
several bone fragments surrounding the fracture site. The skin of the leg is intact. This type
fracture is called:
A. compression fracture
B. comminuted fracture
C. avulsion fracture
D. open fracture
Answer: B
Question: 4
A cancer patient is seen in the emergency department with high fevers and malaise for 2 days.
She received chemotherapy about 10 days ago. Her physical exam is not revealing but her
temperature is 103F A CBC shows a hemoglobin of 10 g/dL, WBC 4000 with 10% polys, 5%
bands, 70% lymphs, 10% monos, and 5% other white or unidentified cells. Platelets are
60,000/mm3. Which of the following is NOT immediately appropriate?
A. blood cultures from different sites
B. electrolytes, liver and renal function tests
C. eask if she has been receiving granulocyte colony-stimulating factor (G-CSF)
D. white blood cell transfusion
Answer: D
Question: 5
Which statement best describes acute respiratory distress syndrome (ARDS)?
A. ARDS is caused by trauma only.
B. ARDS is sudden, progressive, and severe.
C. ARDS is caused by an illness only.
D. ARDS never results in lung scarring.
Answer: B
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Non-Massachusetts certified Emergency Medical Technicians (EMTs) must be nationally certified and receive verification from your home state to apply for a Massachusetts EMT license.

The National Registry of Emergency Medical Technicians® (NREMT) website contains information and outlines the application process for EMT national certification. The NREMT website can also help to find your home state's EMS office (OEMS) in order to request verification. This verification is required to submit as part of your application for Massachusetts EMT licensure. Below you will find information on requesting verification from your home state and applying for national EMT certification.

If you have any questions during this process, please do not hesitate to email us for assistance.

Request Verification from Your Home State

Send the following information to your home state's EMS office to request verification:

National EMT Certification

You must be nationally certified prior to applying for your Massachusetts EMT license through NREMT. The steps are outlined on the the NREMT website on the Certification Process tab under Application Process.

Refer to the NREMT website for login, complete details on the application process and additional information not provided here.

  1. Create an account/login profile.

  2. Complete a National Registry application and including the Licensing Action and criminal statements.

  3. Pay the application fee as noted on the NREMT website. This fee is charged for each attempt of the cognitive examination.

  4. Mail the filled-out Verification of Emergency Medical Technician Status form to NREMT with a self-addressed stamped envelope to National Registry of Emergency Medical Technicians, 6610 Busch Boulevard, Columbus, OH 43229. Be sure to complete this step as it is not detailed on the NREMT website.

  5. Candidates will receive an electronic Authorization to Test (ATT) once you are eligible for the exam. The electronic ATT contains scheduling instructions for the cognitive exam and important details concerning proper identification required at testing centers.

Exception:

  • If you do not have your NREMT certification because you completed your EMT class prior to turning 18, you may be able to transfer your cognitive exam results without repeating the exam. You must have already created an NREMT account and be certified in a state that utilizes the NREMT cognitive and practical exam. Contact your state OEMS to confirm that the following is an option for you.

  • Login and create a new National Registry application. Ensure that your training center has Tested your course and exam results. If you have already paid the required application fee, you will not have to pay this again, however you must pay a processing fee.

  • Send a letter to National Registry of Emergency Medical Technicians, 6610 Busch Boulevard, Columbus, OH 43229, explaining that you would like to transfer your examination results (sample letter requesting transfer of examination results).

  • Your NREMT account will be updated stating that you have successfully earned your national EMS certification. This typically occurs within 7-10 business days.

Next Step

Once you have received verification through your home state and are nationally certified, you can apply for a Massachusetts EMT license through the mail or online.

