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050-CSEDLPS study help - CSE RSA Data Loss Prevention 6.0 Updated: 2024

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Exam Code: 050-CSEDLPS CSE RSA Data Loss Prevention 6.0 study help January 2024 by Killexams.com team

050-CSEDLPS CSE RSA Data Loss Prevention 6.0

Exam: 050-CSEDLPS CSE RSA Data Loss Prevention 6.0

Exam Details:
- Number of Questions: The exam consists of approximately 60 multiple-choice questions.
- Time: Candidates are given 90 minutes to complete the exam.

Course Outline:
The CSE RSA Data Loss Prevention 6.0 course is designed to provide professionals with the knowledge and skills required to implement and manage RSA Data Loss Prevention solutions. The course covers the following topics:

1. Introduction to RSA Data Loss Prevention (DLP)
- Overview of data loss prevention concepts
- Understanding the importance of data security
- RSA DLP architecture and components
- Navigating and accessing RSA DLP interface

2. RSA DLP Policy Creation and Configuration
- Configuring policy servers and agents
- Defining data classification and sensitive data types
- Creating policy rules and enforcement actions
- Implementing incident detection and response

3. RSA DLP Endpoint Protection
- Deploying and managing RSA DLP agents
- Endpoint agent configuration and policies
- Monitoring and controlling endpoint activities
- Implementing data loss prevention on mobile devices

4. RSA DLP Network Protection
- Network DLP deployment and architecture
- Network sensor configuration and policies
- Real-time monitoring and content inspection
- Detecting and preventing data breaches

5. RSA DLP Administration and Reporting
- Managing user roles and permissions
- Configuring system settings and integration
- Generating and analyzing DLP reports
- Monitoring and maintaining RSA DLP solutions

Exam Objectives:
The exam aims to assess candidates' understanding and proficiency in the following areas:

1. RSA Data Loss Prevention fundamentals and concepts
2. Policy creation and configuration in RSA DLP
3. Endpoint protection using RSA DLP agents
4. Network protection and content inspection in RSA DLP
5. Administration and reporting of RSA DLP solutions

Exam Syllabus:
The exam syllabus covers the Topics mentioned in the course outline, including:

- Introduction to RSA Data Loss Prevention (DLP)
- RSA DLP Policy Creation and Configuration
- RSA DLP Endpoint Protection
- RSA DLP Network Protection
- RSA DLP Administration and Reporting
CSE RSA Data Loss Prevention 6.0
RSA Prevention study help

