The Information Technology Infrastructure Library, better known as ITIL, is the pre-eminent framework for managing IT service delivery around the world. ITIL defines a service lifecycle model that prescribes specific processes and activities during the design, development, delivery, and support of IT services. For the purposes of this discussion, IT services are any IT activities that deliver business value to a company’s end users, customers and other internal or external stakeholders. Examples of IT services include centralized corporate email and corporate websites based on back-end IT processes, such as server and network administration. The current version of ITIL is known as ITIL V3.
By adopting the ITIL framework, companies ensure that their services are delivered according to a set of consistent, well-defined processes that incorporate best practices and processes, resulting in a predictable level of service for users. The benefits of ITIL include reduced cost of service development and deployment, improved customer satisfaction with service delivery, increased productivity from IT personnel, quality improvements, better management metrics of services and increased flexibility in adapting services to changing business requirements.
In July 2013, Axelos took ownership of ITIL. It now maintains the ITIL framework and accredits training and examination institutes. Hundreds of ITIL Accredited Training Organizations (ATOs) are available to deliver training, and ITIL certification exams may be administered at the end of a training course or by an Examination Institute (EI), many of which work directly with the ATOs.
ITIL offers five different certification levels:
Be aware that ITIL uses a credit system for the Foundation through Expert levels, in which each certification earns a certain number of credits. Ultimately, a total of 22 credits is required to achieve ITIL Expert certification. (The ITIL Master has its own set of requirements, which you’ll read about shortly). The following graphic shows the structure of that certification scheme and its corresponding credits.
Before you read on for certification details, it’s important to understand how the ITIL IT service framework is structured and what it has to offer.
ITIL was first developed by the U.K. Government’s Central Computer and Telecommunications Agency (CCTA) in the 1980s as a set of standardized best practices for IT services used in government agencies. From that narrowly focused start, ITIL has been adopted, revised and expanded into a comprehensive framework for managing IT service delivery in companies and organizations of all sizes, across all industries and market sectors.
In fact, IT has become a mission-critical service delivery mechanism for companies that rely on complex computing resources to keep their businesses operating and generating revenue. ITIL allows companies to define and implement a documented, repeatable process that assists them in staying focused on the large and small details involved in rolling out new IT services and managing those services afterward.
The ITIL service lifecycle consists of five practice areas or phases, with supporting principles, policies and processes within each phase:
Don’t let the scope of ITIL scare you away from the overall value afforded by this comprehensive lifecycle for IT services. The ITIL framework gives companies the structure and discipline required to design, develop, deliver and manage new or improved services in a timely manner and, most importantly, on a budget. Before ITIL, a lack of service management discipline and expertise led many IT projects to suffer budget overruns, veer off course or fail outright due to scope-creep, mismanagement and a lack of repeatable results. ITIL solves these problems quite nicely. In fact, ITIL is widely regarded as the pre-eminent standard for IT service management frameworks.
The ITIL Foundation certification covers the basics of ITIL and is where most newbies start the process of learning ITIL and becoming certified. The certification has no prerequisites, and anyone with an interest in the subject matter can sit for this exam. ITIL Foundation certification exam prep can be accomplished via classroom or distance learning options, as well as via self-study. There is no requirement for you to complete a training course before you sit for the Foundations exam. The Foundation exam consists of 40 multiple-choice questions that must be answered in 60 minutes with a grade of 65 percent, or 26 correct answers, required to pass the exam.
Although the certification covers all the five practice areas of the ITIL service lifecycle, including how the different lifecycle stages are linked to one another, an IT pro who completes the ITIL Foundation level will likely need to complete the Practitioner or Intermediate certification before being able to qualify for service management positions.
The ITIL Practitioner certification is the latest entry to the ITIL certification scheme. This exam was offered for the first time in February 2016. As the name implies, the ITIL Practitioner certification is based on practical knowledge of ITIL processes and how those principles are implemented in the real world. An ITIL Practitioner can explain how to use the ITIL framework to support business objectives and focuses on organizational change management, communications, and measurement and metrics.
The ITIL Practitioner is considered the next step in the ITIL progression after achieving the ITIL Foundation (which is a prerequisite). It emphasizes the ability to adopt, adapt and apply ITIL concepts in an organization. Although the Practitioner certification is not required for upper-level ITIL credentials, achieving Practitioner certification provides three credits toward ITIL Expert certification. You can prepare for the Practitioner exam through self-study, in-person classroom learning or online and distance learning options. The Practitioner exam is 40 multiple-choice questions and requires a minimum score of 70 percent, or 28 correct answers, to pass.
The ITIL Intermediate certification is module-based, each of which focuses on a different aspect of IT service management. Relevant modules are categorized as either Service Lifecycle or Service Capability.
The Service Lifecycle modules are:
The Service Capability modules are:
To enable candidates to meet their own career goals, AXELOS lets you achieve qualification in one category or by choosing modules from both categories. AXELOS recommends that you have at least two years of IT service management experience. Note that you must complete your Intermediate exam preparation by completing a training course offered by an accredited training organization (ATO), i.e., you cannot self-study then sit for the Intermediate exam.
The ITIL Expert is an advanced certification that encompasses the breadth and depth of ITIL processes and practices across all ITIL disciplines. ITIL Expert certification is a prerequisite for the ITIL Master certification.
