Get excellent grades in 202-450 test with these Questions and Answers and mock exam

Our LPI 202-450 Questions and Answers with sample test are precise of the 202-450 actual test. A total pool of 202-450 exam questions is kept up with in an information base of inquiries. We add and update new Questions and Answers on the customary reasons for contenders to retain the most current substance.

Exam Code: 202-450 Practice exam 2023 by Killexams.com team
202-450 LPIC-2 exam 202, Part 2 of 2, version 4.5

Exam Name LPIC-2 Linux Engineer
Exam Code 202-450
Duration 90 mins
Number of Questions 60
Passing Score 500 / 800

Description: Candidates should be able to configure BIND to function as a caching-only DNS server. This objective includes the ability to manage a running server and configuring logging.

Key Knowledge Areas:
- BIND 9.x configuration files, terms and utilities
- Defining the location of the BIND zone files in BIND configuration files
- Reloading modified configuration and zone files
- Awareness of dnsmasq, djbdns and PowerDNS as alternate name servers

The following is a partial list of the used files, terms and utilities:
- /etc/named.conf
- /var/named/
- /usr/sbin/rndc
- kill
- host
- dig

Description: Candidates should be able to create a zone file for a forward or reverse zone and hints for root level servers. This objective includes setting appropriate values for records, adding hosts in zones and adding zones to the DNS. A candidate should also be able to delegate zones to another DNS server.

Key Knowledge Areas:
- BIND 9 configuration files, terms and utilities
- Utilities to request information from the DNS server
- Layout, content and file location of the BIND zone files
- Various methods to add a new host in the zone files, including reverse zones

Terms and Utilities:
- /var/named/
- zone file syntax
- resource record formats
- named-checkzone
- named-compilezone
- masterfile-format
- dig
- nslookup
- host

Description: Candidates should be able to configure a DNS server to run as a non-root user and run in a chroot jail. This objective includes secure exchange of data between DNS servers.

Key Knowledge Areas:
- BIND 9 configuration files
- Configuring BIND to run in a chroot jail
- Split configuration of BIND using the forwarders statement
- Configuring and using transaction signatures (TSIG)
- Awareness of DNSSEC and basic tools
- Awareness of DANE and related records

Terms and Utilities:
- /etc/named.conf
- /etc/passwd
- DNSSEC
- dnssec-keygen
- dnssec-signzone

Description: Candidates should be able to install and configure a web server. This objective includes monitoring the servers load and performance, restricting client user access, configuring support for scripting languages as modules and setting up client user authentication. Also included is configuring server options to restrict usage of resources. Candidates should be able to configure a web server to use virtual hosts and customize file access.

Key Knowledge Areas:
- Apache 2.4 configuration files, terms and utilities
- Apache log files configuration and content
- Access restriction methods and files
- mod_perl and PHP configuration
- Client user authentication files and utilities
- Configuration of maximum requests, minimum and maximum servers and clients
- Apache 2.4 virtual host implementation (with and without dedicated IP addresses)
- Using redirect statements in Apaches configuration files to customize file access

Terms and Utilities:
- access logs and error logs
- .htaccess
- httpd.conf
- mod_auth_basic, mod_authz_host and mod_access_compat
- htpasswd
- AuthUserFile, AuthGroupFile
- apachectl, apache2ctl
- httpd, apache2

Description: Candidates should be able to configure a web server to provide HTTPS.

Key Knowledge Areas:
- SSL configuration files, tools and utilities
- Generate a server private key and CSR for a commercial CA
- Generate a self-signed Certificate
- Install the key and certificate, including intermediate CAs
- Configure Virtual Hosting using SNI
- Awareness of the issues with Virtual Hosting and use of SSL
- Security issues in SSL use, disable insecure protocols and ciphers

Terms and Utilities:
- Apache2 configuration files
- /etc/ssl/, /etc/pki/
- openssl, CA.pl
- SSLEngine, SSLCertificateKeyFile, SSLCertificateFile
- SSLCACertificateFile, SSLCACertificatePath
- SSLProtocol, SSLCipherSuite, ServerTokens, ServerSignature, TraceEnable

Description: Candidates should be able to install and configure a proxy server, including access policies, authentication and resource usage.

Key Knowledge Areas:
- Squid 3.x configuration files, terms and utilities
- Access restriction methods
- Client user authentication methods
- Layout and content of ACL in the Squid configuration files

Terms and Utilities:
- squid.conf
- acl
- http_access

Description: Candidates should be able to install and configure a reverse proxy server, Nginx. Basic configuration of Nginx as a HTTP server is included.

