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Exam Code: EX200 Practice test 2022 by Killexams.com team
EX200 Red Hat Certified System Administrator (RHCSA)

Understand and use essential tools
Access a shell prompt and issue commands with correct syntax
Use input-output redirection (>, >>, |, 2>, etc.)
Use grep and regular expressions to analyze text
Access remote systems using SSH
Log in and switch users in multiuser targets
Archive, compress, unpack, and uncompress files using tar, star, gzip, and bzip2
Create and edit text files
Create, delete, copy, and move files and directories
Create hard and soft links
List, set, and change standard ugo/rwx permissions
Locate, read, and use system documentation including man, info, and files in /usr/share/doc
Operate running systems
Boot, reboot, and shut down a system normally
Boot systems into different targets manually
Interrupt the boot process in order to gain access to a system
Identify CPU/memory intensive processes and kill processes
Adjust process scheduling
Manage tuning profiles
Locate and interpret system log files and journals
Preserve system journals
Start, stop, and check the status of network services
Securely transfer files between systems
Configure local storage
List, create, delete partitions on MBR and GPT disks
Create and remove physical volumes
Assign physical volumes to volume groups
Create and delete logical volumes
Configure systems to mount file systems at boot by universally unique ID (UUID) or label
Add new partitions and logical volumes, and swap to a system non-destructively
Create and configure file systems
Create, mount, unmount, and use vfat, ext4, and xfs file systems
Mount and unmount network file systems using NFS
Extend existing logical volumes
Create and configure set-GID directories for collaboration
Configure disk compression
Manage layered storage
Diagnose and correct file permission problems
Deploy, configure, and maintain systems
Schedule tasks using at and cron
Start and stop services and configure services to start automatically at boot
Configure systems to boot into a specific target automatically
Configure time service clients
Install and update software packages from Red Hat Network, a remote repository, or from the local file system
Work with package module streams
Modify the system bootloader
Manage basic networking
Configure IPv4 and IPv6 addresses
Configure hostname resolution
Configure network services to start automatically at boot
Restrict network access using firewall-cmd/firewall
Manage users and groups
Create, delete, and modify local user accounts
Change passwords and adjust password aging for local user accounts
Create, delete, and modify local groups and group memberships
Configure superuser access
Manage security
Configure firewall settings using firewall-cmd/firewalld
Create and use file access control lists
Configure key-based authentication for SSH
Set enforcing and permissive modes for SELinux
List and identify SELinux file and process context
Restore default file contexts
Use boolean settings to modify system SELinux settings
Diagnose and address routine SELinux policy violations

Red Hat Certified System Administrator (RHCSA)
RedHat Administrator study help
Killexams : RedHat Administrator study help - BingNews https://killexams.com/pass4sure/exam-detail/EX200 Search results Killexams : RedHat Administrator study help - BingNews https://killexams.com/pass4sure/exam-detail/EX200 https://killexams.com/exam_list/RedHat Killexams : Red Hat Certification Guide: Overview and Career Paths

Red Hat Inc. provides open source software solutions to more than 90% of the Fortune 500 companies, including internet service providers, airlines, healthcare companies and commercial banks. The company has been around for more than two decades and is well known for its Red Hat Enterprise Linux (RHEL) distribution. Red Hat provides a fully open technology stack, which you can alter to suit your needs – you’re not locked into the vendor’s vision of the software or stack components. Red Hat’s portfolio of products and services also include JBoss middleware, cross-platform virtualizationcloud computing (CloudForms and OpenStack) and much more.

Red Hat offers numerous professional certifications based on its software products, including operating systems, virtualization, storage and cloud-based solutions.

Red Hat certification program overview

The Red Hat certification program aims at system administrators, engineers, architects, enterprise developers, and application administrators, as well as cloud and virtualization administrators, who use RHEL in their IT infrastructures. The certification program aims to ensure that candidates are proficient in RHEL by requiring them to pass performance-based certification exams. Whereas many certification exams ask multiple choice or fill-in-the-blank questions about specific technologies, Red Hat requires you to perform and complete real-world tasks using Red Hat technologies to pass its exams.

Red Hat traditionally offered certification exams only upon completion of a training course. Now you can take a Red Hat test on your own schedule, outside of training, if you like. Each test session is performed on a secured system in a professionally proctored testing center. These centers are located in select cities throughout the United States, Europe and Asia.

Once you earn a Red Hat certification, you become a Red Hat Certified Professional. This gives you access to Red Hat Certification Central, which allows you to connect with potential employers, join the Red Hat community, create study groups and collaborate on projects. In addition, you can explore Red Hat’s training options and easily schedule individual test sessions. Discounts on recertification exams are offered there as well.

Red Hat Administrator, Engineer and Architect certifications

The largest group of Red Hat certifications is geared toward system administrators, engineers and architects. Some of the most popular and sought-after Red Hat certifications reside in this category, such as the Red Hat Certified System Administrator (RHCSA), Red Hat Certified Engineer (RHCE) and Red Hat Certified Architect (RHCA).

