Direct download links of 150-230 brain dumps at killexams.com

Rather than wasting period and money upon searching updated ITIL 2011 Foundation queries, you should move forward and sign up on killexams.com. Download 100% free of charge dumps purchase complete 150-230 dumps questions version. Read plus pass the 150-230 examination.

Exam Code: 150-230 Practice test 2022 by Killexams.com team
150-230 ITIL 2011 Foundation

EXAM ID : 150-230
EXAM NAME : ITIL 2011 Foundation

Candidates can expect to gain knowledge and understanding in the following upon successful completion of the education and examination components related to this certification.
 Service management as a practice (comprehension)
 The ITIL service lifecycle (comprehension)
 Generic concepts and definitions (awareness)
 Key principles and models (comprehension)
 Selected processes (awareness)
 Selected functions (awareness)
 Selected roles (awareness)
 Technology and architecture (awareness)
 Competence and training (awareness)

The syllabus will guide the design, development and use of training materials as well as training aimed at raising individual’s understanding of, and competence in, IT service management as described in the ITIL Service Strategy, ITIL Service Design, ITIL Service Transition, ITIL Service Operation, ITIL Continual Service Improvement, ITIL Introduction and ITIL Glossary publications. The syllabus has been designed with ease of reference, extensibility and ease of maintenance in mind.
Candidates for the ITIL Foundation certificate in IT service management have to complete all units and successfully pass the corresponding examination to achieve certification.
Training providers are free to structure and organize their training in the way they find most appropriate, provided the units below are sufficiently covered. It is strongly recommended that training providers do not structure their courses by simply following the order of the training units as described in this document. It has been designed to be flexible so that training providers can add value as appropriate.
The recommended number of study days is 3 when taught in a classroom environment, which can include the final exam.

ITIL 2011 Foundation
PEOPLECERT Foundation study help
Killexams : PEOPLECERT Foundation study help - BingNews https://killexams.com/pass4sure/exam-detail/150-230 Search results Killexams : PEOPLECERT Foundation study help - BingNews https://killexams.com/pass4sure/exam-detail/150-230 https://killexams.com/exam_list/PEOPLECERT Killexams : Foundation Year in Science, Engineering and Maths (CertHE)

The Foundation Year in Science, Engineering and Maths is a one-year introductory course, designed to prepare you to progress to undergraduate study in a non-clinical STEM degree subject.

The course comprises five units: Core Chemistry or Core Physics, two maths units, a study skills unit and a group project.

You will choose either a chemistry or a physics pathway depending on the degree subject you aim to study after the course. You will also take core units in maths, building your confidence and ability in using maths to solve problems in science and engineering.

You will need to dedicate at least 25 hours each week to lectures, seminars and independent study.

The course is designed for students returning to education without prior qualifications and includes tailored support to help you to transition to degree-level study. You will be able to meet with a personal tutor and you will have access to peer mentoring and academic skills development. Tutors on the Foundation Year are specialists in their subject area. You will also learn key academic skills, such as essay writing and making the most of the library.

If you complete the course with the required pass rate of 60 per cent overall, you are guaranteed an offer on an undergraduate degree at Bristol. We cannot certain you will be able to progress to your first choice of degree as this may depend on places available and your attainment on relevant assignments during the course but, if your first choice is not available, we will do our best to offer you a satisfactory alternative. Please note, this course is not suitable preparation for a degree in medicine, veterinary science or dentistry.

Applications are made directly to the University. Applications for 2023 entry will open in Spring 2023.

If you have questions about the Foundation Year or the application process, please contact fystem-info@bristol.ac.uk.

Tue, 11 Oct 2022 03:47:00 -0500 en text/html https://www.bristol.ac.uk/study/undergraduate/2023/foundation-science-engineering-mathematics/cert-foundation-science-engineering-maths/
Killexams : Optical foundations illuminated by quantum light

Optics, the study of light, is one of the oldest fields in physics and has never ceased to surprise researchers. Although the classical description of light as a wave phenomenon is rarely questioned, the physical origins of some optical effects are. A team of researchers at Tampere University have brought the discussion on one fundamental wave effect, the debate around the anomalous behavior of focused light waves, to the quantum domain.

