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Having a photo of your partner on your desk can help keep the spark alive, study finds

  • Keeping a photo of your partner on your desk may just do the trick
  • Researchers studied married people when looking at images of their spouse 
  • They found looking at photos boosted the amount of attachment they felt

For some it is a source of pride, for others unnecessary clutter.

But for those wanting to give their relationship a lift, keeping a photo of your partner on your desk may just do the trick.

Researchers who studied married people found that looking at images of their spouse boosted the amount of attachment – the ‘comforting feeling of emotional bonding’ – they felt towards them. 

For those wanting to give their relationship a lift, keeping a photo of your partner on your desk may just do the trick

The team, from the University of Missouri-St Louis in the US, showed married men and women 25 photos of their other half, as well as 25 ‘pleasant’ photos and 25 ‘neutral’ ones – to check if just looking at photos had any mood-boosting effect.

The study, in Journal of Psychophysiology, found the average attachment level was 90 per cent after viewing the spouse pictures, but 57 and 53 per cent respectively after the other photos.

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Killexams : Making news: Stifler's Mom had 200 'friends', Clive Palmer was not one </head> <body id="readabilityBody" readability="27.959183673469"> <h3>Newscorp Australia are trialling new security software on our mastheads. If you receive "Potential automated action detected!" please try these steps first:</h3> <ol type="1"> <li>Temporarily disable any AdBlockers / pop-up blockers / script blockers you have enabled</li> <li>Add this site in to the allowed list for any AdBlockers / pop-up blockers / script blockers you have enabled</li> <li>Ensure your browser supports JavaScript (this can be done via accessing <a href="https://www.whatismybrowser.com/detect/is-javascript-enabled" target="_blank">https://www.whatismybrowser.com/detect/is-javascript-enabled</a> in your browser)</li> <li>Ensure you are using the latest version of your web browser</li> </ol> <p>If you need to be unblocked please e-mail us at accessissues@news.com.au and provide the IP address and reference number shown here along with why you require access. News Corp Australia.</p><p>Your IP address is: 108.167.164.204 | Your reference number is: 0.2c64cd17.1659875368.17cb862f</p> </body> </description> <pubDate>Fri, 05 Aug 2022 05:43:00 -0500</pubDate> <dc:format>text/html</dc:format> <dc:identifier>https://www.theaustralian.com.au/the-oz/news/making-news-stiflers-mom-was-an-incredibly-fulfilling-role-for-jennifer-coolidge/news-story/63c775d98c972a0892fefa7c057ea77a</dc:identifier> </item> <item> <title>Killexams : Prudential Financial, Inc. (PRU) CEO Charlie Lowrey on Q2 2022 Results - Earnings Call Transcript

Prudential Financial, Inc. (NYSE:PRU) Q2 2022 Earnings Conference Call August 3, 2022 11:00 AM ET

Company Participants

Bob McLaughlin - Head, Investor Relations

Charlie Lowrey - Chairman &amp; Chief Executive Officer

Rob Falzon - Vice Chairman

Ken Tanji - Chief Financial Officer

Andy Sullivan - Head, US Businesses

Scott Sleyster - Head, International Businesses

Rob Axel - Controller &amp; Principal Accounting Officer

Conference Call Participants

Tom Gallagher - Evercore

Ryan Krueger - KBW

John Barnidge - Piper Sandler

Elyse Greenspan - Wells Fargo

Jimmy Bhullar - JPMorgan

Suneet Kamath - Jefferies

Alex Scott - Goldman Sachs

Tracy Benguigui - Barclays

Mike Ward - Citi

Operator

Ladies and gentlemen, thank you for standing by, and welcome to Prudential's Quarterly Earnings Conference Call. At this time, all participants have been placed in a listen-only mode. Later, we will conduct a question-and-answer session, instructions will be given at that time. [Operator Instructions] As a reminder, today's call is being recorded.

I will now turn the call over to Mr. Bob McLaughlin. Please go ahead, sir.

Bob McLaughlin

Good morning, and thank you for joining our call. Representing Prudential on today's call are Charlie Lowrey, Chairman and CEO; Rob Falzon, Vice Chairman; Andy Sullivan, Head of US Businesses; Scott Sleyster, Head of International Businesses; Ken Tanji, Chief Financial Officer; and Rob Axel, Controller and Principal Accounting Officer. We will start with prepared comments by Charlie, Rob, and Ken, and then we will take your questions.

Today's presentation may include forward-looking statements. It is possible that real results may differ materially from the predictions we make today. In addition, this presentation may include references to non-GAAP measures.

For a reconciliation of such measures to the comparable GAAP measures and the discussion of factors that could cause real results to differ materially from those in the forward-looking statements, please see the slide titled Forward-Looking Statements and Non-GAAP Measures in the appendix to today's presentation and the quarterly financial supplement, both of which can be found on our website at investor.prudential.com.

And now I'll turn it over to Charlie.

Charlie Lowrey

Thank you, Bob, and thanks to everyone for joining us today. Our second quarter financial results reflect the impact of macroeconomic environments, including the unusual confluence and magnitude of rising interest rates, widening credit spreads, and equity market declines. In addition, we strengthened our individual life reserves as part of our annual review of assumptions, which had a significant impact on our results. This was primarily driven by an increase in our guaranteed universal life reserves.

As a reminder, we discontinued single life guaranteed universal life sales in 2020 as part of our strategy to derisk our product mix and we continue to make strategic progress in transforming our businesses to be less market-sensitive and more nimble.

We also made additional investments to enhance our long-term sustainable growth. We did this in several ways. First, we significantly reduced our market sensitivity by completing our planned divestitures. Second, we invested in growth businesses and partnerships to address customer needs and expand access to our products and solutions. And third, we continue to advance our cost savings program and now expect to reach our $75 0 million target one year ahead of schedule.

We executed on these strategic initiatives with the support of our solid balance sheet. Our strong financial position provides us with the flexibility to navigate through the current macroeconomic conditions, while continuing to invest in the long-term growth of our businesses and return capital to shareholders. We're also confident that our higher rate environment will benefit our businesses over time despite the short-term impacts on our financial performance.

I'll now provide an update on the progress of our strategic initiatives. Turning to slide three. We plans to reposition the businesses by reducing market sensitivity and making investments to support long-term sustainable growth. We completed the sales of our full service business and a portion of our traditional variable annuities in April. Together, these divestitures resulted in a $1.5 billion pre-tax gain and further reduce the overall market sensitivity of our businesses by approximately 20%.

Moving to our growth investments. We are investing in programmatic acquisitions and partnerships that will help us grow in emerging markets and expand access to investing, insurance and retirement security around the world.

In Africa, we completed our acquisition of an initial minority stake in Alex Forbes, a leading provider of financial advice, retirement, investment and wealth management in South Africa. We are now in the process of increasing our stake in the company by up to an additional 18% through a tender offer.

In June, we established a partnership with Mercado Libre, the largest e-commerce platform in Latin America with approximately 200 million users. This will enable us to deliver life insurance and accident and health products, tailored to the platform's mass market customer base.

At the same time, we are investing in the growth of our products that meet the evolving needs of our customers. Our FlexGuard buffered annuity product recently surpassed $10 billion in sales since launching two years ago. We are also experiencing strong sales from our more recently launched FlexGuard Income offering.

Turning to our cost savings initiative on slide four. We now expect to achieve our full $750 million cost savings target in 2022, one year ahead of schedule. We recorded $175 million in cost savings during the second quarter for a total of $725 million of run rate savings to date since 2019. We've also implemented a process of continuous improvement to identify and execute on additional cost savings opportunities in the future.

Turning now to slide five. Our robust balance sheet is at the core of all our efforts to transform Prudential to be a leader in expanding access to investing insurance and retirement security around the world. This financial strength also provides the flexibility to balance investing in our businesses with delivering attractive returns to our shareholders.

Our robust financial position includes a high-quality, well-diversified investment portfolio, our capital position supports a AA financial strength rating and we had $7 billion in highly liquid assets at the end of the second quarter.

During the second quarter, we returned over $800 million to shareholders. And since the beginning of 2021, we have returned a total of $6 billion towards our objective of $11 billion by the end of 2023.

Finally, a comment on the environmental, social and governance front. In June, we published our third Annual Sustainability Report, which details the progress of our ESG initiatives, including information on our EEO-1 and pay equity disclosures, commitments to racial equity and achieving net-zero emissions. We believe in transparency and hold ourselves accountable to the commitments detailed in our report.

With that, I'll turn it over to Rob for an update on our business performance.

Rob Falzon

Thank you, Charlie. I'll provide an overview of our financial results and business performance for our PGIM, US and International Businesses. I'll begin on slide six with our financial results for the second quarter of 2022. Pre-tax adjusted operating income was $872 million or $1.74 per share on an after-tax basis and included a $1.4 billion increase in reserves from our annual assumption update and other refinements.