To qualify for the ITIL Expert, you must obtain at least 17 credits from the Foundation, Practitioner and Intermediate modules, and pass the Managing Across the Lifecycle (MALC) exam, earning a total of 22 credits.
The pinnacle ITIL Master certification demonstrates an ability to apply the ITIL framework in real-world situations. The ITIL Master encompasses all ITIL principles and processes covered in the Foundation through Expert certifications. An ITIL Master must demonstrate complete mastery of the ITIL framework by completing the following:
The cost of the ITIL Master runs about $4,000, which you pay after an EI accepts your initial application. Given the expense of this certification and its stringent requirements, only serious candidates should pursue the ITIL Master. That said, earning this certification indicates you’ve reached the highest level of achievement in your field.
IT professionals who possess an ITIL certification have always been valued by large corporations who have adopted the ITIL framework as an internal IT standard. What is beginning to change is ITIL’s increasing proliferation. Many small- and medium-sized businesses also now recognize the value of employees with ITIL certifications under their collective belts.
As IT becomes more important, SMBs are realizing the biggest benefits of maintaining ITIL-trained personnel on staff. Though no company wants to see IT projects fail, larger companies can usually absorb the loss of productivity, time and money that accompanies a failed IT service project. SMBs may not have the financial luxury of allowing an important IT project to fail owing to poor management and lack of processes. Thus, the value of an ITIL certification may be greater for enlightened companies that cannot afford IT project failures.
The good news about ITIL certification is that it is a valuable skill for almost any IT professional, from system administrators to chief information officers (CIOs). Many large companies have dedicated ITIL coaches or mentors who help shepherd projects through the various steps of the ITIL framework. These ITIL gurus have a wide understanding of the IT landscape and can usually spot trouble with a service design document or implementation plan in a matter of minutes.
ITIL certification is also a valuable credential for IT project managers, who are in the IT service trenches every day. Most project managers are already familiar with the development lifecycle process, so the principles of ITIL come naturally to them. IT managers, architects and engineers might not ever become ITIL Masters, but even a basic knowledge of the ITIL framework can assist with understanding and supporting the ITIL process.
AXELOS provides a Career Paths chart that maps IT service management job roles with skill levels. This chart is handy for certification candidates interested in specific jobs who need to understand how they fit into the ITIL service lifecycle.
Each ITIL certification webpage provides links to relevant study guides and syllabi. Those pursuing the ITIL Foundation certification should read the three-part blog series on preparing for and taking the ITIL Foundation exam. Those who are thinking about pursuing the Intermediate certification should use the ITIL Intermediate Training Navigator to match desired job roles and skills with the appropriate modules.
Formal ITIL training is available in self-paced online courses, instructor-led distance learning and instructor-led classroom classes. The variety of ITIL training offered and the collection of certified companies offering ITIL training ensures that anyone who is interested in learning about ITIL or becoming ITIL certified has an option that fits their learning preferences.
Although non-accredited ITIL training is available, we strongly recommend that you only utilize an ITIL ATO when you pursue ITIL training. Find a complete list of such training providers on the Axelos ITIL website.
Axelos and the ITIL Development Group, made up of more than 2,000 ITIL stakeholders worldwide, began working on an update to ITIL V3 in late 2017. That work continued throughout 2018, and Axelos has announced upcoming changes to the ITIL certifications known as ITIL 4. ITIL 4 will provide sweeping changes to the ITIL certification program to better align with the growing complexity of modern IT. ITIL 4 also changes some of the certification program terms and titles to align with the new ITIL 4 program structure. Here is a look at the new ITIL 4 program overview:
You’ll recognize some familiar terms as well as some new nomenclature incorporated into the ITIL 4 certification scheme. The certification still starts with the ITIL Foundation, and ITIL Master is still the highest level of ITIL certification, but how you get from Foundation to Master now allows two distinct paths, allowing you to choose the certification knowledge areas that best fit your interests and career goals.
The new Foundation exam is scheduled to be released in Q1 of 2019, with additional certification exam updates scheduled to be released in the second half of 2019. You can find more details on how existing ITIL V3 certifications map to the new program structure here: ITIL 4 Program Updates.
Note: We will update this article as the new ITIL 4 exam preparation courses and certification exams are released by Axelos so check back here often to learn more about ITIL 4.
Credit: Ed Tittel
Ed is a 30-year-plus veteran of the computing industry, who has worked as a programmer, a technical manager, a classroom instructor, a network consultant and a technical evangelist for companies that include Burroughs, Schlumberger, Novell, IBM/Tivoli and NetQoS. He has written for numerous publications, including Tom’s IT Pro, and is the author of more than 140 computing books on information security, web markup languages and development tools, and Windows operating systems.
Credit: Earl Follis
Earl is also a 30-year veteran of the computer industry, who worked in IT training, marketing, technical evangelism and market analysis in the areas of networking and systems technology and management. Ed and Earl met in the late 1980s when Ed hired Earl as a trainer at an Austin-area networking company that’s now part of HP. The two of them have written numerous books together on NetWare, Windows Server and other topics. Earl is also a regular writer for the computer trade press with many e-books, white papers and articles to his credit.
HP Expands All-in-One PC Portfolio, Offering Businesses and Consumers Performance, Reliability and Security
PALO ALTO, Calif., July 9, 2012 - HP today expanded its all-in-one desktop PC portfolio with business and consumer designs that deliver multimedia-rich performance, trusted reliability and enhanced security in a small footprint.
