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DEA-1TT5 Associate - Information Storage and Management


EXAM NAME: Associate - Information Storage and Management V5

This certification validates the learner’s comprehensive understanding of various
storage infrastructure components in modern data center environments. It tests
the learner’s knowledge of storage-related technologies in an increasingly
complex IT environment, which is fast changing with the adoption of new
technologies in a digital transformation era (Cloud, Edge computing, Big Data,
IoT, ML/AI, and 5G). It provides a strong understanding of storage-related
technologies such as storage networking technologies (FC SAN, IP SAN, and
NVMe over Fabric), intelligent storage systems (block, file, and object), data
protection (backup, archive, and replication), and storage infrastructure security
and management.

Modern Data Center Infrastructure (18%)

• Describe the data classification, elements of a data center, key
characteristics of a data center, and key technologies driving digital

• Explain the cloud characteristics, cloud service models, and cloud
deployment models

• Explain the key characteristics of big data, big data analytics, AI/ML,
Internet of Things (IoT) architecture, Edge computing, and 5G

• Describe a compute system, storage, connectivity in a data center, and
application center

• Describe software-defined data center, modern data center architecture,
and options to build a modern data center

Storage Systems (23%)

• Explain the components of an intelligent storage system, and RAID

• Describe storage provisioning and tiering

• Explain the features and components of block, file, object, and unified
storage system

Storage Networking Technologies (19%)

• Explain the FC SAN components, FC ports, topologies, link aggregation,
and SAN virtualization

• Explain the components and connectivity of iSCSI, FCIP, and FCoE

• Explain the NVMe over Fabrics, Software-defined storage and

Backup, Archive, and Replication (24%)

• Describe the information availability measurements and key fault
tolerance techniques

• Explain backup granularity, architecture, backup targets, operations,
and backup methods

• Describe data deduplication and data archiving solutions architecture

• Describe replication uses, and replication and migration techniques

Security and Management (16%)

• Describe the information security goals, terminologies, various security
domains, and threats to a storage infrastructure

• Explain key security controls to protect the storage infrastructure

• Describe the storage infrastructure management functions and

Associate - Information Storage and Management
DELL-EMC Information information hunger

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Associate - Information Storage and Management
Question: 72
A backup administrator has defined a backup policy. The policy requires full backups to be performed at 9 PM every Sunday and incremental backups
performed at 9 PM the remaining days.
If files were accidentally deleted Thursday morning, how many backup copies are required to restore the files?
A. 4
B. 5
C. 2
D. 3
Answer: C
Question: 73
What is an accurate statement regarding virtual LANs?
A. Provides software level connectivity and maintains physical LAN transport paths
B. Provides hardware level connectivity and maintains physical L AN transport paths
C. Supports Fibre Channel network transport data security
D. Supports one or more logical L ANS operating over a single physical LAN
Answer: A
Question: 74
Which type of data protection is used to move primary data to lower cost storage and helps to enforce compliance requirements?
A. Backup
B. Replication
C. Deduplication
D. Archive
Answer: C
Question: 75
What is the lowest to highest order of I/O performance among these storage devices?
Answer: C
Question: 76
Why do organizations prefer to adopt Disaster Recovery as a Service (DRaaS)?
A. Increase the effective utilization of hardware resources in their data centers
B. Eliminate both CAPEX and OPEX in managing disaster recovery at remote sites
C. Understand and learn DRaaS best practices from service providers
D. Avoid maintaining a complete set of IT resources in a remote data center for disaster recovery
Answer: D
Question: 77
What is a benefit of application virtualization?
A. Avoids conflicts between different versions of the same application
B. Enables an application to directly access a LUN on a storage system
C. Runs applications without requiring the use of cache memory
D. Presents more memory to an application than is physically available
Answer: A
Question: 78
Which modem technology enables data to be securely collected and processed at point of creation to create new value?
A. Big Data
B. Edge Computing
C. Private cloud
Answer: B
Question: 79
Refer to the exhibit:
Which operation is represented?
A. Write-through
B. Read Hit
C. Read Miss
D. Write-back
Answer: B
Question: 80
Refer to the Exhibit:
What type of data protection is represented?
A. Deduplication
B. Migration
C. Backup
D. Archiving
Answer: C
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DELL-EMC Information information hunger - BingNews Search results DELL-EMC Information information hunger - BingNews EMC Vs. Dell Top Executive Compensation: How Do They Compare?

It Pays To Be Boss

Dell and EMC executives talk a lot about how well the two companies will fit together once their proposed merger is finalized, but there is one area where things don't really line up: executive pay.

EMC's top executives make vastly more than privately held Dell's. Being publicly traded makes a big difference -- EMC execs get millions in stock awards as part of their pay. The company detailed the 2015 pay packages of top executives recently in its annual proxy filing with the U.S. Securities and Exchange Commission.

The pay discrepancies come with EMC weighing in at less than half the annual revenue weight class of Dell. In its latest fiscal year, Dell's revenue was about $55 billion and EMC's was about $25 billion. However, EMC reported net income of $2.1 billion, while Dell reported a $1.1 billion loss.

CEO Joe Tucci's $1 million base salary is relatively close to the $950,000 CEO Michael Dell made last year, and while the salaries of other top Dell execs are perhaps in the ballpark with EMC's, total pay for EMC brass is consistently more.

Dell, which disclosed executive pay in a separate SEC filing connected to the proposed merger, wouldn't comment on how the company intends to square the pay packages of EMC executives with their new lives inside a privately held firm. Dell expects the acquisition, valued around $60 billion, to close between May and October.

