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Exam Code: ACMP Practice exam 2022 by Killexams.com team
ACMP Aruba Certified Mobility Professional (HPE6-A71)

Exam ID : ACMP - HPE6-A71
Exam Title : Aruba Certified Mobility Professional (ACMP)
Exam type : Proctored
Exam duration : 1 hour 30 minutes
Exam length : 60 questions
Passing score : 65%
Delivery languages : English, Japanese, Latin American Spanish

Aruba Certified Mobility Professional (ACMP)
This certification validate that you have the networking knowledge and skills required to implement, configure and manage advanced Aruba Wireless Local Area Network (WLAN) enterprise solutions utilizing the operating system (AOS8) architecture and features.

This certification validates knowledge and skills in these key areas and more:
Configuring and using the Mobility Master for consolidated network management
Uses and advantages of clustering
Redundancy and providing user seamless failover
Utilizing MultiZone to have multiple and separate secure networks while using the same Access Point (AP)
Utilizing secure Tunneled Node for wired switches
Utilizing AirWave to monitor the health of the wired and wireless network
Troubleshooting devices, users and applications on Aruba Mobile First networks

This exam tests your skills with the WLAN design, deployment, and troubleshooting of Aruba Mobile First Network Solutions in complex highly available campus and branch environments. It also tests your ability to configure specialized applications, management, and security requirements for a WLAN such as UCC Voice and advanced security features.
20%
Integrate and implement Aruba Mobile First architecture components and explain their uses.
Integrate components of the Aruba Mobile First Architecture.
Differentiate between standalone mode and Master Controller Mode (MCM) features and recommend use cases.
Differentiate the use of packet forwarding modes (tunnel, decrypt-tunnel, split-tunnel, and bridge).
Differentiate between redundancy methods, and describe the benefits of L2 and L3 clustering.
Explain Remote Access architectures and how to integrate the architectures.
Describe and differentiate advanced licensing features.

20%
Configure and validate Aruba WLAN secure employee and guest solutions.
• Configure Remote Access with Aruba Solutions such as RAP and VIA.
• Configure and deploy redundant controller solutions based upon a given design.
• Configure a Mesh WLAN.

38%
Implement advanced services and security.
• Enable multicast DNS features to support discovery across VLAN boundaries.
• Configure role derivation, and explain and implement advanced role features.
• Configure an AAA server profile for a user or administrative access.
• Implement Mobility Infrastructure hardening features.
• Explain Clarity features and functions.
• Implement Voice WLAN based upon a given design.
• Configure primary zones and data zones to support MultiZone AP.
• Implement mobility (roaming) in an Aruba wireless environment.
• Implement tunneled node to secure ArubaOS switches.

10%
Manage and monitor Aruba solutions.
• Use AirWave to monitor an Aruba Mobility Master and Mobility Controller.
• Perform maintenance upgrades and operational maintenance.

12%
Troubleshoot Aruba WLAN solutions.
• Troubleshoot controller communication.
• Troubleshoot the WLAN.
• Troubleshoot Remote Access.
• Troubleshoot issues related to services and security.
• Troubleshoot role-based access, per-port based security and Airmatch.

Aruba Certified Mobility Professional (HPE6-A71)
Aruba Professional test
Killexams : Aruba Professional test - BingNews https://killexams.com/pass4sure/exam-detail/ACMP Search results Killexams : Aruba Professional test - BingNews https://killexams.com/pass4sure/exam-detail/ACMP https://killexams.com/exam_list/Aruba Killexams : Aruba Client Insights automatically recognizes and configures endpoints

Aruba added Client Insights to the Aruba Central Foundation licence. Existing customers receive a new, free service that automatically identifies and configures endpoints.

Aruba Central is a software solution for network management and security. An Aruba Central Foundation license provides access to most tools. Aruba recently announced that licensees can now access Client Insights.

Client Insights allows users to automatically identity and configure unknown network devices. The tool has been available for some time. Users required a paid license. Now, Aruba Central Foundation licensees can use the tool without additional costs.

Client Insights

Client Insights starts with a network scan. The tool analyses the network traffic of unknown devices to create profiles. It automatically distinguishes between PCs, video cameras, sensors and so on.

Client Insights proceeds to send the profiles to ClearPass, an Aruba policy management solution. ClearPass reads the device types and applies the policies of similar devices. Finally, Client Insights makes it possible to fully automate onboard devices.

Firmware Recommender and AI Predictions

In addition to Client Insights, Aruba announced a ‘Firmware Recommender‘. The feature will be available in October 2022. Firmware Recommender uses an AI algorithm to recommend appropriate firmware updates for access points. Network administrators don’t need to check model numbers.

Finally, Aruba launches Automated Infrastructure Predictions. According to Aruba, the solution predicts hardware and software problems in infrastructures. Think of a firmware version that will soon become outdated, or a network device that needs to be replaced. The solution’s based on Aruba AI Assist and Aruba Support, two existing tools.

Competition

Aruba operates in a competitive market. Juniper Networks and Cisco recently announced similar updates. Juniper launched ‘AI-Enabled Device Onboarding as a Service‘, a solution that automatically configures network devices. Cisco launched ‘WAN Insights‘ for ThousandEyes WAN, a feature that predicts problems in WAN networks.