The RHCA is probably Red Hat’s most versatile credential. In 2018, Red Hat implemented several changes to the RHCA program. The most notable change is that Red Hat now offers two separate RHCA credentials: the Red Hat Certified Architect in Enterprise Applications and the Red Hat Certified Architect in Infrastructure. Over the past year, Red Hat has retired a great many of its credentials, as you can see from the long list of “Retired Certifications” on the company’s All Certifications page. Candidates who have previously passed certification exams that are now retired may still be able to apply those retired certifications to current certification tracks. Check the certification overview page for each certification to find more details.

RHCSA: Red Hat Certified System Administrator

The RHCSA certification is designed for experienced Red Hat administrators and is required by some organizations to meet U.S. Department of Defense Directive 8570. It’s also a prerequisite credential for the Red Hat Certified Engineer (RHCE).

Red Hat recommends three training classes to prepare for the RHCSA certification. The Windows admin classes are Red Hat System Administration I (RH124) and Red Hat System Administration II (RH134). Candidates may also take a Linux/UNIX admin class – RHCSA Rapid Track Course RH199 – to prepare for the RHCSA exam.

To obtain RHCSA certification, candidates must pass the 2.5 hour RHCSA test (EX200).

RHCE: Red Hat Certified Engineer

The RHCE certification is geared toward experienced senior system administrators and fulfills requirements of U.S. Department of Defense Directive 8570.

To obtain the RHCE certification, you must first become RHCSA certified. The recommended training for the RHCE certification is based on your skill level. Windows admins with minimal Linux experience should take the Red Hat System Administration I and II (RH124 and RH134) courses, along with the Red Hat System Administration III (RH254) course to prepare for the exam.

Linux or UNIX admins with one to three years of experience should take both the RHCSA Rapid Track Course (RH199) and the Red Hat System Administration III (RH254) courses to prepare for the exam. RHCEs looking to recertify, or candidates who’d like the opportunity to engage in a lab-based review before taking the RHCE exam, should take the RHCE Certification lab (RH299). The certification lab is a four-day, instructor-led opportunity to work through all of the labs from the Red Hat System Administration I, II and III courses, along with the Rapid Track course.

To complete the RHCE certification, you must pass the 3.5-hour RHCE test (EX300), which is currently based on Red Hat Enterprise Linux 7.

RHCA: Red Hat Certified Architect

The RHCA certification is the pinnacle cert in the Red Hat Certification program. Red Hat has changed the RHCA program to be more flexible that previous incarnations of the program, depending on the candidate’s particular areas of interest and expertise. Currently, Red Hat offers two RHCA credentials:

  • RHCA in Infrastructure for Red Hat Certified Engineers (RHCE); and
  • RHCA in Enterprise Applications for Red Hat Certified Enterprise Microservices Developer (RHCEMD) or Red Hat Certified JBoss Developers (RHCJD)

Red Hat recommends certain specific certification combinations to achieve the RHCA in Infrastructure or RHCA in Enterprise Applications. Candidates are free to follow the recommended path or select their own certifications based on their professional interests and requirements.

The RHCA in Enterprise Applications has three recommended certifications combinations: application acceleration, and integration; application automation; or DevOps, containers, and OpenShift. While not required, Red Hat recommends that all candidates obtain the Red Hat Certified Specialist in OpenShift Application Development and Red Hat Certified Specialist in Enterprise Application Server Administrations.

There are four recommended certification combinations for the RHCA in Infrastructure: open hybrid cloud; DevOps, containers, and OpenShift; Red Hat OpenStack Platform; and Linux mastery.

RHCA Exams

Certification No. of Req’d Certifications Qualifying Certifcations List
RHCA in Infrastructure 5 Complete five certifications  from the following (listed by recommended combinations):

Open Hybrid Cloud

  • Red Hat Certified Specialist in Hybrid Cloud Management
  • Red Hat Certified Specialist in Gluster Storage Administration
  • Red Hat Certified Specialist in Virtualization
  • Red Hat Certified Specialist in OpenShift Administration
  • Red Hat Certified System Administrator in Red Hat OpenStack
  • Red Hat certified Specialist in Deployment and Systems Management

DevOps, Containers and OpenShift

Red Hat OpenStack Platform

Linux Mastery

  • Red Hat Certified Specialist in Linux Diagnostics and Troubleshooting
  • Red Hat Certified Specialist in Linux Performance Tuning
  • Red Hat Certified Specialist in Server Security and Hardening
  • Red Hat Certified Specialist in Identity Management
  • Red Hat Certified Specialist in High Availability Clustering
  • Red Hat Certified Specialist in Deployment and Systems Management
RHCA in Enterprise Applications 5 Complete five certifications exams from the following (listed by certification combinations): 

Recommended certifications regardless of certification combination:

  • Red Hat Certified Specialist in OpenShift Application Development
  • Red Hat Certified Specialist in Enterprise Application Server Administration

Application, Acceleration and Integration

  • Red Hat Certified Specialist in Fast-Cache Application Development
  • Red Hat Certified Specialist in Camel Development
  • Red Hat Certified Specialist in Data Virtualization
  • Red Hat Certified Specialist in Messaging Administration

Application Automation

  • Red Hat Certified Specialist in Business Process Design
  • Red Hat Certified Specialist in Business Rules

DevOps, Containers and OpenShift

  • Red Hat Certified Specialist in Ansible Automation
  • Red Hat Certified Specialist in Configuration Management

The number of recommended training courses varies for each RHCA concentration (RHCS means “Red Hat Certified Specialist” in the preceding table). At present only candidates who’ve already taken the retired exams in the DevOps category can earn RHCA: DevOps (hopefully, Red Hat will rectify this situation, or retire the credential). There is also some overlap in training course recommendations as shown in the table below.

