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Exam Code: 156-115.80 Practice test 2022 by Killexams.com team
156-115.80 Check Point Certified Security Master - R80 (CCSM)

Exam ID : 156-115.80
Exam Title : Check Point Certified Security Master - R80
Questions : 100
Pass Marks : 70%
Duration : 90 minutes

- How policy changes impact chain module behavior
- Identify the source of UGI client connectivity problems
- Troubleshoot Secure Internal Communication issues
- Configure VPN Tunnel Interface
- Deploy IPv6 in a local environment
- Use commands to clear the connections table
- Configure Open Shortest Path First
- Troubleshoot NAT stages
- Identify connections in ClusterXL debug file

The Check Point Security Master course is designed for security experts who need to perform advanced deployment configurations of a Security Gateway and are working towards their Check Point Certified Cyber Security Master (CCSM) certification.

Our top technical certification proves the ability to perform advanced troubleshooting
• CCSMs get Expert level access to SecureKnowledge
• The CCSM is entitled to fast path access to Tier 3 Support
• Our CCSMs belong to a small group of elite security professionals in the world

CCSM Objectives
Chapter 1 - Advanced Database Management
• Obtain a deeper knowledge of the Security Management Architecture.
• Understand how the Security Management Server uses key processes and debugs.
• Review how objects are represented in the database.
• Understand how GuiDBedit operates.
Do you know…?
What is Solr?
Which ports are used for SIC?
Which database does R80.x use for storing all objects?
What is the syntax of a command for debugging issues with the internal Certificate Authority?
Which process is responsible for the Management HA synchronization?
Which command can be used to see the list of processes monitored by the Watch Dog process?
Chapter 2 – Kernel Mode and User Mode Troubleshooting
• Understand how to use fw monitor to capture packets.
• Understand how to use the fw debug process and debug infrastructures for User mode debugging.
• Discuss how to enable and use core dumps when a User mode process crashes.
Do you know…?
When running a debug with fw monitor, which parameter will create a more verbose output?
What is the proper command for allowing the system to create core files?
Which command will clean the buffer and change all kernel debug properties to the default?
What are benefits of the ‘fw ctl zdebug command?
Which directory are the usermode core files located in?
What are some special considerations that should be taken into consideration while running fw monitor on production firewall?
Chapter 3 - SmartConsole and Policy Management
• Understand how to troubleshoot and debug SmartConsole issues.
• Understand how to troubleshoot and debug issues that may occur during policy installation.
Do you know…?
Which process is first called when the policy installation command is initiated from the SmartConsole?
Explain what the SCConfigManager.exe tool is used for and how to use it?
What information is contained in a crash report from a SmartConsole application crash?
Chapter 4 – Advanced Network Address Translation
• Understand how to troubleshoot and debug NAT issues using Gaia commands.
• Understand Client Side and Server Side NAT.
• Describe how to configure port mapping services.
Do you know…?
Which kernel debug flag should you use to troubleshoot NAT connections?
What is the difference between Client-Side and Server-Side NAT?
What table would you review to investigate a port exhaustion error when using Hide NAT?
Chapter 5 - VPN Troubleshooting
• Recognize how to debug VPN-related issues.
Do you know…?
Which Check Point utility should be used use to assist in analyzing the output of vpn and ike debug?
What is the benefit of running “vpn debug trunc” over “vpn debug on”?
Which command would you use in the process of deleting the IPSec Key to a specific given
• Understand the infrastructure processes and components used for policy installation and processing packets in Access Control policies.
• Understand how to troubleshoot and debug issues that may occur with Application Control and URL Filtering.
• Understand how to debug HTTPS Inspection related issues.
• Understand how to troubleshoot and debug Content Awareness issues.
Do you know…?
Which Daemon should be debugged for HTTPS Inspection related issues?
Which daemon would you debug if you have issues with acquiring identities via identity sharing and sharing identities with other gateways?
What does CMI stand for in relation to the Access Control Policy?
Packet processing infrastructure consists of which components?
• Understand how to troubleshoot and debug issues that may occur with Threat Prevention Policies.
• Understand how to troubleshoot Anti-Bot and Antivirus issues.
• Discuss how to use IPS Bypass to manage performance issues.
• Understand how to configure IPS to reduce false positives.
Do you know…?
Which process is enabled when the Policy Conversion process has the debug turned on using the INTERNAL_POLICY_LOADING=1 command?
Which daemon is the main CLI process and daemon for Threat Extraction?
How many layers are incorporated in IPS detection and what are they called?
Which daemon is responsible for anti-spam?
Which Threat Prevention daemon is the core Threat Emulation engine and responsible for emulation files and communications with Threat Cloud?
What are some measures you can take to prevent IPS false positives?
Chapter 8 – Optimization and Tuning
• Understand how the server hardware and operating system affects the performance of the Security Gateway.
• Understand how to evaluate hardware configurations for optimal performance.
• Discover additional tools to assist in monitoring CPU utilization.
Do you know…?
What is the command to check the number of CoreXL firewall instances?
What is the default and maximum number of entries in the ARP Cache Table in a Check Point appliance?
How long (in hours) does the CPSizeMe script run by default?
Chapter 9 – Advanced Clustering
• Understand how to monitor cluster status and work with critical devices.
• Recognize how to troubleshoot state synchronization.
Do you know…?
Which command would you use in order to test a ClusterXL failover?
What ClusterXL mechanism is used to verify that the interfaces of other cluster members are UP and communicates the status of cluster members?
What ClusterXL mechanism is used to verify that the interfaces of other cluster members are UP and communicates the status of cluster members?
What does changing the cphaconf set_ccp parameter do?
What command can the administrator run to view the status of the registered critical devices?
What does changing the cphaconf set_ccp parameter do?
• Recognize how to use fwaccel and sim to enable and disable accelerated traffic.
• Understand how to use fwaccel dbg and sim dbg commands.
• Understand how to configure CoreXL to enhance Security Gateway performance.
Do you know…?
What mechanism can be used to confirm that important traffic such as control connections are not dropped when a Security Gateway is under high load?
What table does the command "fwaccel conns" pull information from?
Which command would show the synchronization statistics between cluster members?
What is the command to view the SecureXL connection table?
Which command would you use to check CoreXL instances for IPv6 traffic?
What does SIM handle?
Chapter 11 – Deploying IPv6
• Understand how to deploy IPv6 in a local environment
Do you know…?
How would an administrator view the routing table on the Security Gateway of production network where IPv6 is being used?
What is the command to monitor IPv6 traffic in Expert mode?
Which Check Point feature is not supported when running IPv6?