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RSA
050-CSEDLPS
CSE RSA Data Loss Prevention 6.0
https://killexams.com/pass4sure/exam-detail/050-CSEDLPS
Answer: A
Question: 61
What is the maximum peak traffic that the DLP Network Sensor can handle?
A. 150 Mbps
B. 200 Mbps
C. 250 Mbps
D. 350 Mbps
Answer: C
Question: 62
Fred is a member of the Incident Review Group. All incidents are assigned automatically
to the Incident Review Group. Fred is told that there are several hundred incidents
currently in the incident review queue. Fred logs on to the Enterprise Manager using his
account. What will be displayed on his screen when he selects the incident tab?
A. Only Events that have been assigned to Fred
B. Only incidents that have been assigned to Fred
C. All the open events assigned to the Incident Review Group
D. All the open incidents assigned to the Incident Review Group
Answer: B
Question: 63
A sensitive word processing document is fingerprinted and added to an existing policy.
Which of the following can NOT be detected by a policy that uses the document's
fingerprint?
A. Only the first two paragraphs of the document.
B. The exact document being attached to an email
C. A PDF file containing the content of the fingerprinted document on an end user's
computer.
D. The contents of the fingerprinted document pasted into the middle of another
document that is emailed to someone outside your network.
Answer: C
Question: 64
17
Which is of the following is NOT an option that is configured in a policy?
A. Escalation Rules
B. Notification Rules
C. Incident Validity Rules
D. Incident Handling Rules
Answer: C
Question: 65
Which of the following is NOT true about the RSA DLP Suite?
A. RSA DLP Policies can be exported
B. RSA DLP Policies can be imported
C. The DLP Network Appliances run the Centos Linux operating system
D. The Endpoint Enforce Component requires the Network Controller Appliance
Answer: D
Question: 66
Sensitive documents that violate policies are found in RSA DLP Datacenter grid scan on
the corporate network. Incidents have been created by these violations. Which of the
following is NOT a remedial action that can be performed on the sensitive documents?
A. The documents can be deleted.
B. The documents can be blocked
C. The ACL of the documents may be changed.
D. The documents can be moved to a secure location
Answer: B
Question: 67
Which one of the following is NOT an option in rule grouping for described content?
A. May occur
B. Must occur
C. Should occur
D. Should not occur
Answer: C
18
Question: 68
Which of the following endpoint actions can NOT be blocked by the DLP Endpoint
Enforce when sensitive information is detected?
A. Screen capture
B. Printing to a printer
C. Copying to a floppy disk
D. Copying to a USB storage device
Answer: A
Question: 69
The RSA DLP Suite requires a database. Which of the following databases can be used?
(Choose two)
A. MySQL Version 2 and higher
B. Oracle 10g or higher on the DLP Network Controller
C. PostgreSQL pre-installed on the DLP Network Controller
D. Microsoft SQL 2005 on a server supplied by the customer
E. Sybase 12 or higher on a server supplied by the customer
Answer: C, D
19
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RSA Prevention study help - BingNews https://killexams.com/pass4sure/exam-detail/050-CSEDLPS Search results RSA Prevention study help - BingNews https://killexams.com/pass4sure/exam-detail/050-CSEDLPS https://killexams.com/exam_list/RSA RSA: Corporations Looking For Help To Fight Insider Threats

RSA

Hansen said that businesses will increasingly be required to integrate identity management and access control technologies with their security infrastructures in order to prevent data from being lost or stolen. "In a climate where companies are undergoing massive restructuring, this is really where the action is," he said.

Insider threats are becoming more pervasive. Disgruntled employees often retain access to information after being laid off or changing roles within an organization. Meanwhile, access given to remote or contracted workers has resulted in openings in the network perimeter, exposing sensitive company information to possible loss or theft.

Hansen added that a recent CA survey indicated that 59 percent of workers admitted taking confidential data from their employers, and 40 percent of companies said they had suffered financial losses due to a data breach. Subsequently, survey results showed that the majority of businesses said that they planned to increase or maintain their security spending, despite the lagging economy.

"Not surprisingly, companies are willing to invest in security," Hansen said. "Our customers tell us that in every aspect of IT, protecting data tops everyone's list of priorities."

The challenge is heightened by an unstable economic environment. A data breach today could spell disaster for many organizations.

"Companies cannot afford an embarrassing and costly security breach, especially in these uncertain economic times," Hansen said. "Every business challenge is amplified. Improving productivity and efficiency can spell the difference between survival and extinction."

As a result, the work environment requires comprehensive identity and provisioning management in order to prevent data theft and loss. Specifically, he said, the current security environment calls for integrated, interoperable and intelligent security solutions that can keep workers secure while not impeding productivity.

Companies say they want to protect data from every portal across the entire organization. In addition to protecting end points and the network perimeter, customers are required to have comprehensive policies in place for compliance and auditing purposes, as well as identity management, authentication and access control capabilities. Those products need to be "integrated like never before," Hansen said.

"Managing confidential data cannot be at the end point only," Hansen said. "Your security measures need to enable your employees while at the same time guaranteeing a compliance environment."

"Crisis creates opportunity to drive change," Hansen added. "Now is an ideal time to take provisioning to the next level."