The researchers have been able to show that quantum waves behave significantly differently from their classical counterparts and can be used to increase the precision of distance measurements. Their findings also add to the discussion on physical of the anomalous focusing behavior. The results are now published in Nature Photonics.

"Interestingly, we started with an idea based on our earlier results and set out to structure for enhanced measurement precision. However, we then realized that the underlying physics of this application also contributes to the long debate about the origins of the Gouy phase anomaly of focused light fields," explains Robert Fickler, group leader of the Experimental Quantum Optics group at Tampere University.

Quantum waves behave differently but point to the same origin

Over the last decades, methods for structuring light fields down on the single photon level have vastly matured and led to a myriad of novel findings. In addition, a better of optics' foundations has been achieved. However, the physical origin of why light behaves in such an unexpected way when going through a focus, the so-called Gouy phase anomaly, is still often debated. This is despite its widespread use and importance in optical systems. The novelty of the current study is now to put the effect into the quantum domain.

"When developing the theory to describe our experimental results, we realized (after a long debate) that the Gouy phase for quantum light is not only different than the standard one, but its origin can be linked to another quantum effect. This is just like what was speculated in an earlier work," adds Doctoral researcher Markus Hiekkamäki, leading author of the study.

In the quantum domain, the anomalous behavior is sped up when compared to classical light. As the Gouy phase behavior can be used to determine the distance a beam of light has propagated, the speed up of the quantum Gouy could allow for an improvement in the precision of measuring distances.

With this new understanding at hand, the researchers are planning to develop novel techniques to enhance their measurement abilities such that it will be possible to measure more complex beams of structured photons. The team expects that this will help them push forward the application of the observed effect, and potentially bring to light more differences between quantum and classical light fields.



More information: Markus Hiekkamäki et al, Observation of the quantum Gouy phase, Nature Photonics (2022). DOI: 10.1038/s41566-022-01077-w

Provided by Tampere University

Citation: Optical foundations illuminated by quantum light (2022, October 7) retrieved 17 October 2022 from https://phys.org/news/2022-10-optical-foundations-illuminated-quantum.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Thu, 06 Oct 2022 12:00:00 -0500 en text/html https://phys.org/news/2022-10-optical-foundations-illuminated-quantum.html
Killexams : EOU’s Foundation poised to supply away more than $850,000

Mon, 03 Oct 2022 05:00:00 -0500 en text/html https://www.eastoregonian.com/news/local/eou-s-foundation-poised-to-give-away-more-than-850-000/article_0c135c6d-a945-5157-bd2f-f72823f99b49.html Killexams : Study lays foundation to predict antidepressant response in people with suicide attempts

Mayo Clinic researchers have discovered that people with major depressive disorder and a history of attempted suicide have distinct biomarkers that correlate with their response to antidepressant therapy. The new findings, published in Frontiers in Pharmacology, are key to individualized treatment strategies and early identification of patients who are at the highest risk for suicide.

For the study, the researchers used multi-omics technologies—specifically, and genomics—to analyze samples from 350 patients with . They compared samples of patients with and without a history of attempt(s) and found distinct blood-based multi-omics signatures between the two groups, despite all patients having the same diagnosis of major depressive disorder.

Nearly 700,000 people worldwide die by suicide every year, along with 10-20 times as many non-fatal suicide attempts, according to the World Health Organization. A prior suicide attempt is the highest risk factor for suicide in the general population.

"Evaluating suicidal patients can be challenging because clinical risk assessments are inherently subjective and major depressive disorder has high degrees of variability," says Paul Croarkin, D.O., M.S., a psychiatrist in Mayo Clinic's Department of Psychiatry and Psychology, and senior investigator of the study. "Our study lays a foundation for advancing the prognostic potential of this disease and enhancing patient outcomes that use both biological and digital biomarkers."