Key Knowledge Areas:
- Nginx
- Reverse Proxy
- Basic Web Server

Terms and Utilities:
- /etc/nginx/
- nginx

Description: Candidates should be able to set up a Samba server for various clients. This objective includes setting up Samba as a standalone server as well as integrating Samba as a member in an Active Directory. Furthermore, the configuration of simple CIFS and printer shares is covered. Also covered is a configuring a Linux client to use a Samba server. Troubleshooting installations is also tested.

Key Knowledge Areas:
- Samba 4 documentation
- Samba 4 configuration files
- Samba 4 tools and utilities and daemons
- Mounting CIFS shares on Linux
- Mapping Windows user names to Linux user names
- User-Level, Share-Level and AD security

Terms and Utilities:
- smbd, nmbd, winbindd
- smbcontrol, smbstatus, testparm, smbpasswd, nmblookup
- samba-tool
- net
- smbclient
- mount.cifs
- /etc/samba/
- /var/log/samba/

Description: Candidates should be able to export filesystems using NFS. This objective includes access restrictions, mounting an NFS filesystem on a client and securing NFS.

Key Knowledge Areas:
- NFS version 3 configuration files
- NFS tools and utilities
- Access restrictions to certain hosts and/or subnets
- Mount options on server and client
- TCP Wrappers
- Awareness of NFSv4

Terms and Utilities:
- /etc/exports
- exportfs
- showmount
- nfsstat
- /proc/mounts
- /etc/fstab
​- rpcinfo
- mountd
- portmapper

Description: Candidates should be able to configure a DHCP server. This objective includes setting default and per client options, adding static hosts and BOOTP hosts. Also included is configuring a DHCP relay agent and maintaining the DHCP server.

Key Knowledge Areas:
- DHCP configuration files, terms and utilities
- Subnet and dynamically-allocated range setup
- Awareness of DHCPv6 and IPv6 Router Advertisements

Terms and Utilities:
- dhcpd.conf
- dhcpd.leases
- DHCP Log messages in syslog or systemd journal
- arp
- dhcpd
- radvd
- radvd.conf

Description: The candidate should be able to configure PAM to support authentication using various available methods. This includes basic SSSD functionality.

Key Knowledge Areas:
- PAM configuration files, terms and utilities
- passwd and shadow passwords
- Use sssd for LDAP authentication

Terms and Utilities:
- /etc/pam.d/
- pam.conf
- nsswitch.conf
- pam_unix, pam_cracklib, pam_limits, pam_listfile, pam_sss
- sssd.conf

Description: Candidates should be able to perform queries and updates to an LDAP server. Also included is importing and adding items, as well as adding and managing users.

Key Knowledge Areas:
- LDAP utilities for data management and queries
- Change user passwords
- Querying the LDAP directory

Terms and Utilities:
- ldapsearch
- ldappasswd
- ldapadd
- ldapdelete

Description: Candidates should be able to configure a basic OpenLDAP server including knowledge of LDIF format and essential access controls.

Key Knowledge Areas:
- OpenLDAP
- Directory based configuration
- Access Control
- Distinguished Names
- Changetype Operations
- Schemas and Whitepages
- Directories
- Object IDs, Attributes and Classes

Terms and Utilities:
- slapd
- slapd-config
- LDIF
- slapadd
- slapcat
- slapindex
- /var/lib/ldap/
- loglevel

Description: Candidates should be able to manage an e-mail server, including the configuration of e-mail aliases, e-mail quotas and virtual e-mail domains. This objective includes configuring internal e-mail relays and monitoring e-mail servers.

Key Knowledge Areas:
- Configuration files for postfix
- Basic TLS configuration for postfix
- Basic knowledge of the SMTP protocol
- Awareness of sendmail and exim

Terms and Utilities:
- Configuration files and commands for postfix
- /etc/postfix/
- /var/spool/postfix/
- sendmail emulation layer commands
- /etc/aliases
- mail-related logs in /var/log/

Description: Candidates should be able to implement client e-mail management software to filter, sort and monitor incoming user e-mail.

Key Knowledge Areas:
- Understanding of Sieve functionality, syntax and operators
- Use Sieve to filter and sort mail with respect to sender, recipient(s), headers and size
- Awareness of procmail

Terms and Utilities:
- Conditions and comparison operators
- keep, fileinto, redirect, reject, discard, stop
- Dovecot vacation extension

Description: Candidates should be able to install and configure POP and IMAP daemons.

Key Knowledge Areas:
- Dovecot IMAP and POP3 configuration and administration
- Basic TLS configuration for Dovecot
- Awareness of Courier

Terms and Utilities:
- /etc/dovecot/
- dovecot.conf
- doveconf
- doveadm

Description: Candidates should be able to configure a system to forward IP packet and perform network address translation (NAT, IP masquerading) and state its significance in protecting a network. This objective includes configuring port redirection, managing filter rules and averting attacks.