Red Hat Cloud and Virtualization Administrator certifications

Formerly, Red Hat offered certifications geared toward IT professionals familiar with Red Hat virtualization and cloud technologies. In addition to the RHCA: Cloud (mentioned previously in this article), one could find the Red Hat Certified Virtualization Administrator, Red Hat Certified System Administrator in Red Hat OpenStack and the Red Hat Certified Engineer in Red Hat OpenStack. Today, that last item – namely, RHCE in Red Hat OpenStack – is the only remaining member of this category still available.

The Red Hat Certified Engineer in Red Hat OpenStack focuses on IT professionals who possess the skills necessary to install, deploy, and work with Red Hat Ceph Storage, including creation of block devices for Ceph and integration of services with Ceph Storage devices. In addition, Certified Engineers in Red Hat OpenStack can create and manage devices for virtual networks and use the OpenStack Neutron Service. Candidates must possess the Red Hat Certified System Administrator (RHCSA) in Red Hat OpenStack Platform 8 to qualify for the credential. In addition to the RHCSA test (EX210), candidates must also pass Red Hat Certified System Engineer in Red Hat OpenStack (EX310), a three-hour performance-based exam. Red Hat recommends that candidates take the Red Hat OpenStack System Administration Red Hat OpenStack Administration I (CL 110), II (CL210) and III (CL310) courses to prepare.

With the majority of Fortune 500 companies currently using Red Hat open source solutions, the value of IT professionals well-versed in Red Hat Linux technologies has long been recognized. Trained Red Hat professionals are a key ingredient to the successful creation and maintenance of Red Hat solutions that deliver enduring value.

Regardless of the type of Red Hat technology deployed, there is a consistent, established ongoing requirement for IT professionals qualified to serve as administrators, system engineers and architects.

System administrators are the foundation of deploying Red Hat Linux solutions. As operating system experts, system administrators possess an in-depth knowledge of essential Linux tools, as well as file systems and storage. Typical responsibilities include creating, configuring, deploying, and maintaining Linux systems along with performing software updates and maintaining system security.

Red Hat Linux system engineers are the next logical next step in the career ladder for Red Hat professionals. Not only do system engineers possess the same skills as administrators, but they are masters at setting runtime parameters and automating system maintenance through shell scripting. Linux system engineers are also experts at configuring system and remote logging, static routes (including packet filter and translation of network addresses), Internet Small Computer System Interface (iSCSI) initiators, and network services such as File Transfer Protocol (FTP), Simple Mail Transfer Protocol (SMTP), Network Time Protocol (NTP), secure shell (SSH), and more.

If system administrators are the foundation of deploying Red Hat solutions, architects are the authors and finishers when it comes to implementing, deploying, and maintaining Red Hat solutions. Architects define Red Hat Linux programs and are involved in all phases of Red Hat design projects – creation, development and testing of proposed solutions, integration with existing systems, defining the overall solution architecture, and providing support as the solution moves into production. As subject matter experts, Red Hat Linux architects formulate and deliver RHEL technology recommendations, create required documentation, and provide installation guidance and assistance.

Red Hat training and resources

Red Hat offers an extensive training program: in-classroom, online, virtual, remote classroom, onsite team and online learning lab formats are available. Most courses are three to five days in length, depending on delivery format. A remarkably helpful resource is the Red Hat Training Resource Center, which contains links to online tools, references, student guides, a skills assessment and more.

Red Hat now offers the Red Hat Learning Subscription, which gives certification candidates access to a multitude of online, on-demand classes and test prep videos for an annual subscription fee that varies depending on the specific certification you seek. In addition, Red Hat offers multiple ways for you or your company to save on certification and training costs. Browse the Red Hat Ways to Save page for training bundles and success packs.

You can also find lots of third-party study guidebooks to prepare for certification exams. Just search for “Red Hat Certification” on Amazon and be prepared for a lot of results.

Tue, 11 Oct 2022 12:00:00 -0500 en text/html https://www.businessnewsdaily.com/10710-red-hat-certification-guide.html
Killexams : Tips and Tools to Help Students Study, Take Notes, and Focus

With a new academic year rolling around, students of all ages will be looking for help and guidance with their work—and there are a wealth of options on mobile app stores and the web to help you succeed.

Here we've picked out some of the best apps and services across multiple categories, including time management, homework help, note-taking, and more. Put them together and you've got a comprehensive toolkit for making sure that this year is a good one.

No matter what your requirements, courses, or study habits are, there should be something here for you (or for the young student in your life). You might be surprised at just how much difference the right app can make.

Trello

Trello can adapt itself to whatever purpose you have in mind.