The team found that variations in the genes CLOCK and ARNTL differentiate in patients with and without a prior suicide attempt. Both genes are related to the circadian rhythm, which regulates critical functions in the body, including behavior, metabolism, hormone levels and sleep. These specific gene variations are also associated with lower antidepressant response and remission rates.

Metabolomics is the study of metabolites, which are substances created when the body breaks down food, drugs or its own tissue. Genomics is the study of genes, which can influence enzymes that are crucial for metabolizing medicines. While individually they explain aspects of biological processes, analyzing them jointly has potential of revealing interactions that were previously not studied.

Altogether, multi-omics is a combination of two or more "omics" approaches. Additional multi-omics examples include proteomics, the study of proteins; epigenomics, the study of epigenetic changes on DNA; and transcriptomics, the study of RNA molecules.

By simultaneously evaluating the genome and metabolome, the researchers discovered biological signatures that could not be found by the or metabolome alone.

The study is part of ongoing efforts at Mayo Clinic to understand the biology of suicidality to Strengthen diagnostic approaches, treatments, and outcomes for patients with depression and other mood disorders.



More information: Caroline W. Grant et al, Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder, Frontiers in Pharmacology (2022). DOI: 10.3389/fphar.2022.984383

Citation: Study lays foundation to predict antidepressant response in people with suicide attempts (2022, October 3) retrieved 17 October 2022 from https://medicalxpress.com/news/2022-10-foundation-antidepressant-response-people-suicide.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Mon, 03 Oct 2022 05:29:00 -0500 en text/html https://medicalxpress.com/news/2022-10-foundation-antidepressant-response-people-suicide.html
Killexams : Family Heart Foundation Study Shows Some Children With Homozygous Familial Hypercholesterolemia Miss out on Decades of Life-Saving Treatment

Only Children with the Most Severe HoFH are Diagnosed Before Adulthood, Putting those Not Identified Early at Risk for Heart Disease at a Young Age

Findings presented in poster at AAP National Conference

ANAHEIM, Calif., October 11, 2022--(BUSINESS WIRE)--The Family Heart Foundation, a leading research and advocacy organization, shared results from an analysis of patients in its CASCADE FH® Registry showing that children with homozygous familial hypercholesterolemia (HoFH) are diagnosed earlier and have much higher untreated low-density lipoprotein cholesterol (LDL-C) than adults with HoFH. The data raises the possibility that only children with the most severe cases of HoFH are being diagnosed early. In addition, others who may have somewhat lower LDL-C are not identified early and miss out on decades of life-saving treatment, which could lead to heart disease earlier in life. The findings were presented in a poster titled, "Characterization of Children with Homozygous Familial Hypercholesterolemia from the CASCADE FH Registry," at the American Academy of Pediatrics (AAP) National Conference & Exhibition on Oct. 7-11 in Anaheim, Calif.

Findings showed that the median age for developing cardiac disease was 8.9 years, and the earliest reported diagnosis of cardiac disease occurred at ages 2 and 3 years in children who underwent curative liver transplants at 4 and 8 years respectively. HoFH, a rare genetic condition characterized by extremely elevated levels of serum LDL-C, affects both children and adults. People with HoFH have a risk of premature atherosclerotic cardiovascular disease (ASCVD) as early as the first decade of life. Many children do not have physical findings suggestive of HoFH and the only way to determine they have HoFH is to do a lipid panel or genetic testing.

"These findings and exact improvement in lipid-lowering therapies make a compelling case for rigorous compliance with AAP’s guidelines on lipid screening for children with a family history of FH or ASCVD at age 2," said Mary P. McGowan, M.D., chief medical officer, Family Heart Foundation, and study co-author. "This should be followed by cascade family screening. Unfortunately, even routine screening between ages 9 and 11, as recommended by the AAP, is not the standard in the United States. There is a clear need to implement universal screening so that all children with HoFH and the less severe heterozygous familial hypercholesterolemia (HeFH) are consistently identified."