Key Knowledge Areas:
- iptables and ip6tables configuration files, tools and utilities
- Tools, commands and utilities to manage routing tables.
- Private address ranges (IPv4) and Unique Local Addresses as well as Link Local Addresses (IPv6)
- Port redirection and IP forwarding
- List and write filtering and rules that accept or block IP packets based on source or destination protocol, port and address - Save and reload filtering configurations

Terms and Utilities:
- /proc/sys/net/ipv4/
- /proc/sys/net/ipv6/
- /etc/services
- iptables
- ip6tables

Description: Candidates should be able to configure an FTP server for anonymous downloads and uploads. This objective includes precautions to be taken if anonymous uploads are permitted and configuring user access.

Key Knowledge Areas:
- Configuration files, tools and utilities for Pure-FTPd and vsftpd
- Awareness of ProFTPd
- Understanding of passive vs. active FTP connections

Terms and Utilities:
- vsftpd.conf
- important Pure-FTPd command line options

Description: Candidates should be able to configure and secure an SSH daemon. This objective includes managing keys and configuring SSH for users. Candidates should also be able to forward an application protocol over SSH and manage the SSH login.

Key Knowledge Areas:
- OpenSSH configuration files, tools and utilities
- Login restrictions for the superuser and the normal users
- Managing and using server and client keys to login with and without password
- Usage of multiple connections from multiple hosts to guard against loss of connection to remote host following configuration changes

Terms and Utilities:
- ssh
- sshd
- /etc/ssh/sshd_config
- /etc/ssh/
- Private and public key files
- PermitRootLogin, PubKeyAuthentication, AllowUsers, PasswordAuthentication, Protocol

Description: Candidates should be able to receive security alerts from various sources, install, configure and run intrusion detection systems and apply security patches and bugfixes.

Key Knowledge Areas:
- Tools and utilities to scan and test ports on a server
- Locations and organizations that report security alerts as Bugtraq, CERT or other sources
- Tools and utilities to implement an intrusion detection system (IDS)
- Awareness of OpenVAS and Snort

Terms and Utilities:
- telnet
- nmap
- fail2ban
- nc
- iptables

Description: Candidates should be able to configure a VPN (Virtual Private Network) and create secure point-to-point or site-to-site connections.

Key Knowledge Areas:
- OpenVPN

Terms and Utilities:
- /etc/openvpn/
- openvpn

LPIC-2 exam 202, Part 2 of 2, version 4.5
LPI version exam
Killexams : LPI version exam - BingNews https://killexams.com/pass4sure/exam-detail/202-450 Search results Killexams : LPI version exam - BingNews https://killexams.com/pass4sure/exam-detail/202-450 https://killexams.com/exam_list/LPI Killexams : Finra Exams

Series 79, also known as the Investment Banking Representative Exam, is a Representative-Level exam administered by FINRA. Anyone who passes the Series 79 exam is qualified to advise on and/or facilitate debt and equity offerings, mergers and acquisitions, tender offers, financial restructurings, asset sales, divestitures (or other corporate reorganizations), and business combination transactions.

Sun, 16 Aug 2020 14:16:00 -0500 en text/html https://www.investopedia.com/finra-exams-4689804
Killexams : Best No-Exam Life Insurance Of February 2023

We scored companies based on these measurements:

Price (50% of score): We averaged the no-exam life insurance rates for males and females in excellent health at ages 30, 40 and 50 for $500,000 and $1 million and a term length of 20 years.

Maximum face amount for lowest eligible age (10% of score): Companies with higher no-exam life insurance coverage amounts for the lowest age earned more points. Note that maximum no-exam coverage can sometimes become lower if you apply at a higher age.

Age eligible for best length/amount (10% of score): Companies offering no-exam life insurance to folks over age 50 earned extra points.

Accelerated death benefit available (10% of score): This important feature lets you access part of your own death benefit in the event you develop a terminal illness

Option to convert to a permanent life insurance policy (10% of score): This is a good option to have in place if you decide you want a longer policy, especially if your health has declined and you don’t want to shop for new life insurance.

Guaranteed renewals (5% of score): This option lets you extend the coverage after your initial level term period has expired, such as at the end of 10, 20 or 30 years.

Renewal rates can be significantly higher, but renewing can provide extended coverage to someone who may no longer qualify for a new life insurance policy because of health.

Median time from application to approval (5% of score): We gave more points to companies with lower no-exam life insurance approval times.

The timeline for approval could be within seconds or a month, depending on the company and possibly even your health.