2015 Pay Package: Joe Tucci

Tucci's pay totaled $10.4 million last year, a drop of more than 7 percent compared with the year before, thanks to the declining value of stock awards issued to him. The chairman, president and CEO's $1 million salary hasn't changed in latest years, and his bonus, $1.1 million last year, has fluctuated. Stock awards, however, have steadily declined, from $9.4 million in 2013 to $7.9 million last year. Tucci's 2015 package also included $320,964 in "other compensation," including $218,274 in air travel, as well as tax planning service, 401(k) contributions and other benefits. Tucci has been CEO of EMC since 2001, and chairman since 2006. He's staying in that capacity only until the merger with Dell closes. Under EMC's change-in-control policy, Tucci stands to collect about $39 million in cash and stock after the merger closes.

Tucci's Salary-Bonus Is More Than Four Times Michael Dell's Pay Package

If not for an $8.9 million cash payout tied to Dell's $24.9 billion leveraged buyout in 2013, then EMC CEO Joe Tucci earned more than four times what Dell founder, Chairman and CEO Michael Dell (pictured) did for Dell's fiscal year ended Jan. 29, 2016. Dell, in fact, was not the highest paid Dell executive in fiscal 2016. Dell's pay package totaled about $2.4 million for the year. That includes a salary of $950,000, a $1.4 million bonus and just under $18,000 in benefits and perks, including a 401(k) plan, health insurance, life insurance and other items.

2015 Pay Package: David Goulden

Goulden, CEO of EMC Information Infrastructure, the company's largest division, saw his 2015 pay package decline 6.4 percent from the previous year. While his $850,000 salary hasn't changed, his bonus declined 11.2 percent year over year, to $954,415, and he got $7.9 million in stock awards compared with $8.4 million the previous year. Goulden's pay included $103,051 in "other compensation," including just over $9,000 in air travel, as well as other benefits. Goulden has been with EMC for more than a decade, and took the helm at EMC II in 2014. Goulden joined EMC from Getronics, and was also previously an exec at Wang and Unisys.

When the Dell EMC merger is finalized, Goulden stands to receive payments totaling about $31.1 million, including $7.1 million in cash severance and $23.9 million in accelerated equity awards, if he leaves the combined company within two years, according to EMC's change-in-control policy.

Haas' Salary In Ballpark With Goulden's

Dell President and Chief Commercial Officer for Enterprise Solutions Marius Haas (pictured) has been with Dell since 2012, and like Goulden, he'll report directly to CEO Michael Dell after the merger closes. He received a 2016 pay package totaling nearly $3.4 million, including a base salary of $772,890, a $2.6 million bonus, and $1,206 in perks and benefits. In addition, Haas' cash payout tied to Dell's going private transaction was $439,467. As Dell's president and chief commercial officer for enterprise solutions, Haas spearheads global go-to-market efforts for the company's commercial portfolio. Haas' career has included stints at Hewlett-Packard, Compaq and Intel, as well as storied private equity powerhouse Kohlberg Kravis Roberts & Co.

2015 Pay Package: EMC CFO Zane Rowe

Rowe's pay package for 2015 was $6.5 million on a combination of $750,000 in salary, nearly $5 million in stock awards, a $600,741 bonus and $195,373 in "other compensation," including a $180,450 housing allowance that was part of his 2014 new hire package, as well as tax and financial planning services and 401(k) contributions. In January of this year, Rowe was tapped to replace Jonathan Chadwick as CFO of VMware.

When the Dell-EMC merger is finalized, Rowe stands to receive about $6.1 million in payouts, nearly equally split between $3 million in cash severance and $3.1 million in accelerated equity awards, if he leaves the combined company within two years, under the company's change-in-control policy.

Rowe Made Almost Twice As Much As Dell's CFO

Thomas Sweet (pictured), Dell senior vice president and CFO, has been with Dell for nearly 20 years. His pay package for the 2016 fiscal year was $3.4 million, including a base salary of $650,000, a $2.7 million bonus that included a $170,000 cash award as part of a 2013 retention agreement, and about $35,000 in benefits and perks. Sweet also got a cash payout of $169,364 in connection with Dell's leveraged buyout. Sweet has a broad set of responsibilities, including financial planning and analysis, the company's tax accounting, treasury and investor relations. He's also responsible for Dell corporate strategy and development.

2015 Pay Package: Jeremy Burton

Burton, EMC's president of products marketing, was one of two EMC execs who saw their total pay increase in 2015. Burton's $8.5 million pay package was a 23 percent increase compared with the year before. His $800,000 salary was up 4.2 percent from the prior year, while his stock awards of $6.9 million were 32 percent more than his 2014 awards. Burton's bonus, however, shrunk to $665,940 from $717,035. Burton will be chief marketing officer of the combined Dell-EMC. Burton was president and CEO of Serena Software before joining EMC. He's also held executive positions at Symantec, Veritas and Oracle.

When the Dell-EMC merger is finalized, Burton stands to receive about $23.5 million, including $5.6 million in cash severance and $17.9 million in accelerated equity awards, if he leaves the combined company within two years, according to the company's change-in-control policy.

Jeff Clarke's Salary Is In EMC Territory

Clarke, who has been with Dell since 1987, received a 2016 pay package totaling $3.8 million, including an $826,160 base salary, a bonus just shy of $3 million, and $25,146 in benefits and perks. As part of Dell's going-private transaction, Clarke got a cash payout of $684,626 last year. As vice chairman of operations and president of client solutions, Clarke is responsible for Dell's global manufacturing, procurement and supply chain activities, as well as the engineering, design and development of desktops, notebooks and workstations for consumers, SMBs and enterprise. Clarke also leads customer support, as well as global IT planning and governance.