Check Point Certified Security Master - R80 (CCSM)
Checkpoint Certified information
Killexams : Checkpoint Certified information - BingNews https://killexams.com/pass4sure/exam-detail/156-115.80 Search results Killexams : Checkpoint Certified information - BingNews https://killexams.com/pass4sure/exam-detail/156-115.80 https://killexams.com/exam_list/Checkpoint Killexams : Demand for pilots grows as travel increases. TCC aviation program is working to boost the supply.

After COVID restrictions and fears of catching the virus dinged air travel for the past two summers, the summer of 2022 was anticipated to be the industry’s big comeback.

But pent-up demand for travel was tripped up by the consequences of too much pressure on beleaguered airlines struggling with staffing shortages, higher fuel costs and other challenges, resulting in long lines and flight delays or cancellations.

More than 2 million passengers passed through TSA security checkpoints across the country, with the peak this year on July 1, when about 2.5 million cleared checkpoints to board planes. On the same day in 2020, only 718,988 passed through those checkpoints.

Dallas-Fort Worth International Airport recorded 6.8 passengers during June, up from 6.35 million in June 2021, according to an airport report.

- FWBP Digital Partners -

“There is a desperate need for more pilots, said Chad Weigand, flight department chair of Tarrant County College’s Erma C. Johnson Hadley Center for Aviation, Technology and Logistics at the Northwest Campus.

With more people traveling, technology advances and other changes, the demand for additional pilots and other trained staff will be ongoing, Weigand said.