We strengthened our Individual Life reserves, primarily reflecting updates to policyholder behavior and revised mortality assumptions. These updates were based on several industry studies; emerging practices and our own experience, following our well-established annual assumption update process.

Current quarter results also included an $852 million gain from completing the sale of PALAC, a legacy block of Variable Annuities.

Our GAAP net loss was $1.4 billion lower than our after-tax adjusted operating income, primarily driven by the mark-to-market impact from higher interest rates on derivatives that are used for asset liability management, partially offset by a gain on the full -- on the sale of our full service business.

Turning to the operating results of our businesses, excluding the impacts of the annual assumption update and the gain on the sale of PALAC. PGIM, our global investment manager reported lower other related revenues driven by a decrease in seed and co-investment income and incentive fees, as well as lower asset management fees compared to the year ago quarter.

Results of our US businesses were lower than the year ago quarter, reflecting lower spread income due to less favorable variable investment income and lower fee income resulting from the decline in equity markets, partially offset by more favorable underwriting.

The decrease in earnings in our International Businesses primarily reflected lower earnings from joint venture investments, lower net investment results driven by less favorable variable investment income and less favorable underwriting results, partially offset by business growth.

Turning to Slide 7. PGIM, our global active investment manager, has diversified capabilities in both public and private asset classes across fixed income, alternatives, real estate and equities. PGIM's long-term investment performance remains attractive with 75% to 85% of assets under management outperforming their benchmarks over the last three, five and ten-year periods.

PGIM benefited from its diversified business mix, as strong institutional net inflows of $8.1 billion, primarily driven by fixed income, offset retail outflows as investors repositioned their portfolios in a rising rate environment. As the investment engine of Prudential, the success and growth of PGIM and of our US and international insurance and retirement businesses are mutually enhancing.

PGIM's asset origination capabilities, investment management expertise and access to institutional and other sources of private capital are our competitive advantage, helping our businesses bring enhanced solutions, innovation and create more value for our customers. Our insurance and retirement businesses in turn, provide a source of growth for PGIM through affiliated flows and unique access to insurance liabilities that complement its successful third-party track record of growth.

PGIM's average fee rate increased due to the successful execution of our strategy, including the continued mix shift toward higher fee strategies in our alternatives and private credit business. As a result, asset management fees decreased by only 6% despite assets under management declining by 11% due to rising rates, widening spreads and equity market depreciation.

We continue to grow our alternatives in private credit business, which has assets under management of approximately $230 billion across private credit, real estate equity and debt and private equity secondaries and benefits from our global scale and market-leading positions.

Notably, across PGIM's private platform, we deployed nearly $15 billion of capital, up nearly 40% from the year ago quarter, reflecting the continued strong environment for private credit. PGIM also raised nearly $3 billion in new private capital commitments across real estate and private credit.

Turning to Slide 8. Our US businesses produced diversified earnings from fees, net investment spread and underwriting income and benefit from our complementary mix of longevity and mortality businesses. We continue to shift our business mix towards higher growth and less market-sensitive products and businesses to transform our capabilities and cost structure and to further expand our addressable markets.

Retirement Strategies achieved solid sales in the second quarter across its institutional and individual lines of business. Institutional stable value sales were $1.6 billion. International reinsurance closed $1.4 billion of longevity reinsurance transactions during the quarter, and US pension risk transfer closed several transactions totaling more than $725 million.

Our product pivots in individual retirement have resulted in strong sales of more simplified solutions with nearly $1.5 billion of FlexGuard and FlexGuard Income sales in the second quarter. Our strong FlexGuard sales benefited from implementing a fully digital and automated new business experience. This tech-forward approach helps to maintain our record pace of sales.

Our Individual Life sales also reflect our earlier product pivot strategy, with variable life products representing approximately 71% of sales for the quarter. The improved group insurance benefits ratio for the quarter reflects the transition from a pandemic to an endemic phase of COVID, as well as favorable experience in both group life and disability.

In addition, we're focused on creating the next generation of financial solutions to serve the diverse needs of a broader range of customers and clients. This quarter, we launched the Prudential simplified issue final expense product on the Assurance platform.

Turning to slide nine. Our International Businesses include our Japanese life insurance companies, where we have a differentiated multi-channel distribution model, as well as other businesses aimed at expanding our presence in high-growth emerging markets.

In Japan, we are focused on providing high-quality service and expanding our geographic coverage and product offerings. Our needs-based approach and mortality protection focus continue to provide important value to our customers, as we expand our product offerings to meet their evolving needs.

And we continue to enhance customer experience and agent support, including through digital tools. For example, this quarter, Gibraltar launched an exclusive website dedicated to teachers to help serve this market.

In emerging markets, we are focused on creating a carefully selected portfolio of businesses in regions where customer needs are growing, where there are compelling opportunities to build market-leading businesses and where the Prudential enterprise can add value.

In the second quarter, we continued to focus on expanding product and business capabilities in emerging markets to meet the evolving needs of customers. In Brazil, we achieved record sales, driven by the expansion of our third-party distribution channel, where sales increased 120% compared to the year ago quarter, as well as by the continued strength of the Life Planner channel.

We established a partnership with Mercado Libre in Latin America to expand access to customers in the region. In the first two weeks following the launch in June, we have sold Life and A&amp;H policies in every state in Brazil. This was accomplished through a fully digital sales, customer service and claims experience.

We also continue to expand our wellness platform across Latin America by establishing a partnership with Medifé, a health service provider to 300,000 customers in Argentina. In addition, we are expanding our presence in Africa through an investment in South African-based Alex Forbes, as Charlie discussed earlier.

As we look ahead, we're well positioned across our businesses to be a global leader in expanding access to investing, insurance and retirement security. We continue to invest in growth businesses and markets, deliver industry-leading customer experiences and create the next generation of financial solutions to better serve the diverse needs of a broad range of customers.

And with that, I'll hand it over to Ken.

Ken Tanji

Thanks, Rob. I'll begin on slide 10, which provides insight into earnings for the third quarter of 2022 relative to our second quarter results. As noted, pre-tax adjusted operating income in the second quarter was $872 million and resulted in earnings per share of $1.74 on an after-tax basis.

To get a sense for how our third quarter results might develop, we suggest adjustments for the following items. First is an adjustment for two one-time items that net to a charge of $571 million in the second quarter. Our annual assumption update and other refinements resulted in a net charge of $1.4 billion, primarily driven by our Individual Life business, as Rob previously described. This was partially offset by a $852 million gain from the sale of a block of legacy variable annuities.

Next, variable investment income outperformed expectations in the second quarter by $80 million. Third, we adjust underwriting experience by a net $25 million. This adjustment includes a placeholder for COVID-19 claims experience in the third quarter of $5 0 million for our International Businesses, primarily due to hospitalization benefits for policyholders recovering from COVID-19 at home in accordance with the special regulatory provision in Japan that is currently in effect.

We have also updated our mortality assumptions for the US Businesses to include continued COVID-19 mortality with an expected gradual transition to an endemic phase over time. While we have attempted to reflect COVID-19-related claims experience, the real impact will depend on a variety of factors such as infection and fatality rates, geographic and demographic mix, and the effectiveness of vaccines.

And last, we expect other items to be $30 million lower in the third quarter, primarily due to lower than typical expenses in the second quarter that were partially offset by lower other related revenues in PGIM and lower joint venture earnings. These items combined get us to a baseline of $2.63 per share for the third quarter.

I'll note that if you exclude items specific to the third quarter, earnings per share would be $2.75, a modest decline primarily due to lower fee income as a result of market depreciation, lower underwriting income due to the updated actuarial assumptions, and continued COVID-19 mortality that is now reflected in our US Businesses expected results. While we have provided these items to consider, please note there may be other factors that affect earnings per share in the third quarter.

Turning to slide 11. I will now comment on the upcoming adoption of the new accounting standard for long-duration insurance contracts, also known as LDTI, which goes into effect on January 1st, 2023. The new accounting standard applies to our GAAP financial statements and will have no direct effect on our statutory financial statements, cash flows or dividend capacity.

We estimate that adjusted book value, which excludes accumulated other comprehensive income, or AOCI, will be reduced by $1 billion to $2 billion as of December 31st, 2021. This reflects the reclassification of non-performance risk gains from retained earnings to AOCI and other changes in reserves.

We believe adjusted book value, which excludes AOCI, remains a relevant measure as AOCI and GAAP equity will continue to lack symmetry in the valuation of invested assets and insurance liabilities.

We estimate that AOCI will be reduced by approximately $28 billion to $33 billion as of December 31st, 2021, primarily due to the remeasurement of long-duration liabilities with a lower discount rates, primarily in our Japan business.

Also of note, GAAP equity and adjusted book value will continue to exclude certain unrealized insurance margins from products subject to LDTI. As of December 31st, 2021, the estimated after-tax unrealized insurance margins related to those products are expected to be $60 billion to $65 billion, primarily in our Japan business. These margins represent an important factor in determining financial strength.