2015 Pay Package: Howard Elias

Elias, EMC's president and COO of global enterprise services, also saw his pay package increase significantly last year. His package totaled $8.5 million, a 22.5 percent increase over the previous year, and it included a 4.1 increase to his base salary, to $781,923. Like Burton's, Elias' bonus dipped in 2015, but his stock awards were just under $7 million, about 32 percent more than they were a year before. Elias, who along with Dell's Rory Read is heading the integration of the two companies, has been with EMC since 2003. He joined the company from HP, and he also previously held executive positions at Compaq.

When the Dell EMC merger is finalized, Elias stands to receive about $23.9 million, including $5.4 million in cash severance and $18.4 million in accelerated equity awards, if he leaves the combined company within two years, according to EMC's change-in-control policy.

Dell's Rory Read Had A Good Year, But His Salary Is Far Below Elias'

Rory Read, who was hired about a year ago as chief operating officer and is now heading up the integration of Dell and EMC along with EMC COO Howard Elias, received the biggest pay package of any Dell executive in fiscal 2016. His total compensation for 2016 was $10.5 million, including a $750,000 signing bonus, as well as option awards that carried a value of $7.1 million when they were granted to him. His base salary is $496,154. Read's contract also stipulates that if he does not receive a payment of at least $2 million under the company's special incentive bonus plan in fiscal 2016, 2017 and 2018, he may resign and get half that amount. Not counting the $750,000 signing bonus, Read's bonus for 2016 was about $2.2 million.

Lots Of Options

Publicly traded companies award stock and stock options as a way to retain employees. Stock awards vest over time and options are set to be exercisable over time, each on a predetermined schedule. The employee can exercise his or her option to buy company stock at the so-called strike price that was set at the time the stock was awarded, the idea being that the strike price will be a discount to the stock's market value at the time of the exercise. Other stock awards simply vest on a predetermined schedule. In 2015, Tucci realized $8.8 million in value on the exercise of previously awarded options and $10.1 million on the vesting of previously issued stock awards. Goulden realized $912,450 in value on the exercise of previously granted options and $6 million on the vesting of previously awarded stock. Rowe also realized $1.8 million on the vesting of previously awarded stock. Burton realized just under $4 million in the vesting of previously awarded stock. Elias realized about $4.8 million in the value of previously awarded stock that vested during the year.

Mon, 18 Apr 2016 07:17:00 -0500 text/html
CRN Exclusive: Michael Dell On A Rival's Failed Bid To Buy EMC, HPE's Attempts To Recruit EMC Partners And 'Channel Day' At Dell Technologies

The Next Era Of Dell Begins Now

Dell Technologies CEO Michael Dell spoke with CRN after completing the $67 billion acquisition of storage market leader EMC in what is now the largest acquisition in IT history.

Dell, who started Dell in a University of Texas dorm room 32 years ago, is now heading up the largest privately held IT company in the world with $70 billion in annual sales.

Dell spoke with CRN about a rival's failed bid to buy EMC, Hewlett Packard Enterprise's attempts to recruit EMC partners and how competitors are reacting to the blockbuster Dell-EMC deal.

How do you feel now that you have closed the largest acquisition in IT history?

We are doing awesome. It's 'channel day' at Dell Technologies.

What is the history of the deal and what led to the combination of Dell and EMC?

If you go back and look at all the documents that are public about this combination, you will find the discussion between Dell and EMC started in 2014 and before those discussions, there were discussions with another company. You will have to go figure out who that was. You can maybe guess.

My point is the formation of Dell Technologies has changed the industry landscape and all the competitors you are asking us about they are reacting to us. Their strategies will have to respond to what we have created. If you think through that, they have somewhat limited responses.

Hewlett Packard Enterprise claims to be making progress in recruiting EMC partners concerned about the integration. Have you seen any defection of EMC partners to the HPE program?

No, I haven't seen much of that. When you look at the strength of the portfolio we are quite well positioned with channel partners. We are No. 1 in storage, and have an incredibly strong position in x86 servers, and converged, and hyper-converged with VxRail and VCE.

Talk about the close of the transaction and what kind of planning has been done since the deal was announced last October.

This transaction is closing on time, as planned at the original terms that we announced last year and we have used that time carefully to understand how each of these [channel] programs has worked, what has really been key to its success and how we can Strengthen upon them as we bring them together as one. I think you will find a very thoughtful approach and great balance -- preserving the best of both programs but also building something together that is also stronger.

What is the plan to bring EMC partners into the Dell channel program at the same level they are at in the EMC program?

Those are positive actions that all the partners will love. I have had the chance to see all this and also talk with a number of the partners as they have kind of gotten a preview of the coming attractions and they are all quite excited and positive about it. So we have gotten a very strong and positive reaction.

How you are doubling down on EMC partners to get out of the gate fast?

I have been out with [Dell Chief Commercial Officer and President Enterprise Solutions] Marius [Haas] and [Global Vice President of Sales Strategy Operations and Channel] John [Byrne] meeting with a number of the great EMC partners. Look, when you think about the breadth of the portfolio we have and the significant development of the Dell channel over the last eight years, EMC has a long history with many of these partners as well, bringing all this together it is a tremendous opportunity for the partners and for us.

How are you going to bring these two different cultures together and how the two organizations go to market?