The analysis included a total of 67 HoFH patients enrolled at sites participating in the CASCADE FH Registry, a multi-site patient registry created in 2013 by the Family Heart Foundation that tracks the characteristics, treatment patterns and clinical events in HeFH and HoFH patients in the U.S. The current data compares 16 HoFH pediatric patients (<18 years old) to 51 adults. At time of enrollment into the CASCADE FH Registry, nearly 19% and 44% of the children had evidence of aortic valve stenosis and cardiac disease, respectively.

About Familial Hypercholesterolemia

Familial hypercholesterolemia is a common life-threatening genetic condition that causes high cholesterol from birth. As many as 1 in 250 people are estimated to have FH. There are two forms of FH: Heterozygous Familial Hypercholesterolemia and Homozygous Familial Hypercholesterolemia. HoFH is the most serious and more rare form of FH. It is estimated that HoFH affects as many as 1 in 300,000 people around the world. A person who has HoFH has inherited two FH genes, one from each parent. If untreated, the LDL-C level is typically between 400-1000 mg/dL, four to 10 times more than the normal level.

About the Family Heart Foundation

The Family Heart Foundation is a nonprofit research and advocacy organization. The Foundation is a pioneer in the application of real-world evidence, patient-driven advocacy, and multi-stakeholder education to help prevent heart attacks and strokes caused by FH and elevated Lipoprotein(a), or Lp(a), two common genetic disorders that have an impact across generations. The Family Heart Foundation conducts innovative research to break down barriers to diagnosis and management of inherited lipid disorders; educates patients, providers, and policy makers; advocates for change; and provides hope and support for families impacted by heart disease and stroke caused by FH, HoFH, and high Lp(a). The organization was founded in 2011 as the FH Foundation. For more information, visit FamilyHeart.org and follow us on Twitter, Facebook, Instagram and LinkedIn.

View source version on businesswire.com: https://www.businesswire.com/news/home/20221011005248/en/

Contacts

Juliet Babros
310-375-7870
juliet@merrymancommunications.com

Tue, 11 Oct 2022 03:01:00 -0500 en-US text/html https://finance.yahoo.com/news/family-heart-foundation-study-shows-150000502.html
Killexams : Study advances knowledge of role of brain pathology and cognitive fatigue in multiple sclerosis

Using advanced diffusion neuroimaging technology, Kessler Foundation researchers investigated the relationship between the rate of cognitive fatigue to microstructural changes in the brain in persons with multiple sclerosis. Their findings help fill a gap in the current understanding of how brain pathology influences the development of fatigue over time.

Their findings were reported in Frontiers in Neurology on July 04, 2022, in the open access article "Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis." The authors are Cristina Almeida Flores Román, PhD, Glenn Wylie, DPhil, John DeLuca, PhD, and Bing Yao, PhD, and of Kessler Foundation.

The study was conducted at the Rocco Ortenzio Neuroimaging Center at Kessler Foundation, which is dedicated solely to rehabilitation research. Participants were 62 individuals with relapsing-remitting MS. All completed questionnaires measuring depression, state and trait anxiety, and trait fatigue. While in the scanner, participants underwent a cognitively fatiguing task. In addition to measuring rate of cognitive fatigue, researchers measured whole brain lesion volume and performance during the fatigue-inducing task.

"We found that the cognitive rate related to white matter tracts, many with associations with the basal ganglia or what we have proposed as the 'fatigue network'," said lead author Dr. Román, National MS Society postdoctoral fellow at Kessler Foundation. "These findings bring us closer to understanding how brain pathology impacts the experience in the moment. This is fundamental to developing effective interventions for managing the disabling fatigue of MS and other neurological conditions."

Funding: Kessler Foundation, National Multiple Sclerosis Society (RG-1701-26930)

Story Source:

Materials provided by Kessler Foundation. Note: Content may be edited for style and length.

Wed, 05 Oct 2022 12:00:00 -0500 en text/html https://www.sciencedaily.com/releases/2022/10/221001104312.htm
Killexams : Study finds setting sleep schedule can help adolescents get an hour of more sleep study finds setting sleep schedule can help adolescents get an hour of more sleep © Provided by Times Now study finds setting sleep schedule can help adolescents get an hour of more sleep

Washington: According to the National Sleep Foundation and the American Academy of Sleep Medicine, most adolescents get less than eight, especially on school nights, even though they need eight to 10 hours of sleep per night to maintain physical health, emotional well-being and school performance.