Turning to Slide 12. We continue to maintain a robust capital position and adequate sources of funding. Our capital position continues to support a AA financial strength rating and we have substantial sources of funding. Our cash and liquid assets were $7 billion and above our $3 billion to $5 billion liquidity target range, due to the receipt of proceeds from the sales of our full service retirement business and a block of legacy Variable Annuities and other sources of funds include free cash flow from our businesses as well as contingent capital facilities.

Turning to Slide 13 and in summary, we are executing on our plans to reposition our businesses. We are expecting to reach our targeted cost savings one year ahead of plan and our rock-solid balance sheet provides financial flexibility to execute on our transformation and thoughtfully deploy capital.

Now I'll turn it to your operator for questions.

Question-and-Answer Session

Operator

Thank you. [Operator Instructions] Our first question today is coming from Tom Gallagher from Evercore. Your line is now live.

Tom Gallagher

Good morning. I'd like to start on the mortality assumption review, the charge. Can you talk a little bit about what drove it? Was it more the mortality side? Was it more the lapse side? Was it mainly mortality assumptions pre-pandemic? Was there a meaningful adjustment from the experience that you've seen through the pandemic? A little bit of color there would be helpful? Thanks.

Ken Tanji

Yes. Hey Tom, it's Ken. Let me give you a little bit of background on the assumption update. As I think most people know, each year in the second quarter, we examined our updated experience that's available from our own business, but we also look at information that's available from industry studies and other surveys.

And again, this year, we followed our process that's quite comprehensive and well established. We did make updates to our individual life insurance actuarial assumptions, primarily for policyholder persistency and mortality. Let me start with the policy persistency changes, that was mainly with our guaranteed Universal Life products, where we lowered our lapse and surrender assumptions and that revision reflected information, we gained from recently released studies and surveys, as well as our recent emerging experience.

And so, we essentially refined into a more dynamic lapse assumptions for that portion of the business. In terms of mortality, we also included the impact of COVID-19 claims with the expectation of shifting from endemic to -- or from a pandemic to endemic phase. And we also lowered future mortality improvement, as well given recent trends. Now the majority of the reserve strengthening was the result of the policyholder persistency assumption. The mortality updates were more modest and across all of our businesses.

Tom Gallagher

That's really helpful, Ken. Appreciate that color. My follow-up is just, will the -- will this also result in a statutory impact in addition to the GAAP impact? And if so, can you help quantify that and talk about how that could impact capital management, if at all?

Ken Tanji

Yes. The updated assumptions are applied to our statutory reserves as well. It will have a comparable magnitude of impact but we're well positioned to maintain strong regulatory capital ratios. We have a strong capital position overall, and we continue to have diverse sources of free cash flow going forward as well.

Operator

Your next question is coming from Ryan Krueger from KBW. Your line is now live.

Ryan Krueger

Hi, thanks. Good morning. Would you expect much of an impact from updated Q2 factors for longevity risk, which I don't think was in the RBC ratio previously and an updated mortality risk factor when that is implemented, I believe, which may be at year-end?

Ken Tanji

Yes. Ryan, it's Ken again. I'll take those. No, we don't expect a significant overall impact for either of those. The longevity factors were incorporated, I believe, last year and including some correlation benefits between longevity and mortality and given the updated -- the updates to mortality that have been proposed, those will be manageable and again, reflective of the good combination of business that we have that is both longevity-based and mortality-based.

Ryan Krueger

Got it. Thanks. And then I had a question on the Bermuda subsidiary that you had established earlier this year and contributed capital to last year -- or last quarter. Can you give any more color on kind of what your longer-term plans are for that? And what -- to what extent you may be able to start shifting US Business into Bermuda to get an offsetting benefit from the capital you had contributed last quarter. Thanks.

Ken Tanji

Okay. Yes, Ryan, yes. The -- we did launch a new company last quarter. It's a new reinsurance company that's based in Bermuda, which we call LOTUS Re. We think it's a really good capability to have. We've reinsured a block of variable life policies to that company. We're obviously following the BMA standards. The business is well reserved and capitalized, including the capital that we put in, in it last quarter. But it's also very well aligned with the economics of that business. So going forward, we do believe this will be a more efficient capital framework for our Variable Life business that's well aligned with the economics of that business as well.

Operator

Thank you. Our next question is coming from John Barnidge from Piper Sandler. Your line is now live.

John Barnidge

Thank you very much. Can you maybe talk about persistency trends in group life and visibility? There's been increased lapse activity seen by other market participants, given kind of the movements in the war on talent among employees. It looks like persistency did go down in 2Q for disability, but not life. Thank you.

Andy Sullivan

Hey, John, good morning, it's Andy. Ill take your question. Maybe I'll bring it up a level and say that the general effect that we saw during the pandemic was companies really pulled back on switching their benefit plans.

As we've come through the pandemic and as hopefully we're coming out the other side, and it's becoming more endemic, we've seen, basically, in the marketplace, a normal level of RFP activity. So things have gotten sort of back to normal.

When we talk about our persistency, we're very pleased with our persistency results. And as you would imagine, we track very closely the profitability of the business that we retain versus the profitability of the business that we lose.

And part of the secret sauce of managing group insurance businesses is, sometimes addition by subtraction. If we can't get the rates that we want to get to move a case to profitability, we -- our plan and our intention and our follow-through is always to let it go. But we're quite pleased at the persistency levels in the business.

John Barnidge

Great. Thank you very much. And then, my follow-up question, if I may. That unrealized insurance margin in Japan, is that a gain that can be harvested through a risk transfer, or how should we be thinking about Pru realizing those?

Ken Tanji

Yes. Hey, John, it's Ken. Let me just -- the unrealized insurance margin is -- that we're referencing here and quantified is under the GAAP constructs. And you can think of it as basically the present value of future premiums less the amounts of the premiums needed to provide claims -- to provide for claims. So it's margin above and beyond what's needed to support the expected claims.

It is indicative of the profitability of the business, and the majority is from our Japan business, and it's reflective of what we think is the strong profitability of our Japan business. It's -- there is good embedded profits there and value, and it is a potential source of free cash flow over time. And if we choose to reinsure a block of it as well, we could release capital that way.

Operator

Thank you. Our next question is coming from Elyse Greenspan from Wells Fargo. Your line is now live.

Elyse Greenspan

Hi. Thanks. My first question, going back to Individual Life. When we normalize for the assumption review, VII and underwriting, it looks like the underlying earnings power of that segment is in the range of $100 million. And I think in the slides, you guys put the Q3 baseline at $96 million. So can you talk about if there are any ongoing earnings impact from the assumption review? And is roughly $100 million pre-tax a good quarterly level run rate earnings for that segment?

Andy Sullivan

Yes, Elyse, this is Andy. I'll take your question. The assumption update does have an ongoing impact on our Individual Life business. It reduces our core earnings capability in the neighborhood of $30 million per quarter. So our core run rate was about $105 million before, so it brings it down to $75 million.

What you're seeing in our walk on the slide, remember that we expect to have $20 million of higher underwriting gains seasonally in third quarter of 2022. So if you make that adjustment, that gets you to that 96 baseline.

Elyse Greenspan

Okay. Thank you. And then my second question is on Assurance IQ, if you guys can just give us some color on the upcoming enrollment season. And then revenues declined there roughly 30% in the second quarter. Were revenues, for some reason, impacted by the assumption review, or should we just think about that $78 million perhaps indicating a lower baseline for that segment?

Andy Sullivan

Yes, Elyse, it's Andy. I'll take the question. Let me start by reiterating that we're still very focused on scaling up revenue in each of the distinct product lines in the Assurance IQ platform, as that really is what's required to get the business to achieve profitability.

With that said and you sort of pointed to this, there are a number of things that are important to discuss this quarter as we've made really good progress in Medicare Advantage that was somewhat masked. First, we did have a $17 million negative LTV adjustment, that is a direct impact on revenue, that was an adjustment -- assumption adjustment based on our persistency.

Second, we saw an impact on the under 65 healthcare business versus the year ago quarter as the Biden administration did not open up a special enrollment period like they did last year. Those two factors really masked a 64% improvement in Medicare Advantage enrollments and a resulting 35% increase in Medicare Advantage Commission revenue versus a year ago quarter.

So, we are pleased with the continued underlying fundamental strengthening in the Medicare Advantage product line. The first part of your question is, how we're feeling about our preparation. We're making very good progress in becoming ready for the fourth quarter open enrollment season from an agent preparedness perspective specifically. We've now -- we'll be entering our third year, so we have the benefit of two full cycles underneath us. And candidly, we're seeing great success in hiring agents, partly due to the difficult time that some of the smaller players in the space are having.

Operator

Thank you. [Operator Instructions] Our next question is coming from Jimmy Bhullar from JPMorgan. Your line is now live.

Jimmy Bhullar

Hi, good morning. I just had a question first on the actuarial review and its impact on future income. I think you mentioned $120 million on GAAP. Should we assume a commensurate impact on stat income going forward as well?