The new all-in-ones are designed as cost-, space- and energy-efficient alternatives to a
traditional desktop and monitor combination for consumers and businesses, including
government, healthcare, education and retail customers. The new lineup also includes
touch-enabled solutions for businesses, building on 30 years of touch-technology
innovation for convenient and intuitive computing.
"Customers have been asking for all-in-one PC designs that do not compromise on
performance, reliability or security," said Emilio Ghilardi, vice president, PC Division,
Americas, HP. "With these sleek, elegant designs and powerful options, HP continues to
innovate to meet the needs of a growing marketplace."
Products announced today are:
- HP Compaq Elite 8300 All-in-One, HP's highest-quality all-in-one business PC,
featuring security and management features with optional touch capability
- HP Compaq Pro 6300 All-in-One, offering the optimal combination of productivity,
performance and serviceability needed to satisfy most everyday business and public
sector computing requirements
- HP ENVY 23 All-in-One, an ideal PC for consumers who demand a sleek design and
- HP Pavilion 23 All-in-One, offering essential features and processing power for
everyday computing tasks
"All-in-one PCs are expected to grow in popularity, accounting for 27 percent ofvworldwide desktop PC sales by 2016," said Danielle Levitas, group vice president, IDC. "In a exact commercial PC buyer study in the United States, IDC found that the purchase intent
for all-in-ones was up across the range of small to large businesses. This trend puts
vendors with a broad offering of all-in-one products and options-like HP-in a very good
position to meet that growing commercial demand."
Smart designs for accelerated business efficiency
The HP Compaq Elite 8300 All-in-One Business PC, HP's most powerful and multimediarich all-in-one PC, provides demanding enterprise users with proven performance and the option for intuitive touch experiences. An attractive, space-efficient solution ideal for customer-facing work areas, kiosks and more, the PC features a 23-inch diagonal, full high-definition (HD) display with an optional built-in 2-megapixel (MP) webcam and dual microphone array. SRS Premium Sound PRO™ also comes standard for high-frequency definition in a variety of listening environments.
Powered by third- and second-generation Intel® Core™ vPro™ processors that provide
outstanding performance, the HP Compaq Elite 8300 All-in-One offers IntelHD Graphics
or a choice of discrete graphics to enhance imagery and multimedia capabilities. Intel
Smart Response Technology disk cache solution also delivers a level of performance
normally associated with solid state drives, while retaining the data-storage capacity of
today's large hard disk drives.
With its added touch functionality, the HP Compaq Elite 8300 Touch All-in-One employs
multitouch, optical technology for interactive healthcare, retail and other applications. The
multitouch technology recognizes simultaneous input from two fingers to enable the use
of gestures, and the onboard suite of HP touch-enabled software provides interaction
with files, media and productivity applications.
The HP Compaq Elite 8300 Touch All-in-One provides a solution for healthcare patients to
conveniently enter personal data and for students to stay engaged. Both of the spacesaving HP Compaq Elite 8300 models also feature VESA-compatible mounting which
allows retail business to save valuable floor space while manufacturing facilities can
deploy systems in easily accessible areas without cluttering work space.
The HP Compaq Pro 6300 All-in-One Business PC is a mainstream business-class all-inone designed for reliable and consistent computing. The non-touch PC sports third- and second-generation Intel Core processors with optional discrete graphics for solid performance and simple manageability for growing business environments, including government organizations. It offers a 21.5-inch diagonal, full HD, LED backlit display, internal stereo speakers and optional 2MP webcam.
The new business all-in-ones include multilayered client security features that safeguard
data, devices and user identities. Simple, centralized deployment through HP
ProtectTools delivers defense features, such as hard-drive encryption, HP Face
Recognition, HP Disk Sanitizer and HP File Sanitizer. HP BIOS Protection offers
hardware-level defense against virus attacks and other security threats.
Each of the announced desktops is preinstalled with Microsoft® Windows®. Microsoft also
recognized HP as the 2012 Communications Market Acceleration Partner of the Year, in
celebration of the company's advanced sales and deployment of Microsoft Lync, which
provides instant access to applications for collaboration. The business desktops also offer a choice of available tools with HP Client Management and include the new HP Premier Image, which features a full suite of business software and antivirus protection, while eliminating trial-ware and other distractions. Globally consistent SKUs further simplify enterprise deployment and management, while a multitiered testing process of more than 115,000 hours helps ensure a lasting investment.
Stylish, affordable all-in-one PCs for every consumer
The HP ENVY 23 and HP Pavilion 23 All-in-One PCs combine elegant design with robust
performance. Both offer full 1080p HD 23-inch diagonal displays, multicore processors,
advanced graphics and up to 2 terabytes (TB) of storage to accommodate the demands of
any user. The HP ENVY 23 All-in-One PC offers an elegant, free-standing display with edge-to-edge glass that can be wall-mounted.
Engineered for an enriched entertainment experience, the HP ENVY 23 comes standard with Beats Audio™ and offers optional HDMI-in port, Bluray disc drive and TV tuner. The HP Pavilion 23 All-in-One PC features a slim and elegant easel design and provides a choice of Intel or AMD processors that deliver exceptional performance at an affordable price.