Fri, 10 May 2019 03:36:00 -0500 en text/html https://www.brandeis.edu/bemco/join/mass-reciprocity.html
Ohio transgender candidate disqualified for not disclosing deadname No result found, try new keyword!A transgender woman running for a house seat in Ohio was disqualified for failing to disclose her pretransition name on petitions circulated to voters. Thu, 04 Jan 2024 07:26:18 -0600 en-us text/html https://www.msn.com/ Ohio transgender candidate disqualified for not including former name No result found, try new keyword!A transgender candidate for the Ohio House has been disqualified because she only circulated petitions with her legal name, instead of her former name — and it has put other candidates in flux. Thu, 04 Jan 2024 01:20:03 -0600 en-us text/html https://www.msn.com/ 29 seats vacant after round 3 CPS Admissions, DME Gujarat Releases Reporting Schedule For candidates

Gujarat: The Director of Medical Education (DME Gujarat) has released the schedule for the reporting process for round 3 of CPS Diploma courses. The rank-wise result, list of candidates required to report to the help center, and vacant seats after exhaustion of the merit list have also been released.

The selected candidates can pay the fee online or at a designated branch of Axis Bank up to 3.30 pm on 5th January 2024. The last date to report to the help center is 6th January 2024 up to 12:00 pm. Help center working hours from 10.00 am to 4.00 pm (on working days only). Offline payment of fees at a designated branch of Axis Bank can be done during Banking hours on working days only.

The candidate has to pay Tuition Fees for one term (6 months) by Cash OR Demand Draft in favor of ACPUGMEC payable at Gandhinagar.

Sr. No.

Purpose

Amount (Rs.)

Details for Demand Draft (DD)

In favor of

Payable at

1

Tuition Fees for one term (6

months in Govt Institutes/ Self-financed institute

3,00,000/- (3.00 Lakh) – for Merit Quota seat

ACPUGMEC

Gandhinagar

Tuition Fees for one term (6 months for Self- financed institute

6,00,000/- (6.00 Lakh) for Institutional Quot seats (other than DDV & DMRE)

ACPUGMEC

Gandhinagar

Tuition Fees for one term (6 months for Self- financed institute

9,00,000/- (9.00 Lakh) for Institutional Quot seats for DDV & DMRE

ACPUGMEC

Gandhinagar

All candidates must write USER ID, Name, Mobile Number, and General Merit No. of CPS behind the Demand Drafts.

The candidates must pay Provisional Enrollment Fees) by DEMAND DRAFTS (DD) at the time of enrollment of admission of CPS courses after Completion of the whole admission process to the CPS, Mumbai as per the following details:

Sr. No.

Purpose

Amount (Rs.)

Details for Demand Draft (DD)

In favor of

Payable at

1

Provisional Enrollment Fee

85,000/- (Non-Refundable)

College of Physicians & Surgeons of Mumbai

Mumbai

At present, this DD is not required to be submitted at the help center of the Admission committee. After completion of the admission process, whenever CPS, Mumbai informs you of the enrollment process of CPS, Admission, at that time only you have to submit this DD to an authorized person of CPS Mumbai directly.

The candidate has to take an appointment at the nearest help center. After taking the appointment, the candidate can obtain his allotment letter and fees challan from his account after login with the help of User ID & Password.

The tuition fees of CPS Diploma Courses - 6 Lakh/Year for Merit Quota Seats and 12 to 18 Lakh/Year for Institutional Quota Seats in private institutions.

The candidates have to submit their original documents as follows -

1. Allotment Letter of ACPPGME

2. Tuition Fees Receipt

3. All-year MBBS mark sheets

4. 12 months internship completion certificate (Must be completed on or before Dt.11/08/2023)

5. Copy of NEET-PG-2023 Marksheet

6. Document showing Place of birth and date of Birth & Indian Citizenship (School leaving Certificate Transfer Certificate/ Passport/ Birth Certificate

7. Provisional Registration of State Medical Council OR Medical Council of India (In case of fresh candidates only who have just completed their internship)/Permanent Registration of S Medical Council OR Medical Council of India (In case of old pass-out candidates

8. For SEBC, ST, and SC Category: Caste certificate issued by Competent Authorities of Gujarat State only

9. For SEBC Category: Non-creamy layer certificate (Parishistha ‘4’ in Gujarati/English) issued by Competent Authorities of Gujarat State only as per Govt. norms issued after Dt: 01/04/2021

10. For EWS (Economically Weaker Sections) Category: EWS certificate issued by Competent Authorities Gujarat State only issued after Dt: 01/04/2021

11. Copy of Passport- If Citizenship is Dual/ Foreign

12. 12th Marksheet (For candidates who have done MBBS outside Gujarat

13. Domicile certificate of Gujarat state: For candidates who have done MBBS outside Gujarat& only if birthplace is outside Gujarat

14. Photo Copy of Disability Certificate issued by a Competent Authority (For PwD Candidates)

Failing to bring any original documents, the candidate will have no right of admission.