Ken Tanji

It would have a similar impact on GAAP earnings. I'm not -- we'll have to get back to on the quantum of that, but there would be a future impact to strengthening going forward.

Q – Jimmy Bhullar

Okay. And then can you talk about your – the decline in the Life Planner Count and Gibraltar Life Consultants and whether it's sort of -- and what your expectations are for growth in both of those agency channels? Is the decline being caused more by sort of COVID-related factors right now or should we assume modest growth going forward in both of those?

Scott Sleyster

Hi Jimmy, this is Scott. The LP count has been essentially flat with new recruits roughly offsetting LP resignations and our LC count has actually been slightly negative. As you might expect, it's been more challenging to recruit in a pandemic environment. It's actually a little bit harder to mentor new hires in this kind of environment. We expect this situation to remain challenging until the pandemic eases. But we would then expect to see improvement in kind of a return to normal beyond the pandemic. I think it's also worth noting that we continue to focus a great deal of energy on expanding our third-party distribution channels across all of our markets.

Operator

Thanks. The next question is coming from Suneet Kamath from Jefferies. Your line is now live.

Suneet Kamath

Thanks. Just wanted to come back to the assumption review and the impact on statutory. Just given the size of the charge, does this suggest that you're going to need to infuse capital into PICA or is there enough excess RBC in there to sort of absorb the similar charge that you took on a GAAP basis?

Ken Tanji

Yeah, overall this will be very manageable, as I mentioned, where we think we're well positioned to maintain strong RBC statutory ratios. And right now, we're not expecting to have to infuse additional capital as a result.

Suneet Kamath

Okay. Got it. And then I guess for, Charlie, I'll ask the same question I always ask on the strategy. And this idea of improving the earnings contribution from growth businesses to over 30%, it still seems like you'll need pretty sizable inorganic M&amp;A to get there.

So just curious, what you're seeing out there in the landscape? Are you seeing opportunities to put some of the $7 billion of liquid assets at the holding company to work? I mean, just thinking about inorganic growth, what are you seeing out there? Thanks.

Charlie Lowrey

Yea, sure. We’re seeing a number of different opportunities at this point in the cycle. You're beginning to see other things or some things free up that wouldn't have been there before and at reduced multiple. So it's a good time to have flexibility in order to be able to think about that kind of acquisition.

What I would say is, I'll make a couple of observations. The first is our strong balance sheet provides us with the flexibility to manage through whatever macroeconomic conditions we may face as we look forward. And that's going to be an important consideration for us as we go forward.

But second, to your point, having a strong balance sheet in a dislocated market means that we can take advantage of opportunities that present themselves. So we're going to be -- we do have a strong balance sheet. We're going to remain flexible with that balance sheet, and we're going to look for opportunities that may present themselves in the current economic environment.

Operator

Thank you. Your next question is coming from Alex Scott from Goldman Sachs. Your line is now live.

Alex Scott

Hi. First question I had was on the Annuities business. Now that the transaction is closed, I was just wondering if you could help us think through earnings power there and just given a lot of moving parts to the transaction, equity markets. And then I think, maybe, the runoff of the block, how should we think of that over the next several quarters?

Andy Sullivan

So, Alex --

Ken Tanji

Go ahead, Andy. All right. I was talking about that. Maybe I'll just comment. The -- we did close the PALAC transaction. And it was -- it came in as we were expecting and would reduce our earnings by about $75 million a quarter, and that is very consistent with what we had announced at the time of the transaction.

Andy Sullivan

Yes, Ken, maybe I'll just jump in and add. I just may bring it up a level back to our intentional strategy to reduce our exposure to traditional variable annuities with guaranteed living benefits to be less than 10% of our enterprise earnings. And so that reduction is very intentional, and it was the two-step process of pivoting and runoff that remains on track.

We saw $2.9 billion in runoff this quarter. And then, obviously, the derisking transaction. But the other major part of that was pivot to our FlexGuard chassis, a more simpler design, less volatile design. And we're certainly pleased with the continued strength of those sales.

Alex Scott

Got it. And the second one I had for you was on the LDTI. You gave some good disclosure on the book value impact. And I know you mentioned that there's a lot of margin that's sort of left in the reserve, because of the pivot sort of approach to LDTI. What does that mean to the earnings power? Can you help us think through that, particularly in Japan, where it's a lot of 60, I assume that a lot of that margin probably has to do with that business. Will this materially change the earnings power?

Ken Tanji

Yes. Overall -- and we'll be providing more disclosure around the whole transition to the new accounting standard as we -- around the time that it is implemented. But let me provide some overall thoughts on earnings. First, overall, we don't expect a significant impact on the level of core operating earnings. Certain businesses have little or no impact like PGIM and group insurance. And from our insurance and retirement businesses in the US and internationally, some will be a bit higher, some will be a bit lower. But overall, that's generally offsetting. So again, overall, we don't expect a significant change in the level of our core operating earnings.

Operator

Thanks. Our next question today is from Tracy Benguigui from Barclays. Your line is now live.

Tracy Benguigui

Good morning. I have another question on the assumption of that you mentioned industry study. We're in the cheap speed tier. Is that something that is widely available or if you could provide context regarding who participated in that study and who conducted the study, that would be very helpful.

Ken Tanji

Yes. Tracy, that was done by a private party, and it did involve a number of people in the industry. We're not at liberty to disclose who was in there. That's proprietary information of the study. So that's about what I can tell you.

Tracy Benguigui

Okay. Got it. Also noticed that your corporate expenses were low in the quarter compared to the baseline you provided last year. And I'm just wondering how you're thinking about the full year of $1.65 billion guidance.

Ken Tanji

Yes. During the quarter, we did have some favorable items. We did have an FX gain that was helpful this quarter. We did have some other lower expenses and then there is some timing. And we do expect to have seasonally higher expenses in the second half of the year. But given where we are in the first half, we would expect to be modestly below the 1.650 billion guidance that we originally gave.

Operator

Thanks. Our next question is coming from Jack Maton [ph] from Wolfe Research. Your line is now live.

Unidentified Analyst

Hi, good morning. I wanted to ask on the investment portfolio. Are there any metrics you can provide regarding new money rates relative to current portfolio yields? And then what percentage of the portfolio turns over on average in a given year?

Rob Axel

Jack, it's Rob. I can provide that for you. In the -- if you compare the new money rates to our portfolio yields, they're up about 20 basis points in the US and 50 basis points in terms of a positive spread in Japan. So the rise in rates means we're no longer having a drag on our earnings when we measure our new money rates against that portfolio yield. In terms of rollover, it's somewhere between 5% and 10% on an annual basis.

Unidentified Analyst

Got it. Thank you. And then just a question on the drivers and the outlook for net flows in the PGIM business. And clearly, this quarter, there was a strong recovery in institutional flows, but some pressure on retail flows. I guess could you just talk about what's driving some of the divergence across those customer types and maybe your outlook moving forward?

Andy Sullivan

Yes, Jack, it's Andy. I'll take your question on flows. As we've talked about in the past, flows at PGIM will vary quarter-to-quarter. So we stay very focused on the long-term track record.

In Q2, third-party net flows were roughly flat as very strong institutional inflows of $8.1 billion were offset by the retail outflows of $8.3 billion. Let me give you some color on that. So the $8.1 billion of institutional inflows represented our best quarter since 2018, and those flows were positive across every geography that we operate in.

The real drivers where we continue to see clients, their algorithms, institutional clients algorithm shifting into fixed income as the rates rise, and we also see those clients continuing to seek yield in our private and alternative strategies.

On the retail side, I would say the story is we were impacted like the rest of the industry by headwinds in the active fixed income and growth equity space. The industry experienced $305 billion in outflows across active US mutual funds as individual investors continue to reposition.

Every top 10 fixed income manager and nine of the top 10 active growth equity managers posted negative flows. So, -- but despite that environment, our PGIM investments moved up to the number 16 US mutual fund family in the quarter by assets under management.

I'll end the way I typically do, which is we're confident that we're going to be a net flow winner over time. As we look at our business, we have a broad and diversified product portfolio. We continue to put up very strong long-term investment performance, and we have great distribution. So, we'll continue to build on our track record of 18 of the last 19 years of positive flows, and we're quite proud of that.

Operator

Thank you. Next question is coming from Mike Ward from Citi. Your line is now live.

Mike Ward

Thanks guys. Just wanted to follow up on Suneet's question about the transformation. And I think you touched on your strategy in terms of acquisitions. But to his point, it seems like that would require a very decent chunk of inorganic growth.

So, I guess just wondering, should we assume from here that the strategy is primarily around organic growth acquisitions or opportunistic buys, or do you still look at material kind of divestments or reinsurance from your existing business mix?

Charlie Lowrey

Yes. This is Charlie. Let me take that one. It's going to be a combination of both, right? Because in the -- as we've done in the past, we're going to continue to be thoughtful about the deployment of proceeds, especially in light of the macroeconomic conditions, and we've always said we're going to be good stewards of capital.