Sources: Bestow, Ethos, Fabric, Haven Life, Jenny Life, Ladder, Policygenius and Forbes Advisor research.

Looking For Life Insurance?

Compare Policies With Leading Life Insurance Companies

Tue, 31 Jan 2023 23:20:00 -0600 Ashlee Tilford en-US text/html https://www.forbes.com/advisor/life-insurance/best-no-exam-life-insurance/
Killexams : Best SIE exam Prep Courses

We recommend the best products through an independent review process, and advertisers do not influence our picks. We may receive compensation if you visit partners we recommend. Read our advertiser disclosure for more info.

The Securities Industry Essentials (SIE) exam is an entry-level assessment that covers products, risks, regulatory agencies, prohibited practices, and markets administered by the Financial Industry Regulatory Authority (FINRA). The exam has 75 multiple-choice questions, takes an hour and 45 minutes to complete, and it's a tough test, even if you have financial experience.

One of the best ways to get ready for it is to enroll in an SIE exam prep course, so you can make sure to make the grade of 70 or above needed to pass. Many companies offer SIE test prep, so when searching for your best fit, consider cost, pass guarantees, the structure of courses, venues (virtual live streams versus on-demand ), and study materials offered.

Tue, 25 Feb 2020 09:09:00 -0600 en text/html https://www.investopedia.com/best-sie-exam-prep-courses-4795763
Killexams : Why seniors should buy no-exam life insurance
senior couple on beach
No-exam life insurance policies offer flexibility and an expedited approval process. Getty Images

Life insurance is considered to be a vital part of financial planning for millions of adults. But for seniors, the benefits are not always clear. The cost of getting a policy relative to the coverage that can be secured can be inconsistent.

But that doesn't always mean life insurance for seniors isn't worth it. This particular financial protection can be beneficial in multiple ways - from covering end-of-life expenses to serving as an inheritance to loved ones and more. To get the most out of a policy, seniors should do their homework to discover the most valuable and cost-effective type.

Enter no-exam life insurance. This type of insurance can be secured more easily than other common life insurance types - and it doesn't need to be expensive either. There are multiple advantages to no-exam life insurance for seniors that we will explore below.

If you're considering life insurance then start by getting a free price quote now.

Why seniors should buy no-exam life insurance

Here are three reasons why seniors should buy no-exam life insurance now.

They don't need to take an exam

The best reason for seniors to purchase this type of life insurance is obvious: They don't need to take a medical exam to secure a policy. While the absence of a medical examination is beneficial on multiple fronts, it's especially helpful for older adults. That's because life insurance medical exams are thorough, testing blood, urine, blood pressure and more. You'll need to answer a questionnaire online and sit for the exam with a medical professional. This vetting could reveal problematic health issues that could result in limited coverage and higher costs. Depending on the results of the exam, seniors could even risk having their application rejected altogether.

But with no exam, all of these concerns are removed from the equation, leaving the applicant one big step closer to securing a policy.

Get a free price estimate online now to see what it could cost.

They can get approved quickly

It can take days - if not weeks - to schedule a medical exam at a time and place that's convenient for both you and the insurance provider. The results of that exam then need to go back to the provider for closer inspection, at which point they will either approve you for the coverage you applied for or counter with an amount they feel comfortable with. They may also turn down your application in full. All of this takes time and, depending on the ultimate result, could leave you back at square one.

But with no medical exam, you'll significantly expedite the approval process. Some providers will approve you within days while others may sign off on an application the same day it was submitted.

Nobody likes to waste their time. For seniors, especially those enjoying their retirement, an arduous and lengthy process can be discouraging. Fortunately, they can hasten the life insurance application by choosing a no-exam policy.

They have options to choose from

No-exam life insurance isn't tied to one specific type of life insurance. Whole life insurance, for example, has an attractive cash reserve that can potentially be used by the policyholder while they're alive. It also lasts for the duration of the insured's lifetime. Term life insurance lasts only for specific timeframes before expiring. It's also generally cheaper than whole life insurance policies.

You can get a no-exam policy with either type of insurance. If you prefer whole life insurance you can apply for it minus a medical exam. You can do the same for term life insurance policies if you think that's the better fit. No-exam life insurance policies won't limit you to a specific type, giving you more freedom and options to choose from.

The bottom line

Life insurance can be helpful to have for adults of all ages - even seniors. But for older adults to get the most value from a plan they need to choose the right type. No-exam life insurance, in particular, with its lack of a medical exam and expedited process, is an insurance worth pursuing. It can be tied to either a whole or term life insurance policy, too, giving seniors the flexibility to secure the best policy for their needs. 