Courtesy of Trello

The main appeal of Trello is its versatility: You can adapt the simple card-based interface in whichever way you want—whether to keep track of individual homework assignments or to log multiple research strands in an essay—and the software will adapt accordingly.

You can assign categories and deadlines to cards, attach files to them, and drop in to-do lists. However you decide to use Trello, you're going to find it straightforward to get around the app with easy drag-and-drop operations and a ton of options and features.

Trello (freemium for web, Android, iOS)

Socratic

Get help from Socratic with just about any topic.

Courtesy of Socratic

Powered by Google's artificial intelligence engines, Socratic is here to answer any question on any topic, whether you need step-by-step math explanations, a quick overview of a historical event or work of literature, or details of a particular set of biological processes.

Sun, 09 Oct 2022 23:10:00 -0500 en-US text/html https://www.wired.com/story/tips-apps-help-students-study-notes-homework-help/
Killexams : Study hacks to help you ace your midterms

If you’re stuck on a problem or a concept discussed in class, ask for help. Ask a classmate, visit office hours or a help lab. Consider joining or starting a study group. And take advantage of other free resources. If you live on campus or are a first-year student, check out the Academic Success & Achievement Program (ASAP) for free tutoring support. If you need help writing a paper, visit The Writing Center. If you have a big research project, University Libraries offers consultations to help you get started. Review more academic resources for students. 

Sometimes the hardest part of studying is just getting started. Schedule out time in your week to study and do your best to get started right away. Find a favorite place that can become your study spot, like a coffee shop, library or community room in your residence hall. Establishing study routines and finding the right study spot can help you feel prepared for midterms.

Tue, 13 Sep 2022 12:00:00 -0500 en text/html https://www.colorado.edu/studentaffairs/2022/09/14/study-hacks-help-you-ace-your-midterms
Killexams : Why this Stanford researcher says you should ask your friends for more favors: 'We are a collaborative society'

Need a ride to the airport? Or help hanging your curtain rod? These pesky tasks are often made easier by asking a friend for help, but many of us are reluctant to do so.

People consistently underestimate others' willingness to lend them a hand, according to a new study published in the journal Psychological Science.

Help-seekers also overestimate how inconvenienced the person they are asking for a favor will feel.

"It can be nerve-wracking to ask a stranger for help," says Xuan Zhao, a social science research scholar at Stanford University who co-authored the study with Nicholas Epley, a social cognition professor at the University of Chicago.

"In our research we found people underestimate both strangers' and friends' [desire to help]."

'We are a pro-social and collaborative society'

Throughout history, there has been a debate about whether we live in a selfish society or a collaborative society, Zhao says.

 "Over the past few accurate decades, there has been more and more evidence that we are a pro-social and collaborative society," she says. "That's part of our winning strategy of evolution."

If you think about how you feel when you've helped out a friend, it might start to make sense.  

"Helping other people makes you feel good because it creates a moment of social connection," she says. "It makes you feel valued and needed by other people and if you are successful at helping them it makes you feel competent, and everyone likes feeling competent."

Helping other people makes you feel good because it creates a moment of social connection.

Xuan Zhao

Stanford Researcher

'People are taught to be self-sufficient'

Mon, 19 Sep 2022 02:30:00 -0500 en text/html https://www.cnbc.com/2022/09/17/new-study-you-should-ask-your-friends-for-help-more-heres-why.html
Killexams : Study Shows Lifting Weights Can Help You Live Longer

Weightlifting is now linked to as much as a 47% decrease in early death, according to a new study. (Photo: Grace Cary via Getty Images)

Weightlifting is now linked to as much as a 47% decrease in early death, according to a new study. (Photo: Grace Cary via Getty Images)

The notion that working out is good for you certainly is not anything new — it’s been shown over and over that exercise cuts your risk of heart disease, can help maintain a healthy weight, reduces stress and more.

While the benefits of aerobic exercises like spinning, swimming and running are often what first come to mind, a new study published in the British Journal of Sports Medicine found that weightlifting ― when combined with the recommended amount of aerobic exercise ― has serious health benefits, too.

For the study, the recommended amount of aerobic exercise was defined as the current fitness guidelines, which state adults should do at least two days of strength training each week and should participate in 150 minutes of moderate aerobic activity (like gardening, brisk walking or dancing) or 75 minutes of vigorous aerobic activity (like running, swimming or jumping rope). You can also do a combination of both moderate and vigorous activities.

The new study analyzed data from 99,713 adults over a 10-year period. At the beginning of the study, participants were asked how often they had lifted weights in the past 12 months. They were given the options of less than once a month, one to three times per month, one to two times per week, or three to seven times per week.

The study found that people who met the guidelines for aerobic activity and lifted weights one to two times each week were associated with a 41% to 47% reduction in all-cause mortality when compared with people who did not exercise, according to CNN. People who only met the guidelines for aerobic activity but did not lift weights had a 32% lower risk of all-cause mortality.

What’s more, those who lifted weights but did not do aerobic fitness saw as much as a 22% lower risk in all-cause mortality, CNN reported.

Additionally, those who lifted weights saw a 15% lower risk of dying from cancer, Medical News Today reported. While aerobic activity also resulted in a lower risk of death from cancer, that mortality risk was not reduced further when weightlifting was combined with aerobic activity.