Fri, 29 Jul 2022 03:25:00 -0500 en text/html https://www.techzine.eu/news/infrastructure/84670/aruba-client-insights-automatically-recognizes-and-configures-endpoints/
Killexams : 7 Hotel Gyms That Will Motivate You To Work Out On Vacation
Courtesy The Vines Resort & Spa

The hotel gym has hit its stride exact years. Gone are the days where you’d trek down to some windowless closet with a set of mismatched dumbbells and a treadmill that has clearly seen better days. Today’s healthy-minded travelers demand a quality fitness experience, and smart hotels are finally delivering with state-of-the-art cardio equipment, boutique-style workout classes, personal training sessions and amenities galore. With hotel gyms like these, you have no more excuses to ditch your workout on a trip.

Courtesy ARIA

ARIA (Las Vegas, NV)

In effort to offer guests “the gym of the future,” the ARIA has outfitted its fitness center with top-of-the-line cardio and strength-training equipment from Technogym’s elite fitness line, Artis. For this collection, Technogym’s scientific research department finessed the designs of each sleek machine to mimic the way bodies naturally move. The result is ellipticals that seamlessly glide beneath your feet and provide incredible range of motion, treadmills that gently adjust in speed and incline and climbers that challenge even the most dedicated athletes. The machines also include interactive technology that can provide custom training routines and instructions on how to use the equipment, effectively putting a virtual trainer at your fingertips. What happens in Vegas doesn’t have to stay in Vegas, though. The Technogym equipment in the ARIA integrates with the MyWellness app to track your workouts and supply you progress reports you can use back at home. Plus, the fitness center’s floor-to-ceiling windows and polished atmosphere make it a pleasant space to work up a sweat, day or night.

Courtesy The Westin Riverfront

Westin Riverfront (Avon, CO)

Working out on vacation doesn’t get much better than swimming in a 25-yard saline lap pool nestled at the base of Beaver Creek Mountain. But that’s just the beginning of what fitness travelers find at The Westin Riverfront in Avon, CO. The hotel’s 27,000-square-foot athletic club features more than 70 classes a week, including aerial yoga, kickboxing, barre and Pilates reformer. Prefer a solo workout? Bounce around the gym’s athletic equipment from top brands, including Peloton bikes. What really sets the Westin Riverfront’s athletic club apart from other hotel gyms is its resident athletes program, which allows guests to attend lectures and special workshops from triathlon world champion Josiah Middaugh and Olympic gold medalist and World Cup alpine skier Mikaela Shiffrin. That opportunity alone is worth the trip to Vail Valley.

The Vines Resort & Spa

The Vines Resort & Spa (Mendoza, Argentina)

Start running on the Technogym treadmill at The Vines Resort & Spa and you might find yourself out of breath, fast—and it's not just because you’re putting your running skills to the test. The outdoor gym floats above 1,500 acres of private vineyards in the Uco Valley set at the base of the Andes, giving athletic travelers some of the most breathtaking views in the region. The elevated fitness center also features a variety of other cardio and strength-training equipment, along with a massive climbing wall, to supply guests a full-body workout. Looking to get up close with the landscape? Try the resort’s in-vineyard yoga classes, or hit the running trails that weave throughout the scenic property.

Courtesy Divi Aruba

Divi Aruba (Oranjestad, Aruba)

Just built last year, Divi Aruba’s brand-new fitness and water sports center is giving other hotel gyms in Aruba a run for their money. Whether running on one of the dozen treadmills or seven ellipticals or spinning on the bikes, guests from Divi and its sister property, Tamarijn Aruba, are treated to sweeping floor-to-ceiling views of the bright turquoise Caribbean Sea—a welcome distraction from tough cardio sessions. Visitors can also sign up for Zumba, aqua-exercise, yoga and Pilates classes, or meet with a personal trainer most days of the week. Up for an epic challenge? See if you can make it to the top of Divi’s 30-foot rock climbing wall, right on the beach.

Courtesy Upgrade Labs

The Beverly Hilton (Beverly Hills, CA)

Take your vacation workout into the future at The Beverly Hilton’s new fitness center, Upgrade Labs. Billing itself as the “word’s first biohacking health and fitness facility,” Upgrade Labs offers a series of exclusive treatments and exercises customized to each guest’s body composition, goals and abilities. Upgrade Labs’ mission is to help guests “hack” their workouts to maximize efficiency and get better results. With facilities like a cryotherapy chamber chilled to -220°F, cold HIIT classes (currently part of NASA experimental training programs for flights to Mars) and the “Cheat Machine” (adaptive resistance technology that promises to supply you a week’s worth of weightlifting in less than 15 minutes), no wonder the gym has become a favorite of high-profile celebrities and athletes.

Courtesy The Hilton Sedona

Hilton Sedona Resort (Sedona, AZ)

Workout warriors, meet your new favorite hotel gym: Hilton Sedona Resort’s athletic club. This is not your typical fitness facility—the bootcamp playground features everything you need for the ultimate cross-training workout, including massive tires, battle ropes, sledge hammers and anchors. You’ll get covered in Sedona’s signature red sand as you try one of the most rugged (and inspirational) hotel gyms in the Southwest. The rough-and-tumble equipment can intimidate even seasoned athletes, so consider signing up for one of the 40 weekly classes for some expert guidance from professional instructors.