Fri, 29 Dec 2023 10:36:00 -0600 text/html https://www.crn.com/news/security/217100297/rsa-corporations-looking-for-help-to-fight-insider-threats
Prevention of Asthma

Dietary Factors

Nutrients

Various nutrients have been investigated in terms of their involvement in the onset of asthma. The increase in asthma prevalence in the last quarter of the 20th century was paralleled by the increased use of folic acid in pregnancy and increased fortification of foods with folate. Studies have found that maternal folate intake during pregnancy was associated with an increased risk of asthma in the offspring.[18,19] This association was stronger for synthetic folic acid supplements possibly because they contain more potent methyl donors than dietary folate.[20] One could hypothesize that methyl donors may be responsible for epigenetic effects on disease expression by increasing DNA methylation, particularly for expression of some immune modulating genes allowing for more likely development of asthma. Still, studies are needed to better define this issue.

A number of factors associated with pro- or anti-inflammatory or antioxidant effects have been studied. For example, higher levels of n-6 polyunsaturated fatty acids (PUFAs), which are more pro-inflammatory, in food were shown to relate to elevated levels of exhaled nitric oxide and asthma symptoms.[21] However, total fat intake, saturated fatty acids, monounsaturated fatty acids and cholesterol were found to have no effect on wheeze.[21,22] Hodge et al.[23] have shown an association between decreased asthma and regular ingestion of cold water fish high in n-3 fatty acids.

Vitamin D intake may be through diet, sunlight or supplementation and may be beneficial in the prevention of childhood asthma. Currently, clinical trials of vitamin D supplementation on subsequent asthma are being conducted. These stem from findings by Weiss and Litonjua,[24] suggesting that there may be a role for vitamin D in asthma intake and lung function development. Likewise, Erkkola, Kaila and Nwaru[25] found that maternal vitamin D levels during pregnancy were associated with a decreased risk of asthma and allergic rhinitis in children at the age of 5 years. Although studies seem to point to a beneficial effect of vitamin D on asthma prevention, the issue remains controversial. For example, Gale et al.[26] found that maternal exposure to higher concentrations of vitamin D during pregnancy were associated with an increased risk of asthma in children at the age of 9 years. A recent systematic review by Nurmatov, Devereux and Sheikh[27] concluded that maternal intake of vitamins D and E was protective for the development of wheezing illnesses in the offspring. Although research regarding this Topic is still in its infancy stage, studies have suggested that vitamin D may protect infants from asthma through the regulation of chromatin modification enzymes.[28,29]

Childhood asthma had also been associated with reduced dietary vitamin E intake by the mother[30,31] but a meta-analysis by Allen, Britton and Leonardi-Bee[32] concluded that vitamin E intake had no effect on asthma.

High levels of cord blood selenium and iron in pregnant mothers have been associated with a lower prevalence of persistent and late onset wheeze in their children.[33] Selenium deficiencies in pregnancy have therefore been associated with an increased risk of persistent asthma in the child.[34]

Introduction of 'Allergenic' Foods

Beginning in the 1990s, many national pediatric agencies and societies recommended delay of solid food introduction, especially for children at a high risk for development of allergy. These recommendations were widely adopted based on a belief that this would reduce the risk of developing food allergy. The theory that the immune system is not yet matured and that the gastrointestinal tract is more permeable during the first year of life appeared to be the rationale for these recommendations. Data from our SAGE 1995 provincial birth cohort showed no relationship of prematurity or low birth weight with development of food allergy[35] and there are data showing a lack of protective effect of food restriction on the incidence of childhood asthma.[36–38] In fact, there are new data comparing early versus delayed introduction of peanut that show a much higher prevalence of peanut allergy in children where introduction of peanut was delayed.[39] On the other hand, intake of certain foods may play a preventative role. Nagel et al.[40] found that eating green vegetables, fruit and fish was protective against allergic asthma. Mediterranean diets have a high vegetable and fruit content and provide a potential protective factor against asthma.[41,42]

Probiotics

An extensively hydrolyzed formula with a mixture of synbiotics (prebiotics plus probiotics) has been shown to lower the risk of asthma-like symptoms in infants with atopic dermatitis compared to infants receiving a placebo.[43] Even so, researchers are uncertain and even doubtful about the role played by probiotics in development of asthma. In fact, a meta-analysis by Osborn and Sinn[44] showed insufficient evidence to recommend probiotics for prevention of any allergic disease (asthma, rhinitis, eczema or food allergy).