A few caveats to keep in mind: Participants did not share how much weight they lifted or the number of sets or reps they did, so it’s unclear whether those factors played into the beneficial results. Also, the average age of study participants was 71, so it’s unclear whether weightlifting has a similar benefit on younger people.

Lifting weights one to two times a week is linked to a lower risk of early death in a new study. (Photo: Mireya Acierto via Getty Images)

Lifting weights one to two times a week is linked to a lower risk of early death in a new study. (Photo: Mireya Acierto via Getty Images)

Beyond a reduction in the risk of early death, weightlifting has other benefits, too

According to Katie Gould, a trainer andowner of KG Strong in Philadelphia, “strength training is one of the greatest tools for getting out of pain, as long as you’re doing it with good technique and alignment.”

By lifting weights, you’re strengthening muscles that were likely weak to begin with and may be the underlying cause of pain, she told HuffPost.

Another benefit of weightlifting may seem pretty straightforward but is actually a big deal: You’re getting stronger. Gould noted that many of her clients are excited to be able to properly and safely move things like the couch or the bed.

And with new strength comes increased confidence, Gould noted — and she has witnessed that confidence in her clients in and out of the gym.

Do weight training exercises that involve your full body

“It is important to work all the major muscle groups of the body — the legs, hips, back, abdomen, chest, shoulders and arms,” lead study author Jessica Gorzelitz, assistant professor in the department of health and human physiology at the University of Iowa, told HuffPost. This way, you’ll strengthen your body as a whole, not just a specific body part.

To get started, Gould recommended you commit to 30 minutes of weightlifting once a week with an eventual goal of two to three times a week. She stressed that your workout program should incorporate a range of exercises.

“A really good program is going to have a bilateral lower body push exercise — so think about a squat — [and] a bilateral lower body pull exercise like a deadlift. And, really, you want at least one exercise that is going to be unilateral, or one side dominant, like a lunge,” she said.

Gould said you should also be sure to focus on your upper body. Try incorporating an upper-body push like a pushup and an upper-body pull like a pullup. Lastly, make sure your workout targets your core. Gould noted that her favorite core exercises are Turkish get-ups or a classic plank.

“You’d do three sets for about eight to 12 reps depending on whether or not you’re using [weights],” Gould said. If you are doing bodyweight exercises (meaning, without weights), you can try to get closer to the 12-rep number.

Before you start weightlifting, seek some guidance

“People may be unfamiliar with weightlifting and not know how to get started. Our results suggest that some is better than none, and it’s OK to get started slowly and progress as strength and confidence increases,” Gorzelitz said.

But, improper weightlifting form can lead to injuries and intense soreness, which is why Gould encouraged folks to get help from a professional before lifting up some dumbbells.

“My favorite choice is you go to a studio and you either get some private training or semi-private training,” she said. But, if you can’t do that, she added that many gyms offer virtual training sessions where they’ll create a workout program that is ideal for you and your goals.

Additionally, there are people online who deliver weightlifting guidance. Gould recommended Girls Gone Strong, an online program that has free, downloadable fitness guides. The program also shares technique tips on its Instagram account.

Gould said Perform Better is a great resource for general movement tips and so is Katie St. Clair Fitness. She noted that her own gym’s Instagram account shares weightlifting advice, too.

Also on HuffPost

This article originally appeared on HuffPost and has been updated.

Related...

Wed, 12 Oct 2022 21:47:00 -0500 en-US text/html https://news.yahoo.com/study-shows-lifting-weights-help-094503851.html
Killexams : Folic Acid May Help Decrease Risk of Suicide, Study Finds
  • A accurate study investigated of taking folic acid was linked to a decrease in suicide attempts.
  • Over 12 million adults thought about suicide – with 1.2 million actually attempting to end their lives, in 2020 according to data from the CDC.
  • Researchers found people with a folic acid prescription experienced a 44% reduction in suicidal events.

New research published last week in JAMA Psychiatry investigated if taking the inexpensive vitamin folic acid may help reduce the risk of suicide.

“The importance of our study is that we have identified an inexpensive, widely available potential suicide prevention tool that has minimal if any side-effects,” lead author Robert Gibbons, PhD, Blum-Riese Professor of Biostatistics and Medicine at the University of Chicago, told Healthline.

In 2020, over 12 million adults thought about suicide – with 1.2 million actually attempting to end their lives, according to data from the Centers for Disease Control and Prevention (CDC).

“Folic acid is a type of B vitamin,” said Nicole Roach, a registered dietician at Lenox Hill Hospital in New York. “Many foods contain folate or will be enriched with folic acid.”

She added that this nutrient is naturally high in foods such as vegetables, especially dark green leafy vegetables such as spinach, mustard greens, and asparagus.

“Other foods which contain folate include nuts, beans, oranges and orange juice,” she continued.

According to Roach, while these foods are naturally high in folate, there are other foods that will be fortified with folate, which means that while not naturally a good source, the vitamin is added during the manufacturing process.

“These foods include enriched breads, flours, pastas, rice, and cornmeal,” she said.