Courtesy Hotel X Toronto

Hotel X Toronto (Toronto, Canada)

At 90,000-square-feet, Hotel X Toronto’s fitness center 10XTO proves that size does matter—at least when it comes to your vacation workout. Canada’s largest hotel fitness facility offers guests access to an incredible array of equipment and athletic spaces, including nine glass back squash courts, four DecoTurf indoor tennis courts, four dedicated studios for hot yoga and fitness classes and a golf simulator with more than 85 course options. The floor-to-ceiling glass windows in the fitness center overlooking downtown Toronto and Lake Ontario set the perfect backdrop for a sweat session on some of the 50 pieces of cardio, strength and flexibility machines from Technogym’s Artis collection.

Sun, 31 Mar 2019 11:40:00 -0500 Joni Sweet en text/html https://www.forbes.com/sites/jonisweet/2019/03/31/best-hotel-gyms-in-the-world/
Killexams : Aruba AIOps Solution Combines Network and Security Insights

SAN JOSE, Calif., July 26, 2022 — Aruba, a Hewlett Packard Enterprise company (NYSE: HPE), today announced new Aruba ESP (Edge Services Platform) AIOps capabilities that allow IT professionals to greatly reduce the time spent on manual tasks such as network troubleshooting, performance tuning, and Zero Trust/SASE security enforcement. Part of Aruba’s growing family of AIOps solutions, the new capabilities supplement overtaxed IT teams as they grapple with increasing network complexity and the rapid growth of IoT. For the first time, AIOps can be utilized for not just network troubleshooting but also performance optimization and critical security controls.

As organizations pursue digital transformation initiatives, network modernization is critical for achieving new business outcomes. However, with the growth of hybrid work, new user engagement models, and challenges resulting from the ‘Great Resignation’ and widening skills gaps, IT teams must find ways to achieve greater efficiencies. Yesterday’s time-intensive manual processes are simply inadequate for today’s quickly-changing business environment. Powerful analytics, AI-based insights, and automation supplement – not replace – networking teams by reducing manual tasks so they can focus on more strategic and higher-value projects.

In development since 2013, Aruba AIOps capabilities leverage Aruba’s industry-leading data lake, which continuously and anonymously collects and analyzes device, user, and location data from over 120,000 Aruba Central customers, from more than 2 million network devices and 200 million clients per day. The unmatched reliability of Aruba’s AI is directly related to the high volume and wide variety of network and client data, the constant training of models, and the unique ability to provide insights that tackle both network and security concerns. This allows network teams from every industry and size to trust that Aruba AIOps will automate mundane tasks, shrink the time needed to find and fix problems, increase security controls, and help ensure that all network users have the best possible experience.

“For AI results that customers can trust, the key ingredient is not a mathematical model, but access to a large volume and variety of data to train the models to produce reliable results across all network topologies. Without that foundation, so-called “AI” is nothing more than demoware,” said Larry Lunetta, vice president of portfolio solutions marketing at Aruba. “Fueled by our data lake, our AIOps solutions help enterprises reduce trouble tickets by up to 75 percent while optimizing their network performance by 25 percent or more.”

The new AI-powered IT efficiency features include:

  • Aruba Client Insights: Automatically identifies each endpoint connecting to the network with up to 99% accuracy, which is especially important as increasing numbers of IoT devices are added to networks, sometimes without approval from IT. This allows organizations to better understand what’s on their networks, automate access privileges, and monitor the behavior of each client’s traffic flows to more rapidly spot attacks and take action.
  • AI-powered Firmware Recommender: Provides IT teams with the best version of firmware to run for the wireless access points in their environments – regardless of model numbers. This greatly reduces support calls and guesswork that network admins face, and helps ensure new features and fixes are implemented more quickly.
  • AI Search in Spanish: The same built-in natural language search function in Aruba Central shows its versatility by now supporting queries and responses in Spanish to satisfy the needs of our second largest geographical user community.
  • Automated Infrastructure Predictions: Leverages Aruba’s AI Assist feature and Aruba Support outreach to recognize possible hardware and software infrastructure issues for preemptive engagement that can consist of firmware upgrades or recommended hardware replacement.

“With hybrid work and new customer engagement models, network complexity is unavoidable as organizations modernize their network infrastructure to successfully support corporate initiatives,” said Bob Laliberte, principal analyst at Enterprise Strategy Group. “When a network vendor demonstrates reliable, real-world AI solutions, NetOps teams are increasingly adopting and trusting the actions of machine learning and other automation technologies. In fact, ESG research highlights that almost a quarter (21%) of organizations are comfortable with software that automatically detects, analyses, recommends, and makes network changes, and 59% report being comfortable with technology that alerts and provides recommendations, which are then manually executed. We expect these percentages to climb as more organizations gain experience with and recognize the benefits AI delivers.”