Start by getting a free price quote online today.

Thu, 09 Feb 2023 05:26:00 -0600 en-US text/html https://www.cbsnews.com/news/why-seniors-should-buy-no-exam-life-insurance/
Killexams : Is no-exam life insurance worth it?
Senior woman using laptop at home
Because no-exam life insurance doesn't test for any medical issues, it can be a preferred option for seniors and older adults. Getty Images

Life insurance can be valuable for millions of American adults. How valuable a policy is, however, is specific both to the individual and the type of life insurance under discussion.

Term life insurance is generally favorable for those who want the security and protection a policy can provide without having to break the bank to get it. Since these policies only last for a select time frame (hence the name) they tend to be less expensive than their more robust counterparts.

Whole life insurance, meanwhile, lasts for the duration of the policyholder's life. And it comes with an attractive cash reserve that can be used to pay down debt or other expenses while the insured is still alive. But they tend to be pricier than other policies on the market.

While the benefits of these two types of policies are clear, there are other types on the market that may also be advantageous to have. No-exam life insurance can be great for a variety of prospective policyholders. But how do you know if it's worth it for you? That's what we will explore below. 

If you're currently in the market for life insurance then start by getting a free price quote so you know exactly what to expect.

Is no-exam life insurance worth it?

No-exam life insurance is exactly what its name implies: No medical exam is required to secure approval. But is it right for everyone? Here are three groups that could find this insurance valuable.

Seniors

Because this type of life insurance doesn't test for any medical issues, it can be a preferred option for many seniors and older adults. A medical exam, after all, tests blood, urine, blood pressure and more - all elements that could be below standard for seniors. When using these results for a traditional life insurance policy applicants could have their coverage severely limited (assuming they're approved at all).

By skipping the exam, you won't have to worry about getting approved. Whichever nagging health issues or pre-existing conditions you have will stay under wraps, allowing you to secure the life insurance that you and your beneficiaries need.

Get a free price estimate now so you know exactly what a policy would cost.

Young people

If you're young and healthy and want to make the life insurance application process as short as possible then no-exam life insurance could be beneficial for you. Because no medical exam is required for this type of coverage you could end up getting approved within days (if not within hours) after applying. 

Younger applicants will generally be offered more favorable rates and terms than older applicants, offsetting the typically higher cost connected to no-exam life insurance. It also has the benefit of providing immediate protection while you focus on other things. And because you're young, you can afford to wait to take a medical exam and go through a thorough vetting at a later date. 

Smokers and those with pre-existing conditions

If you're a smoker or were for a significant period of time, a life insurance provider could charge you significantly more. Similarly, if you're suffering from pre-existing medical conditions, with little chance of recovery, a life insurance provider would bill you more and/or limit the coverage provided.

By applying for a no-exam policy, you boost your chances of getting approved. And since no-exam policies can be offered with both whole and term life insurance types, you still may be able to secure the type of coverage you wanted.

Just note that each life insurance provider has different requirements so make sure to do your homework first. Start by getting a free price quote now or use the table below to review some top providers on the market.

The bottom line

No-exam life insurance can be a quick and painless way to secure financial protection for you and your loved ones. 

It can benefit a wide swath of applicants, particularly younger people who want the security a life insurance policy can provide without the hassle of going through the traditional application process. Seniors with existing medical concerns that otherwise may disqualify them from a policy would also benefit from this insurance type as would smokers and those with pre-existing medical conditions. 

Thu, 09 Feb 2023 10:04:00 -0600 en-US text/html https://www.cbsnews.com/news/is-no-exam-life-insurance-worth-it/
Killexams : Meet The World's First Modified Lamborghini Countach LPI 800-4

Eye-Catching Modifications

A Lamborghini Countach sporting a unique factory-applied Blu Hal finish that has been lowered and paired with attention-grabbing, mirror-polished golden wheels makes it the only one of its kind on the planet.

An Automotive Masterpiece

This breathtaking Countach LPI 800-4 by Lamborghini stands out from 112 other special edition models. The iridescent pearlescent finish is reminiscent of the Tuscans with ChromaFlair, and reminds us of the Nissan Skyline Midnight Purple.

The Modifications

The car is fitted with two-piece ANRKY Wheels' X Series S2-X0 and red brake calipers. It has been lowered with a static lowering kit. Considering these mods are easily reversible, these changes should not negatively impact the car's value in the future.

Head-Turning And Neck-Breaking

This combination of a $60,000 Blu Hal finish and bright polished gold wheels is likely to turn some heads - and make some purists a little less than thrilled. But the Sant'Agata brand has always embraced standing out from the crowd, and this car certainly does that.