But we're going to -- what we're going to do is to continue to demonstrate a discipline, a consistent and a balanced approach to the redeployment of capital within our businesses for acquisitions and to our shareholders, while fulfilling a commitment to our financial strength by maintaining a strong balance sheet.

So, we're going to look at a combination of, again, investment in our businesses, acquisitions, returns to shareholders, but also divestitures if they make sense. And we've always said we'll look at additional divestitures of blocks of business, but only if they make sense. And that's what we're going to do as we go forward. So, it will be -- we'll get to our goals through both addition and potentially subtraction, but it has to make sense on both sides for shareholders.

Mike Ward

Okay. Thanks very much. And so I guess, kind of relatedly, it sounds like a pretty comprehensive review in the Life business, just thinking about some of the difficulties that segment has faced over the last few years. I guess, does this have any impact on your strategic view of the Life business? It almost seems like at this point, even if you were to sell it or offload it at a loss, it might be beneficial, or is the diversification benefit, mortality longevity offset? Is that important to the extent that you're going to hang on to Life? Thanks.

Charlie Lowrey

Yes. Let me start, and then Andy, you may want to add some commentary on it. But for the Life business, we still think there's a significant potential for growth in the industry. You have a $12 trillion insurance -- life insurance gap. You have increasing sales as shown by last year's industry, with sales being the best they have been in about two decades.

And from an enterprise perspective, the Life business continues to be a really helpful component in balancing our longevity with our mortality. So there's a lot of interconnection with the other businesses along with PGIM, and it's a business that we would like to remain in, but we'll do so very, very carefully as we go forward. Andy?

Andy Sullivan

Yes, Charlie, I would just add that we've had a very explicit strategy that we remain committed to, and the path forward is clear. We recognize the disappointing and volatile aspects of GUL. But remember that our strategy has been about pivoting and derisking the business.

We see selling GUL -- single life GUL in third quarter of 2020 and we began to rotate the product portfolio towards simpler designs, inclusive of variable universal life final expense and simply term. We also have been very much leaned into reducing expenses to make the business more efficient.

So as we're doing that, we're seeing the new business sales, where we have a lot of pricing power and we like the positive returns of that block of business that we're putting on, and we're filling that gap that Charlie talked about.

Operator

Thank you. We've reached the end of our question-and-answer session. I'd like to turn the floor back over to Mr. Lowrey for any further closing comments.

Charlie Lowrey

Okay. Thank you very much, and thank you for joining us today. We've made significant progress reducing our market sensitivity, while investing in sustainable long-term growth, advancing our cost savings program and returning capital to shareholders.

Looking ahead, we are confident that our strategy, along with our solid financial position will help us deliver an even more meaningful difference in the lives of our customers and delivering value to all our stakeholders, including providing attractive returns to our shareholders, while enabling us to fulfill our vision to become a global leader in expanding access to investing insurance and retirement security. Thank you again for joining us and for your time today.

Operator

Thank you. That does conclude today's teleconference and webcast. You may disconnect your line at this time, and have a wonderful day. We thank you for your participation today.

Wed, 03 Aug 2022 04:45:00 -0500 en text/html https://seekingalpha.com/article/4529185-prudential-financial-inc-pru-ceo-charlie-lowrey-on-q2-2022-results-earnings-call-transcript
Killexams : Rainwater everywhere on Earth contains unsafe levels of 'forever chemicals' linked to cancer and other illnesses, study finds

Rainwater everywhere on Earth contains unsafe levels of 'forever chemicals' linked to cancer and other illnesses, study finds

  • Unsafe levels of man-made PFAS have been found in rain across the world
  • Maximum concentrations of the chemicals have been decreasing for decades
  • This is because knowledge of their dangers to human health has increased
  • However their environmental levels have not changed, according to researchers 

Rainwater everywhere on Earth has been found to contain dangerous levels of man-made 'forever chemicals' linked to cancer and other illnesses, a study has found.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have many uses, including in firefighting foams, the non-stick coatings on frying pans, and textiles.

They are thought to get into the environment through industrial emissions, transfer from packaging, wastewater and evaporation from the foams.

Researchers from Stockholm University and ETH Zurich have conducted laboratory and field work on the presence and transport of PFAS for the past decade.

They claim they can be found in rainwater and snow in even the most remote locations on Earth, like Antarctica and Tibet.

The fluorinated chemicals have been linked to a wide range of human health concerns, including cancer, immune system disorders, obesity and fertility issues.

 The researchers detected PFAS in the rainwater and snow in even the most remote locations on Earth, like Antarctica and Tibet (pictured)

Levels of (A) PFOA, (B) PFOS, and (C) PFAAs (PFOA + PFNA + PFHxS + PFOS) in wet depositions collected at various global locations from 2010 to the present

WHAT ARE PFAS? 

PFAS are manmade chemicals used as oil and water repellents and coatings for common products including cookware, carpets, and textiles.

These endocrine-disrupting chemicals do not break down when they are released into the environment, and they continue to accumulate over time.

PFAS chemicals can contaminate drinking water supplies near facilities where the chemicals are used.

PFAS contamination has been detected in water near manufacturing facilities as well as military bases and firefighting training facilities where foam containing PFAS is used.

They also enter the food supply through food packaging materials and contaminated soil.

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PFAS are known as 'forever chemicals' because of their extreme persistence in the environment - some take over a thousand years to degrade. 

Major chemical company 3M first started manufacturing the two most notorious members of the PFAS family, PFOS and PFOA, in the 1950s.

Many scientific tests over the decades proved that the chemicals caused multiple health problems and, by 2002, 3M had largely phased them out.

Over the past 20 years, knowledge of the toxicity of PFAS has continued to increase, and thus guideline values of PFAS in drinking water, surface waters and soils have decreased.

The US environmental protection agency (EPA) now advises a safe PFOA concentration of 0.004 nanograms per litre (ng/L); the EU Environmental Quality Standards says PFOS should be 0.65 ng/L, while the US EPA suggests 0.020 ng/L for PFOS; and the Danish drinking water guideline for four PFAAs (PFOA + PFNA + PFHxS + PFOS) is 2 ng/L.

Despite this, the researchers have found that levels of some harmful PFAS in the atmosphere are not declining notably. 

This is due to their degradation time, as well as the natural processes that continually cycle them back to the atmosphere from the surface environment.

One of the most significant natural cycling process for PFAS is the transport from seawater to marine air by sea spray.

Professor Ian Cousins, the lead author of the study, said; 'The drinking water guideline value for one well-known substance in the PFAS class, namely the cancer-causing perfluorooctanoic acid (PFOA), has declined by 37.5 million times in the U.S.

'Based on the latest US guidelines for PFOA in drinking water, rainwater everywhere would be judged unsafe to drink. 

'Although in the industrial world we don't often drink rainwater, many people around the world expect it to be safe to drink and it supplies many of our drinking water sources.'

Major chemical company 3M first started manufacturing the two most notorious members of the PFAS family, PFOS and PFOA, in the 1950s. Many scientific tests over the decades proved that the chemicals caused multiple health problems and, by 2002, it had largely phased them out. Over the past 20 years, knowledge of the toxicity of PFAS has continued to increase, and thus guideline values of PFAS in drinking water, surface waters and soils have decreased

Pollution from four different PFAS were found to exceed advisory levels in Europe and the US.

These findings, published in Environmental Science &amp; Technology, led the authors to conclude that a 'planetary boundary' has been crossed - there is no place on Earth where one is able to avoid the substances. 

The researchers therefore suggest that PFAS usage and emissions are 'rapidly reduced', as the chemicals have poor reversibility.

Study co-author Professor Martin Scheringer said: 'The extreme persistence and continual global cycling of certain PFAS will lead to the continued exceedance of the above-mentioned guidelines.

'So now, due to the global spread of PFAS, environmental media everywhere will exceed environmental quality guidelines designed to protect human health and we can do very little to reduce the PFAS contamination. 

'In other words, it makes sense to define a planetary boundary specifically for PFAS and, as we conclude in the paper, this boundary has now been exceeded.'

Women exposed to PFAS used in takeaway containers and non-stick pans 'may go through menopause two years earlier' 

Exposure to a type of man-made chemicals may cause menopause to occur two years earlier in women, a new study warns.

Researchers from the University of Michigan found that high levels of PFAS in blood samples contributed to an earlier menopause in women.

PFAS, which are used as oil and water repellents and coatings for consumer products, can enter water sources and disrupt ovarian function, they say.

The chemicals, which are widely used in food packaging, cookware and industrial foams, disrupt the endocrine system – the hormone-producing collection of glands that regulate sexual function.