“We rely on the AIOps capabilities in Aruba Central. With these new features, not only can we quickly see if our network users are experiencing problems, but we can also identify actual issues and take steps to address them before any users are impacted, saving us many hours of after-the-fact issue investigation and remediation,” said Justin Kuzara, network engineer at CIC Group. “Additionally, having client-oriented security analytics helps our team better protect the organization without having to use a separate product.”

Pricing and Availability

Aruba Client Insights is available now. AI Search, AI-powered Firmware Recommender, and Infrastructure Predictions are available for early access and will be generally available in October 2022. Each of these features are included in Aruba Central Foundation licensing.

About Aruba, a Hewlett Packard Enterprise company

Aruba, a Hewlett Packard Enterprise company, is the global leader in secure, intelligent edge-to-cloud networking solutions that use AI to automate the network, while harnessing data to drive powerful business outcomes. With Aruba ESP (Edge Services Platform) and as-a-service options, Aruba takes a cloud-native approach to helping customers meet their connectivity, security, and financial requirements across campus, branch, data center, and remote worker environments, covering all aspects of wired, wireless LAN, and wide area networking (WAN).

To learn more, visit Aruba at www.arubanetworks.com. For the latest technical discussions on mobility and Aruba products, visit the Airheads Community at community.arubanetworks.com.


Source: Aruba

Tue, 26 Jul 2022 03:21:00 -0500 text/html https://www.datanami.com/this-just-in/aruba-aiops-solution-combines-network-and-security-insights/
Killexams : Tag "Aruba" No result found, try new keyword!Siemens and Aruba, a Hewlett Packard Enterprise company announces a strategic partnership focused on bridging the Operational Technology (OT) and Information Technology (IT) worlds. Based on the ... Fri, 19 Jun 2020 09:09:00 -0500 text/html https://www.ciol.com/tag/aruba/ Killexams : Virgin Voyages Standardizes on Aruba ESP to Deliver Exceptional Sailor Experiences

TMCNet: Virgin Voyages Standardizes on Aruba ESP to Deliver Exceptional Sailor Experiences

Aruba, a Hewlett Packard Enterprise company (NYSE: HPE), today announced that Virgin Voyages is deploying an end-to-end Aruba ESP (Edge Services Platform) network to deliver world-class, premium experiences aboard all four of their inaugural fleet of "lady ships." Working with DeCurtis Corporation, Virgin Voyages set out to create an extraordinary, technology-enabled cruise experience. Headquartered in Plantation, Florida, Virgin Voyages is a joint venture between the Virgin Group and Bain Capital.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220802005471/en/

Virgin Voyages is deploying an end-to-end Aruba ESP network to deliver world-class, premium experiences aboard all four of their inaugural fleet of

Virgin Voyages is deploying an end-to-end Aruba ESP network to deliver world-class, premium experiences aboard all four of their inaugural fleet of "lady ships." (Source: Virgin Voyages)

Virgin Voyages currently has two award-winning ships deployed, and two more in development, all with a capacity of nearly 4,000 passengers and crew members on each ship. Scarlet Lady was named Cruise Critic's "Best New Cruise Ship for 2021," and both Scarlet and Valiant Lady received top spots on Condé Nast Traveler's Cruising Hot List for 2022. As an exclusively adult cruise experience, Virgin Voyages offers a sanctuary at sea for the 18+ traveler with 20+ unique dining options, immersive entertainment and wellness-forward programming.

"From the time a Sailor books their trip or uses mobile ticketing, all on-board experiences up through departure at the end of their journey, is enhanced by technology," said Frank Farro, vice president of Technology at Virgin Voyages. "A favorite luxury indulgence for Sailors is our unique "Shake for Champagne™" feature. By simply shaking their phone with the Virgin Voyages app open, and pressing a button, crew is alerted to deliver chilled champagne to the Sailor wherever they are on the ship. The same capability is extended to other services such as Ship Eats, to guarantee high-touch service to each Sailor's dining, snacking and eating experience."

A primary goal for Virgin Voyages is to deliver a premier Sailor experience by providing real-time services and always-on connectivity for crew members to facilitate fast, reliable service. For example, if a crew member see a maintenance issue, they can open a repair ticket on their issued device, and it immediately goes to the right person to address the issue. The technology behind these capabilities is ubiquitous for crew members and transparent to Sailors, creating a seamless five-star experience wherever they are on the ship.

Another important goal for Virgin Voyages is to provide location-based quality of service via location-based data. One powerful example of this is by dramatically reducing the time Sailors stand in line. Virgin Voyages created a virtual queuing system so that Sailors don't have to congregate in long lines. Instead, the Virgin Voyages app alerts them when it's their turn to board the ship, sit for dinner, enter the spa, or disembark in their Port of Call. Virgin Voyages' focus on a frictionless experience allows Sailors to relax and enjoy the amenities, rather than waiting in lines or dealing with service-related issues.

To achieve frictionless, location-based services that enable world-class Sailor services, Virgin Voyages looked to trusted technology partner DeCurtis Corporation. With a vast range of experience working with some of the world's best, most-recognized hospitality brands, DeCurtis and Virgin Voyages were looking to transform existing Sailor experiences to make them better, faster and more impactful through creative application of the latest technology.