Mon, 18 Dec 2023 10:00:00 -0600 en text/html https://www.medscape.com/viewarticle/814415_4
Group Help/Study Opportunities

In a relaxed environment, these student-led, question and answer sessions provide you with encouragement and support while permitting you to come and go as needed. Remember, all ASC services are free!
Three Hope students during a group study session

Please check with individual departments for up-to-date drop-in group help/study session offerings. Additional information will be available shortly after the start of each semester.

Accounting

Accounting Help Sessions
Wednesdays and Thursdays, 5:30-7:30 p.m.
VanZoeren 153
Led by upper-level asccounting students

Chemistry

CHEMISTRY 221
Peer-Led Help Sessions
Thursdays, 6:30–9:30 p.m.
Schaap 3130
Led by upper-level chemistry students

Computer Science
COMPUTER SCIENCE HELP CENTER
CSCI 112, 125, 235, 245, 255
Sundays, 6–8 p.m.
Mondays–Thurdays, 7–9 p.m.
VanderWerf 115
Led by computer science students
Education
Education 225
Help Session
Tuesdays, 11–11:50 a.m.
Van Zoeren 245
Led by Professor Susan Cherup
Engineering

Engineering 100 Help Sessions
Sundays–Thursdays, 7–9 p.m.
Van Zoeren 134
Led by upper-level engineering students

Engineering 210 Help Sessions
Wednesdays, 7–9 p.m.
VanderWerf 228 (CAD Lab)
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Engineering 220 Help Sessions
Tuesdays, 7–9 p.m.
Van Zoeren 134
Led by upper-level engineering students

Thursdays, 12:30–1:30 p.m.
Schaap 3128
Led by engineering faculty

Japanese

Japanese Assistance
Mondays and Wednesdays, 12:30–1:20 p.m.
Fridays, 4:10–5 p.m.
Martha Miller 231
Led by Professor Tsuda

Japanese 101 Drill Sessions
Monday, 4–5 p.m.
Martha Miller 242

Friday, 4–5 p.m.
Martha Miller 243

Japanese 201 Drill Sessions
Monday, 5–6 p.m.
Martha Miller 242

Mathematics
MATH LAB
Drop-in help for students enrolled in quantitative courses
Mondays–Thursdays, 7:30–9:15 p.m.
Schaap 1118
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*For students in a math or quantitative course
Physics

Physics 105 and 121 Help Sessions
Mondays, 6:30–8:30 p.m.
VanZoeren B24
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Thursdays, 6:30–8:30 p.m.
VanZoeren 151
Led by upper-level physics students 

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Study Suggests Horticulture Therapy Could Help Fight Depression No result found, try new keyword!A study suggests that horticulture therapy, which focuses on gardening activities, may help reduce depression symptoms in older adults. The greatest benefits were found when therapy lasted 4-8 ... Thu, 14 Dec 2023 10:00:00 -0600 en-us text/html https://www.msn.com/ Ozempic could help curb alcohol abuse, study reveals

The latest weight loss craze could also help people control their drinking.

Semaglutide treatments such as Ozempic and Wegovy have been shown to reduce the symptoms of alcohol use disorder (AUD), according to a study published in The Journal of Clinical Psychiatry on Nov. 27.

The collaborative study from The University of Oklahoma (OU) and Oklahoma State University (OSU) found a “significant and noteworthy decrease” in the Alcohol Use Disorders Identification Test (AUDIT) scores of six patients who were receiving semaglutide treatment for weight loss.