Previous studies have also linked them to infertility, behavioural problems, birth defects, high cholesterol levels and even cancer  

Read more here 

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Tue, 02 Aug 2022 10:45:00 -0500 text/html https://www.dailymail.co.uk/sciencetech/article-11073139/Rainwater-locations-Earth-contains-unsafe-levels-forever-chemicals-linked-cancer.html
Killexams : Best Undergraduate Business Marketing Programs No result found, try new keyword!Students can study in one of four schools that grant undergraduate ... Arts and entertainment performances, such as the annual Lotus World Music & Arts Festival, take place year-round. Tue, 18 Aug 2020 15:26:00 -0500 text/html https://www.usnews.com/best-colleges/rankings/business-marketing Killexams : First Lotus Eletre SUV Rolls Off Brand New Production Line In China No result found, try new keyword!This marks the beginning of a brand new era for the British sports car manufacturer with plans to sell cars 100,000 annually by 2027. Thu, 28 Jul 2022 07:00:36 -0500 en-au text/html https://www.msn.com/en-au/news/travelinspirations/First-Lotus-Eletre-SUV-Rolls-Off-Brand-New-Production-Line-In-China/ar-AA104TLg Killexams : Concerned about COVID-19?

A worker stands on a platform near a Chinese national flag, Friday, July 15, 2022, in Beijing. China's economy contracted in the three months ending in June compared with the previous quarter after Shanghai and other cities shut down to fight coronavirus outbreaks, but the government said a "stable recovery" is under way after businesses reopened.

Thu, 28 Jul 2022 03:49:00 -0500 en text/html https://omaha.com/lifestyles/health-med-fit/china-backs-away-from-growth-goal-sticks-to-virus-controls/article_6a08b7f2-75df-5a5f-9b59-360efc5ddbf4.html
Killexams : Buoyancy aids are not life vests: expert
  • By Hsu Li-chuan and Jonathan Chin / Staff reporter, with staff writer

Buoyancy aids are not life jackets and should not be used as personal flotation devices, the proprietor of a water sports center said on Thursday after two people the previous day drowned when their raft overturned on Lotus Pond in Kaohsiung’s Zuoying District (左營).

The Kaohsiung District Prosecutors’ Office said that instructor Tsai Mao-yao (蔡茂耀) and a boy surnamed Wang (王), who Tsai was training, died in the incident.

A preliminary investigation showed that Tsai was not wearing a life jacket, while Wang was wearing a buoyancy vest, the office told local media.

Photo: Hsu Li-chuan, Taipei Times

Lotus Pond Water Sports Center chief executive officer Chu Wen-hsiang (朱文祥) said that inappropriate use of a buoyancy aid could have contributed to the drowning.

Many buoyancy aids are designed as a light vest to offer kayakers or rowers ease of movement and some support should their vessel capsize, he said.

Although the vests provide some flotation to help swimmers, they are not intended as a life-saving device, he said.

Buoyancy aids not are designed to generate positive buoyancy, meaning that a person would sink if they stopped swimming, with the additional risk that their head could be submerged even if the vest helped them stay partially afloat, he said.

According to European Standards, a buoyancy device can only be considered a life jacket if it has a load-bearing capacity of 100 newtons, while a life jacket is only suitable for an unconscious person at 150 newtons. A device with a load-bearing capacity of 50 newtons is a buoyancy aid.

As a result, buoyancy vests are rarely used outside of professional water sports, which are governed by different safety regulations, he said.

In Taiwan, only dragon boat rowing festivals in Taipei and Kaohsiung require rowers to wear personal flotation devices, he said, adding that Wang was reportedly wearing a light-duty buoyancy vest used by surfers.

Life jackets can often be distinguished from buoyancy vests as they have crotch straps, which are only utilized due to their greater weight, he said.

In addition, advanced devices have buckles and straps for the chest that help keep the user’s head above the water and make sure the life jacket would not come off when pulled during a rescue attempt, he added.

People should ensure their life jacket has an appropriate European Standards rating, which changes with the body weight of the intended user, he said.

Jackets made by brand names with good reputations that make use of clear technical labeling and an insurance policy are also important issues to consider before making a purchase, he said.

Comments will be moderated. Keep comments relevant to the article. Remarks containing abusive and obscene language, personal attacks of any kind or promotion will be removed and the user banned. Final decision will be at the discretion of the Taipei Times.

Sat, 23 Jul 2022 12:00:00 -0500 text/html https://www.taipeitimes.com/News/taiwan/archives/2022/07/24/2003782323
Killexams : Alvotech Initiates Patient Study for AVT06, a Proposed Biosimilar for Eylea®

Alvotech

  • AVT06 is the third biosimilar candidate developed by Alvotech to enter clinical studies

  • Eylea® (aflibercept) is used for the treatment of eye disorders and reached global sales of nearly US$10 billion in 2021

  • The patient study is expected to enroll approximately 444 participants globally

REYKJAVIK, ICELAND (July 7, 2022) – Alvotech (NASDAQ: ALVO), a global biotech company specializing in the development and manufacture of biosimilar medicines for patients worldwide, announced today the initiation of the company’s confirmatory clinical study for AVT06 (aflibercept), a biosimilar candidate to Eylea®. The objective of the study is to compare AVT06 and Eylea® in terms of efficacy, safety, and immunogenicity in adult patients with neovascular (wet) age-related macular degeneration (AMD).

The study (ALVOEYE) is a randomized, double-masked, parallel-group, multicenter, therapeutic equivalence study, and is expected to enroll approximately 444 participants globally. The study’s primary endpoint is the change in best corrected visual acuity (BVCA) from baseline to week 8.

Eylea® (aflibercept) is a widely used biologic for the treatment of a variety of eye disorders including ones which can lead to vision loss or blindness, such as wet AMD, macular edema, and diabetic retinopathy. In 2021, world-wide sales of Eylea® were nearly US$10 billion1.

“We are delighted at the sustained progress of our product pipeline as we continue to leverage our integrated development and manufacturing platform and execute our global biosimilar strategy,” said Robert Wessman, Founder and Executive Chairman.

Joseph McClellan, Chief Scientific Officer, added: “The initiation of this patient study marks an important step in the development of our AVT06 biosimilar candidate, and demonstrates Alvotech’s commitment to developing biosimilars addressing key therapeutic areas in order to Excellerate the lives of people around the world.”

Alvotech’s current portfolio of eight products and product candidates target treating autoimmune disease, eye disorders, osteoporosis, respiratory disease, and cancer. Alvotech’s lead product, AVT02 (adalimumab), a biosimilar to Humira®, the world’s highest grossing medicine (excluding COVID-19 vaccines), has already been approved and launched in Canada and Europe and is expected to launch in the United States on July 1, 20232. Alvotech has also announced positive topline results for AVT04 (ustekinumab), a proposed biosimilar to Stelara®, from both a confirmatory clinical, safety and efficacy study and a pharmacokinetic (PK) study.

1EVALUATE Pharma
2Subject to regulatory approval

About AVT06 (aflibercept)

AVT06 is a recombinant fusion protein and a biosimilar candidate to Eylea® (aflibercept). Aflibercept binds vascular endothelial growth factors (VEGF), inhibiting the binding and activation of VEGF receptors, neovascularization, and vascular permeability. AVT06 is an investigational product and has not received regulatory approval in any country. Biosimilarity has not been established by regulatory authorities and is not claimed.

About AVT02 (adalimumab)

AVT02 is a monoclonal antibody and a biosimilar to Humira® (adalimumab), which inhibits tumor necrosis factor alpha (TNF-alpha).  AVT02 is not approved outside of the EU, Norway, Iceland, Lichtenstein, the UK, Switzerland, and Canada. AVT02 dossiers are under review in multiple countries; in the U.S. the initial BLA for approval as a biosimilar is in deferred status, pending the result of FDA inspections.

About AVT04 (ustekinumab)

AVT04 is a monoclonal antibody and a biosimilar candidate to Stelara® (ustekinumab). Ustekinumab binds to two cytokines called interleukin-12 and interleukin-23 that are involved in inflammatory and immune responses.  Abnormal regulation of these cytokines has been associated with immune mediated diseases, such as psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. AVT04 is an investigational product and has not received regulatory approval in any country. Biosimilarity has not been established by regulatory authorities and is not claimed.

About Alvotech

Alvotech is a biotech company, founded by Robert Wessman, focused solely on the development and manufacture of biosimilar medicines for patients worldwide. Alvotech seeks to be a global leader in the biosimilar space by delivering high quality, cost-effective products, and services, enabled by a fully integrated approach and broad in-house capabilities. Alvotech’s current pipeline contains eight biosimilar candidates aimed at treating autoimmune disorders, eye disorders, osteoporosis, respiratory disease, and cancer. Alvotech has formed a network of strategic commercial partnerships to provide global reach and leverage local expertise in markets that include the United States, Europe, Japan, China, and other Asian countries and large parts of South America, Africa and the Middle East. Alvotech’s commercial partners include Teva Pharmaceuticals, a US affiliate of Teva Pharmaceutical Industries Ltd. (US), STADA Arzneimittel AG (EU and select other territories), Fuji Pharma Co., Ltd (Japan), Cipla/Cipla Gulf/Cipla Med Pro (Australia, New Zealand, South Africa/Africa), JAMP Pharma Corporation (Canada), Yangtze River Pharmaceutical (Group) Co., Ltd. (China), DKSH (Taiwan, Hong Kong, Cambodia, Malaysia, Singapore, Indonesia, India, Bangladesh and Pakistan), YAS Holding LLC (Middle East and North Africa), Abdi Ibrahim (Turkey), Kamada Ltd. (Israel), Mega Labs, Stein, Libbs, Tuteur and Saval (Latin America) and Lotus Pharmaceuticals Co., Ltd. (Thailand, Vietnam, Philippines, and South Korea). Each commercial partnership covers a unique set of product(s) and territories. Except as specifically set forth therein, Alvotech disclaims responsibility for the content of periodic filings, disclosures and other reports made available by its partners. For more information, please visit www.alvotech.com. None of the information on the Alvotech website shall be deemed part of this press release.