Both PCs offer wireless capabilities and exclusive features such as the HP TrueVision HD
Webcam, HP Magic Canvas and HP LinkUp for the latest in connected entertainment and
convenience. HP Magic Canvas software enables users to expand the desktop horizontally to accommodate photos, videos and applications. Microsoft Windows desktop shortcuts, task bar and start menu can all be accessed through the HP Magic Canvas, so users can use entertainment and work applications in the same place.
Pricing and availability
- The HP Compaq Elite 8300 All-in-One Business PC starts at $879 and is expected to be
available on Sept. 10. The HP Compaq Elite 8300 Touch All-in-One starts at $929 and is
expected to be available on Sept. 10.
- The HP Compaq Pro 6300 All-in-One Business PC starts at $799 and is expected to be
available on Sept. 3.
- The HP ENVY 23 All-in-One starts at $949.99 and is expected to be available at HP
Home & Home Office on Aug. 2 and select retailers nationwide on Aug. 5.
- The HP Pavilion 23 All-in-One starts at $649.99 and is expected to be available at HP
Home & Home Office on Aug. 2 and select retailers nationwide on Aug. 5.
The artificial-intelligence revolution sweeping the computing industry is bringing plenty of problems along with the progress, the nonprofit concludes.
June 24, 2022 / 01:33 PM IST
HP has unveiled its latest-generation gaming portfolio comprising new OMEN and Victus notebooks and desktops, and a slew of updates to the OMEN Gaming Hub. Announcing the gaming line-up, HP said the upgrades offer performance geared to boost gameplay for both professional and casual gamers.
All the components of the new gaming devices, including the stamped aluminum cover, are made from post-consumer recycled ocean-bound plastic, in line with HP’s commitment to driving sustainable impact, the company said in a statement.
The new line-up includes OMEN 16, OMEN 17, Victus 15 and Victus 16 laptops with Intel core 12th Gen and AMD Ryzen 6,000 series processors, the OMEN and Victus desktops, and a variety of updates to the OMEN Gaming Hub.
Ketan Patel, Managing Director of HP India Market noted that India’s youth is embracing PC gaming in an unprecedented way, placing India as one of the top PC gaming countries in the world. "With these insights, we at HP, are bringing our latest gaming portfolio of OMEN and Victus notebooks and desktops, to cater to all segment of gamers and elevate their gameplay to the next level," Patel said.
The OMEN 16 comes with a 16.1-inch display and 16:9 aspect ratio, and offers gamers an "immersive visual experience" whereas the micro-edge bezel display on the OMEN 17’s 17.3-inch screen gives edge-to-edge immersion for a more screen-to-chassis ratio. The Victus 15 offers a conventional backlit keyboard and a performance blue and mica silver colour schemes."With exceptional processors and graphics, gamers can multitask between gaming, browsing, and editing with the Victus portfolio," HP added.
Dr. Ali Tinazli is the CEO of lifespin.health and has 15+ years in Fortune 100 corporate strategy and entrepreneurship (SONY, HP).
Society has benefited from remarkable scientific advances in the 21st century; perhaps few are more profound than the extraordinary achievements in human health, thanks to the convergence of biology, medical science and information technology. It is now possible, for instance, to sequence an individual's entire genome rapidly and inexpensively.
At the same time, developments in wireless technologies and big data make it easier to collect and store large amounts of health-related information. The convergence of these two trends and others is revolutionizing the diagnosis and treatment of disease and ushering in a new era of deeply precise, individualized medicine that may forever alter healthcare delivery to millions of people.
One of these significant advances is in using bioinformatics, specifically the identification and utilization of human "biomarkers" to accelerate the development of improved and innovative diagnostics. An offshoot of this field is called "metabolomics," a relatively new branch of medical science that holds great promise in making precision medicine affordable and more accessible.
Metabolomics, from a health standpoint, is the study of how disease impacts a person's normal metabolism, representing the biochemical process involved in virtually everything human beings do—from moving and growing to thinking. Diseases are believed to cause a disturbance of healthy metabolism, which leaves biochemical patterns in the human body, e.g., in blood.
Physician-scientists have long believed and found, through research, that these changes in a person's biomarkers, i.e., their metabolism, can provide valuable and early indicators for disease states and other health-related conditions. For example, if two patients come to their physician with identical symptoms, a blood test would differentiate their illnesses and accurately diagnose them. But only until relatively recently, because of advances in the convergence of various technologies, has this promise become a reality.
Today, these metabolic signatures are not only traceable but are also beginning to be very accurately correlated to specific disease states, utilizing powerful digital platforms that use deep learning, advanced software solutions and artificial intelligence, all cost-efficiently scalable via the cloud. Powered by metabolomics as a new and near-universal health diagnostics modality, early and rapid identification and treatment of diseases—as well as general wellness information—may, for the first time, become far more accessible and cost-effective, not just for those living in industrialized nations with well-developed health care systems, but for the global population as well.
Here is a brief explanation of how technology will contribute to the innovative digitization of diagnostics.
Deep learning algorithms map out disease progression based on quantitatively "scanned" patient samples.
Deep learning algorithms have the potential to Boost diagnostic accuracy by providing a more comprehensive analysis of a patient's medical history, lab results and symptoms. Doctors can then use a more accurate picture of their condition to identify any early warning signs of illness.
In addition, deep learning algorithms can enable healthcare providers to monitor a patient's condition over time, making it possible to detect changes that might indicate the need for further testing or treatment. As a result, deep learning algorithms have the potential to vastly Boost the accuracy of diagnosis and Boost outcomes in the treatment of complex illnesses.