In cooperation with DeCurtis and Aruba, Virgin Voyages selected and deployed a flexible, resilient Aruba ESP network including Aruba Wi-Fi 6 access points with built-in location services, as well as access switches. Additionally, Virgin Voyages uses ClearPass for network access control (NAC) and policy management, and AirWave for network management.

"It was the Aruba team that stepped up to work with our Virgin Voyages team as well as our partners DeCurtis and Axians to solidify and enhance a comprehensive network for our ships," explained Farro. "The Aruba team in the yard, on the ship, and the team behind helping those two teams, have all been responsive and engaged."

Virgin Voyages has seen multiple benefits of their new Aruba network, including reliability, seamlessness, and scalability. "The network is built to accommodate around 15,000 devices," said Farro. "This includes crew devices, PCs, laptops and tablets, in addition to tablets and TVs in each cabin, as well as in the crew rooms. Add on top of that the myriad of devices each Sailor brings onboard. The seamless experience is best illustrated in our ability to duplicate 'smart home' features in each cabin, which are controlled by the app on the cabin tablets. When a Sailor walks in and their cabin is in nighttime mode, the lights automatically come on and the curtains close. It's just an incredible experience."

Looking to the future, Virgin Voyages will continue delivering transparent but ubiquitous high-touch Sailor services and expand features such as wayfinding. Their focus will remain on making sure that Sailors' devices seamlessly connect to the internal Wi-Fi network, so they don't even have to think about connectivity from boarding to departure and everything in between.

About Aruba, a Hewlett Packard Enterprise company

Aruba, a Hewlett Packard Enterprise company, is the global leader in secure, intelligent edge-to-cloud networking solutions that use AI to automate the network, while harnessing data to drive powerful business outcomes. With Aruba ESP (Edge Services Platform) and as-a-service options, Aruba takes a cloud-native approach to helping customers meet their connectivity, security, and financial requirements across campus, branch, data center, and remote worker environments, covering all aspects of wired, wireless LAN, and wide area networking (WAN).

To learn more, visit Aruba at www.arubanetworks.com. For real-time news updates, follow Aruba on Twitter and Facebook, and for the latest technical discussions on mobility and Aruba products, visit the Airheads Community at community.arubanetworks.com.

[ Back To www.mobilitytechzone.com\LTE's Homepage ]

Tue, 02 Aug 2022 01:52:00 -0500 text/html https://www.mobilitytechzone.com/lte/news/2022/08/02/9648813.htm
Killexams : How a 31-year-old from Suffolk is transforming the Cayman Islands No result found, try new keyword!and Aruba (200). Their journey begins with tough tests against Suriname and Canada. “They’re two excellent teams but it gives us the opportunity to play against outstanding players. Mon, 22 Mar 2021 04:25:00 -0500 en text/html https://www.fifa.com/tournaments/mens/worldcup/qatar2022/news/how-a-31-year-old-from-suffolk-is-transforming-the-cayman-islands Killexams : Blood Test Rapidly Indicates Cellular Immunity to SARS-CoV-2

A MedUni Vienna research team has developed a new blood test that indicates a person's status of cellular immunity to SARS-CoV-2 within just 48 hours. This test is particularly relevant for vulnerable patient groups, whose own antibody response is not meaningful. The test can even indicate whether immunity is the result of vaccination against SARS-CoV-2 or of survived infection. The study data were recently published in the esteemed journal "Allergy".

The new test, developed by Bernhard Kratzer in a study conducted at MedUni Vienna's Center for Pathophysiology, Infectiology and Immunology under the leadership of Winfried Pickl and Rudolf Valenta, is based on the memory response of T cells to three different SARS-CoV-2 peptide mixtures. T cells are an important part of the specific cellular immune defense: they eliminate cells infected with SARS-CoV-2 and support antibody production by B cells. "Currently, it takes at least a week to perform and evaluate such T-cell tests, and the tests can only be performed in specialised laboratories. In contrast, our newly developed test is performed directly with a whole blood trial and can be evaluated after only 48 hours," explains study leader Winfried Pickl.

From September, the new test will be available at the Institute of Immunology at MedUni Vienna's Center for Pathophysiology, Infectiology and Immunology and is particularly useful for those who are unable to produce antibodies against SARS-CoV-2.

Discriminating between vaccinated and recovered

Analyses of blood samples from COVID-19-recovered patients, based on peptide mixtures of S-, M- and NC-proteins, enabled the research team to not only detect the two antiviral cytokines interleukin (IL)-2 and interferon-gamma in large quantities but also to identify the cytokine IL-13 as a marker for the highly specific T-cell immune response against SARS-CoV-2. IL-13 was previously known as a marker for allergic immune responses, but it apparently also plays a key role in establishing a long-lasting antibody response.

By using the three different peptide mixtures, it is also possible to discriminate between those who have been vaccinated against SARS-CoV-2 and those who have had COVID-19. Samples from recovered volunteers responded with significant cytokine production to all three peptide mixtures, whereas samples from vaccinated volunteers only responded to the specific peptide mixture in which the protein was induced by vaccination (S protein), and to which the vaccinated subjects then went on to build up cellular immunity. The novel test therefore allows a specific cellular immune response to SARS-CoV-2 to be identified even in individuals who, for various reasons, are unable to develop meaningful antibody responses.