Newly published research from RUSH in the journal SLEEP sheds light on how adolescents can get more shut-eye.

"There are a lot of changes a teen goes through," said Stephanie J. Crowley, PhD, associate professor of psychiatry and behavioural sciences and the director of the Pediatric Chronobiology and Sleep Research Program at RUSH. "One specifically is a change to sleep biology that happens during puberty."

"The brain systems that control sleep change in such a way that it's easier for an adolescent to stay awake later into the evening. One of these systems -- the 24-hour circadian clock -- shifts later in time," Crowley said.

So there are two competing forces: one to go to bed earlier for the school schedule and the other a biological change that happens naturally to a teen's body.

Because of this complex conflict, RUSH researchers set out to test a two-week intervention that targets the circadian system with different behavioural measures and tries to help the teens figure out a better nighttime routine.

To combat teen sleep deprivation, the researchers used bright light therapy on two weekend mornings for a total of 2.5 hours. The bright light cues the internal clock to wake up a little earlier. This shift should make it easier for the teen to fall asleep at an appropriate time.

Less tired, irritable

Crowley and her team then helped counteract sleep deprivation by providing time management tools and addressing barriers to an earlier bedtime, like limiting certain after-school activities.

Researchers were able to shift the teens' bedtime by an hour and a half earlier, and their total sleep time increased by approximately an hour.

"The interesting thing is that teens with late circadian clocks shifted by up to two hours earlier," Crowley said. "And the teens who had an earlier circadian clock didn't need to be shifted any earlier. They just needed the behavioural support of trying to manage their time in the evening and increase their sleep duration."

The researchers also found that the teens in the intervention group were less tired, less irritable and less worried, and they exhibited better concentration. The students' morning alertness improved as well.

The RUSH researchers are following the participants in another study to determine whether the adolescents were able to maintain their improved sleep routine.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a dietician before starting any fitness programme or making any changes to your diet.

Mon, 10 Oct 2022 02:48:00 -0500 en-IN text/html https://www.msn.com/en-in/health/healthnews/study-finds-setting-sleep-schedule-can-help-adolescents-get-an-hour-of-more-sleep/ar-AA12NF54
Killexams : Guide Dogs for the Blind and American Foundation for the Blind Release Research Study Findings

Report Reveals Travel Trends and Mixed Results for Rideshare

SAN RAFAEL, Calif., & WASHINGTON, D.C., September 22, 2022--(BUSINESS WIRE)--Guide Dogs for the Blind (GDB) and the American Foundation for the Blind (AFB) have announced the findings of The Role of Guide Dogs in 2022 and Beyond, a joint, two-year research study to examine the long-term outlook for guide dog use in the United States and Canada.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220922005306/en/

Ever Arreola and his guide dog, Falante (Photo: Business Wire)

Top findings for the first-of-its-kind study, revealed a greatly expanded use of technology among travelers who are blind or visually impaired, and a shift to using rideshare services from public transit and walking.

The study was conducted in 2020 and 2021 through a survey of more than 500 people who are blind or visually impaired including both guide dog users and nonusers. It included focus groups and interviews with more than 50 individuals, including graduates from various guide dog schools in the U.S. and Canada, people who use a white cane instead of a guide dog, and instructors who work with the blindness community around orientation and mobility (O&M) skills needed to qualify for a guide dog.

An increase in use of smartphones and apps has shed new light on the importance of integration of technology in travel for people who are blind or visually impaired. Approximately three-fourths of guide dog users surveyed reported use of smartphones during travel, with wayfinding apps (Google Maps, Soundscapes) as well as visual interpreting apps (Be My Eyes, AIRA) among the most commonly used.

Participants in the study also reported that they walk and use public transit less often because of the increased availability of door-to-door rideshare services. While the convenience of rideshare has great appeal to travelers who are blind or visually impaired, the study also showed that rideshare access denials and concerns about fraudulent service dogs often played a devastating role in the lives of guide dog users.