At my company, our focus is on using proprietary deep learning algorithms to identify significant deviations in metabolic networks of different health conditions. These deviations are captured quantitatively by "scanning" blood samples for metabolites with a physical method called nuclear magnetic resonance (NMR). This interface between the classical diagnostics world with patient samples in a wet lab combined with information technology elevates the technology convergence in healthcare to the next level.
We use these algorithms to map out how diseases progress, which is crucial for diagnosing and developing more effective treatments. For example, our algorithms might identify that a particular illness progresses by causing a build-up of toxins in cells. We can then use this information to develop a treatment that targets the build-up of toxins rather than the disease itself.
AI elevates the analysis of metabolic data.
Understanding how different parts of the human body interact is essential for developing new diagnostics and effective treatments for various medical conditions. However, this information is often scattered across multiple databases, making it difficult to access and use—AI keeps all the data in one place.
AI is beneficial in clinical research because it can differentiate and diagnose chronic diseases through patterns in human metabolism. Doctors can now diagnose and treat chronic diseases more accurately by using AI to analyze these patterns. Analyzing metabolomic data, AI can help identify new drugs that could effectively treat diseases.
Cloud-based platforms are improving access to human health technologies.
Standard diagnostics are typically slow, cumbersome and tedious, making them costly and difficult to access. New technologies sought after for deeper clinical insights are associated with the same attributes, making it challenging to get accepted into the standard of care. These technologies at the interface of biology and IT typically require a lot of computational power but can now be handled cost-effectively in the cloud. A new diagnostics platform that can scale cost-efficiently as a cloud-based solution will lower the barriers to entry. It will be intrinsically more accessible to providers and patients.
Complex diseases are often challenging to diagnose and treat. Cloud-based digital platforms provide new opportunities for providers to offer precise diagnostics tools to their patients and facilitate tailored treatments for these conditions. These platforms can help identify patterns and trends useful in differential diagnosis by analyzing large amounts of data. Therefore, cloud-based digital platforms will be essential in supporting better treatments for chronic diseases.
The future of human health is now.
Human health has been monitored and managed for centuries using crude tools and methods. With the advent of technology, we can now digitize every aspect of our health for accelerated and improved healthcare services. Most importantly, these next-generation cloud-based tools for precision medicine will be more accessible and affordable, enabling adoption on a broad population level. Imagine the impact for millions worldwide as expedited diagnoses and disease prevention becomes an everyday reality.
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The Global Large Format Printer Market research report consists of a detailed study of the market and the market dynamics that are related to the same. The in-depth data on the development of the market is presented in the Research report. Not only this but also the detailed data on the performance of the market for the forecast period are presented in the Large Format Printer Market research report. The performance analysis is included in the data which will help the readers to get detailed knowledge on the change in the market dynamics. Apart from this the comprehensive study of all the crucial elements of the Large Format Printer Market is presented in the market report like production, market share, region and key players. The market research report contains a detailed study of the market dynamics as we have already mentioned above and it is being presented with the help of table, graphs and pie charts with an aim to provide the reader with a better presentation of the data.
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Key Market Overview
The documentation of the market research report contains various market analysis strategies that are involved to study the Large Format Printer Market such as PESTLE analysis, SWOT analysis and Five point analysis. All these strategies will help the readers to understand the environmental, social and economic as well as political aspects that are associated with the Large Format Printer Market. The market research report on the Large Format Printer Market offers a detailed analysis of the present market demand along with the data for the future prediction of the industry. When it comes to the in-depth study the market research report is recognised to be a useful guide for the market leaders. The market research study contains the study of all the important strategies that are involved in the growth process of the market.
Market Segment Are
By Printing Technology:
By Print Width:
By Ink Type:
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Impact Of COVID 19 On Global Large Format Printer Market
The onset of coronavirus pandemic has brought along a global recession that has severely impacted various industries. Not only the impact of the COVID pandemic has also introduced new business opportunities for the Large Format Printer Market. Overall the competitive landscape and the market and a mix of the Large Format Printer Market have severely disrupted due to this pandemic. And all these impacts, as well as disruptions, are studied and analysed quantifiably in this market research report.
Geographical Outlook Of Global Large Format Printer Market
In the past few years, the global Large Format Printer Market was dominated by few regions which we have mentioned in this research report owing to the increasing demand as well as fast population growth. The key regions which are covered in the market research report are Canada, the US, and Mexico in North America, France, the UK, Switzerland, Netherlands, Russia, Belgium, Spain, Turkey, Italy and the Rest of Europe in Europe, Japan, China, India, Thailand, Australia, South Korea, Malaysia, Singapore, Philippines and Rest of Asia Pacific in the Asia Pacific, UAE, Saudia Arabia, Egypt, Israel, South Africa in Rest of the Middle East and Africa, Brazil, Argentina and Rest of South America in South America.
The market research report provides detailed analysis for the forecast period, Apart from this the global study also consists of the segmental analysis and overview of the current market trends as well as factors. These market dynamics factors also consist of opportunities, barriers, restrains and threats and effects of certain factors on the global market.
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HP-3070, an asenapine transdermal system, is superior to placebo in reducing schizophrenia-associated hostility, results of a phase 3 study show.