A Bit Too Bold A Build

Swipe up to watch the video featuring the customized exclusive supercar. Do you think the owner has gone too over the top with this specification?

Wed, 01 Feb 2023 02:38:00 -0600 en text/html https://carbuzz.com/stories/meet-the-worlds-first-modified-lamborghini-countach-lpi-800-4
Killexams : Study reveals how CBD counters epileptic seizures

A study reveals a previously unknown way in which cannabidiol (CBD), a substance found in cannabis, reduces seizures in many treatment-resistant forms of pediatric epilepsy.

Led by researchers at NYU Grossman School of Medicine, the new study found that CBD blocked signals carried by a molecule called lysophosphatidylinositol (LPI). Found in called neurons, LPI is thought to amplify as part of normal function, but can be hijacked by disease to promote seizures.

Published online February 13 in Neuron, the work confirmed a previous finding that CBD blocks the ability of LPI to amplify nerve signals in a brain region called the hippocampus. The current findings argue for the first time that LPI also weakens signals that counter seizures, further explaining the value of CBD treatment.

"Our results deepen the field's understanding of a central seizure-inducing mechanism, with many implications for the pursuit of new treatment approaches," said corresponding author Richard W. Tsien, chair of the Department of Physiology and Neuroscience at NYU Langone Health.

"The study also clarified, not just how CBD counters seizures, but more broadly how circuits are balanced in the brain," added Tsien. "Related imbalances are present in autism and schizophrenia, so the paper may have a broader impact."

The study results build on how each neuron "fires" to send an electrical pulse down an extension of itself until it reaches a synapse, the gap that connects it to the next cell in a neuronal pathway. When it reaches the cell's end before the synapse, the pulse triggers the release of compounds called neurotransmitters that float across the gap to affect the next cell in line. Upon crossing, such signals either encourage the cell to fire (excitation), or apply the brakes on firing (inhibition). Balance between the two are essential to brain function; too much excitation promotes seizures.

The new study looked at several rodent models to explore mechanisms behind seizures, often by measuring information-carrying electrical current flows with fine-tipped electrodes. Other experiments looked at the effect of LPI by genetically removing its main signaling partner, or by measuring the release of LPI following seizures.

The tests confirmed past findings that LPI influences nerve signals by binding to a protein called G-coupled receptor 55 (GPR55), on neuron cell surfaces. This LPI-GPR55 presynaptic interaction was found to cause the release of calcium ions within the cell, which encouraged cells to release glutamate, the main excitatory neurotransmitter. Further, when LPI activated GPR55 on the other side of the synapse, it weakened inhibition, by decreasing the supply and proper arrangement of proteins necessary for inhibition. Collectively, this creates a "dangerous" two-pronged mechanism to increase excitability, say the authors.

The research team found that either genetically engineering mice to lack GPR55, or treating mice with plant-derived CBD prior to seizure-inducing stimuli, blocked LPI-mediated effects on both excitatory and inhibitory synaptic transmission. While prior studies had implicated GPR55 as a -reducing target of CBD, the current work provided a more detailed, proposed mechanism of action.

The authors propose that CBD blocks a "positive feedback loop" in which seizures increase LPI-GPR55 signaling, which likely encourages more seizures, which in turn increases levels of both LPI and GPR55. The proposed vicious cycle provides one process that could explain repeated , although future studies are needed to confirm this.

Further, the current study examined the plant-based cannabinoid CBD, but the authors note that LPI is part of signaling network that includes "endocannabinoids" like 2-Arachidonoylglycerol (2-AG) that occur naturally in human tissues. LPI and 2-AG target receptors also regulated by CBD, but have different actions at the synapse. While LPI amplifies incoming electrical signals, endocannabinoids like 2-AG respond to increases in by dialing down the release of neurotransmitters from nerve cells. Interestingly, LPI and 2-AG can be converted into each other through actions of enzymes.

"Theoretically, the brain could control activity by toggling between pro-excitatory LPI and the restorative actions of 2-AG," said first study author Evan Rosenberg, Ph.D., a post-doctoral scholar in the Tsein's lab. "Drug designers could inhibit the enzymes that underpin LPI production or promote its conversion to 2-AG, as an additional approach to control seizures. LPI could also serve as a biomarker of or predictor of clinical responsiveness to CBD, providing an area of future research."