Roach emphasized the importance of making sure you consume enough folic acid, because it plays an important role in cell functioning and growth.

She said we typically need about 400 micrograms of folate per day, while people who are pregnant should aim for 600 micrograms per day and those who are breastfeeding should aim for 500 micrograms per day.

Gibbons and team collected the data of almost 870,000 patients from a U.S. pharmacoepidemiologic database of medical claims for patients filling a folic acid (vitamin B9) prescription from 2012 to 2017.

This process was then repeated with a control supplement (vitamin B-12).

Over 80 percent of patients in this study were female, and a little over 10 percent were aged 60 years or older.

Researchers found the group that filled a folic acid prescription experienced a 44% reduction in suicidal events, which includes suicide attempts and intentional self-harm.

Researchers also found that the longer people took folic acid, the lower their risk tended to be. Each month of taking folic acid was associated with an extra five percent decrease in the risk of attempted suicide during a 24-month follow-up period.

“We were surprised by the strong association between reduction is suicide attempt risk with increased duration of folic acid treatment, said Gibbons. “We were also pleased to see that our negative control, vitamin B12 showed no association with suicide attempt.”

He said that a randomized clinical trial of folic acid is already in the works.

“If confirmed in a large-scale randomized clinical trial, which we are pursuing with one of our nation’s largest healthcare providers, it could have the potential to save thousands of lives,” said Gibbons

Naomi Torres-Mackie, PhD, a clinical psychologist at Lenox Hill Hospital said the impact of vitamin deficiency on mood has been previously studied, with B vitamins being the most commonly examined, particularly B12.

“There have also previously been studies on folate and depression, she said. “Being mindful not to conflate depression and suicide, this study only looked at the latter, which is an important contribution to separate out and examine suicide in particular.”

Experts stress that more study is needed and that people in mental health crisis or who have thoughts of suicide should immediately seek medical help.

Torres-Mackie noted that it’s important that people who have thoughts of suicide are seen by a mental health professional who has training in suicide and crisis management.

“The specific way in which suicidal ideation is treated depends on the underlying cause, as thoughts of suicide can be related to a mental health condition, commonly psychosis, or depression.”

This study seems to have promise,” said Torres-Mackie.

However, she cautioned that more study is needed before folic acid can be accepted as a new way to prevent suicide.

“There are some barriers for access to traditional forms of suicide treatment, but if folic acid can be helpful in reducing suicide attempts, it has the potential to provide help on a large-scale basis to individuals who very much need it,” she said.

Torres-Mackie cautioned that “much more” research is necessary before getting to that point.

“And as the authors point out, a large-scale randomized clinical trial is needed before a causal relationship can be determined or before treatment recommendations should include folic acid,” Torres-Mackie concluded.

Dr. Alex Dimitriu, double board-certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine and BrainfoodMD, said that people who have thoughts of suicide are typically treated with a combination of medication and therapy.

“Lithium, ketamine, and anti-depressants have been shown to reduce suicidal behavior,” he continued. “I believe that neuroplasticity – our ability to adapt and think differently, is essential, especially when someone is in a crisis-like state such as suicidal ideation.”

He explained that certain medications might Strengthen neuroplasticity.

“In the case of folic acid, it plays a key role in the formation of various neurotransmitters, serotonin, norepinephrine and even BDNF – brain derived neurotrophic factor, which is like ‘miracle grow’ for certain brain areas,” said Dimitriu.

He considered the study “impressive.”

“Given the low downside or side effect profile of using folic acid, I would certainly deliver it a go,” Dimitriu said.

“Always seek professional help with anyone having suicidal thoughts,” said Dimitriu. “If it is truly urgent, safety first, call 911 or get the person to an emergency room to assure safety.”

He added that in his years of experience work, he cannot underscore how many people, who considered suicide, were so happy to be alive months later.

“Time heals, and you have to be safe to allow the healing to occur,” Dimitriu pointed out. “We live in a time of treatment options, use them.”

New research finds that the B-vitamin called folic acid may reduce risk of self-harm or attempted suicide by up to 44 percent.

Experts say that this might be due to the vitamin’s crucial role in brain health.

They also say much more research is needed before folic acid can be considered a viable way to prevent suicide.

Tue, 04 Oct 2022 10:00:00 -0500 en text/html https://www.healthline.com/health-news/folic-acid-may-help-decrease-risk-of-suicide-study-finds
Killexams : How Fat Cells Help Kick Parasites Out of Mice: Study

Fat cells play a surprising role in combating parasites, according to a study published today (October 14) in Science Immunology, which finds that fatty tissue surrounding the intestinal tracts of mice helps eject gut-infesting worms and fight future infections.

Jorge Caamaňo, an immunologist at the University of Birmingham who was not involved in the work, says that “the study brings to focus the idea that when we’re looking at the immune response, we shouldn’t just focus on” immune cells.

Scientists already knew that mesenteric adipose tissue—the fat that lines the intestines—contributes to the immune response to pathogens and cancer. But its role in fighting parasites wasn’t well-defined until study coauthor and immunologist Edward Pearce and his colleagues at Johns Hopkins Medical Institute examined how fat cells and immune cells each respond to parasitic infection. 