Vacant seat after round 3 –

A total of 29 seats are vacant after round 3.

Detailed seat matrix –

Diploma in Child Health (DCH)

2

Diploma in Gynecology and Obstetrics (DGO)

7

Diploma in Pathology and Bacteriology (DPB)

10

Diploma in Anesthesiology (DA)

5

Diploma in Ophthalmic Medicine and Surgery (DOMS)

3

Diploma in Tuberculosis Diseases

2

The rank-wise result and list of candidates required to report to the help center have also been released. The detailed list and results are enclosed in the notice below.

To view the notices, click on the link below –

https://medicaldialogues.in/pdf_upload/vacfull-229378.pdf

Thu, 04 Jan 2024 14:00:00 -0600 en text/html https://medicaldialogues.in/news/education/medical-admissions/29-seats-vacant-after-round-3-cps-admissions-dme-gujarat-releases-reporting-schedule-for-candidates-122620
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Diseases, Conditions, Syndromes

The chikungunya virus is widespread in tropical regions, where it is spread to humans by mosquitoes of the genus Aedes. Chikungunya is characterized by high fever, headache, muscle and joint pain, rash, and sometimes diarrhea. ...

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Hawaii Medical College Encourages Candidates To Begin New Careers In 2024

(MENAFN- EIN Presswire)

HMC HomeCare Logo

Happy Healthcare Worker

Healthcare Collaboration

Offering Programs to Start a New Healthcare Career Within a Year

The need in Hawaii is great for trained medical assistants, administrators/billers/coders and pharmacy techs. We are working diligently with healthcare institutions to help them with staffing.” - Ashton Cudjoe, CEO of Hawaii Medical CollegeHONOLULU, HAWAII, UNITED STATES, January 3, 2024 /EINPresswire / -- Hawaii Medical College has been helping students begin stable, well-paying careers in healthcare for the past 16 years. Offering both Diploma and Degree programs, the college is helping to fill the needs of the healthcare industry in Hawaii . Now, more than ever the need for Medical Assistants, Nurse Aides, Healthcare Administrators / Billing & Coding, and Pharmacy Technicians is at an all-time high. Those seeking a new path can benefit from the multitude of available positions.

Popular diploma level programs take just 10 months, while AAS degree programs take 18 months to complete. Admissions are on a rolling schedule, so students can enroll year-round. HMC staff is there to help at every step of the enrollment process, from the admissions forms to attaining financial aid.

The school makes learning and completion of programs easy because the classes are mostly online, offering students flexibility to fit classwork into their busy lives. HMC also offers students the use of a laptop computer, Microsoft Office 365 software and the training they need to use it effectively. And the laptop is theirs to keep when they have completed their diploma or degree.

“The need in Hawaii is great for trained medical assistants, administrators/billers/coders and pharmacy techs,” stated Ashton Cudjoe, CEO of Hawaii Medical College.“We are working diligently with healthcare institutions to help them with staffing.”

The employment opportunities abound in these stable well-paying careers. The annual wages for healthcare practitioners such as Clinical Medical Assistants, range from about $36,000 to $54,000, depending on the diploma or degree. Healthcare Administrator, Billing & Coders are paid Billing & Coders are paid between $29,000 to $44,000, Pharmacy Technician's salary range is $29,000 to $78,000 while Advanced Nurse Aides will make around $31,000. The range of pay varies widely, and Hawaii Medical College has strong relationships with hospitals, clinics, and other healthcare facilities to assist students with job placement. Hawaii Medical College is working to increase the number of qualified applicants for these jobs.