More information: Richard Tsien & colleauges, Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity, Neuron (2023). DOI: 10.1016/j.neuron.2023.01.018. www.cell.com/neuron/fulltext/S0896-6273(23)00066-1

Citation: Study reveals how CBD counters epileptic seizures (2023, February 13) retrieved 19 February 2023 from https://medicalxpress.com/news/2023-02-reveals-cbd-counters-epileptic-seizures.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Sun, 12 Feb 2023 10:01:00 -0600 en text/html https://medicalxpress.com/news/2023-02-reveals-cbd-counters-epileptic-seizures.html
Killexams : LPI confident of tackling challenges in 2023

KUALA LUMPUR: LPI Capital Bhd said it will remain focused on business growth to offset an expected compression in margins following the implementation of Phase 2A of the market liberalisation plan.

Presenting its outlook for 2023, the insurer said it remains confident of its ability to adapt and innovate despite the insurance industry facing rising claims and reinsurance costs.

It noted also the global political and economic uncertainties and rapidly changing operating models.

"The LPI Group’s prudent underwriting approach and diversified business development channels will facilitate it to weather the numerous challenges in FY2023," it added in a statement.

In the fourth quarter of FY22 ended Dec 31, 2022, LPI said net profit was RM83.57mil, 14.47% improved from RM73.07mil in the previous corresponding quarter.

This came on the back of revenue of RM433.17mil in 4QFY22, up from RM429.04mil in 4QFY21.

According to the group, the improved quarterly performance was mainly contributed by an increase in investment income and a lower provision for fair value losses on investment.

For the full year, LPI's net profit came to RM276.61mil, down from RM344.68mil a year earlier.

The company's earnings per share dropped to 69.43 sen FY22 as compared with 86.52 sen in FY21.

The company reported revenue of RM1.66bil for the year under review, 3.5% lower from RM1.72bil in FY21.

The group announced a second interim dividend of 35 sen per share amounting to RM139.4mil despite the lower profitability in FY22.

This brings LPI's total dividend payout in FY22 to 60 sen a share or RM239mil, representing 86.4% of the group's net profit attributable to shareholders.

"In FY2022, the group’s performance was affected by significant changes to the operating environment as the domestic economy reopened following two years of pandemic-related restrictions under the Movement Control Order (MCO).

"While the resumption of business and social activities catalysed a return to growth, it also gave rise to insurance claims returning to pre-pandemic level following a significant decline over the past two years," said LPI.

It said its wholly owned subsidiary Lonpac Insurance Bhd continued to see an increase in claims frequency and value with its claims incurred ratio deteriorating to 40.5% from 37.7% in the previous corresponding quarter.

"With management expense ratio at 18% and commission ratio at 7.6%, Lonpac’s combined ratio for the 4th quarter of FY22 rose to 66.1% against 62.8% reported in the previous corresponding Quarter.

"With the higher claims experience, the Underwriting Profit of Lonpac was 4.5% lower at RM91mil against RM95.3mil achieved in FY2021," said LPI.

Mon, 06 Feb 2023 15:21:00 -0600 en text/html https://www.thestar.com.my/business/business-news/2023/02/07/lpi-confident-of-tackling-challenges-in-2023
Killexams : LPI Capital Bhd (KLSE:LPI) most popular amongst private companies who own 45% of the shares, institutions hold 28%

To get a sense of who is truly in control of LPI Capital Bhd (KLSE:LPI), it is important to understand the ownership structure of the business. With 45% stake, private companies possess the maximum shares in the company. Put another way, the group faces the maximum upside potential (or downside risk).

Institutions, on the other hand, account for 28% of the company's stockholders. Generally speaking, as a company grows, institutions will increase their ownership. Conversely, insiders often decrease their ownership over time.

Let's take a closer look to see what the different types of shareholders can tell us about LPI Capital Bhd.

See our latest analysis for LPI Capital Bhd

ownership-breakdown

What Does The Institutional Ownership Tell Us About LPI Capital Bhd?

Institutions typically measure themselves against a benchmark when reporting to their own investors, so they often become more enthusiastic about a stock once it's included in a major index. We would expect most companies to have some institutions on the register, especially if they are growing.

We can see that LPI Capital Bhd does have institutional investors; and they hold a good portion of the company's stock. This can indicate that the company has a certain degree of credibility in the investment community. However, it is best to be wary of relying on the supposed validation that comes with institutional investors. They too, get it wrong sometimes. It is not uncommon to see a big share price drop if two large institutional investors try to sell out of a stock at the same time. So it is worth checking the past earnings trajectory of LPI Capital Bhd, (below). Of course, keep in mind that there are other factors to consider, too.

earnings-and-revenue-growth

LPI Capital Bhd is not owned by hedge funds. Looking at our data, we can see that the largest shareholder is Consolidated Teh Holdings Sdn Berhad with 43% of shares outstanding. Public Mutual Berhad is the second largest shareholder owning 9.4% of common stock, and Sompo Asset Management Co.,Ltd. holds about 8.5% of the company stock.