T-cell immunity post infection is detectable longer than antibody responses

In the study, the T-cell response was also analysed ten months after infection. It was found that the T-cell response was still as strong as that measured ten weeks after an infection. This is remarkable in that antibody levels in the blood have already dropped significantly ten months after infection. This long-lasting T-cell response may protect against severe disease in the event of re-infection with SARS-CoV-2.

The results of this study make a significant contribution to our understanding of the immune response to SARS-CoV-2 and will enable us to quickly establish whether specific individuals have built up cellular immunity to SARS-CoV-2.

Reference: Kratzer B, Schlax LC, Gattinger P, et al. Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post–infection and post-vaccination cellular SARS-CoV-2-specific immune response. Allergy. 2022. doi: 10.1111/all.15406

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Mon, 25 Jul 2022 06:52:00 -0500 en text/html https://www.technologynetworks.com/diagnostics/news/blood-test-rapidly-indicates-cellular-immunity-to-sars-cov-2-363989
Killexams : Genetic Testing Could Help Patients With Depression

A new VA study found that pharmacogenomic testing can help providers avoid prescribing antidepressant medications that may have undesirable outcomes. Pharmacogenomics is the study of how genes affect the body’s response to drugs.

The researchers also found that the patients who underwent genetic testing had more positive outcomes, compared with patients in usual care. Over 24 weeks of treatment, the group with genetic testing had in a drop in depression symptoms—with a peak effect at 12 weeks. Each patient in the study had major depressive disorder. Symptoms of that health condition include insomnia, loss of appetite, feelings of sadness and depression, and thoughts of dying by suicide.

The study results appeared in July 2022 in the Journal of the American Medical Association.

Dr. David Oslin, director of VA’s VISN 4 Mental Illness, Research, Education, and Clinical Center (MIRECC), led the study. He thinks the results will encourage providers to consider using pharmacogenomic testing, with patient consent, to help drive treatment decisions.

“From a VA policy perspective, I don’t think that we would say the study is robust enough that we recommend testing everybody,” says Oslin, who is also a psychiatrist at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia. “The results were not a slam dunk, and in fact, an important outcome of the study is that only about 15% to 20% of the patients had genes that would significantly interfere with the prescribed medication. But I think the results favoring a positive effect on treatment, although small, will encourage providers to test patients and get this genetic information. Future research should explore if there are subgroups of patients who would benefit more from testing.”

The focus on metabolizing the drug

In exact years, pharmacogenomic testing has received greater attention as a tool to personalize medication selection and is often used to treat patients with health conditions such as cancer and heart disease. Many in the medical community hope the testing can also be helpful in treating people with major depressive disorder. Research has been limited, however, on demonstrating improved clinical outcomes.

Currently, most of the pharmacogenomic testing focuses on a variant in the genes that encode hepatic CYP450 enzymes, a pathway that metabolizes drugs in the liver. Oslin and his team used a commercial battery of genes that focused on the CYP450 system. The battery tested eight genes, six of which test for variants in enzymes of the liver.

What do genes have to do with antidepressants?

“The genes we tested don’t actually relate to depression,” Oslin says. “They relate to how a person metabolizes the drugs once they’re in the body. Some of these genes will cause the medications to metabolize much faster than normal. Others will cause the drugs to metabolize much slower than normal, which means you’ll end up with a lot of medication in your body.”

The patients enrolled in the study were initiating or switching treatment with an antidepressant drug. The study included nearly 2,000 patients from 22 VA medical centers who were randomized evenly, with half receiving pharmacogenomic testing and the other half getting usual care. Oslin and his colleagues aimed to learn if genetic testing helped patients receive fewer medications with predicted drug-gene interactions and if that produced better outcomes.

A drug-gene interaction is an association between a medication and a genetic variant that may affect a patient's response to drug treatment. Having that information helps the provider select the appropriate dosage for a specific patient.

The ‘crux’ of the study

The patients in the control group received genetic testing, but their providers didn’t see the results. That meant those providers made medication choices for their patients that weren’t supported by pharmacogenomic tests.

“That was really the crux of the study,” Oslin says. “Does the pharmacogenetic test help you choose the medicine that you want to use with this particular patient?”

The study found a marked shift in prescribing away from medications with significant drug-gene interactions or moderate drug-gene interactions. Overall, 59% of the patients in the genetic testing group received a medication with no predicted drug-gene interaction, compared with 26% in the control group. The researchers defined that difference as “statistically significant and clinically meaningful.”

Oslin says he went into the study thinking the research team would not see such a dramatic effect in predicted drug-gene interactions. He was “somewhat surprised” by the result. “There was essentially a major shift in avoiding medicines that had a predicted drug-gene interaction,” he says.

To test their DNA, the patients used a cheek swab.

“Some companies do use a blood draw,” Oslin explained. “There’s no advantage or disadvantage to one versus the other. It really has to do with how the company processes the sample. Cheek swabs and blood samples are the most common sources of DNA. The trial is then used to look at several very specific genes that are known to relate to the metabolism of antidepressants and many other drugs. But in this study, we were interested only in antidepressants.”