The results suggest that these effects are at least partially independent of general antipsychotic effects or effects on sedation or akathisia.
"It's important not to assume that antipsychotics decrease hostility by having people feel more sedated and that the only way to treat someone hostile is by sedating them," lead investigator Leslie Citrome, MD, MPH, clinical professor of psychiatry and behavioral sciences, New York Medical College, Valhalla, New York, told Medscape Medical News.
"Our findings suggest that transdermal asenapine has a specific antihostility effect in patients with schizophrenia," he added.
The study was published online on June 6 in the Journal of Clinical Psychiatry.
"Patients with schizophrenia are known to potentially exhibit aggressive, hostile behavior, especially during the acute phase of the illness, thus making effective management critical," the authors write.
Citrome said schizophrenia is a complex condition that consists of five different symptom domains. These include positive (hallucinations, delusions), negative (amotivation, apathy), disorganization (cognitive symptoms), depression/anxiety, and excitability/hostility symptoms.
"These five domains are more or less independent of each other, in terms of treatment effects," he noted
Citrome has long been interested in the activity of antipsychotics and their impact on these various symptoms — particularly hostility — and recently published a review focusing on the impact of an array of antipsychotics on this symptom domain.
"What struck me here is that this is a transdermal system, a patch," Citrome said. "None of the sedation that would ordinarily be associated with a sublingual asenapine would be present here."
Citrome wanted to investigate whether the transdermal system would have an impact on hostility because, if so, "it would support the notion that hostility is an independent treatment target in schizophrenia."
To investigate, Citrome and co-authors analyzed data from the pivotal HP-3070 phase 3 randomized, double-blind, placebo-controlled study of adults with schizophrenia who were randomly selected to receive either HP-3070 7.6 mg/24h, HP-3070 3.8 mg/24h, or placebo for 6 weeks.
The trial found that once-daily applications of HP-3070 demonstrated significant improvement in Positive and Negative Syndrome Scale (PANSS) total scores after 2-3 weeks of treatment, with the improvements sustained through week 6.
The current study was a post hoc analysis focusing specifically on 442 patients with hostility and agitation (defined as PANSS hostility item score > 1).
The outcome was the least-squares mean (LSM) changes in the PANSS hostility item. They also analyzed PANSS–Excited Component (PANSS-EC) from baseline to week 6 in all study participants. Findings were adjusted for the presence of somnolence or akathisia.
Demographic and baseline disease characteristics were "balanced" between the HP-3070–6.6-mg and the HP-3070–3.8-mg groups (n = 151 and n = 147, respectively) and the placebo group (n = 144) in the intent-to-treat analysis, with a mean (standard deviation) age of between 41.5 and 42.3 (11.6-11.9) years. Roughly three quarters of participants were White, and most participants had a mean duration of between 15 and 16 years since diagnosis.
At week 6, the LSM mean change from baseline (CFB) in the PANSS hostility score was superior in both treatment groups at 6 weeks compared with placebo.
CFB (95% CI)
-0.4 (-0.6 to -0.2)
-0.3 (-0.6 to -0.1)
The findings remained significant, even after the researchers adjusted for covariates.
For all patients, regardless of baseline PANSS hostility item score, PANSS-EC week 6 LSM CFB was greater in both treatment groups compared with placebo.
CFB (95% CI)
-1.1 (-1.9 to -0.4)
-1.3 (-2.0 to -0.6)
Patients with a PANSS hostility score > 1 at baseline in both treatment groups also showed significant improvement in PANSS-EC score compared with the placebo, beginning at week 2 and continuing through week 6.
"These effects of HP-3070 treatment on the PANSS hostility item score remained, even after adjustment for confounding variables, suggesting that the effect of HP-3070 on reducing symptoms of hostility may at be at least partially independent of general antipsychotic effects on hallucinations or delusions or the presence or absence of relevant medication-induced adverse effects, such as sedation or akathisia," the authors comment.
They note that a limitation of the study is that it was conducted post hoc. In addition, the mean baseline PANSS hostility score was "low," even among those with a score > 1, "translating to a severity level of minimal to mild," which "limits the generalizability" of the analysis.
Commenting for Medscape Medical News, Rifaat El-Mallakh, MD, MS, director of the Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Kentucky, said, "aggression and hostility may exhibit themselves as symptoms of a psychotic illness or independent of psychosis and are an important treatment target."
El-Mallakh, who was not involved with the study, said the "most effective anti-aggression medicine is clozapine." He believes that it is this effect that "gives clozapine its stellar reputation," rather than its antipsychotic effect.
"Of importance, the anti-aggression effect of clozapine is independent of its antipsychotic effect, which is an important point because if the behavior is rooted in psychosis, then successful treatment of psychosis with any agent should reduce aggression."
The researchers "demonstrated that the effect was independent of psychosis" but because the study only recruited people with schizophrenia, the researchers "could not examine to see if the effect is independent of diagnosis" El-Mallakh said.
"It is important to consider aggression/hostility as an independent behavior in pharmacologic studies because it probably has its own biochemistry and neuroanatomy," he added.