Forward-Looking Statements

Certain statements in this communication may be considered “forward-looking statements.” Forward-looking statements generally relate to future events or the future financial operating performance of Alvotech. For example, Alvotech’s expectations regarding capitalization through equity or debt financing, future growth, results of operations, performance, future capital and other expenditures including the development of critical infrastructure for the global healthcare markets, competitive advantages, business prospects and opportunities including pipeline product development, future plans and intentions, results, level of activities, performance, goals or achievements or other future events, expected patient enrollment, the potential approval and commercial launch of its product candidates and the timing of the announcement of clinical study results, regulatory approvals and market launches, and the estimated size of the total addressable market of Alvotech’s pipeline products. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause real results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Alvotech and its management, are inherently uncertain and are inherently subject to risks, variability, and contingencies, many of which are beyond Alvotech’s control. Factors that may cause real results to differ materially from current expectations include, but are not limited to: (1) the outcome of any legal proceedings that may be instituted against Alvotech or others following the business combination between Alvotech Holdings S.A., Oaktree Acquisition Corp. II and Alvotech, with Alvotech as the surviving company (the “Business Combination”); (2) the ability to maintain stock exchange listing standards; (3) the risk that the Business Combination disrupts current plans and operations of Alvotech; (4) the ability to recognize the anticipated benefits of the Business Combination, which may be affected by, among other things, competition, the ability of the Alvotech to grow and manage growth profitably, maintain key relationships and retain its management and key employees; (5) changes in applicable laws or regulations; (6) the possibility that Alvotech may be adversely affected by other economic, business, and/or competitive factors; (7) Alvotech’s estimates of expenses and profitability; (8) Alvotech’s ability to develop, manufacture and commercialize the product candidates in its pipeline; (9) actions of regulatory authorities, which may affect the initiation, timing and progress of clinical studies or future regulatory approvals or marketing authorizations; (10) the ability of Alvotech or its partners to enroll and retain patients in clinical studies; (11) the ability of Alvotech or its partners to gain approval from regulators for planned clinical studies, study plans or sites; (12) The ability of Alvotech’s partners to conduct, supervise and monitor existing and potential future clinical studies, which may impact development timelines and plans; (13) Alvotech’s ability to obtain and maintain regulatory approval or authorizations of its product candidates, including the timing or likelihood of expansion into additional markets or geographies; (14) the success of Alvotech’s current and future collaborations, joint ventures, partnerships or licensing arrangements; (15) Alvotech’s ability, and that of its commercial partners, to execute their commercialization strategy for approved products; (16) Alvotech’s ability to manufacture sufficient commercial supply of its approved products; (17) the outcome of ongoing and future litigation regarding Alvotech’s products and product candidates; (18) the potential impact of the ongoing COVID-19 pandemic on the FDA’s review timelines, including its ability to complete timely inspection of manufacturing sites; and (16) other risks and uncertainties set forth in the section entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements” in Alvotech’s Registration Statement on Form F-4 or in other documents filed with the SEC. There may be additional risks that Alvotech does not presently know or that Alvotech currently believes are immaterial that could also cause real results to differ from those contained in the forward-looking statements. Nothing in this communication should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. Alvotech does not undertake any duty to update these forward-looking statements or to inform the recipient of any matters of which any of them becomes aware of which may affect any matter referred to in this communication. Alvotech disclaims any and all liability for any loss or damage (whether foreseeable or not) suffered or incurred by any person or entity as a result of anything contained or omitted from this communication and such liability is expressly disclaimed. The recipient agrees that it shall not seek to sue or otherwise hold Alvotech or any of its directors, officers, employees, affiliates, agents, advisors, or representatives liable in any respect for the provision of this communication, the information contained in this communication, or the omission of any information from this communication.

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Thu, 07 Jul 2022 09:35:00 -0500 en-US text/html https://finance.yahoo.com/news/alvotech-initiates-patient-study-avt06-152800898.html
Killexams : Why This Is the Year to Rally Around ‘Better Call Saul’ at the Emmys — A Respectful Demand

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With the final round of 2022 Emmy voting on the horizon, IndieWire TV writers Ben Travers and Steve Greene decided the time was right for a Double Take discussion on — and a call to arms for — the beloved, long-running AMC drama “Better Call Saul.” This is that discussion. 

Ben Travers: A great philosopher once said, “Ain’t nuthin’ over ’til it’s over,” and for the great AMC cable drama “Better Call Saul,” the final bell won’t ring until 2023 — at least, when it comes to the Emmys. Vince Gilligan and Peter Gould’s acclaimed prequel to “Breaking Bad” has only three episodes left before it’s lights out, with the series finale set to air Monday, August 15. But splitting its final season into two parts — the first of which wrapped in May — means Season 6a is eligible for this year’s Emmys and Season 6b will be eligible for next year’s awards.

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Its predecessor’s closing hours shared a similar rollout, albeit with a much longer wait in between. “Breaking Bad” Season 5a ran through late summer 2012 before Season 5b picked up in August 2013, resulting in 13 nominations (and three wins) at the 2013 Emmys (for 5a) and 16 nominations (and six wins) at the 2014 Emmys (for 5b). Despite the nine-month wait between its initial airing and Emmy voting, the final half-season of “Breaking Bad” earned more nominations and more wins than any previous season, even topping major competitors like “True Detective” (Season 1), “Game of Thrones,” and the first half of the “Mad Men” goodbye.

So, Stephen, why the urgency? Why have we convened our two-person emergency campaign committee to insist voters get behind “Better Call Saul” now, rather than sit back and trust the flowers are coming for Season 6b? Why, beyond the subjective merit of the submitted episodes (which, it must be said, is of the highest regard) does it feel like gold will be bestowed this September or not at all?

Among other specific trends — like the series’ decline in yearly nominations since peaking with nine in 2019, compared to “Breaking Bad” rising or breaking even while winning at least once every year — I’d first cite that the TV world has changed drastically since “Breaking Bad” was honored. The Emmys have, too. In 2014, “House of Cards” was nominated for its second season. Streaming had yet to place its stranglehold on TV, the Emmys, and Hollywood at large. Premium and basic cable were still the (relatively) new kids on the block, boxing out broadcast before they, too, started to be boxed out by Netflix, Hulu, Disney+, and more. When “Breaking Bad” ended, AMC’s clout was at its peak. “Mad Men” had already scored four Drama wins. “The Walking Dead” was a ratings juggernaut. A little show called “Halt and Catch Fire” was set to pick up the mantle as AMC’s next great drama.

But ever since “Halt” never sparked with Emmy voters (or the public at large), the TV Academy’s attention has drifted — or, more accurately, it’s been overwhelmed. In 2013, when “Breaking Bad” last aired, 349 TV shows were released. Just two years later, when “Better Call Saul” premiered, the total jumped to 422 —and kept climbing. In 2021, there were 559 shows. At the same time, cords were cut and streaming ascended. People don’t watch TV the way they used to, and there’s also more TV than ever.

That’s made things hard on cable dramas like “Better Call Saul,” but even I didn’t realize how hard until I reviewed the series’ Emmy stats this morning. While a consistent presence on nominations’ day, “Better Call Saul” has never won an Emmy. Let me say that again, because it’s truly shocking: Despite 118 categories, five years of eligibility, and multiple nominations in every eligible year, “Better Call Saul” has gone 0-39 at the Emmys.

It’s safe to say “Better Call Saul” is long overdue, which is reason enough for our rallying cry, but before I get too carried away, Stephen, help me out. You’ve been reviewing every episode of this series for years now. You’ve been in the trenches, week in and week out. You’re looking at the same Emmy figures as I am. What are the categories where “Better Call Saul” most demands recognition, and do you agree the odds of being recognized this year are better than a year from now?