The researchers interviewed the patients about their depression outcomes. All three outcomes—depression remission, depression response, and symptom improvement—favored the group that received the genetic tests. They were all statistically significant over the course of 24 weeks, with a peak effect at 12 weeks. Depression outcomes were not statistically different between the groups at 24 weeks.

“We were not powered to look specifically at 24 weeks,” Oslin explains. “That wasn’t part of our primary hypothesis. Our primary hypothesis was an overall effect. And we showed an overall effect in all three of the ways that we measured outcomes. So, it’s a glass half full, glass half empty kind of thing. Another way to think about the results is the group that had the pharmacogenetic test results had a faster response. That also was not something that we tested. But clearly if you look at 12 weeks in all three outcomes, the group that got the genetic test showed a better improvement in remission, response, and symptom improvement.

“It’s important to realize that the test is not telling you whether the patient is going to respond to the treatment or not,” he adds. “It’s telling you something about how the patient metabolizes the medication. So it’s not telling me that this is a good medicine for the patient. It’s telling me not to prescribe this medicine, or perhaps to adjust the dosing, because the patient doesn’t metabolize it well.”

PTSD affected treatment response

In supplemental material, the researchers noted that the presence of PTSD in patients had a profound negative impact on remission from depression. Basically, the patients with PTSD responded poorly to antidepressants. “We know from the literature that PTSD doesn’t respond well to antidepressants,” Oslin says. The main psychotherapies for patients with PTSD, he points out, are cognitive processing therapy and prolonged exposure—both widely used in VA.

“One of the special ways that we did this study is as a pragmatic study in frontline clinical practices,” Oslin says. “We used clinicians and their patients. The providers all had to say that the patients were being treated for depression. But they could have had comorbidities, and many of them had comorbid PTSD, which had a big influence on treatment outcomes in a negative way.”

For providers who would like to do pharmacogenomic testing in the future, the burden is low across the board, says Oslin. There’s no risk to patients in getting the test.

“The costs actually are very low because the results can be used over the patient’s lifetime,” Oslin says. “So you’re not talking about a test that has a shelf life of only five minutes. And there’s really no risk to getting the test. You’re just getting the cheek swab or a blood test. Cost is low, risk is low, and the population benefits are probably low. But overall, this test likely benefits some patients substantially.”

Reference: Oslin DW, Lynch KG, Shih MC, et al. Effect of pharmacogenomic testing for drug-gene interactions on medication selection and remission of symptoms in major depressive disorder: The PRIME Care Randomized Clinical Trial. JAMA. 2022;328(2):151-161. doi: 10.1001/jama.2022.9805


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Wed, 13 Jul 2022 05:11:00 -0500 en text/html https://www.technologynetworks.com/genomics/news/genetic-testing-could-help-patients-with-depression-363652
Killexams : New COVID-19 cases may be under reported due to home tests

Wed, 27 Jul 2022 12:03:00 -0500 en text/html https://www.rockymounttelegram.com/news/local/new-covid-19-cases-may-be-under-reported-due-to-home-tests/article_e81dbef5-6136-5795-b5b2-43075416be9d.html Killexams : What Travel Insurance Do You Need For Yacht Charters?

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A private yacht charter offers a personalized experience on the water. You can choose how and where you sail, as well as your menu, activities and guest list.

Most charter companies have top-notch experts who can lead you through the process of planning your sailing adventure to ensure you have a safe and enjoyable yacht experience.

If you are planning a yacht charter trip, travel insurance is important to consider. Comprehensive travel insurance plans combine several coverage types together to protect your trip investment, your health and your belongings.

What Travel Insurance Coverage Should You Buy for a Yacht Charter?

We’ve asked travel insurance experts about what coverage types you should buy so you can have smooth sailing on your next voyage at sea.

Trip cancellation insurance

Chartering a yacht is expensive, and you should protect your trip accordingly.

“Yacht charters typically require a significant up-front deposit, so individuals considering a yacht charter should consider trip cancellation insurance for the trip and travel medical insurance for all passengers on the trip,” says Don Van Scyoc, a spokesperson with GeoBlue travel insurance.

“In the current environment with changing travel restrictions and guidelines, a trip cancellation plan can be used to protect non-refundable deposits and other costs related to the charter,” Van Scyoc says.

Typical travel insurance policies list several reasons you can file a trip cancellation insurance claim to recoup prepaid and non-refundable trip expenses if you need to cancel your trip. Check your policy for the list.

Acceptable reasons for canceling vary by company but often include:

  • Illness or injury to you, a travel companion or an immediate family member
  • Death in the immediate family
  • Death of your travel companion
  • Your travel supplier is going out of business
  • Military orders
  • Severe weather
  • Sudden job loss
  • Civil unrest
  • Serious family emergency

So if a week before your sea adventure, you dislocate your knee and can’t travel, you can file a claim for reimbursement of the pre-paid, non-refundable trip costs you have lost.

“Cancel for any reason” coverage

Not all reasons to cancel will be covered by a standard travel insurance policy. For example, if you read online reviews about the charter company that the food offerings are unappetizing and the staterooms are dirty, these are not reasons covered by insurance for canceling your trip.