This study was funded by Hisamitsu Pharmaceutical Co, Inc. Citrome has received nonfinancial support from Hisamitsu Pharmaceutical Co, Inc, and personal fees from Noven Pharmaceuticals, Inc, during the conduct of the study; personal fees from AbbVie/Allergan, Acadia, Adamas, Alkermes, Angelini, Astellas, Avanir, Axsome, BioXcel, Boehringer Ingelheim, Cadent Therapeutics, Eisai, Enteris BioPharma, HLS Therapeutics, Impel, Intra-Cellular Therapies, Janssen, Karuna, Lundbeck, Lyndra, MedAvante-ProPhase, Merck, Neurocrine, Novartis, Noven, Otsuka, Ovid, Relmada, Reviva, Sage, Sunovion, Takeda, Teva, and University of Arizona and for one-off ad hoc consulting for individuals/entities conducting marketing, commercial or scientific scoping research and CME activities organized by medical education companies such as Medscape, NACCME, NEI, Vindico, and universities and professional organizations/societies, outside the submitted work. He has stocks (small number of shares of common stock) in Bristol-Myers Squibb, Eli Lilly, Johnson & Johnson, Merck, and Pfizer purchased more than 10 years ago and has received royalties from Springer Healthcare (book), UpToDate (reviewer), Wiley (Editor-in-Chief, International Journal of Clinical Practice, through end of 2019), and Elsevier (Topic Editor, Psychiatry, Clinical Therapeutics). The other authors' disclosures are listed on the original paper. El-Mallakh is a speaker for Noven, as well as Indivior, Intracellular, Janssen, Lundbeck, Otsuka, Sunovion, and Teva.
J Clin Psychiatry. Published online June 6, 2022. Full text
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HP has introduced a new portfolio of Omen and Victus gaming laptops, and desktops in India. The new devices feature Intel Core 12th Gen and Ryzen 6000 series processors, along with options for Nvidia's RTX 30 series graphics.
HP is aiming for the creator and game enthusiast market with new products, and HP says that all components within the machines, are made from post-consumer recycled ocean-bound plastic.
HP Omen gaming laptops
Both the Omen 16 and 17 laptops feature upgraded thermals, that helps the devices run cooler and 5% quieter than previous generation models. HP has introduced a new thermopile sensor, that can be tracked with the Omen Gaming Hub, and can dynamically allocate CPU resources, where they are needed.
HP says that this helped them see a 18% performance increase in benchmarks like 3D Mark Time Spy, and up to 36% more CPU performance over the last model.
Both laptops can be configured with up to a 12th Gen Intel Core i7-12700H processor, up to Nvidia's GeForce RTX 3080 Ti graphics, or AMD's Radeon RX 6650M graphics, up to 32GB of DDR5 RAM, and up to 2TB PCIe SSD storage.
The Omen 16 features a 16.1-inch display, while the Omen 17 flaunts a larger 17.2-inch display. Both are IPS QHD panels with refresh rates of 165Hz and a 3ms response time.
HP Victus 15 and 16 gaming laptops
The HP Victus 15 has a 15.6-inch display, and comes with a new design with softer edges and an elevated Omen inspired chassis. HP says that the new laptops have Temporal Noise Reduction (TNR), that can clean up "noisy areas to deliver grain-free, low-light video quality, and Super Resolution Auto Scene Setting."
The Victus 15 can be configured with 12th Gen Intel Core i5 and i7 processors, and Nvidia's RTX 3050Ti graphics.
The Victus 16 has a 16.1-inch display that can be configured with up to FHD resolution with a refresh rate of 144Hz, and Eyesafe low-blue light filters for ease of use. The rest of the specifications include AMD's Ryzen 7 6800H processor, with Nvidia's RTX 3050Ti Graphics. You can also opt for up to 512GB of SSD storage.
HP Omen 45L, 40L and 25L gaming desktops
The new Omen desktops feature configurations of up to 12th Gen Intel Core i7-12700K, up to Nvidia GeForce RTX 3080 graphics and up to HyperX 32GB dual-channel DDR 4 RAM.
HP says the new patented Cryo chamber cooling in the desktops, use ambient air and "precise placement of the fans" to keep temperatures in check. Of course, there is complete RGB control as well.
The chassis is built with tempered glass panels, a full metal body, and enables complete tools-free access to the internals for easy swapping.
The Omen Hub on the devices enables a wide range of functions like software based fan control, BIOS access, RAM frequency tuning and intelligent overclocking.
HP Victus 15L gaming desktop
The Victus 15L can be configured with up to 12th Gen Intel Core i7-12700F processor, or AMD Ryzen 7 5700G processor. The 15L comes with Nvidia's GeForce RTX 3060Ti graphics.
The Omen 16 laptops can be purchased now and start at Rs 1,09,999, while the Omen 17 will hit the store in August 2022 and starts at Rs 1,99,999. The Victus 15 laptop will be avaialble from July 2022 starting at Rs 67,999. and the Victus 16 laptop is available now starting at Rs 84,999.The Omen 45L, 40L, and 25L desktops start at Rs 1,49,999 and the Victus 15L desktop starts at Rs 93,999.
The cross-sectional study ‘A population‑based study of macronutrient intake according to mental health status with a focus on pure and comorbid anxiety and eating disorders’ evaluated the relationship between macronutrient intake and mental health status, with a specific focus on anxiety and eating disorders (ED).
Scientists uncovered some significant differences in macronutrient intake, although observations were largely dependent on ED type.
Findings revealed a link between cholesterol and pure hyperphagic (HP), where intake was nearly 20 mg/day higher than the ‘no disorder’ group.