Steve Greene: Well, Benjamin, let’s look at where this show has been overlooked in the past. For years, it was a given that “Better Call Saul” would take at least one slot in the Supporting Actor in a Drama category, and the recognition always went to Jonathan Banks and/or Giancarlo Esposito, two people reprising iconic roles. But there was no room for the iconic newcomer, Michael McKean, whose lone nomination came in the Guest Actor category. (Here’s my turn at reemphasizing something: Not only was that McKean’s only nomination for this show — he should have won the dang category three years running — it’s his only Emmy nom… ever? Unacceptable. I know the Academy’s list of egregious oversights is reaching the length of a few “Pacific Reporter volumes” these days, but let McKean’s slight be on the first few pages, at least.)

“Better Call Saul” - Credit: Greg Lewis/AMC/Sony Pictures Television

Greg Lewis/AMC/Sony Pictures Television

Both Banks and Esposito are absent from this year’s list, which is partly due to the “Succession”/”Severance”/Squid Game” wave taking a giant chunk of the category for themselves. But it’s also an indication that this is a show that has been a victim of its own success. Not only do Esposito and Banks continue to turn in meticulous, dazzling work, you could easily make an airtight case that the inimitable Tony Dalton deserved serious attention for Season 6a (to say nothing of Michael Mando, who would have been a worthy Guest Actor contender). With so many worthy options, there wasn’t a clear choice to knock off Billy Crudup for that last 2022 spot. The fact that none of them made the final cut does mean that Bob Odenkirk and Rhea Seehorn can get the full acting nominee push over the coming weeks. The show’s recent string of episodes is a week-by-week showcase, something that none of their competition have at the moment.

There’s also an argument to be made for the show’s other categories, where “Better Call Saul” is offering something that the presumed favorites aren’t. Take Sound Editing, where it’s up against five shows that have aliens and monsters. For a show set in mid-2000s Albuquerque to break through a genre-heavy clutter like that, the Nacho stakeout scenes in their submission episode stand out in a way that a space-heavy soup might not. Same goes for music supervisor Thomas Golubić, who has consistently foregone easy nostalgia bait for a true atmospheric complement to this season’s hop across multiple continents. Had “Succession” not snaked almost half the Directing category, Michael Morris’ work on the season premiere or Gilligan’s on the following episode would have been a shoo-in for one of those extra slots. But if there’s any episode of the show that could convince an outsider or a newcomer that “Better Call Saul” is worthy of a writing award, Tom Schnauz’s nominated midseason finale is the one.

I’m guessing, though, that Odenkirk and Seehorn are going to have to be the rising tides that lift all those other boats. We clearly both think they’re deserving, but do you think there are enough Academy voters who haven’t seen all six seasons but will still vote for it to put “Better Call Saul” over the top?

Ben: Ah, the million-dollar question: What are Emmy voters actually watching?

“Better Call Saul’s” consistency at the Emmys — earning seven-to-nine nominations each year — is an indication both of the show’s promise and its impediments. Getting an Outstanding Drama Series nod six years in a row, with two ineligible years in between and a steady fluctuation of competitors, is quite a feat. Every member of the TV Academy votes in the Outstanding Program categories, which means there’s a strong base of “Better Call Saul” viewers who like what they see, year in and year out.

But that group does not appear to be expanding. The show’s 46 nominations have come in only 12 categories. Most of them repeat from year to year, like Drama Series, Lead Actor, Writing, and Supporting Actor, with only minor and occasional moves into new areas. The show’s only previously-not-nominated category this year is Supporting Actress, and the lack of a Supporting Actor contender in 2022, as you noted Steve, seems to indicate the shift is more about the math of a given year than a sudden influx of Rhea Seehorn fans. The actors got boxed out, while Seehorn (finally) found her path in.

Now, to answer your question directly — can Bob Odenkirk and Rhea Seehorn actually win — here’s where I hope the math helps out. Voting for the winners opens August 12. “Better Call Saul” airs its series finale three days later. There are few campaign materials more convincing than exciting new episodes airing as people cast their ballots, and the ending of this series will certainly be exciting. And that excitement transcends what happens onscreen. There’s fan excitement, critical excitement, and even industry excitement (AMC still knows how to campaign) over a landmark series reaching its conclusion. There’s nostalgia for folks who loved “Breaking Bad” but only sporadically kept up with “Better Call Saul” (and those viewers should be activated by the impending returns of Bryan Cranston and Aaron Paul), and there’s binge-viewers who are only catching up on the full series now, timed to its ending. The fervor around the series should be peaking, just as voters are deciding who to honor.

Given these factors — plus the show’s continued support from the TV Academy’s acting body — I have to believe Bob Odenkirk and Rhea Seehorn have more than a fighting chance to take home their (and their series’) first Emmys. Supporting Actress is such a consistent mystery that Julia Garner managed to shock experts twice: first by topping every nominee from the final season of “Game of Thrones,” then by winning again the next year, absent any vote-splitting explanations. Garner is again nominated this year, and for the final season of her breakout role in “Ozark,” but there’s a reasonable path to victory for every nominee. Seehorn’s is simple: She’s the best. She’s arguably the most beloved performer on the series, above “Breaking Bad” veterans like Esposito and Banks, not to mention the titular lead himself, Bob Odenkirk.

“Better Call Saul” - Credit: Greg Lewis/AMC/Sony Pictures Television

Greg Lewis/AMC/Sony Pictures Television

But Odenkirk has a decent shot, too. If the “Succession” leads split the vote among the dominant HBO series’ die-hard Academy contingent (some folks’ favorites are set in stone), that leaves “Squid Game’s” Lee Jung-jae as the leader in the clubhouse. To be perfectly honest, he’s my bet at the moment (purely as a prognosticator), but that’s where the well-timed swell of support could lift Odenkirk to victory. “Breaking Bad” won its first Drama Series Emmy as its last episodes were airing. While Drama Series may be out of reach, “Better Call Saul” certainly deserves a comparable boost.

From the outside looking in, it feels like such a surge is possible — and much more likely to happen now than a year from now, when the TV Academy’s attention either drifts to the shiny new show or gets overwhelmed by hundreds of fresh competitors — but Steve, as our “BCS” expert, what are your thoughts on the elusive momentum “Better Call Saul” has yet to catch? What about the show has kept it from reaching the same heights as its predecessor, both at the Emmys and in the culture at large? The reviews are incredibly strong. The fandom seems quite pleased. The release model is similar, airing first on AMC before eventually landing on Netflix (and, now, AMC+). Yet the lead-up to this ending feels far removed from the intense, all-consuming build-up to “Breaking Bad’s.” Is it simply a “lightning doesn’t strike twice” scenario? Is “too much TV” to blame? And could the added benefit of seeing the full picture lead to a reappraisal — if not now, then next year?

SG: Part of me wonders if “Game of Thrones” just fundamentally broke the Emmys in some way that hasn’t quite healed, at least when it comes to the Drama category. It set an expectation of spectacle, one that the show itself spent multiple years chasing. The other two shows to win in its wake may not have explosions or giant monsters (depending on your views on Logan Roy or Margaret Thatcher), but they’re marked by decadence and opulence. Add in “The Handmaid’s Tale,” which had to destroy the entire country (and Fenway Park) in order to succeed creatively, and there’s a precedent where substance has to come paired with size.

The beauty of “Better Call Saul” is that it’s resisted a lot of those instincts. As noted earlier, the show has a global scope, but it’s built by late-night conversations, not dazzling helicopter shots. The same is true on the performance side. Odenkirk hasn’t gotten his “I am the danger” moment, because he doesn’t need one. The Jimmy-to-Saul pipeline is more gradual and insidious than Mr. Chips-to-Scarface. It’s a character capable of his own menace and misdeeds, but it comes with a more internal struggle against forces way beyond his control.

Without sounding too callous, I think Season 6a ended with the closest thing this show can get to those pre-set expectations. “Better Call Saul” has always toyed with its own ticking time bomb tension, but that nominated midseason finale culminates in a shocking moment of violence that felt both inevitable for the show and completely earned. It also happens to be the form of stakes-raising that a wide viewing audience associates with “good drama,” even on shows that haven’t done a fraction of the character work to make a shocking moment like that mean something.

There are plenty of moving parts in that sequence, including the aforementioned Schnauz’s writing. What really sells the gravity of the moment and everything that led to it is Odenkirk and Seehorn, who look as viscerally shaken as any two fictional people have ever been on screen. The Academy tends to go for capital-a Acting. Even a more muted performance like Matthew Rhys’ likely benefited from his character having to become multiple people as much as having last-season goodwill. “Better Call Saul” now has the centerpiece that can grab those playing catch-up and validate everyone who for years has been saluting the work that both of them have done on other parts of the emotional spectrum.

Regardless of the reason, as Ben mentioned, the pieces are in place now for “Better Call Saul” to get the recognition that it’s deserved for almost a decade. Sure, there’ll be next year, but to quote a morally suspect attorney quoting a morally suspect director (quoting himself), “It’s showtime, folks!”

“Better Call Saul” airs Mondays at 9 p.m. ET on AMC and is available on AMC+. 

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Thu, 28 Jul 2022 14:25:00 -0500 en-US text/html https://www.yahoo.com/video/why-rally-around-better-call-193038556.html
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