Pearce’s group was studying how animals gain immunity to such infections in a mouse model when, during a routine autopsy, a veterinarian on the team noticed that the mesenteric adipose tissue of mice infected with parasitic helminths (Heligmosomoides polygyru) stiffened over the course of an infection. Helminths are microscopic worms that infect the gut (and only the gut), leeching nourishment from their host. In mice, they’re used to model human parasitic infections.

The researchers then sought to determine the cause of the tissue stiffness. As they were investigating how different cell types in the tissue responded to infection, they discovered a previously undescribed communication between two cell types that they later found to be important for long-term immunity to parasites: Th2 cells, a type of T cell known to fight parasites, and stromal cells, which are stem cell-like cells found in fat tissue that can differentiate into cells that provide structural support for tissues.

The researchers first isolated the stiffened fat tissue from parasite-infected mice and normal fat tissue from their healthy counterparts. They then separated the tissue into its component cells. And to study how infection restructures the immune cells and structural cells in the tissue, the team employed a combination of single-cell RNA sequencing, flow cytometry, cell culture, and histology.

Their first observation was that in addition to their presence in the gut, Th2 cells infiltrated the animals’ adipose tissue during infection—which the researchers found surprising, says Pearce, “because this infection actually never gets into the adipose tissue. It stays in the gut.”

Then, the team found that these fat-infiltrating immune cells differ from typical Th2 cells, as they were releasing the powerful cytokine TGFβ as well as Amphiregulin, a molecule that stimulates wound healing. They were also activated differently. Instead of being activated by a T cell receptor, a protein complex that typically triggers T cell activity during infection, the Th2 cells identified in the study were activated by cytokines. “They behaved in a way like cells that are part of the innate immune system rather than the adaptive,” says Pearce. 

The researchers then cultured the stromal cells and discovered they became highly metabolically active in response to Amphiregulin and TGFβ produced by Th2 cells. The stromal cells also started to produce cytokines, which further activated Th2 cells as they fought the helminth infection. The researchers also blocked the Amphiregulin receptor EGRF in stromal cells and observed that the severity of infection increased, highlighting the importance of stromal cell activation in fighting infection. 

When the researchers took a closer look at the animals’ tissues, they realized Th2 cells and stromal cells were meeting up in special spaces in the tissue called interstitial spaces, which become enlarged during infection. There, Th2 cells triggered stromal cells to secrete collagen and extracellular matrix, resulting in the observed tissue-stiffening. 

The team also found that some of these changes are long-lasting. Though their tissues returned to normal stiffness shortly after infection, the mice still had elevated levels of Th2 cells for up to a year after their initial infection was cleared with a drug (the mice were infected with the parasite for 11 to 14 days). Th2 cells and stromal cells also mobilized more quickly in response to subsequent infections.

Though Pearce and his team are not quite sure why Th2 cells are invading adipose tissue in the first place, they intend to find out. 

The findings from the study could help scientists fight disease—and not just parasitic infections, says Pearce. The rapid softening seen after a parasitic infection stands in contrast to other diseases where tissue becomes stiffer over time, like fibrosis. “There are strong resolving mechanisms at work here. And if we can understand more about those, perhaps they can be used to treat the type of fibrosis that goes too far.”

Fri, 14 Oct 2022 09:06:00 -0500 en text/html https://www.the-scientist.com/news-opinion/how-fat-cells-help-kick-parasites-out-of-mice-study-70627
Killexams : Study could help recommend the best treatment for women with early-stage mucinous ovarian cancer

A global study into mucinous ovarian cancer could help oncologists recommend the best treatment for women who are diagnosed early with the condition.

By looking down a microscope for two different 'patterns of invasion' – the way that cancer cells invade ovarian tissue – oncologists can better predict which patients may have better or worse prognoses and can target treatment accordingly. The finding was reported in a paper published today in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"Mucinous ovarian cancer is a rare type of ovarian cancer. It actually has more in common with gastrointestinal cancers, and can be hard to diagnose and hard to treat once it has spread beyond the ovaries," says lead author Nicki Meagher, who has just completed her PhD in the Molecular Oncology group, UNSW School of Clinical Medicine.

She says that observing which of the two types of invasion patterns that the cancer cells form could help specialists decide on treatment strategies.

We've shown for the first time that women who have early-stage disease – meaning they have tumors that haven't spread beyond the ovary – have much poorer survival chances in the first two years from diagnosis if they have what we call an infiltrative pattern of invasion.

Knowing this in the early stage of the disease means we can identify patients who could benefit from additional chemotherapy following surgery to remove their ovaries."

Nicki Meagher, Lead Author

The two patterns of invasion are defined by the way the cancer cells organize themselves when viewed under a microscope. The infiltrative pattern of invasion associated with poorer health outcomes shows cancer cells spreading in an uneven, haphazard way through the ovarian tissue. The other pattern is known as expansile, where cells expand through tissue in a more orderly manner, and is associated with better prognoses.

Up until now, other studies had suggested that the infiltrative pattern of invasion was associated with poorer patient outcomes, but no study had large enough numbers of patients with early-stage cancer to reach statistical significance.