Lead study author Dr. Jesse Richards, director of obesity medicine and assistant professor of medicine at the OU-TU School of Community Medicine, said the study was inspired by his conversation with Dr. Kyle Simmons, professor of pharmacology and physiology at the OSU Center for Health Sciences.

“I had been hearing from a significant number of patients that their alcohol intake was spontaneously decreasing while [they were] on the medication,” Richards told Fox News Digital.

As a bariatric surgery clinic employee, Richards noted that it’s standard to screen patients for alcohol use.

Studies found that there was a decrease in Alcohol Use Disorders Identification Test (AUDIT) scores for six patients receiving weight-loss treatments. AP

At the clinic, a number of patients tested positive for alcohol consumption, sometimes in concerning amounts.

Later, while on semaglutide medication, they reported reduced alcohol intake.

One of Richards’ patients — who previously drank large amounts of alcohol — shared a new inability to drink more than two cans of beer now because it “just doesn’t sound good.”

After semaglutide medication, a patient who formerly drank beer regularly began to think that alcohol just didn’t “sound good.” Getty Images

This response piqued Richards’ interest in learning more about patients’ aversion to alcohol, which directly correlated to his research.

Research has shown that this effect is “mediated through adjustments in the reward pathway in the brain,” he said.

“The GLP-1s are actually modifying dopamine, decreasing the craving and decreasing the motivation to acquire things in that compulsive intake category.”

The most surprising takeaway from the study, Richards said, was that the same significant treatment response was seen even at very low doses.

“We found that even patients on the lowest dose of semaglutide — a quarter milligram — had a quite significant and relatively … quick onset reduction in alcohol intake,” he said.

Of the six patients studied, all but one were on low doses — from a quarter to a half milligram.

“And that’s very encouraging because we know that the lower doses of these medications are tolerated much better,” said Richards.

While the results seem promising, the doctor said he does not recommend that patients use semaglutide treatments for alcohol use disorder at this time, due to supply and safety issues.

“If patients have [obesity and diabetes] indications for the medication and they also struggle with alcohol intake … having them on this treatment may potentially be beneficial,” Richards said.

Due to medication shortages and a lack of long-term data, it may not be advisable to take Ozempic to target alcoholism specifically. NurPhoto via Getty Images

“But because there has been a global medication shortage, and because we don’t have prospective trials and don’t know what the specific safety is versus the well-established safety data in obesity and diabetes, [I] would not recommend it just for patients who have AUD.”

There are three FDA-approved drugs available for alcoholic use disorder that are currently underused, the doctor noted.

Given that five million people in the U.S. are currently taking semaglutide medications, if it is proven that those drugs have a significant effect on alcohol use disorder, “by default, they are going to become the most widely used drug to Improve these symptoms — just by virtue of the fact that so many people are on them for diabetes or obesity,” Richards noted.

Trials are underway to gather more information on the weight-loss medication and its effect on alcohol intake. UCG/Universal Images Group via G

He confirmed that additional research is underway with two ongoing trials.

“Since we were able to show clinically meaningful reductions in alcohol intake and AUD symptomatology in a real-world setting, that bodes very well for these types of medications,” he said.

Looking ahead, Richard said there is a need for higher-quality evidence of the medication’s impact on AUD compared to placebo drugs or environmental factors.

People struggling with alcohol use should speak with their healthcare provider. Getty Images

Even though it’s unclear whether GLP-1 producers will market the medication to AUD patients in the future, Richards said this could become an “established medical practice once the safety and efficacy has been determined.”

For patients who struggle with AUD, Richards recommended they talk to their health care providers about available treatment.

He also alerted patients that if they experience a reduced appetite and usually consume “a bunch of calories” in alcohol, it may be necessary to look into a more balanced diet.

Avantika Waring, 9amHealth’s chief medical officer and a trained physician and endocrinologist in San Francisco, applauded the OU and OSU study findings for further supporting what clinicians “are already seeing in practice,” she told Fox News Digital.