Critical pilot shortages were identified as far back as 2008 but the problems worsened during the pandemic as flight instruction was curtailed by shutdowns and airlines offered early retirement packages to pilots and other employees as cost-cutting measures.

Meanwhile, the largest group of airline pilots falls within the age range of 50 to 64, rapidly approaching the mandatory retirement age of 65. Congress increased the retirement age from 60 in 2007 in an attempt to stave off a crisis.

- Advertisement -

Congressional Republicans are again looking at proposed legislation to raise the pilot retirement age to 67. The Allied Pilots Association, representing 14,000 pilots of American Airlines, opposes the plan.

“It’s not at all clear that raising pilot retirement age would actually increase the pilot supply,” Capt. Eric Ferguson, president of the pilots association, said in a statement. “Moreover, while it might not be less safe, ‘might not’ must never be a rationale on which to base safety-sensitive decisions in our industry.

A new Boeing Co. report on the state of commercial air travel states that global demand for new airline personnel through 2041 is 602,000 pilots, 610,000 aircraft technicians and 899,000 cabin crew members. The North America need alone is 435,000 new employees.

Programs like TCC’s Center for Aviation, Technology and Logistics are trying to fill the void with professional pilot and aviation maintenance technician programs.

- Advertisement -

“Personnel is a growing global issue so we at TCC are looking at how we can step up to the plate,” Weigand.

While there are many private flight schools that train pilots, collegiate programs such as TCC’s offer advantages that include an associate’s degree upon completion. And, TCC is the only school in North Texas that offers the Federal Aviation Administration’s Part-141 flight-training curriculum.

Another advantage is the opportunity for scholarships and veterans’ benefits to help with tuition costs that aren’t available at commercial flight schools.

But even with financial assistance, the cost of a degree program with airplane pilot certification can cost between $68,000 and $72,000, including the cost of fees for aircraft rental, insurance, tuition and other expenses. Training for prospective helicopter pilots, which TCC’s program offers, costs more than $100,000.

Despite the demand for more pilots and the desirability of this high-paying career, the expense of training and education has been a detriment.

“People who want to do this have to convince themselves that they are willing to take on the debt,” Weigand said. “Our program is rigorous but it provides a pathway to the pipeline of the airlines.”

Alternatives routes to becoming a pilot include training academies offered by some airlines, including American Airlines, but slots are limited and competition is stiff, Weigand said.

Even the military, which historically has been the ultimate training ground for airline pilots, offers no guarantees that enlistees will be selected for pilot training, according to Weigand, a former airline pilot. A military-trained pilot also must commit to up to 10 years in the service, with the possibility of flying combat missions.

TCC’s aviation maintenance technician program was founded in 1967 and has turned out hundreds of mechanics over the years. About 200 students are currently enrolled and 187 students graduated during the 2021-22 school year.

Introduced in 2014, the professional pilot training program has an enrollment of about 150 and graduated 51 students in 2021-22.

TCC’s program is one of only a handful of nonprofit flight programs in Texas. Its use of the FAA’s Part-141 flight training curriculum permits graduates to apply for Restricted Airline Transport Pilot Certification, an option that shortens the pathway to certification for those as young as age 21 and with slightly fewer flight hours of flight training time.

All the benefits of TCC’s program, including its status as one of the largest aviation training facilities in Texas with $3 million in training equipment, checked off every box for Anique Jonathan Fazal Din, a Fort Worth resident whose lifelong dream has been to become an airline pilot.

At age 38, Fazal Din is as excited to be en route to the career he wished for at age 18, when circumstances stood in his way.

A native of Pakistan, Fazal Din immigrated to the United States and arrived in the Dallas-Fort Worth area when he was about 13 years old. As he was looking toward graduation from Grand Prairie High School in 2002, he told a school guidance counselor of his career dream.

“I was told that was probably not a good idea,” he said. “A guy from Pakistan couldn’t become an airline pilot a year after the 9/11 attack.”

Although he enjoyed studying and learning, Fazal Din struggled to find direction. He tried college, but couldn’t stick with it. So he played drums in a band. Eventually, he got married and started a family.

Then he earned his U.S. citizenship and became a stockbroker for Fidelity.