These mixed rideshare findings point to a need for greater awareness and advocacy to defend guide dog users’ access to Uber and Lyft, among both the public and rideshare companies. Some participants also expressed interest in receiving training and resources to aid them when they are denied access.

Overall, the guide dog lifestyle received high praise and enthusiasm from respondents. Guide dog users cited both practical advantages of traveling with a guide dog, such as the ability to walk faster, avoid objects, move smoothly through crowds, and maintain a straight line of travel, as well as emotional benefits. Many conveyed that the companionship, confidence, safety, and social bridge to their community were significant, irreplaceable benefits of using a guide dog.

While the guide dog lifestyle is not a fit for all people who are blind or visually impaired, the study uncovered there is a substantial subset of potential guide dog users who have not acquired the prerequisite mastery of O&M skills to qualify for a guide dog. These skills include spatial orientation, the ability to learn and navigate routes, and the fundamentals of white cane use. Multiple study participants emphasized that there is an extreme shortage of O&M services and instructors, particularly in the U.S., with many reporting that there are huge swaths of the country where it seems that O&M services aren’t available at all.

"These robust findings are very heartening about the future of guide dog use in the U.S. and Canada, but they are also instructive in helping us to remove barriers to enjoying the benefits of the guide dog lifestyle, especially in the areas of rideshare access, travel technology, and O&M training," said Theresa Stern, vice president of interdisciplinary client services and engagement for GDB. "We’re grateful to AFB, who designed this research, and look forward to continuing our partnership with them to Strengthen the lives of people who are blind and visually impaired."

"These research findings point to a number of areas where organizations like AFB and GDB can collaborate with O&M professionals and people who are blind or have low vision to maximize opportunities for independent, safe and efficient travel," said Dr. Arielle Silverman, AFB director of research. "With the general aging of the population and the increasing prevalence of age-related vision loss, studies like this will become imperative to serving the blindness community in the coming decades."

Study findings will be published in peer-reviewed research journals and will be presented at conferences focused on blindness. For a copy of the report, visit guidedogs.com/study.

About Guide Dogs for the Blind

Headquartered in San Rafael, Calif., Guide Dogs for the Blind (GDB) is the largest guide dog school in North America. It is a passionate community that prepares highly qualified guide dogs to empower individuals who are blind or visually impaired to move through the world more safely and confidently. This year marks the organization’s 80th anniversary of helping its clients live the lives they want to live. More than 16,000 guide teams have graduated from GDB since it was founded in 1942. GDB not only improves mobility for its clients, but it also furthers inclusion and advocates for policy reforms that change how the world views blindness. GDB’s services are provided free of charge, and it receives no government funding. The organization was the subject of an award-winning 2018 documentary feature film called Pick of the Litter, which can be found on most popular streaming platforms. The film was developed into a television docu-series by the same name that debuted in 2019 on Disney+. For more information, visit guidedogs.com, or call 800.295.4050.

About the American Foundation for the Blind

The American Foundation for the Blind (AFB) mobilizes leaders, advances understanding, and champions impactful policies and practices using research and data. Publisher of the Journal of Visual Impairment & Blindness for over a century and counting, AFB is also proud to steward the accessible Helen Keller Archive, honoring the legacy of our most famous ambassador. AFB’s mission is to expand pathways to leadership, education, inclusive technology, and career opportunities to create a world of no limits for people who are blind, deafblind, or have low vision. To learn more, visit www.afb.org.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220922005306/en/

Contacts

Barbara Zamost
barbara@zamostpr.com
(415) 389-0210

Thu, 22 Sep 2022 02:02:00 -0500 en-US text/html https://finance.yahoo.com/news/guide-dogs-blind-american-foundation-140000587.html
Killexams : Family Heart Foundation Study Shows Some Children With Homozygous Familial Hypercholesterolemia Miss out on Decades of Life-Saving Treatment

Only Children with the Most Severe HoFH are Diagnosed Before Adulthood, Putting those Not Identified Early at Risk for Heart Disease at a Young Age