Let's talk about culture. I have heard this and it is sort of a common thing that people talk about. We did a survey of 75,000 people across Dell and EMC and we asked them to rank and rate 22 different cultural attributes and we found something kind of amazing, which was the top five attributes ranked by the Dell team and the EMC team were exactly the same five things. Even more remarkable is they were ranked in exactly the same order.

So while there is a lot of perception that the cultures are different, actually when you ask 75,000 people at Dell EMC what is important, what do you value, why do you value it, you come up with exactly the same answers.

Now you do find differences in culture across function. So, for example, your salespeople are not like your engineers, and your lawyers are not like your marketers. That is not a bad thing. You don't want them all to hold hands and sing songs and be the same. You want to get the best out of the cultures and we do that with a guiding set of principles and fact-based decision-making.

Has the Dell reseller partnership with EMC from 2001 to 2011 been a factor as you look to integrate the two companies?

We have had a long relationship with a lot of the key folks at EMC as a function of the prior Dell-EMC alliance, which lasted close to a decade and got up to a couple of billion dollars in revenue.

During the last 10 months and even before that – discussions started in 2014 -- we had a long time to work together with [Senior Vice President Worldwide Channels] Gregg Ambulos, [EMC President Global Sales and Operations] Bill Scannell, [EMC Products and Marketing President] Jeremy Burton, [EMC Information Infrastructure CEO] David Goulden, [President, VCE, the Converged Platform Division of EMC] Chad Sakac, [EMC President Core Technologies] Guy Churchward, [EMC President Emerging Technologies] CJ Desai, [EMC Virtustream Chairman] Rodney Rodgers and [VMware CEO] Pat Gelsinger. The teams have really come together in a powerful way. So I am excited.

Wed, 07 Sep 2016 04:18:00 -0500 text/html
We’ve never understood how hunger works. That might be about to change.

You haven’t seen hungry until you’ve seen Brad Lowell’s mice. 

A few years ago, Lowell—a Harvard University neuro­scientist—and a postdoc, Mike Krashes, figured out how to turn up the volume on the drive for food as high as it can go. They did it by stimulating a bundle of neurons in the hypothalamus, an area of the brain thought to play a key role in regulating our basic needs. 

A video captures what happened next. Initially, the scene is calm as a camera pans slowly along a series of plastic cages, each occupied by a docile, well-fed mouse, reclining on a bed of wood chips. None of the eight mice shown are interested in the food pellets arrayed above them on the other side of a triangular metal grate that drops down from the ceiling. Which is not surprising, since each mouse has just consumed the rodent equivalent of a Thanksgiving dinner.

But as the seconds displayed on a timer at the bottom of the screen tick away, half the mice begin to stir—the first evidence that a chemical agent designed to turn on specific neurons associated with appetite is reaching its targets. 

Soon, the mice seem possessed. Some stand on their hind legs, thrusting their noses through the grates above them at the inaccessible pellets. Others climb the walls, hang from the bars of the grate, or dig frantically through the wood chips.

“It looks like they’re losing their minds,” Lowell says.

Lowell, who is one of the world’s leading experts on the circuits in the brain that control hunger, satiety, and weight regulation, sometimes references this video to make a point: When you’re starving, hunger is like a demon. It awakens in the most ancient and primitive parts of the brain and then commandeers other neural machinery to do its bidding until it gets what it wants. 

“Sure, we managed to have the brain say ‘Go eat,’” Lowell says. “But that’s not really an explanation. How does that actually work?”

What might begin as a small sensation quickly spirals. Intrusive thoughts pulled from our memory centers burst into our consciousness. Images of meatball sandwiches. The smell of bread. The imagined taste of a cork-like food pellet. The motivational and emotional areas of our brain infuse the need to eat with a nonverbal imperative that feels so powerful it eclipses all else. Our prefrontal cortex kicks into gear, considering how we might obtain food. (If we are in a dangerous situation like a war zone, we weigh how much danger we are willing to risk to get it.) Then we mobilize our sensory and motor areas. We steal a chicken, attempt to spear a fish in a pond, raid the work refrigerator, or hurl our body against a metal grate, hoping to get a taste of a food pellet.

So by exciting the hunger neurons in those mice, Lowell catalyzed a storm of neural activity that spread to the cerebral cortex and other higher-order processing centers, leading directly to a chain of complex goal-directed behaviors (ineffective though they turned out to be). 

It also drove home for Lowell just how much we still have to learn. 

“Sure, we managed to have the brain say ‘Go eat,’” he says. “But that’s not really an explanation. How does that actually work?” 

To answer that question, Lowell has teamed up with Mark Andermann, a neuroscientist who studies how motivation shapes perception (and who also happens to occupy the office next to his at Boston’s Beth Israel Deaconess Medical Center). Together they are following known parts of the neural hunger circuits into uncharted parts of the brain, in some cases activating one neuron at a time to methodically trace new connections through areas so primitive that we share them with lizards. 

Their work could have important implications for public health. More than 1.9 billion adults worldwide are overweight and more than 650 million are obese, a condition correlated with a wide range of chronic health conditions, including diabetes, fatty liver disease, heart disease, and some types of cancer. Understanding the circuits involved could shed new light on the factors that have caused those numbers to skyrocket in latest years.

Bradford Lowell in the lab
Neuroscientist Brad Lowell has spent decades trying to understand the brain circuitry that explains hunger.