But he never gave up on his dream.

In 2019, he attended an information meeting about TCC’s flight training program and decided that was what he would do. He quit his job at Fidelity and used retirement savings to cover the costs. Having a wife who could financially support the family also helped.

On July 5, he fulfilled his final requirements and graduated from TCC’s professional pilot program with an associate’s degree.

His next goal is a position as a flight instructor, where 95 percent of TCC’s flight program graduates begin their careers.

Most TCC graduates initially work for U.S. Aviation, a vendor of Envoy Air and a wholly owned subsidiary of American Airlines. Through TCC’s partnership with Envoy Air, graduates who start as Envoy flight instructors have the opportunity to advance through its pilot pipeline program to major U.S. airlines such as American, United, Delta and Southwest, according to TCC officials.

Fazal Din’s eventual goal is American Airlines.

“I’m ready, I’m thrilled,” he said. “It’s my dream come true.”

The starting salary for flight instructors is $24,000 annually but the median annual salary for all pilots was $134,630 in 2021. However, airline pilots, co-pilots and flight engineers earned a median annual salary $202,180 in 2021.

The median annual wage for aircraft mechanics and service technicians was $65,380 in 2021, according to the federal agency.

TCC soon will launch a new program with high schools in Tarrant County that will allows students to earn dual credit from their schools and TCC in flight and maintenance classroom instruction via distance learning.

Mon, 08 Aug 2022 06:46:00 -0500 en-US text/html https://fortworthbusiness.com/business/demand-for-pilots-grows-as-travel-increases-tcc-aviation-program-is-boosting-the-supply/
Killexams : TSA at Palm Springs International Airport introduces new security technology

Officials with the Transportation Security Administration (TSA) hosted a media day at Palm Springs International Airport today for first looks at how their new technology is supposed to make travelers' security checkpoint experience more efficient.

This new technology is called Credential Authentication Technology (CAT) and it has a two-part component. First, when approaching the TSA security checkpoint, you will only need their Identification card. You do not need to have your boarding pass. Second, there is a 3d scanning machine that allows TSA to identify objects inside a carry-on more efficiently. The traditional 2d machines are still being used because PSP only has one 3d machine.

The spokesperson Lorie Dankers explained how CAT works, saying "Travelers will just hand over their photo ID, the officer will scan that into the cat unit. And the unit pulls up the basic biographical information of the traveler as well as all their flight information". Even though this technology has been in PSP since November of 2020, the PSP staff shared with us that foot traffic is climbing in number again and more people are becoming aware of the updates they have made since the start of COVID.

In June 2022, TSA screened approximately 75,500 people at Palm Springs International Airport.
That’s seven thousand more than what they saw in June 2021.

Second, there is a 3d scanning machine that allows TSA to identify objects inside a carry-on more efficiently. When travels get to the section where TSA checks carry-on bags, you do not have to take out electronics, such as Ipads and laptops. There are special bins that have an identification tag on them so when a bin passes through the machine, the contents inside are assigned to the bin until cleared by an agent.

Dankers explained, "This is a 3d x-ray scanner that when we screen the contents of a traveler's carry-on luggage, this screen, this scanner creates a 3d image of the contents of the bag".

She also explained the day-to-day of a TSA Agent who is certified to operate the new technology saying, "people travel with the same types of things, generally speaking, in their carry-on luggage. And so he sees a lot of the same kinds of things, but he has to even find things like explosive, I'm trying to be like a blasting cap, those kinds of things that might be used any type of item that could be prohibited. The focus really is explosives, because they're catastrophic on an aircraft. But in terms of the prohibited items, it's the types of items we saw on that table, as well as the other types of items. If somebody really wanted to be disruptive to the system, he's responsible for making sure those don't get through the checkpoint".

TSA shared a collection of prohibited items that exact travelers had in their carry-on luggage.

Wed, 13 Jul 2022 07:52:00 -0500 By Miyoshi Price en-US text/html https://kesq.com/news/news-headlines/2022/07/13/tsa-at-palm-springs-international-airport-introduces-new-security-technology/
Killexams : Groundbreaking CAP Guideline Clarifies Biomarker Testing, Impacts Multiple Cancer Types

Press release content from Business Wire. The AP news staff was not involved in its creation.