Findings presented in poster at AAP National Conference

The Family Heart Foundation, a leading research and advocacy organization, shared results from an analysis of patients in its CASCADE FH® Registry showing that children with homozygous familial hypercholesterolemia (HoFH) are diagnosed earlier and have much higher untreated low-density lipoprotein cholesterol (LDL-C) than adults with HoFH. The data raises the possibility that only children with the most severe cases of HoFH are being diagnosed early. In addition, others who may have somewhat lower LDL-C are not identified early and miss out on decades of life-saving treatment, which could lead to heart disease earlier in life. The findings were presented in a poster titled, "Characterization of Children with Homozygous Familial Hypercholesterolemia from the CASCADE FH Registry," at the American Academy of Pediatrics (AAP) National Conference & Exhibition on Oct. 7-11 in Anaheim, Calif.

Findings showed that the median age for developing cardiac disease was 8.9 years, and the earliest reported diagnosis of cardiac disease occurred at ages 2 and 3 years in children who underwent curative liver transplants at 4 and 8 years respectively. HoFH, a rare genetic condition characterized by extremely elevated levels of serum LDL-C, affects both children and adults. People with HoFH have a risk of premature atherosclerotic cardiovascular disease (ASCVD) as early as the first decade of life. Many children do not have physical findings suggestive of HoFH and the only way to determine they have HoFH is to do a lipid panel or genetic testing.

"These findings and exact improvement in lipid-lowering therapies make a compelling case for rigorous compliance with AAP's guidelines on lipid screening for children with a family history of FH or ASCVD at age 2," said Mary P. McGowan, M.D., chief medical officer, Family Heart Foundation, and study co-author. "This should be followed by cascade family screening. Unfortunately, even routine screening between ages 9 and 11, as recommended by the AAP, is not the standard in the United States. There is a clear need to implement universal screening so that all children with HoFH and the less severe heterozygous familial hypercholesterolemia (HeFH) are consistently identified."

The analysis included a total of 67 HoFH patients enrolled at sites participating in the CASCADE FH Registry, a multi-site patient registry created in 2013 by the Family Heart Foundation that tracks the characteristics, treatment patterns and clinical events in HeFH and HoFH patients in the U.S. The current data compares 16 HoFH pediatric patients (<18 years old) to 51 adults. At time of enrollment into the CASCADE FH Registry, nearly 19% and 44% of the children had evidence of aortic valve stenosis and cardiac disease, respectively.

About Familial Hypercholesterolemia

Familial hypercholesterolemia is a common life-threatening genetic condition that causes high cholesterol from birth. As many as 1 in 250 people are estimated to have FH. There are two forms of FH: Heterozygous Familial Hypercholesterolemia and Homozygous Familial Hypercholesterolemia. HoFH is the most serious and more rare form of FH. It is estimated that HoFH affects as many as 1 in 300,000 people around the world. A person who has HoFH has inherited two FH genes, one from each parent. If untreated, the LDL-C level is typically between 400-1000 mg/dL, four to 10 times more than the normal level.

About the Family Heart Foundation

The Family Heart Foundation is a nonprofit research and advocacy organization. The Foundation is a pioneer in the application of real-world evidence, patient-driven advocacy, and multi-stakeholder education to help prevent heart attacks and strokes caused by FH and elevated Lipoprotein(a), or Lp(a), two common genetic disorders that have an impact across generations. The Family Heart Foundation conducts innovative research to break down barriers to diagnosis and management of inherited lipid disorders; educates patients, providers, and policy makers; advocates for change; and provides hope and support for families impacted by heart disease and stroke caused by FH, HoFH, and high Lp(a). The organization was founded in 2011 as the FH Foundation. For more information, visit FamilyHeart.org and follow us on Twitter, Facebook, Instagram and LinkedIn.

© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Tue, 11 Oct 2022 03:09:00 -0500 text/html https://www.benzinga.com/pressreleases/22/10/b29220493/family-heart-foundation-study-shows-some-children-with-homozygous-familial-hypercholesterolemia-mi
150-230 exam dump and training guide direct download
Training Exams List