And it could also help solve the mystery behind a new class of weight-loss drugs known as GLP-1 agonists. Many in the field of public health are billing these drugs, which include Wegovy and Ozempic, as transformative, providing the first effective method of combating obesity, and allowing some individuals to lose more than 15% of their body weight. They’ve also become something of a cultural phenomenon; in the last three months of 2022, US health-care providers wrote more than 9 million prescriptions for the drugs. Yet no one can explain precisely how and why they work. Part of the reason is that scientists still ­haven’t decoded the complex neural machinery involved in the control of appetite. 

“The drugs are producing the good effects, the satiety effects, through some aspect of this larger system,” says Lowell, who has watched their emergence with surprise and genuine fascination. “One of the most important components in figuring out how they work is to define what the system is. And that is what we are doing.” 

But the ultimate goal for Lowell and Andermann is far loftier than simply reverse-engineering the way hunger works. The scientists are searching for the elusive bundle of neurons that allow our instinctual urge to eat to commandeer higher-­order brain structures involved in human motivation, decision-­making, memory, conscious thought, and action. They believe identifying these neurons will make it possible to study how a simple basic impulse—in this case, a signal from the body that energy stores are beginning to run low and need to be replenished—propagates through the brain to dominate our conscious experience and turn into something far more complex: a series of complicated, often well-thought-out actions designed to get food.

This quest has so consumed Lowell in latest years that his graduate students have coined a term for the elusive bundle of brain cells he is seeking: “Holy Grail” neurons. 

It might sound like a tired scientific trope. But for the understated Lowell, the term is perfectly apt: what he’s seeking gets at the very heart of human will. Finding it would be the culmination of decades of work, and something he never imagined would become possible in his lifetime. 

The hunger mystery

Brad Lowell likes to joke that he is the token local at Beth Israel Deaconess Medical Center. Born in the hospital next door to where he now conducts research, he grew up 25 miles north in the town of Boxford and attended the University of Massachusetts, Amherst, a couple of hours’ drive away. 

Soon after arriving at UMass as an undergrad in the late 1970s, he was accepted into the physiological psychology lab of Richard Gold, a pioneering neuroscientist who was working to identify neural structures involved in regulating appetite. 

Gold’s focus was the hypothalamus—a primitive structure deep in the brain that hasn’t changed much through evolution. It is thought to be responsible for keeping the body in “homeostasis” by monitoring and balancing important functions like body temperature, blood pressure, our need for food and water, and other basic drives. 

Gold suspected that the paraventricular hypothalamic nucleus (PVH), a tiny patch of roughly 50,000 neurons in the hypothalamus, played a role in controlling appetite. By today’s standards, the tools to study it back then were “stone age”—Lowell says he used a “retracting wire knife” to sever bundles of neuronal projections that emanated from the PVH and connected to neurons outside it—but they were effective. When the anesthetized rodents Lowell had operated on woke up, they were crazed with hunger, and they quickly became obese. 

The experience made a lasting impression. Lowell, then an athletic 19-year-old soccer aficionado, had always assumed that anyone who was overweight was just “lazy.” The experiment suggested there was likely far more to it than that. It also convinced Lowell to become a scientist. 

But further research into how precisely the brain worked to control hunger and satiety had reached something of an impasse. 

“Gold and a few other labs put the PVH on the map as a site required to restrain what you eat,” Lowell explains. “But they didn’t have the tools to look any further.”

Figuring out which of the 50,000 neurons in the PVH were actually important to appetite, the ones that could essentially mute the hunger switch, was a challenge that seemed insurmountable—akin to, as Lowell puts it, trying to untangle a “huge bowl of spaghetti.” 

“How do you differentiate one strand of spaghetti from another? These being neurons, right?” he asks. “There’s no way. They all look the same.”

When Lowell opened his own lab at Beth Israel Deaconess Medical Center in the early 1990s, after earning an MD and PhD at Boston University, he studied metabolism in tissues like muscle, organs, and fat that were connected to the brain through the peripheral nervous system. But his undergrad experience in Gold’s lab nagged at him.

“The brain is the Lord of the Rings,” Lowell says. “It’s the one ring that rules them all. And it was not that interesting to study these other things with the master player up there.” 

Chart titled, Mapping the hunger-satiety circuit: How do subconscious signals make it to the conscious part of the brain." Part one shows the Hypothalamus containing the Hunger/satiety hormones, Leptin which excites satiety producing neurons, and Ghrelin which excites hunger producing neurons. These neurons are both located within the Arcuate Nucleus and they inhibit each other. The melanocortin neurons that make up the PVH (paraventricular hypothalamic nucleus which acts as a Satiety Switch. High activity in the PVH causes the feeling of satiety; low activity causes hunger. In the second section is the Brain stem where the melanocortin neurons of the PVH have excited the "Holy Grail" neurons of the parabrachial nucleus, containing tens of thousands of unmapped neurons which also receives input from the gut and acts as a way station to higher-order brain areas. Although much of this area remains unmapped, the area is thought to pass information to subcortical structures involved in emotioon and reward, eventually reaching the Cortex where we experience Conscious, Action-Oriented Activity.

The entry point

Early in his career, Lowell envied his colleagues who studied vision. For decades, neuroscientists had been able to trace the neural circuits involved in that function by shining light into the eyes of mice, identifying which neurons lit up, and then following them to map out the relevant brain circuits. Lowell and his peers who were interested in hunger had never had a similar entry point. 

That changed in 1994, when Jeffrey Friedman, a researcher at Rockefeller University, gave Lowell and others a way to identify the first important neurons—or individual “strands of spaghetti”—involved in hunger regulation. 