But the current study, that involved more than 100 researchers in Australia, UK, Canada, Asia, Europe and the US, was able to test this hypothesis in much larger numbers by examining the tissue of 604 patients. The researchers also looked for the expression of 19 genes including THBS2 and TAGLN in addition to the patterns of invasion.

Professor Susan Ramus who oversaw the global study and heads the Ovarian Tumour Tissue Analysis consortium says that guidelines on how to treat women with early-stage mucinous ovarian cancer have differed around the world due to limited data on infiltrative patterns of invasion associated with survival rates.

"For example, in some parts of the world, an infiltrative pattern was acknowledged as an important feature and determined what treatment those women receive," Professor Ramus says.

"Whereas in others, all patients are recommended for the same pathway of treatment. We hope that after this large study treatment guidelines can be aligned and that we can target treatment for women who may have these more serious indicators, even if they are diagnosed in early stages."

The researchers also noted that women with higher expression of two genes, THBS2 and TAGLN in their tumors, had poorer overall survival.

"We're hoping that this may be able to help explain some of the biology potentially down the track," says Ms Meagher.

"Another avenue could be that knowledge of expression of these genes could assist in developing targeted drugs."

The researchers are part of a wide network of experts who plan to carry out a validation study to further investigate these genomic markers as the basis for a targeted treatment strategy.

Source:

Journal reference:

Meagher, N.S., et al. (2022) Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes. Clinical Cancer Research. doi.org/10.1158/1078-0432.CCR-22-1206.

Tue, 11 Oct 2022 12:00:00 -0500 en text/html https://www.news-medical.net/news/20221012/Study-could-help-recommend-the-best-treatment-for-women-with-early-stage-mucinous-ovarian-cancer.aspx
Killexams : Study: Eating a bigger breakfast may help control appetite

Sep 16, 2022, 12:02pmUpdated on Sep 16, 2022

By: News 12 Staff

A new study from the The University of Aberdeen shows bigger breakfasts might be better for controlling appetite.

Scientists controlled people's meals to see the effects of large breakfasts and dinners.

They found people seemed to burn the same calories whenever they had their biggest meal of the day.

However, people's appetites were noticeably smaller after a big breakfast.

Fri, 16 Sep 2022 00:03:00 -0500 text/html https://longisland.news12.com/study-eating-a-bigger-breakfast-may-help-control-appetite
Killexams : Snacking on Walnuts May Help Add Years to Your Life: Study

Snacking on walnuts instead of biscuits or sweets may add years to your life, according to research. A handful of nuts a day reduces the risk of heart attacks, strokes, and other life-threatening conditions linked to obesity.

The superfood is packed with chemicals that protect DNA by destroying reactive molecules, or oxidants. The study was published in the Nutrition, Metabolism, & Cardiovascular Diseases journal.

A study found regular consumers were slimmer and fitter as they got older. They had fewer harmful fats, called triglycerides, and lower blood pressure.

A picture showing walnuts. Snacking on walnuts instead of biscuits or sweets may add years to your life, according to new research. Unsplash

"Walnut eaters seem to have a unique body phenotype that carries with it other positive impacts on health like better diet quality," said lead author Professor Lyn Steffen of the University of Minnesota.

"This is especially so when they start eating walnuts from young into middle adulthood—as the risk of chronic diseases like heart disease, obesity, and diabetes elevates," Steffen said.

The findings are based on more than 3,000 individuals across the U.S. who were tracked for three decades, into their fifties.

Among walnut eaters, average weight gain was less, there were fewer cases of obesity, and fasting blood glucose was lower. They also had lower bad cholesterol than eaters of other nuts.

A model of a human heart. Among walnut eaters, average weight gain was less, there were fewer cases of obesity, and fasting blood glucose was lower. Unsplash

Nut consumers showed an advantage in relation to diet quality, but walnut consumers appear to have a better heart disease risk factor profile than other groups, even after accounting for overall diet quality.

"The surprising, healthy shifts in the overall dietary pattern of walnut consumers suggests walnuts may act as a bridge or 'carrier' food," Steffen said.

Walnuts are rich in healthy plant chemicals including polyunsaturated fat and omega fatty acids which combat bad cholesterol. They dampen inflammation that can lead to a clotted vessel—and trigger a heart attack or stroke.

A picture showing walnuts. Walnuts are rich in healthy plant chemicals including polyunsaturated fat and omega fatty acids which combat bad cholesterol. Unsplash

The study says walnuts might be an easy and accessible food choice to boost the heart when eaten up to middle age. It could be due to the "unique combination of nutrients" and their effect on health, Steffen said.

About an ounce a day—equivalent to seven whole walnuts—has four grams of protein and two grams of fiber. It is also a good source of magnesium which is important for the muscles and nerves and increases energy.

The study—backed by the National Heart, Lung, and Blood Institute in the U.S.—was also partly funded by the California Walnut Commission.

It took into account other heart disease risk factors including overall diet, smoking, and body composition.

Produced in association with SWNS Talker.

This story was provided to Newsweek by Zenger News.

Tue, 20 Sep 2022 09:14:00 -0500 en text/html https://www.newsweek.com/snacking-walnuts-help-years-your-life-study-1744388
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