Tuition assistance is available for those who qualify through federal grants and loans. Professionals on staff at HMC can assist with applications and finding the financial aid candidates need.

About Hawaii Medical College
Opened in May 2007, Hawaii Medical College is Hawaii's successful locally owned, accredited career institution. Hawaii Medical College provides a supportive and care-oriented learning environment for students. Its professional staff trains students to be successful in a variety of careers from medical assistants, medical billing and coding to office assistants, and nurse aides. The college provides support and guidance to a variety of students from military veteran to high-school graduates ensuring that they are successful in their chosen careers. Each year the college reports program completions of between 200 – 400, high certification pass rates and placement rates. The mission of Hawaii Medical College is to provide a supportive environment where staff and students develop the necessary talents to be successful in their chosen careers.

Ashton Cudjoe
Hawaii Medical College
8082566759 ext.
email us here
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These Are The Best Dermatologist Tips For Getting Rid Of Dark Spots No result found, try new keyword!Meet the experts: Kiran Mian, DO, FAAD, is a New York City-based board-certified medical and aesthetic dermatologist at Hudson Dermatology & Laser Surgery. Jeannette Graf, MD, is a board-certified ... Thu, 04 Jan 2024 23:00:00 -0600 en-us text/html https://www.msn.com/ Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.

Due to a lack of currently available medical therapy, patients suffering from corneal endothelial disease, which leads to corneal swelling and potentially blindness, commonly require corneal transplantation. In fact, corneal transplantation is the most common type of transplant performed.

There is an urgent unmet need for safe and effective medical strategies for the prevention and reversal of persistent corneal edema, according to the investigators at Mass Eye and Ear of the Harvard Medical School Department of Ophthalmology. Therefore, there is a pressing need for the development of efficacious treatment for preventing, and potentially reversing, corneal edema due to corneal endothelial cell (CenC) loss following corneal injury.

This study examined the effect of local administration of α-MSH on persistent corneal edema and endothelial regeneration in an established model of injury-induced endothelial decompensation. The results show the impressive therapeutic potential of promoting the melanocortin pathway using α-MSH, thus opening new avenues of therapy.

Lead investigator Reza Dana, MD, MSc, MPH, Director of the Cornea and Refractive Surgery Service at Mass Eye and Ear, and Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School, explains, "Our data, demonstrating the potent therapeutic effects of α-MSH through melanocortin receptor agonism, provide compelling evidence for the therapeutic potential of this pathway for a wide array of ocular disorders such as Fuchs Dystrophy, a common disease and indication for corneal transplantation, as well as other disorders of the corneal endothelium that lead to corneal swelling."

α-MSH is an evolutionarily conserved neuropeptide derived from the proteolysis of the pro-opiomelanocortin and exerts an array of functions through different melanocortin receptors expressed in various tissues. Findings in this seminal study show that administration of α-MSH:

  • Prevents corneal endothelial cell death
  • Restores normal endothelial function
  • Permits the cornea to resume normal thickness after a severe injury that normally leads to corneal thickening
  • Causes corneal cells to regenerate

Interventions to prevent corneal edema following ocular injury are currently limited to topical hypertonic saline and topical anti-inflammatory drugs. However, these interventions have limited efficacy, and they do not prevent CEnC decompensation.

Dr. Dana concludes: "The findings of our study suggest the therapeutic potential of α-MSH, or analogs that work by activating the melanocortin receptor system, in management of pathologies where there is a risk of corneal endothelial dysfunction, such as corneal injury or intraocular surgery. This study outlines the critical role played by neuropeptides in CEnC maintenance and offers a novel perspective on their potential application in corneal endothelial regeneration."

Source:

Journal reference:

Alemi, H., et al. (2024). The Neuropeptide α-Melanocyte–Stimulating Hormone Prevents Persistent Corneal Edema following Injury. The American Journal of Pathology. doi.org/10.1016/j.ajpath.2023.09.007.

Mon, 01 Jan 2024 10:00:00 -0600 en text/html https://www.news-medical.net/news/20240102/Study-identifies-ceb1-MSH-as-therapeutic-candidate-for-corneal-endothelial-disease.aspx




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