“GLP-1 medications have a lot of effects that we are still learning about, and the ability to decrease cravings and the reward signals related to alcohol use are just some of the benefits,” she said.

“It’s an important starting point for further clinical trials,” she added.

Waring also warned that GLP-1 medications should not be used to treat AUD specifically, as they can cause side effects such as nausea and changes in appetite.

“People struggling with alcohol use disorder should consult with their physicians before starting GLP-1 medications to make sure that they can stay hydrated and safe on therapy,” she said.

Waring noted that if ongoing clinical trials find semaglutide treatments to be effective for AUD, the medical community will “have another tool to help people living with alcohol addiction and we’ll see expanded use of these already popular drugs.”

Fox News Digital reached out to Novo Nordisk for comment on the potential link between semaglutide medications and alcohol use disorder.

Sun, 10 Dec 2023 02:53:00 -0600 en-US text/html https://nypost.com/2023/12/10/lifestyle/ozempic-could-help-curb-alcohol-abuse-study-reveals/ How Crying Can Help You, Here Is What A Study Says
Getty

They say that there's no sense in crying over spilled milk. But what do they know? Crying can get you another glass of milk if you do it loud enough. Plus, crying may serve a real physiologic purpose, according to a study published recently in Emotion, meaning the journal and not in an Emo-kind of way.

For the study, three researchers from the University of Queensland (Leah S. Sharman, Genevieve A. Dingle, and Eric J. Vanman) and one from Tilberg University (Ad J. J. M. Vingerhoets) recruited 197 female undergraduate students. They said that they choose all women rather than including men because pilot testing of sad videos had revealed that more women than men cried or at least more women revealed that they were crying. This did not account for the men who cried inside or used some bro-language or high fives to hide the crying.

The research team then showed each of the study participants either a video that are supposed to make them feel sad (sad videos) or a video that was not supposed to elicit any emotion (neutral videos) like something from a documentary or a ted talk. Each video lasted for close to 18 minutes. After the video, the researchers noted whether or not each participant had cried while watching the video. Ultimately, 65 participants watched the neutral video, 71 watched the sad video and cried during it, and 61 watched the sad video and did not cry. Presumably, no one cried during the neutral video. But then again, actor Bryce Dallas Howard was able to cry when Conan O'Brien talked about Home Depot in this Conan clip:

Then, each participant underwent a Cold Pressor Stress Test (CPT), which involved placing the participant's left hand, up to the wrist, in cold 0° to 5°C water. Unless you are the Iceman or Killer Frost, this is supposed to be painful. The research team measured how long each participant could stay in this position until pulling her hand out of the water. During the study, the research team continuously measured each participant's heart rate and respiratory rate and periodically measured cortisol levels from saliva samples. Cortisol is a stress-hormone that's produced by the body.

Also, at four points during the study, participants answered questions from the Positive and Negative Affect Scale short form (PANAS). These questions asked the degree to which the participant was experiencing ten different emotions and to rank each on a five-point scale that ranged from a one (very slightly or not at all) to a five (extremely).

When it came to cortisol levels and how long the participants could keep their hands submerged in the cold water, the study ended up finding not much difference between the neutral video watchers, the sad video non-criers, and the sad video criers. So if you are about to dunk yourself in cold water or take a cold shower, it may not help to cry first.

But here's a difference that the study found. Are you ready? Take a deep breath. The difference was breathing rates. While watching the videos, the non-criers tended to have elevations in their breathing rates, whereas, by contrast, the criers tended to maintain their initial breathing rates. In other words, tearing up could have helped participants better control their breathing rates. This provides further evidence that crying may help you better regulate arousal, serving as an emotional release.

Another interesting finding was that right before crying, participants tended to experience decreases in their heart rates, seemingly in anticipation of the crying. Once the crying began, their heart rates then tended to creep back up but not above where their heart rates had been before everything began. This may be further evidence that crying has a beneficial regulatory effect on your physiology.