Back in 1949, scientists at the Jackson Laboratory in Bar Harbor, Maine, had bred mice with an unidentified genetic mutation that caused them to grow massively obese. They hypothesized that the obesity stemmed from the mice’s inability to produce a crucial protein involved in weight regulation.

Decades later, Friedman was the first to apply cutting-edge genetic technologies to clone the DNA sequences that were abnormal in the obese mice; he then confirmed that their obesity was caused by an inability to produce a key hormone released by fat cells, which the brain uses to track the body’s available energy stores. Friedman purified the hormone and named it leptin. He also identified the DNA sequence needed to make the leptin “receptor”—the specialized proteins that stick out of brain cells involved in appetite regulation like microscopic antennae, sensing whenever leptin is present and kicking off a chemical cascade that promotes a sense of satiety. 

The discovery added further evidence to the idea that obesity was biologically determined, and more specifically to the concept of a “set point” when it comes to weight—a predetermined weight, fat mass, or other measurable physiological characteristic that the body will defend. Appetite is the means by which the body performs “error correction” and mobilizes to devote energy and attention to the task of restoring homeostasis. 

A “cure” for obesity suddenly seemed within reach. The biotech firm Amgen licensed the rights to leptin for $20 million, hoping to develop a drug that could mimic its effects. But the drug it came up with had very little effect on most people with obesity, suggesting that leptin was only part of the story—a hypothesis that seemed to be confirmed when other labs discovered additional hormones and signals that seemed to be involved in hunger. Further experiments showed that many obese humans in fact had normal or high levels of leptin.

It stood to reason, then, that somewhere in the brain leptin was being combined with other signals related to available energy, and that this information would then have to be compared with a homeostatic “set point.”

This suggested a highly complex set of neurological circuits involved in hunger regulation. Understanding how this process worked would require a detailed wiring diagram that might explain how all the parts fit together. And while Friedman’s discoveries regarding leptin didn’t answer all the questions, they provided the entry point that Lowell and the rest of the field had been waiting for, allowing them to begin to draw such a map.

Following the path of leptin, scientists in other labs found the hormone’s first target, and therefore the first important way station in the hunger circuit: a specific patch of neurons known as the arcuate nucleus (ARC). Located at the base of the hypothalamus, the ARC, we now know, integrates information coming from other brain structures, as well as circulating nutrients and hormones like leptin and insulin. All of these inputs convey key information about the current state of the body, such as the level of existing energy stores and nutrient availability.

Determining how the ARC worked—and where it sent information after taking it in—was the next question facing the field. By then, Lowell had abandoned studies on peripheral systems and joined the hunt.

Switching hunger on and off 

In 1997, the next part of the puzzle fell into place after Roger Cone, then a researcher at Oregon Health and Science University, discovered a key part of the switch that essentially turned hunger on and off. 

He bred mice with a gene mutation that interferes with another class of key signaling proteins, called melanocortins. Mice with this mutation more closely resembled obese humans than did mice with leptin mutations: their obesity set in relatively late, and they had diabetes-causing levels of insulin and glucose. This particular mutation prevented key receptors from detecting melanocortin hormones, which in turn interfered with the feeling of satiety and caused mice to continue to eat. But when these melanocortin receptors were functioning normally, detecting the presence of the melanocortin hormones seemed to turn down appetite. In essence, Cone had found the brain’s “satiety switches.”

This discovery was critical in helping scientists determine how leptin worked its magic in the ARC, the first stop in the hunger circuit. It turned out that when leptin reached the ARC, it set off a biochemical chain reaction that caused more melanocortin hormones to be released, eventually activating these “satiety switches.” 

But these satiety switches were not present just in the ARC; they were on neurons distributed throughout the hypothalamus, the hindbrain, and the forebrain, suggesting that one of these areas was the next key hub in the hunger circuit. So which one was it?

It still did not answer perhaps the most fascinating question of all: How did these signals eventually make it into the conscious parts of the brain?

Some of these switches were in the paraventricular hypothalamic nucleus—the brain area Lowell had studied in the lab of Richard Gold as an undergraduate. Since Lowell had seen with his own eyes that mice ate voraciously if you took it offline, he had long believed the PVH to be a stop in that circuit. 

Now he had the tools to prove it. Over the years, Lowell had developed an expertise in cutting-edge genetic engineering techniques that allowed him to target and delete specific genes and create new strains of “knockout” mice—meaning specific genes had been knocked out in an embryo, causing a mouse to be born without a functional copy. 

In 2005, Lowell and a colleague, Joel Elmquist, engineered mice to carry a genetic sequence that prevented them from making functional copies of satiety switches anywhere in the brain. As expected, the mice grew obese. 

Lowell and Elmquist then created pairs of microscopic molecular scissors. Using genes unique to neurons in the PVH as a homing beacon, they programmed these scissors to seek out only DNA associated with PVH neurons and snip away the small sequence that prevented the development of functional satiety switches in that part of the brain. In other words, they “fixed” the satiety switches in the PVH, while they remained disabled in the rest of the brain. If the PVH was where the magic happened, restoring the satiety switches there would fix the problem of obesity. 

Indeed, Lowell’s knockout mice were effectively “cured” of obesity—confirming his hypothesis. He had proved that the PVH was the next key relay point in the hunger-satiety circuit. 

For Lowell, confirming the PVH’s place in the circuit was huge‚ but it still did not answer perhaps the most fascinating question of all: How did these signals eventually make it into the conscious parts of the brain, the parts that could make an animal take action to get food? How did hunger, in other words, manage to commandeer the neural machinery of those crazed mice? How do intrusive thoughts of a meatball sandwich compel someone to put on shoes and a coat and track one down?