NORTHFIELD, Ill.--(BUSINESS WIRE)--Aug 3, 2022--

A new College of American Pathologists (CAP) evidence-based guideline is among the first to address testing based less on the cancer type or tumor origin and more on the methodology and status of a biomarker—in this case, microsatellite testing and deficient mismatch repair process assessment.

The “Mismatch Repair (MMR) and Microsatellite Instability (MSI) Testing for Immune Checkpoint Inhibitor Therapy” guideline provides clarity for pathologists and oncologists to Boost the evaluation of patients with colorectal, endometrial, gastroesophageal, small bowel, and certain other cancers who may be eligible for immunotherapies known as immune checkpoint inhibitors.

Published today in an early online release in Archives of Pathology & Laboratory Medicine, the guideline also breaks new ground with recommendations on the role of tumor mutational burden in MMR testing and the evaluation for Lynch Syndrome, a hereditary cancer syndrome that may be unexpectedly detected in the work-up of these patients with advanced cancers. The CAP developed the guideline in collaboration with experts from the Association for Molecular Pathology (AMP), the American Society of Clinical Oncology (ASCO), and the patient advocacy group Fight Colorectal Cancer (Fight CRC).

“We’ve seen that patients whose cancers had high levels of MSI or defective MMR can respond well to immune checkpoint inhibitor therapy, and now we have objective guidance to assess that status across a range of cancer types,” explains pathologist Russell Broaddus, MD, PhD, FCAP, who led the expert panel to develop the guideline.

Dr. Broaddus noted that when the FDA approved immunotherapy treatment for patients with MSI-high or MMR-deficient tumor status, regardless of cancer type, it did not detail how to test for that status. The new CAP guideline helps to fill that gap, providing oncologists, pathologists, and laboratories of all sizes with objective, evidence-based recommendations to efficiently deploy specific assays and accurately identify patients eligible for treatment.

With six recommendations and three good practice statements, the guideline provides data and details regarding the efficacy and utility of specific testing modalities across applicable cancer types, including MMR by immunohistochemistry, MSI by polymerase chain reaction, and MSI by next generation sequencing, for patients being treated with immune checkpoint inhibitors. In addition, the guideline identifies gaps in our current knowledge base, which, when addressed, may represent opportunities to help Boost the methodological approach for identifying the patients with advanced cancers who are most likely to respond to this therapeutic approach.

To ensure patients receive more effective testing with consistent, high-quality results, and expert interpretations, the CAP provides free, open access tools and resources with each evidence-based guideline to help clinical and laboratory teams adopt the recommendations. MMR-MSI guideline resources are downloadable on cap.org.

About the College of American Pathologists

As the world’s largest organization of board-certified pathologists and leading provider of laboratory accreditation and proficiency testing programs, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. For more information, READ THE CAP ANNUAL REPORT at CAP.ORG.

View source version on businesswire.com:https://www.businesswire.com/news/home/20220803005040/en/

CONTACT: Kerry Lydon

800-323-4040, ext. 7844

Email:media@cap.org

KEYWORD: ILLINOIS UNITED STATES NORTH AMERICA

INDUSTRY KEYWORD: SCIENCE RESEARCH ONCOLOGY GENERAL HEALTH HEALTH UNIVERSITY GENETICS EDUCATION

SOURCE: College of American Pathologists

Copyright Business Wire 2022.

PUB: 08/03/2022 04:18 PM/DISC: 08/03/2022 04:18 PM

http://www.businesswire.com/news/home/20220803005040/en

Wed, 03 Aug 2022 08:18:00 -0500 en text/html https://apnews.com/press-release/BusinessWire/health-cancer-3441da7d8ab2439e8c75a1ced0b43289
Killexams : Is summer travel causing long TSA lines at airports? Sort of. Here's how to prepare.

palmbeachpost.com cannot provide a good user experience to your browser. To use this site and continue to benefit from our journalism and site features, please upgrade to the latest version of Chrome, Edge, Firefox or Safari.