So perhaps next time you start crying you can tell people that you are regulating your physiology. You've probably heard of people saying that they had a good cry and feel better after they've let the tears flow. It can be important to find reasonable ways to periodically release your emotions. Otherwise, you may end up bottling everything up like a hot air balloon that can explode when you least expect it.

Moreover, crying can be a way of communicating. It's really the only way that babies can express their needs before they learn how to say things like "why you throwing shade on me," or "I'm not Gucci." Crying can help communicate to others that you need more sympathy, comfort, or help. Of course, this can be misused. You don't want to cry every time your order at a restaurant doesn't come out right. And of course, there is the whole concept of crocodile tears: people crying to get something when they don't really mean it.

Crying can also be a way of communicating with yourself. Even when you cry alone, you may be telling yourself about your own state because, like many people, you could be terrible at practicing your own emotions and situation. Tears could be your body's way of saying, "hey, take a break," or "something's not right," or "take care of yourself." Tearing up can then be a way of your body literally crying out to you.

Your body is a complex system. Crying can be complex. Your tears can flow when you are very sad, very angry, or even very happy. Better understanding what causes us to cry and what happens as a result could help us better handle our emotions and stress.

Sun, 21 Jul 2019 07:48:00 -0500 Bruce Y. Lee en text/html https://www.forbes.com/sites/brucelee/2019/07/21/how-crying-can-help-you-here-is-what-a-study-says/
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Prevention of Asthma

Psychosocial Factors

The social environment, in which a child is exposed to, may also contribute to the development and severity of asthma. Lower SES has been shown to associate with higher asthma prevalence rates and hospitalizations.[111] Still to be answered is whether early life lower SES increases vulnerability for asthma later in life. Most studies on the Topic are cross-sectional, and find associations between current SES and numerous child health outcomes.[111] Higher levels of parental stress, related to the lower SES, may also relate to increases in the risk of infant wheezing.[112] Prenatal maternal stress has also been found to associate with elevated cord blood IgE[113] as well as childhood wheeze,[114–116] asthma, eczema and allergic rhinitis.[116] Additionally, maternal distress that persisted from birth to early school age was associated with an increased risk for asthma in the child.[117] These relationships are not explained by an increased level of stress in the child[118] leading Wright et al.,[119] to propose an impact of the hypothalamic-pituitary-adrenal axis on fetal immune developmental processes. Consistent with this, we have shown a lower cortisol response to a stressor among school aged children with asthma who had been exposed to persistent maternal stress in early life.[120]

The connection of asthma with psychosocial aspects seems logical because data showing a connection between stress and immune-related Th cells. One murine model looked at the impact of perceived stress and learned helplessness on airway inflammation.[121] Mice that experienced uncontrollable stress also experienced more narrowing of airways and goblet cell hyperplasia, features of asthma pathogenesis, than those mice in the control group. After an ovalbumin (OVA) challenge, Deshmukh et al., reported a lymphocyte population highly saturated with CD4+ T cells, indicative of increases in IL-4, IL-13 and lack of IFN-γ production. Mice that experienced control over the stressful situation were able to dampen inflammatory disease by limiting CD4+ T cells and production of cytokines related to Th2 cells. Helpless mice, however, were unable to do this and, in fact, had increased levels of B cells and eosinophils.

Research supporting this model has found an association between lower levels of family support and higher levels of nighttime asthma symptoms, lower pulmonary functioning in the morning and higher eosinophil and IL-4. Likewise, in a sample of 15,357 adults, increasing numbers of adverse childhood experiences related to a 70% increase in risk for hospitalization with Th1, 80% increase in risk for hospitalization with Th2 and 100% increased risk for rheumatic disease.[122]

Wed, 03 Jan 2024 10:00:00 -0600 en text/html https://www.medscape.com/viewarticle/814415_9




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