To find out, Lowell needed to determine where the signals in the PVH led, in the hopes that if he continued to follow the string it would lead him to the gateway to higher-order brain structures. This was complicated by the fact that neurons in the PVH sent signals to a number of different areas, including the brain stem, regions that affect thyroid function, and others. 

Lowell was stymied. “We could knock out these genes and then measure how much food the mice ate or measure how fat they got, but we couldn’t go much further,” he says.

A magic “remote control”

In the summer of 2009, four years after the PVH discovery, Lowell was visiting Colgate in upstate New York with his high-school-age son. Lying on the grass outside the administrative building while his son did an interview, he flipped open the latest issue of the scientific journal Neuron. An article detailed a new laboratory tool developed by Bryan Roth at the University of North Carolina, Chapel Hill: a “chemical-genetic remote control” that could be used to turn specific neurons on and off in mice. Lowell recognized instantly it was the breakthrough he had been waiting for his entire career. 

Instead of just knocking out populations of neurons permanently in mice, Lowell could instead create new strains of mice that were bred to have this genetic “remote control” switch, allowing him to turn distinct populations of neurons on and off simply by administering a chemical agent. (A separate technique known as optogenetics also allows him to do this by beaming a specific wavelength of light into the brain through a fiber-optic cable.) He could then observe the behavioral effect of turning specific neurons on and off in real time. 

“Suddenly I was able to do things that when I was an undergraduate I never dreamed I’d be able to do,” he says. 

In 2014, Lowell used the remote-control tool to methodically turn each bundle of neurons leading out of the PVH on and off, to see which ones produced satiety. Once he identified the neurons that affected satiety, he followed them out of the hypothalamus. It led him to an area in the brain stem called the parabrachial nucleus (PBN)—the third key hub involved in the hunger-satiety circuit. 

It was a scientific watershed. Lowell had finally arrived at an area of the brain with direct connections to higher-order brain structures affecting all aspects of our conscious experience, including areas involved in motivation, reward, emotion, processing sensory stimuli, memory, selective attention, and a wide array of other functions. 

Somewhere in that area of the brain was the last way station, the “Holy Grail” neurons: those finally telling the rest of the brain to “go eat.” 

Hunting for the Holy Grail

For the past eight years, Lowell and Andermann have been looking for the PBN neurons involved in hunger. It’s a painstaking hunt—the PBN contains hundreds of thousands of neurons. Lowell’s lab is tracing the hunger-satiety circuit forward out of the PBN while Andermann’s lab works backwards toward it from the insular cortex, an area associated with the conscious experience of bodily states like hunger. The goal is to meet in the middle. 

If they can trace this circuit, then they will begin to examine how it is that a simple signal—a signal that we are hungry—works to recruit higher-order brain areas and focuses them on the completion of a task. They will have the opportunity to develop a model of how animals translate desire into action. Put simply, they might be able to characterize a complex action from beginning to end.

Mark Andermann seated
For the past eight years, neuroscientist Mark Andermann has worked with Lowell to hunt for the Holy Grail neurons.


The sheer number of neurons in the PBN makes the task daunting. It’s made even more complicated by the fact that the PBN isn’t just involved in sending hunger signals to higher-order brain processing centers but is also the final stop for scores of other impulses and needs. It is a huge way station for all sorts of information, most of which has nothing to with hunger—like sexual arousal; the sensations associated with pain; the detection of heat and cold, itches and nausea; and signals associated with a wide array of autonomic functions, including respiration, blood pressure, and temperature regulation. Each one of these signals likely has its own set of dedicated, genetically distinct neurons in the PBN. Most of these neurons have never been identified or studied. And they all look identical. 

At times, the researchers have had to trace the path of nerve impulses one neuron at a time—activating a neuron they know is part of the hunger-satiety circuit using the “remote control” technologies, and then watching to see which neurons light up in response. (The DNA of the mice he works with also contains sequences for fluorescent tracers that light up when certain neurons fire, and that light can be detected, using sophisticated optical sensing technology, through a window in the skull and then reproduced on a computer screen.) This has allowed Lowell and Andermann to reduce the number of candidate neurons he is considering from hundreds of thousands to about 10,000.

To further narrow down the possibilities, Lowell spent three years sorting these 10,000 neurons into different subtypes using their genetic signatures. He has identified 37 genetically distinct subtypes.

Now Lowell and Andermann are experimenting with subtype after subtype to see which ones are involved in the hunger circuit. 

To do so, they are exposing live mice to different conditions and watching to see which neurons fire in response. They can see if a neuron fires when, for instance, the mice are shown pictures they’ve learned to associate with a tasty treat.

Once they identify neurons that are activated in the PBN by the food cue, they are using other experimental techniques to figure out which of the 37 distinct genetic profiles these neurons carry.   

The process, which involves sacrificing the mice and dissecting their brain tissue, can be painstaking. But Lowell and Andermann insist they are closing in on their target. They hope that within the next five years they will have found the neurons they are looking for. From there, they can proceed into higher-order areas of the brain. 

The latest development of the new class of weight-loss drugs—and the experiences reported by patients—tantalizingly illustrate how much power the circuits they are tracing can have on those areas. Not only is the physical experience of hunger absent—because the drugs seem to lower the body’s “set point”—but everything else that usually goes along with hunger seems to fade away. Patients report that they are no longer plagued by intrusive thoughts of food. (These reports parallel what Andermann and Lowell are seeing in the lab. Using their neural imaging techniques, the researchers can actually tell when mice are thinking about visual cues they have seen in the last minute or hour.) 