A more detailed study of the shareholder registry showed us that 2 of the top shareholders have a considerable amount of ownership in the company, via their 52% stake.

While studying institutional ownership for a company can add value to your research, it is also a good practice to research analyst recommendations to get a deeper understand of a stock's expected performance. There are a reasonable number of analysts covering the stock, so it might be useful to find out their aggregate view on the future.

Insider Ownership Of LPI Capital Bhd

The definition of an insider can differ slightly between different countries, but members of the board of directors always count. Company management run the business, but the CEO will answer to the board, even if he or she is a member of it.

Insider ownership is positive when it signals leadership are thinking like the true owners of the company. However, high insider ownership can also deliver immense power to a small group within the company. This can be negative in some circumstances.

Shareholders would probably be interested to learn that insiders own shares in LPI Capital Bhd. It is a pretty big company, so it is generally a positive to see some potentially meaningful alignment. In this case, they own around RM182m worth of shares (at current prices). If you would like to explore the question of insider alignment, you can click here to see if insiders have been buying or selling.

General Public Ownership

The general public, who are usually individual investors, hold a 23% stake in LPI Capital Bhd. While this group can't necessarily call the shots, it can certainly have a real influence on how the company is run.

Private Company Ownership

It seems that Private Companies own 45%, of the LPI Capital Bhd stock. Private companies may be related parties. Sometimes insiders have an interest in a public company through a holding in a private company, rather than in their own capacity as an individual. While it's hard to draw any broad stroke conclusions, it is worth noting as an area for further research.

Next Steps:

I find it very interesting to look at who exactly owns a company. But to truly gain insight, we need to consider other information, too. Be aware that LPI Capital Bhd is showing 1 warning sign in our investment analysis , you should know about...

Ultimately the future is most important. You can access this free report on analyst forecasts for the company.

NB: Figures in this article are calculated using data from the last twelve months, which refer to the 12-month period ending on the last date of the month the financial statement is dated. This may not be consistent with full year annual report figures.

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team (at) simplywallst.com.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Join A Paid User Research Session
You’ll receive a US$30 Amazon Gift card for 1 hour of your time while helping us build better investing tools for the individual investors like yourself. Sign up here

Sun, 01 Jan 2023 17:43:00 -0600 en-US text/html https://www.yahoo.com/now/lpi-capital-bhd-klse-lpi-073129019.html
Killexams : This Might Be The World’s Most Striking Lamborghini Countach LPI 800-4

This Lamborghini Countach LPI 800-4 sits on a bespoke set of Anrky wheels

January 30, 2023 at 13:47

by Brad Anderson

While many remain unconvinced by Lamborghini’s decision to revive the famed Countach nameplate with an Aventador-based model, there’s no denying that this particular example is a real head-turner.

This Countach LPI 800-4 resides in Japan and is quite possibly the most outlandish anywhere on earth. This is thanks to Lamborghini itself, as well as Anrky Wheels.

Read: Lamborghini Delivered The First Two U.S. Countach LPI 800-4s At Monterey

For starters, the exterior of this Countach LPI 800-4 is bathed in a Chameleon-inspired paint scheme that changes color depending on the angle at which it is viewed. The main colors you’ll notice are orange, red, pink, purple, blue, and an eye-catching shade of bronze. Then there are the wheels.

Dubbed the X|Series S3-X0, these wheels have a gold-painted finish and suit the design of the modern-day Countach absolutely perfectly. They sit over a set of red brake calipers.

advertisement scroll to continue

Lamborghini is building just 112 examples of the Countach LPI 800-4 and ever since deliveries commenced in mid-2022, we’ve seen a host of particularly eye-catching examples handed over to their owners. One of the more intriguing was delivered in Canada back in October and is painted in Verde Abete, a British Racing Green that’s been contrasted with a set of bronze wheels.

As you may know already, the Countach LPI 800-4 has the same hybrid powertrain as the limited-run Sian FKP 37. This means it is rocking a 6.5-liter naturally-aspirated V12 supplemented by a 48-volt hybrid system and an electric motor to deliver a total of 803 hp and 531 lb-ft (735 Nm) of torque. The car can hit 60 mph (96 km/h) in just 2.8 seconds and won’t stop accelerating until it hits 221 mph (355 km/h).

 This Might Be The World’s Most Striking Lamborghini Countach LPI 800-4
Ankywheels/Lager_Corp
Mon, 30 Jan 2023 06:27:00 -0600 en text/html https://www.carscoops.com/2023/01/this-might-be-the-worlds-most-striking-lamborghini-countach-lpi-800-4/
202-450 exam dump and training guide direct download
Training Exams List