If you want a higher degree of flexibility to cancel, consider adding “cancel for any reason” coverage to your travel insurance plan. This upgrade will increase your policy cost by about 50% but will supply you the liberty to cancel your trip for any reason, including fear or a big fight with your partner.

To make a “cancel for any reason” insurance claim, you must cancel your trip at least 48 hours before your scheduled departure. Reimbursement varies by policy but is often 50% or 75% of your trip expenses.

Travel medical insurance

It’s especially important if you’re planning a yacht charter to check the travel medical insurance requirements for all the places you will visit.

“Some places like Aruba require each visitor to purchase local Covid health insurance for each trip, even if you’re there for one night,” says Van Scyoc at GeoBlue.

In this case, the Aruba Visitors Insurance is a Covid-only health plan that only provides benefits for medical expenses related to a positive Covid test. “Other medical expenses are not covered,” cautions Van Scyoc.

Even though there’s mandated insurance to visit a particular destination, Van Scyoc says each individual traveling on the charter should have travel medical insurance, so purchasing a robust travel insurance policy is vital.

“Travel medical plans typically have much higher medical limits,” he points out.

The most generous travel insurance plans provide $500,000 per person for emergency medical expenses. They can also provide $1 million for emergency medical evacuation.

Emergency medical evacuation

Having a good exit strategy is necessary for this pandemic environment, where it’s possible that some ports could be unexpectedly closed to private owners.

“The medical evacuation benefits are particularly important for travelers on a chartered yacht,” Van Scyoc points out.

To that end, he says that “travelers should read the fine print of any plans they are considering as some plans determine coverage based on the location of the yacht.”

Lisa Conway, the chief underwriting officer of Battleface, a travel insurance company, points out that yacht charters often spend significant time away from land. Yachts sail in open waters where fast access to medical facilities in the event of an emergency is not readily available. This makes emergency medical evacuation coverage especially important.

“Due to the nature of yacht vacations,” Conway says, “I recommend purchasing a medical evacuation benefit of at least $100,000, as well as coverages like trip cancellation, trip delay, and travel medical.”

Telehealth benefits

Van Scyoc says that an important travel insurance benefit to consider for those chartering a yacht is access to telemedicine consultations with physicians. Many travel insurance companies, including GeoBlue, offer mobile services for policyholders, including medical guidance and consultations for non-emergencies.

“If you’re on a boat, access to a physician may require hours or even days of travel,” Van Scyoc says. “With telemedicine, a covered individual may be able to access care without any interruption to their trip.”

Water activities and sports upgrade

Another consideration when buying travel insurance for yacht charters is adding an optional sporting and adventure upgrade for activities. This can cover activities like scuba diving, a popular activity for guests on a yacht charter.

World Nomads travel insurance plans cover about 200 adventure and extreme sports activities, but not all plans from other companies do.

Check the limits in your plan for hazardous or adventure activities. For example, Van Scyoc says that some insurance companies will only pay claims from a scuba incident if the insured person is certified by the Professional Association of Diving Instructors (PADI) or the National Association of Underwater Instructors (NAUI), or diving under the supervision of a certified instructor.

Other plans, he says, may include diving depth limits for their coverage. “As an example, some plans will only cover divers up to 10 meters,” Van Scyoc. Be sure to speak with your insurance company to make sure you are covered for activities you plan to enjoy on your yacht charter experience.

If not, see what sporting and adventure upgrades are available to purchase. AIG travel insurance, for example, offers an upgrade to its Travel Guard Deluxe plan that covers extreme activities that are excluded from its standard policy.

What Does Travel Insurance Not Cover?

Conway with Battleface notes that government regulation or prohibition is not covered by travel insurance. So if you are denied entry to a port based on current entry rules and restrictions, you are not eligible to file a travel insurance claim for reimbursement.

Also, if you are severely intoxicated and slip and suffer an injury due to your condition, you will not be covered. Most travel insurance policies have exclusions in the policy language that will not cover a traveler’s negligence due to excessive alcohol or illegal drug use.

Do Yacht Charter Companies Offer Travel Insurance?

You may be able to purchase travel insurance directly through your yacht charter company. Mitja Mirtič, CEO of Goolets, a private charter expert company in Slovenia, says such plans come in several variations and are very adaptable.

“Our portfolio includes international medical insurance plans, short and long term, which can cover citizens of any country when they travel out of their borders,” Mirtič says.

Travel insurance costs will depend on factors including:

  • Charter amount
  • Number of guests
  • Upgrades purchased to the policy

Goolets, for example, offers travel insurance plans from the International Medical Group (IMG). You can buy a standard Travel Lite plan, the Travel SE plan with additional benefits like coverage for missed connections, or the more extensive Travel LX plan, which offers the most coverage.

Travel LX also offers optional upgrades, like “cancel for any reason” coverage and “interruption for any reason” coverage.

According to Mirtič, the Travel LX plan for a nine-person yacht charter trip costing $35,000, with “cancel for any reason” coverage added, would cost you around 11% of your trip total.

Tue, 19 Jul 2022 19:00:00 -0500 Erica Lamberg en-US text/html https://www.forbes.com/advisor/travel-insurance/yacht-charters/
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