It remains to be seen whether Lowell and Andermann’s work will actually resolve the intense debate in the field over how these drugs work, and what parts of the brain they act on. But the researchers hope that by decoding the circuit, their findings may inform the development of new generations of drugs that are even more effective and lack side effects such as nausea, vomiting, diarrhea, abdominal pain, and, in some cases, pancreatitis and changes in vision. 

Though this would be newsworthy, it’s still not what excites Lowell the most. He remains most committed to the idea that his research could yield new insights into motivation, decision-making, and a wide array of other functions—into human will and survival. To illustrate why he is excited, he talks about a video he’s seen of a hungry squirrel navigating a “Mission Impossible” course to access food; the squirrel climbs up a pole, hurls itself through the air and lands on a windmill, and shimmies through a small opening in a plastic barrier while hanging upside-down from a clothesline.  

“The squirrel isn’t operating on reflex,” he says. “It’s a totally novel environment. It has to use all of its higher processes to achieve that goal.” How does this very simple system manage to take over? 

“That’s the big question,” he says. “We don’t know how any of that works, those higher processes.”

Now that he’s finally equipped with all the tools he needs to untangle the dizzyingly complex bowl of neural spaghetti, it may just be a matter of time before he finds out. 

Adam Piore is a freelance journalist based in New York. He is the author of The Body Builders: Inside the Science of the Engineered Human, about how bioengineering is changing modern medicine.

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  • This is a valid program, but it is up to you whether or not you want it to run on startup.

    Whether or not you need to run this program on startup must be decided by you. If you feel that you want this program starting automatically so that you have it available as needed, then do not disable it. The following information is a brief description of what is known about this file. If you require f urther assistance for this file, feel free to ask about in the forums.

  • Name


  • Filename


  • Command

    %programfiles%\Dell\Dell ControlPoint\Dell.ControlPoint.exe

  • Description

  • File Location

    %programfiles%\Dell\Dell ControlPoint\Dell.ControlPoint.exe

  • Startup Type

    This startup entry is started automatically from a Run, RunOnce, RunServices, or RunServicesOnce entry in the registry.

  • HijackThis Category

  • Note

    %ProgramFiles% refers to the Program Files folder. The path to this folder is C:\Program Files\ or C:\Program Files (X86)\ depending on whether the version of Windows or the program being installed is 32-bit or 64-bit.

  • This entry has been requested 8,510 times.


It is assumed that users are familiar with the operating system they are using and comfortable with making the suggested changes. will not be held responsible if changes you make cause a system failure.

This is NOT a list of tasks/processes taken from Task Manager or the Close Program window (CTRL+ALT+DEL) but a list of startup applications, although you will find some of them listed via this method. Pressing CTRL+ALT+DEL identifies programs that are currently running - not necessarily at startup. Therefore, before ending a task/process via CTRL+ALT+DEL just because it has an "X" recommendation, please check whether it's in MSCONFIG or the registry first. An example would be "svchost.exe" - which doesn't appear in either under normal conditions but does via CTRL+ALT+DEL. If in doubt, don't do anything.

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The Hunger Games: Muttation, Explained No result found, try new keyword!Muttation is the practice of growing and enhancing animals by Capitol scientists, resulting in Mutts with deadly abilities. The mockingjay is the franchise's most iconic mutt and symbolizes rebellion ... Sun, 31 Dec 2023 01:00:20 -0600 en-us text/html Food, farming, and hunger

Of the 5.9 million children who die each year, poor nutrition plays a role in at least half these deaths. That’s wrong. Hunger isn’t about too many people and too little food. It’s about power, and its roots lie in inequalities in access to resources and opportunities.

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DELL.UCM.EXE Information
  • This is a valid program, but it is up to you whether or not you want it to run on startup.

    Whether or not you need to run this program on startup must be decided by you. If you feel that you want this program starting automatically so that you have it available as needed, then do not disable it. The following information is a brief description of what is known about this file. If you require f urther assistance for this file, feel free to ask about in the forums.

  • Name


  • Filename


  • Command

    %programfiles%\dell\dell controlpoint\connection manager\dell.ucm.exe

  • Description

  • File Location

    %programfiles%\dell\dell controlpoint\connection manager\dell.ucm.exe

  • Startup Type

    This startup entry is started automatically from a Run, RunOnce, RunServices, or RunServicesOnce entry in the registry.

  • HijackThis Category

  • Note

    %ProgramFiles% refers to the Program Files folder. The path to this folder is C:\Program Files\ or C:\Program Files (X86)\ depending on whether the version of Windows or the program being installed is 32-bit or 64-bit.

  • This entry has been requested 5,764 times.


It is assumed that users are familiar with the operating system they are using and comfortable with making the suggested changes. will not be held responsible if changes you make cause a system failure.

This is NOT a list of tasks/processes taken from Task Manager or the Close Program window (CTRL+ALT+DEL) but a list of startup applications, although you will find some of them listed via this method. Pressing CTRL+ALT+DEL identifies programs that are currently running - not necessarily at startup. Therefore, before ending a task/process via CTRL+ALT+DEL just because it has an "X" recommendation, please check whether it's in MSCONFIG or the registry first. An example would be "svchost.exe" - which doesn't appear in either under normal conditions but does via CTRL+ALT+DEL. If in doubt, don't do anything.

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