Sun, 31 Jul 2022 14:58:00 -0500 en-US text/html https://www.palmbeachpost.com/story/travel/airline-news/2022/07/22/travel-tsa-lines-airport/10123548002/
Killexams : Check Point Software Technologies Ltd - Stock News

Maintaining independence and editorial freedom is essential to our mission of empowering investor success. We provide a platform for our authors to report on investments fairly, accurately, and from the investor’s point of view. We also respect individual opinions––they represent the unvarnished thinking of our people and exacting analysis of our research processes. Our authors can publish views that we may or may not agree with, but they show their work, distinguish facts from opinions, and make sure their analysis is clear and in no way misleading or deceptive.

To further protect the integrity of our editorial content, we keep a strict separation between our sales teams and authors to remove any pressure or influence on our analyses and research.

Read our editorial policy to learn more about our process.

Tue, 12 Jul 2022 00:28:00 -0500 en text/html https://www.morningstar.com/stocks/xnas/chkp/news
Killexams : Fobi AI highlights success of its CheckPoint digital ticketing solution at the Oscars in new case study

Fobi AI (TSX-V:FOBI, OTCQB:FOBIF) Inc has released a case study highlighting the success of its CheckPoint digital ticketing solution at the Oscars, an annual awards ceremony for cinematic achievements held by The Academy of Motion Picture Arts and Sciences.

In partnership with Janam Technologies, a leading provider of rugged mobile computers and contactless solutions for venue access, the company said its CheckPoint system was used to create, distribute, and manage digital Wallet Pass tickets to the Oscars awards show and the Governor’s Ball that followed the show.

Fobi said it rolled out new functionality and was able to provide multi-location tickets for the Oscars so that guests who were able to attend both events needed only one ticket.

READ: Fobi AI says leading Caribbean digital proof of insurance provider Minubia has chosen Passcreator by Fobi to streamline and expand its services

Leveraging Janam’s mobile entry pedestals, equipped with the most advanced NFC technology, guests were able to self-scan their digital passes upon their arrival for a contactless, tap-and-go experience that moved attendees quickly and safely into the venues, Fobi reported.

Further, CheckPoint was integrated with the Oscars' existing venue systems and back-end CRM enabling event management staff to view ticket information and status for each guest from within their own CRM system.

Fobi CEO Rob Anson said the company’s partnership with Janam enabled Fobi to deliver a very efficient user experience for venue access and entry along with its digital ticketing and Verified credential offering.

“We are always focussed on streamlining and automating processes for venue operators as well as providing the means to an efficient and enhanced visitor experience,” Anson said.

Janam CEO Harry Lerner added that the wildly successful outcome of the partnership created at the Oscars was a model for how the two companies could collaborate going forward to deliver powerful, easy-to-use solutions that enabled any organization to share information and interact with guests in more meaningful ways.

“Together, Janam and Fobi provided The Academy of Motion Picture Arts and Sciences with a highly effective, super affordable technology solution that integrated with existing entry systems and enabled an entirely new level of service at the prestigious awards ceremony,” he said.

Fobi and Janam will be highlighting the case study in a joint webinar to be held at 9am PST on Thursday, July 28, 2022. You can register for the webinar here. The full case study can be found here

Fobi AI (TSX-V:FOBI, OTCQB:FOBIF) is a cutting-edge data intelligence company that helps its clients turn real-time data into actionable insights and personalized customer engagement to generate increased profits. 

Contact the author Emily Jarvie at emily.jarvie@proactiveinvestors.com

Follow her on Twitter @emilyjjarvie

Tue, 12 Jul 2022 00:54:00 -0500 en text/html https://www.proactiveinvestors.com/companies/news/987249/fobi-ai-highlights-success-of-its-checkpoint-digital-ticketing-solution-at-the-oscars-in-new-case-study-987249.html
Killexams : Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

From the Division of Hematology–Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston.

Address reprint requests to Dr. Boussiotis at Beth Israel Deaconess Medical Center, 330 Brookline Ave., Dana 513, Boston MA 02215, or at .