Reduced dietary diversity typical of anorexia was observed in subjects with comorbid restrictive (RS) eating behaviour, compared with the pure form, and researchers also noted differences in fibre intake between mental health status and ED forms.
Mental health disorders have a negative impact on daily life and are frequently associated with comorbidity. As global mental health declines, there is urgent need for more research into the mechanisms linking these conditions, the authors write.
Comorbidity can lead to increased symptom severity, poorer health outcomes, and reduced quality of life.
Previous research revealed a decrease in total calorific intake and increase in sugar consumption among young adults with anxiety symptoms, however there is a distinct paucity of research on macronutrient intake and anxiety.
The report states that: “Despite reported associations between trait anxiety and food/nutrient intake, possible mediating and/or moderating effects of anxiety regarding ED, and the high ED-anxiety comorbidity, no study, to our knowledge, has investigated dietary/nutrient intake among individuals with such comorbidity.”
Participants 18 years and over were recruited from the general population through the French web-cohort NutriNet-Sante.
Recruits were asked to fill in a set of five questionnaires at inclusion and yearly over 13 years. Data was gathered on socio-demographic and lifestyle characteristics, anthropometrics, physical activity, diet, and health status.
Further questionnaires on nutrition or health-related were completed per month, as part of follow-up.
Researchers examined macronutrient intake according to mental health status (no disorder, pure and co-morbid anxiety, and ED).
Significant differences were observed in macronutrient intake between the pure and comorbid forms, especially for restrictive (RS) and hyperphagic (HP). Restrictive disorders included anorexia nervosa (AN), bulimic disorders, and binge-eating disorders (BED).
Compared to the ‘no disorder’ group, a significantly higher percentage of energy from carbohydrates, higher intakes of total carbohydrates, simple sugars, and plant-based protein, lower intakes of total fat, saturated and monounsaturated fatty acids, and cholesterol were observed in the comorbid anxiety plus RS group but were not observed in the pure RS group.
This suggests that “that dietary homogeneity (eg exclusion of red meat and meat products) is more pronounced in the case of comorbidity”, they write.
In contrast, significantly lower intake of added sugar and plant-based protein, and a higher intake of cholesterol were observed in the pure HP group, but not in the comorbid anxiety with HP group. For bulimic (BL) and other ED, similar results were observed between the pure and comorbid forms.
Additional findings revealed that fibre intake was higher in both pure and comorbid RS, whereas the pure anxiety group had a significantly lower fibre intake in comparison with the ‘no disorder’ group.
The authors assert that future studies are needed to clarify causality and the “potential effect modification of the observed associations”.
Source: European Journal of Nutrition
Published online: https://doi.org/10.1007/s00394-022-02923-x
‘A population‑based study of macronutrient intake according to mental health status with a focus on pure and comorbid anxiety and eating disorders’
Authors: Junko Kose et al.
HP today announced it is building a new VR headset, called Reverb G2, in collaboration with Valve and Microsoft.
There’s very little to go on, as the only thing available right now is a single teaser video. Here it is, in all its ambiguous glory:
HP also left us with this statement, which may give us at least one clue as to what we’re seeing here:
“Through this collaboration, Valve, Microsoft and HP are bringing a more immersive, comfortable and compatible VR experience,” an HP spokesperson told Road to VR.
Healthy speculation: by the looks of it, the Reverb G2 may make use of Microsoft’s Windows MR optical inside-out tracking, which is available on a host of Windows MR headsets dating back to the first generation of devices in 2017, including the original HP Reverb.
Launched just last summer and aimed at enterprise users, the HP Reverb was an impressive piece of kit despite the compromises on its generally tepid Windows tracking quality and aging WMR controllers. It includes 2,160 × 2,160 per-display resolution, which is a big step up over the next highest resolution headsets in the same class—the Valve Index, showcasing a resolution of 1,440 × 1,600 per display, and HTC Vive Pro’s dual 1,440 × 1,600 AMOLEDs, making the OG Reverb an impressively pixel-dense headset.
The “more compatible” part of the statement however might just point to the inclusion of SteamVR tracking as a secondary standard, embedded within the headset’s exterior. Windows MR headsets are already compatible with SteamVR by default, and their controllers have a standard input layout, so making it “more compatible” from a software perspective seems like a moot point.
Here’s a better look, brightened for clarity.
If it includes SteamVR tracking, where are the dimples then? Although HTC Vive and more recently Vive Cosmos Elite contain characteristically dimpled faceplates for SteamVR tracking, Valve’s Index has them invisibly embedded, so there’s no telling what lurks underneath that front portion of the headset.
Another bit of speculation: the headset’s integrated audio looks strikingly similar to Valve Index’s, which might suggest an off-ear headphone design. Should that be the case, it’s not out of the realm of possibility that they’ve also borrowed some of Valve’s optics as well.
What definitely isn’t clear is whether Reverb G2 will come with the aging Windows MR controllers, or whether that reveal will come later with a prospective Windows MR/SteamVR tracking combo. We’ll have our eyes peeled for more info on Reverb G2, which symbolizes Valve’s first headset collab outside of the original HTC Vive from 2016.
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Is HP pushing out another enterprise headset, or heading HTC off at the pass with an impressively speced headset which could potentially trump the Vive Cosmos’ modularity? We’ll be keeping our eyes peeled in the coming weeks for more info on Reverb G2, so make sure to check back soon.