Wed, 13 Jul 2022 12:00:00 -0500 en text/html https://www.nejm.org/doi/full/10.1056/NEJMra1514296
Killexams : Check Point: Q2 Earnings Snapshot

TEL AVIV, Israel (AP) _ Check Point Software Technologies Ltd. (CHKP) on Monday reported second-quarter profit of $173.6 million.

The Tel Aviv, Israel-based company said it had profit of $1.36 per share. Earnings, adjusted for one-time gains and costs, came to $1.64 per share.

The results beat Wall Street expectations. The average estimate of 12 analysts surveyed by Zacks Investment Research was for earnings of $1.62 per share.

The data security company posted revenue of $571.1 million in the period, also exceeding Street forecasts. Thirteen analysts surveyed by Zacks expected $560 million.

_____

This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on CHKP at https://www.zacks.com/ap/CHKP

Mon, 01 Aug 2022 01:11:00 -0500 en-US text/html https://www.wiltonbulletin.com/business/article/Check-Point-Q2-Earnings-Snapshot-17342314.php Killexams : Groundbreaking CAP Guideline Clarifies Biomarker Testing, Impacts Multiple Cancer Types

A new College of American Pathologists (CAP) evidence-based guideline is among the first to address testing based less on the cancer type or tumor origin and more on the methodology and status of a biomarker—in this case, microsatellite testing and deficient mismatch repair process assessment.

The "Mismatch Repair (MMR) and Microsatellite Instability (MSI) Testing for Immune Checkpoint Inhibitor Therapy" guideline provides clarity for pathologists and oncologists to Boost the evaluation of patients with colorectal, endometrial, gastroesophageal, small bowel, and certain other cancers who may be eligible for immunotherapies known as immune checkpoint inhibitors.

Published today in an early online release in Archives of Pathology & Laboratory Medicine, the guideline also breaks new ground with recommendations on the role of tumor mutational burden in MMR testing and the evaluation for Lynch Syndrome, a hereditary cancer syndrome that may be unexpectedly detected in the work-up of these patients with advanced cancers. The CAP developed the guideline in collaboration with experts from the Association for Molecular Pathology (AMP), the American Society of Clinical Oncology (ASCO), and the patient advocacy group Fight Colorectal Cancer (Fight CRC).

"We've seen that patients whose cancers had high levels of MSI or defective MMR can respond well to immune checkpoint inhibitor therapy, and now we have objective guidance to assess that status across a range of cancer types," explains pathologist Russell Broaddus, MD, PhD, FCAP, who led the expert panel to develop the guideline.

Dr. Broaddus noted that when the FDA approved immunotherapy treatment for patients with MSI-high or MMR-deficient tumor status, regardless of cancer type, it did not detail how to test for that status. The new CAP guideline helps to fill that gap, providing oncologists, pathologists, and laboratories of all sizes with objective, evidence-based recommendations to efficiently deploy specific assays and accurately identify patients eligible for treatment.

With six recommendations and three good practice statements, the guideline provides data and details regarding the efficacy and utility of specific testing modalities across applicable cancer types, including MMR by immunohistochemistry, MSI by polymerase chain reaction, and MSI by next generation sequencing, for patients being treated with immune checkpoint inhibitors. In addition, the guideline identifies gaps in our current knowledge base, which, when addressed, may represent opportunities to help Boost the methodological approach for identifying the patients with advanced cancers who are most likely to respond to this therapeutic approach.

To ensure patients receive more effective testing with consistent, high-quality results, and expert interpretations, the CAP provides free, open access tools and resources with each evidence-based guideline to help clinical and laboratory teams adopt the recommendations. MMR-MSI guideline resources are downloadable on cap.org.

About the College of American Pathologists

As the world's largest organization of board-certified pathologists and leading provider of laboratory accreditation and proficiency testing programs, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. For more information, READ THE CAP ANNUAL REPORT at CAP.ORG.

© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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Wed, 03 Aug 2022 08:22:00 -0500 text/html https://www.benzinga.com/pressreleases/22/08/b28341149/groundbreaking-cap-guideline-clarifies-biomarker-testing-impacts-multiple-cancer-types
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